KOBAYASHI Atsushi

J-GLOBAL         Last updated: Nov 12, 2019 at 08:28
 
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Name
KOBAYASHI Atsushi
Affiliation
Hokkaido University
Job title
Lecturer

Research Areas

 
 

Education

 
 
 - 
2006
Graduate School, Division of Medical Sciences, Tohoku University
 
 
 - 
2002
Faculty of Veterinary Medicine, Hokkaido University
 

Awards & Honors

 
Jan 2016
獲得性クロイツフェルト・ヤコブ病の確定診断法の確立, 平成27年度医学奨励賞, 公益社団法人 宮城県医師会
 
Jan 2016
獲得性クロイツフェルト・ヤコブ病の確定診断法の確立, 平成27年度医学部奨学賞銀賞, 東北大学医学部
 
May 2010
平成22年度匂坂記念賞
 
Aug 2007
2007年ベストポスター賞
 

Published Papers

 
Susceptibility of rat immortalized neuronal cell line Rn33B to equine herpesvirus-1 infection is differentiation-dependent
Minato E, Kobayashi A, Aoshima K, Fukushi H, Kimura T
Microbiol Immunol      2019   [Refereed]
Kato Y, Takei J, Sayama Y, Sano M, Konnai S, Kobayashi A, Harada H, Yamada S, Kaneko MK
Monoclon Antib Immunodiagn Immunother.   38(5)    2019   [Refereed]
Yamada S, Itai S, Takei J, Konnai S, Kobayashi A, Nakagun S, Kobayashi Y, Kaneko MK, Kato Y
Monoclon Antib Immunodiagn Immunother.   38(3) 104-107   Jun 2019   [Refereed]
Morita A, Aoshima K, Onishi S, Shibata Y, Yasui H, Kobayashi A, Kimura T
Res Vet Sci   127 1-10   Dec 2019   [Refereed]
Sajiki Y, Konnai S, Okagawa T, Nishimori A, Maekawa N, Goto S, Watari K, Minato E, Kobayashi A, Kohara J, Yamada S, Kato Y, Takahashi H, Terasaki N, Takeda A, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K
J Immunol   203(5) 1313-1324   Sep 2019   [Refereed]
Kobayashi A, Iwasaki Y, Takao M, Saito Y, Iwaki T, Qi Z, Torimoto R, Shimazaki T, Munesue Y, Isoda N, Sawa H, Aoshima K, Kimura T, Kondo H, Mohri S, Kitamoto T
Am J Pathol   189(6) 1276-1283   Jun 2019   [Refereed]
Iwasaki Y, Kato H, Ando T, Akagi A, Mimuro M, Miyahara H, Kobayashi A, Kitamoto T, Yoshida M
Neuropathology   39(3) 240-247   Jun 2019   [Refereed]
Minato E, Aoshima K, Kobayashi A, Ohnishi N, Sasa N, Kimura T
Vet Pathol   56(5) 703-710   Sep 2019   [Refereed]
Aoshima K, Fukui Y, Gulay KCM, Erdemsurakh O, Morita A, Kobayashi A, Kimura T.
BMC Vet Res   14(1) 301   Oct 2018   [Refereed]
Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T.
Prion   12(5-6) 315-319   Nov 2018   [Refereed]
Kato Y, Yamada S, Itai S, Kobayashi A, Konnai S, Kaneko MK
Monoclon Antib Immunodiagn Immunother.   37(6) 272-274   Dec 2018   [Refereed]
Kato Y, Yamada S, Itai S, Konnai S, Kobayashi A, Kaneko MK
Monoclon Antib Immunodiagn Immunother.   37(6) 269-271   Dec 2018   [Refereed]
Kato Y, Yamada S, Itai S, Kobayashi A, Konnai S, Kaneko MK
Monoclon Antib Immunodiagn Immunother.   37(6) 265-268   Dec 2018   [Refereed]
Kobayashi A, Qi Z, Shimazaki T, Munesue Y, Miyamoto T, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Yamashita T, Miyoshi I.
Am J Pathol   189(3) 677-686   Mar 2019   [Refereed]
Kobayashi A, Matsuura Y, Takeuchi A, Yamada M, Miyoshi I, Mohri S, Kitamoto T.
Brain Pathol   29(2) 155-163   Mar 2019   [Refereed]
