2007年9月
Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis
MULTIPLE SCLEROSIS
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- 巻
- 13
- 号
- 8
- 開始ページ
- 968
- 終了ページ
- 974
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1177/1352458507077189
- 出版者・発行元
- SAGE PUBLICATIONS LTD
Neuromyelitis optica (NMO) is a relapsing neurologic disease characterized by severe optic neuritis and transverse myelitis. A disease-modifying therapy for NMO has not been established. We retrospectively analysed the effect of low-dose corticosteroid (CS) monotherapy on the annual relapse rate in nine patients with NMO. We divided the clinical course in each patient into two periods; the CS Period in which CS was administered, and the No CS Period in which CS was not administered. Periods related to other immunological therapies, such as high-dose methylprednisolone, immuno-suppressants, interferon -beta, and plasma exchange, were excluded. As a result, the annual relapse rate during the CS Periods [median, 0.49 (range, 0-1.31)] was found to be significantly lower than that during the No CS Periods [1.48 (0.65-5.54)]. As for the dose of CS, relapses occurred significantly more frequently with '10 mg/day or less' than with 'over 10 mg/day' (odds ratio: 8.75). The results of the present study suggest a beneficial effect of low-dose CS monotherapy in reducing relapses in NMO.
- リンク情報
- ID情報
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- DOI : 10.1177/1352458507077189
- ISSN : 1352-4585
- Web of Science ID : WOS:000250669600004