Ishizawa K, Mitsufuji T, Shioda K, Kobayashi A, Komori T, Nakazato Y, Kitamoto T, Araki N, Yamamoto T, Sasaki A
Brain Behav   8(10) e01117   Oct 2018   [Refereed]
Shimamoto Y, Nio-Kobayashi J, Watarai H, Nagano M, Saito N, Takahashi E, Higuchi H, Kobayashi A, Kimura T, Kitamura H
Vet Immunol Immunopathol   198 6-13   Apr 2018   [Refereed]
Ito Y, Sanjo N, Hizume M, Kobayashi A, Ohgami T, Satoh K, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T.
Biochem Biophys Res Commun   496(4) 1055-1061   Feb 2018   [Refereed]
Munesue Y, Shimazaki T, Qi Z, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Kobayashi A
Neurosci Lett   668 43-47   Mar 2018   [Refereed]
Rahpaya SS, Tsuchiaka S, Kishimoto M, Oba M, Katayama Y, Nunomura Y, Kokawa S, Kimura T, Kobayashi A, Kirino Y, Okabayashi T, Nonaka N, Mekata H, Aoki H, Shiokawa M, Umetsu M, Morita T, Hasebe A, Otsu K, Asai T, Yamaguchi T, Makino S, Murata Y, Abi AJ, Omatsu T, Mizutani T.
J Vet Sci   19(3) 350-357   May 2018   [Refereed]
Maharani A, *Aoshima K, Oonishi S, Gulay KCM, Kobayashi A, Kimura T
Journal of Veterinary Medical Science   80(2) 213-218   Feb 2018   [Refereed]
Iwasaki Y, Saito Y, Aiba I, Kobayashi A, Mimuro M, Kitamoto T, Yoshida M.
Neuropathology   37(3) 241-248   Jun 2017   [Refereed]
Application of protein misfolding cyclic amplification for the rapid diagnosis of acquired Creutzfeldt-Jakob disease
Takeuchi A, Kobayashi A, Morita M, Kitamoto T
Med Res Arch   5(4)    Apr 2017   [Refereed]
Anuj Sehgal, Atsushi Kobayashi, David S. Donaldson, Neil A. Mabbott
Immunobiology   222(2) 316-326   Feb 2017   [Refereed]
Yamazaki M, Fukuda T, Kobayashi A, Takubo H.
Brain Nerve   68(10) 1229-1238   Oct 2016   [Refereed][Invited]
Kobayashi A, Parchi P, Yamada M, Mohri S, Kitamoto T
Neuropathology   36(3) 305-310   Jun 2016   [Refereed][Invited]
Takeuchi A, Kobayashi A, Parchi P, Yamada M, Morita M, Uno S, Kitamoto T.
Lab Invest   96(5) 581-587   May 2016   [Refereed]
Kobayashi A, Teruya K, Matsuura Y, Shirai T, Nakamura Y, Yamada M, Mizusawa H, Mohri S, Kitamoto T
Acta Neuropathol   130(2) 159-170   Aug 2015   [Refereed]
Kobayashi A, Matsuura Y, Iwaki T, Iwasaki Y, Yoshida M, Takahashi H, Murayama S, Takao M, Kato S, Yamada M, Mohri S, Kitamoto T
Brain Pathol   26(1) 95-101   Jan 2016   [Refereed]
Kobayashi A, Parchi P, Yamada M, Brown P, Saverioni D, Matsuura Y, Takeuchi A, Mohri S, Kitamoto T
J Virol   89(7) 3939-3946   Apr 2015   [Refereed]
Araki K, Nakano Y, Kobayashi A, Matsudaira T, Sugiura A, Takao M, Kitamoto T, Murayama S, Obi T
Neuropathology   34(6) 541-546   Jul 2014   [Refereed]
Qina T, Sanjo N, Hizume M, Higuma M, Tomita M, Atarashi R, Satoh K, Nozaki I, Hamaguchi T, Nakamura Y, Kobayashi A, Kitamoto T, Murayama S, Murai H, Yamada M, Mizusawa H
BMJ open   4 e004968   May 2014   [Refereed]
Shirai T, Saito M, Kobayashi A, Asano M, Hizume M, Ikeda S, Teruya K, Morita M, Kitamoto T
Structure   22(4) 560-571   Feb 2014   [Refereed]
Kobayashi A, Matsuura Y, Mohri S, Kitamoto T
Acta Neuropathol Commun   2 32   Mar 2014   [Refereed]
Mabbott NA, Kobayashi A, Sehgal A, Bradford BM, Pattison M, Donaldson DS.
Biogerontology   16(2) 133-145   Apr 2015   [Refereed]
Kobayashi A, Iwasaki Y, Otsuka H, Yamada M, Yoshida M, Matsuura Y, Mohri S, Kitamoto T
Acta Neuropathol Commun   1 74   Nov 2013   [Refereed]
Takeuchi A, Kobayashi A, Ironside JW, Mohri S, Kitamoto T
J Biol Chem   288(30) 21659-21666   Jul 2013   [Refereed]
Kobayashi A* Donaldson DS* Erridge C Kanaya T Williams IR Ohno H Mahajan A Mabbott NA (*equal contribution)
Mucosal Immunol   6(5) 1027-1037   Jan 2013   [Refereed]
Kobayashi A, Donaldson DS, Kanaya T, Fukuda S, Baillie JK, Freeman TC, Ohno H, Williams IR, Mabbott NA
DNA Res   19(5) 407-422   Sep 2012   [Refereed]
Kobayashi A* Donaldson DS* Ohno H Yagita H Williams IR Mabbott NA (*equal contribution)
Mucosal Immunol   5(2) 216-225   Feb 2012   [Refereed]
Mabbott NA, Kenneth Baillie J, Kobayashi A, Donaldson DS, Ohmori H, Yoon SO, Freedman AS, Freeman TC, Summers KM
Immunology   133(4) 482-498   Jan 2011   [Refereed]
Kobayashi A, Mizukoshi K, Iwasaki Y, Miyata H, Yoshida Y, Kitamoto T
Am J Pathol   178(3) 1309-1315   Mar 2011   [Refereed]
Kobayashi A, Sakuma N, Matsuura Y, Mohri S, Aguzzi A, Kitamoto T
J Virol   84(7) 3230-3238   Apr 2010   [Refereed]
Hizume M, Kobayashi A, Mizusawa H, Kitamoto T
Biochem Biophys Res Commun   391(4) 1681-1686   Jan 2010   [Refereed]
Kobayashi A, Asano M, Mohri S, Kitamoto T
Neuropathology   29(5) 619-624   Jul 2009   [Refereed]
Hiraga C, Kobayashi A, Kitamoto T
Biochem Biophys Res Commun   382(4) 715-719   May 2009   [Refereed]
Hizume M, Kobayashi A, Teruya K, Ohashi H, Ironside JW, Mohri S, Kitamoto T
J Biol Chem   284(6) 3603-3609   Feb 2009   [Refereed]
Kobayashi A Hizume M Teruya K Mohri S Kitamoto T.
Prion   3(1) 27-30   Jan 2009   [Refereed]
Kobayashi A, Arima K, Ogawa M, Murata M, Fukuda T, Kitamoto T
Acta Neuropathol   116(5) 561-566   Aug 2008   [Refereed]
Tomoya Morita, Kensuke Nakamura, Osuga Tatsuyuki, Atsushi Kobayashi, Osamu Ichii, Akira Yabuki, Mitsuyoshi Takiguchi
J Vet Med Sci   80(6) 939-944   Apr 2018   [Refereed]
Ikeda S, Kobayashi A, Kitamoto T
Biochem Biophys Res Commun   369(4) 1195-1198   Mar 2008   [Refereed]
Kobayashi A, Asano M, Mohri S, Kitamoto T
J Biol Chem   282(41) 30022-30028   Aug 2007   [Refereed]
Kobayashi A, Satoh S, Ironside JW, Mohri S, Kitamoto T
J Gen Virol   86(Pt1) 237-240   Jan 2005   [Refereed]
Kobayashi A, Katagiri S, Kimura T, Ochiai K, Umemura T
J Vet Med Sci   64(9) 773-777   Sep 2002   [Refereed]
Takei J, Furusawa Y, Yamada S, Nakamura T, SayamaY, Sano M, Konnai S, Kobayashi A, Harada H, Kaneko MK, Kato Y
Monoclon Antib Immunodiagn Immunother.   38(4) 171-174   Jun 2019   [Refereed]
Iwasaki Y, Hiraga K, Ito S, Ando T, Akagi A, Riku Y, Mimuro M, Miyahara H, Kobayashi A, Kitamoto T, Yoshida M
Neuropathology      2019   [Refereed]

Books etc

 
Handbook of Clinical Neurology, Vol. 153, Human Prion Diseases.
Kobayashi A, Kitamoto T, Mizusawa H. (Part:Joint Work, Chapter 12. Iatrogenic Creutzfeldt-Jakob disease.)
Elsevier.   Jun 2018   ISBN:978-0-444-63945-5
Kobayashi A, Kitamoto T, Mizusawa H. Iatrogenic Creutzfeldt-Jakob disease. In: Pocchiari M, Manson J, eds. Human Prion Diseases. San Diego: Elsevier BV, 2018: 207-218.
Clinical Neuroscience, ニューロジェネティクス新時代-次世代シークエンサーが拓く新しい世界.
小林篤史 (Part:Joint Work, 筋疾患・神経疾患のジェネティクス-プリオン病.)
中外医学社   Feb 2018   

Conference Activities & Talks

 
Characterization of “sporadic CJD” with history of neurosurgery to identify potentially iatrogenic cases
*Tsuyoshi Hamaguchi,1 Kenji Sakai,1 Atsushi Kobayashi,2 Tetsuyuki Kitamoto,3 Ryusuke Ae,4 Yosikazu Nakamura,4 Nobuo Sanjo,5 Kimihito Arai,6 Mizuho Koide,6 Fumiaki Katada,7 Masafumi Harada,8 Hiroyuki Murai,9 Shigeo Murayama,10 Tadashi Tsukamoto,11 Hidehiro Mizusawa,11 Masahito Yamada.1
Asian Pacific Prion Symposium 2019   3 Oct 2019   
A novel combination of prion strain co-occurrence in patients with sporadic Creutzfeldt-Jakob disease
*Atsushi Kobayashi1, Yasushi Iwasaki2, Masaki Takao3, Yuko Saito4, Toru Iwaki5, Shirou Mohri6, Tetsuyuki Kitamoto6
Asian Pacific Prion Symposium 2019   3 Oct 2019   
鉛散弾の経口投与によるバルバリーガモの鉛の血中濃度の経時変化および体内分布 の解析
佐藤裕、石井千尋、中山翔太、一瀬貴大、齊藤慶輔、渡邊有希子、小笠原浩平、鳥本亮太、小林篤史、木村亨史、池中良徳、石塚真由美
第162回日本獣医学会学術集会   11 Sep 2019   
A novel combination of prion strain co-occurrence in sporadic Creutzfeldt-Jakob disease
小林 篤史、岩崎 靖、高尾 昌樹、齊藤 祐子、岩城 徹、毛利 資郎、北本 哲之
第60回日本神経病理学会総会学術研究会   16 Jul 2019   
死亡雄アフリカゾウ生殖器における繁殖および病理学的検査
鳥居佳子,Sittinee Kulprasertsri, 小林篤史, 永野昌志, 片桐成二, 栁川洋二郎
第3回野生動物保全繁殖研究会   4 Jul 2019   
Potentiation of High Fat Diet-induced Diabetogenesis by Neonicotinoid insecticides: Elucidation of the Mechanistic Pathways using Invivo Assays
Collins Nimako, Yoshinori Ikenaka, Yukiko OKAMATSU, Atsushi KOBAYASHI
International CHEMICAL HAZARD Symposium 2019   20 Mar 2019   
3P-0570 Analysis of the KDM2B-Mediated Regulation of the Growth, Development, and Maintenance of Canine Hemangiosarcoma
Kevin Christian Montecillo Gulay、青島 圭佑、小林 篤史、木村 享史
第41回日本分子生物学会年会   29 Nov 2018   
Characterization of “sporadic CJD” with history of neurosurgery to identify iatrogenic cases
Tsuyoshi Hamaguchi, Kenji Sakai, Atsushi Kobayashi, Tetsuyuki Kitamoto, Ryusuke Ae, Yosikazu Nakamura, Nobuo Sanjo, Kimihito Arai, Mizuho Koide, Fumiaki Katada, Masafumi Harada, Hiroyuki Murai, Shigeo Murayama, Tadashi Tsukamoto, Hidehiro Mizusawa, Masahito Yamada.
EuroCJD meeting 2018   1 Oct 2018   
What is abnormal prion protein (PrPSc)? [Invited]
Atsushi Kobayashi
19th International Congress of Neuropathology   27 Sep 2018   
ドキソルビシン耐性イヌ血管肉腫細胞株の樹立と薬剤耐性機構の解析
森田敦也、青島圭祐、小林篤史、木村享史
第161回日本獣医学会学術集会   11 Sep 2018   
Notch2 シグナルはイヌ血管肉腫がん幹細胞様細胞の増殖に必要である
青島 圭佑,福井 佑基,小林 篤史,木村 享史
30 Mar 2018   
Neuropathological and biochemical criteria for a new subtype of acquired Creutzfeldt-Jakob disease (MMiK) [Invited]
Atsushi Kobayashi, Masahito Yamada, Atsuko Takeuchi, Shirou Mohri, and Tetsuyuki Kitamoto
24 Nov 2017   
Diagnosis of MMiK type acquired Creutzfeldt-Jakob disease with cell- protein misfolding amplification (PMCA) [Invited]
Atsuko Takeuchi, Atsushi Kobayashi, Masanori Morita, and Tetsuyuki Kitamoto
24 Nov 2017   
Diagnostic approach for a novel acquired CJD subgroup, acquired CJD-MMiK [Invited]
Atsushi Kobayashi
Asian Pacific Prion Symposium 2017   21 Oct 2017   
脳外科手術歴を有するCreutzfeldt-Jakob病の特徴
浜口毅, 坂井健二, 小林篤史, 北本哲之, 阿江竜介, 中村好一, 三條伸夫, 新井公人, 小出瑞穂, 片多史明, 塚本 忠, 水澤英洋, 山田正仁
13 Oct 2017   
Investigation of clinical and pathological features of “sporadic Creutzfeldt-Jakob disease” with history of neurosurgery to identify iatrogenic cases
Tsuyoshi Hamaguchi,1 Kenji Sakai,1 Atsushi Kobayashi,2 Tetsuyuki Kitamoto,3 Ryusuke Ae,4 Yosikazu Nakamura,4 Nobuo Sanjo,5 Kimihito Arai,6 Mizuho Koide,6 Fumiaki Katada,7 Tadashi Tsukamoto,8 Hidehiro Mizusawa,8 Masahito Yamada.1
XXIII World Congress of Neurology   17 Sep 2017   
Iatrogenic Creutzfeldt-Jakob disease related to dura mater grafts [Invited]
Masahito Yamada, Tsuyoshi Hamaguchi, Kenji Sakai, Moeko Noguchi-Shinohara, Ichiro Nozaki, Yu Taniguchi, Atsushi Kobayashi, Atsuko Takeuchi, Tetsuyuki Kitamoto, Yosikazu Nakamura, Nobuo Sanjo, Tadashi Tsukamoto, Masaki Takao, Shigeo Murayama, Yasushi Iwasaki, Mari Yoshida, Hiroshi Shimizu, Akiyoshi Kakita, Hitoshi Takahashi, Hiroyoshi Suzuki, Hironobu Naiki, Hidehiro Mizusawa
PRION2017   26 May 2017   
Clinical and pathological characterization of “sporadic Creutzfeldt-Jakob disease” with histories of neurosurgery to identify iatrogenic cases
Tsuyoshi Hamaguchi, Kenji Sakai, Atsushi Kobayashi, Tetsuyuki Kitamoto, Ryusuke Ae, Yosikazu Nakamura, Nobuo Sanjo, Tadashi Tsukamoto, Hidehiro Mizusawa, Masahito Yamada.
PRION2017   25 May 2017   
Colocalization of Aβ42 with PrPSc-plaques in the brain of the Gerstmann-Sträussler-Scheinker disease with the P105L mutation.
Fumiko Furukawa, Nobuo Sanjo, Atsushi Kobayashi, Tsuyoshi Hamaguchi, Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota
Alzheimer's Association International Conference   24 Jul 2016   
Mechanisms of transmission of prion diseases [Invited]
Atsushi Kobayashi
第57回日本神経学会学術大会   20 May 2016   
Iatrogenic transmission of Creutzfeldt-Jakob disease [Invited]
Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Paul Brown, Daniela Saverioni, Yuichi Matsuura, Atsuko Takeuchi, Shirou Mohri, Tetsuyuki Kitamoto
PRION2016   11 May 2016   
Identification of the origin of Creutzfeldt-Jakob disease after cadaver-sourced pituitary growth hormone treatment using an amplification property in protein misfolding cyclic amplificatiton.
Takeuchi A, Yamamoto M, Parchi P, HaïK S, Morita M, Kobayashi A, Kitamoto T
PRION2016   11 May 2016   
Differential association of amyloid-β with PrPSc pathology in each genetic prion disease.
Fumiko Furukawa, Nobuo Sanjo, Atsushi Kobayashi, Tsuyoshi Hamaguchi, Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota
PRION2016   11 May 2016   
Cell-PMCA of acquired Creutzfeldt-Jakob disease
Atsuko Takeuchi, Atsushi Kobayashi, Piero Parchi, Masahito Yamada, Masanori Morita, Shuusei Uno, Tetsuyuki Kitamoto
Asian Pacific Prion Symposium 2015   4 Sep 2015   
Neuropathological and biochemical criteria to identify acquired Creutzfeldt-Jakob disease among presumed sporadic cases
Atsushi Kobayashi, Masahito Yamada, Yuichi Matsuura, Shirou Mohri, and Tetsuyuki Kitamoto
Asian Pacific Prion Symposium 2015   4 Sep 2015   
Amyloid-β42 deposition in the brain of the Gerstmann-Sträussler-Scheinker disease with the P105L mutation.
Fumiko Furukawa, Nobuo Sanjo, Atsushi Kobayashi, Tsuyoshi Hamaguchi, Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota
Asian Pacific Prion Symposium 2015   4 Sep 2015   
Recent advances in experimental transmission studies of human prion diseases [Invited]
KOBAYASHI Atsushi
4 Jun 2015   
プリオン病 Update [Invited]
KOBAYASHI Atsushi
NeuroCPC   6 Mar 2015   
V180I変異遺伝性プリオン病の臨床・病理解析
日本認知症学会学術集会   2014   
プリオン蛋白遺伝子コドン105変異(P105L)によるGerstmann-Sträussler- Scheinker 症候群(GSS)の臨床像 ―GSS(P102L)との比較解析―
日本神経感染症学会総会学術集会   2014   
Involvement of the dorsal root ganglion in GSS with P105L mutation
Furukawa F, Sanjo N, Kobayashi A, Shiraishi A, Ishikawa K, Yamada M, Kitamoto T, Eishi Y, Mizusawa H.
Asian Pacific Prion Symposium 2014   6 Jul 2014   
Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems.
Kobayashi A, Matsuura Y, Mohri S, Kitamoto T.
Asian Pacific Prion Symposium 2014   6 Jul 2014   
非プリオン病脳におけるプリオンの凝集について
第55回日本神経病理学会総会学術研究会   5 Jun 2014   
皮質や基底核に及ぶ広範囲な海綿状変性と小脳にkuru斑を認めた孤発性Creutzfeldt-Jakob病MV2型の1剖検例
日本神経病理学会総会学術研究会   2014   
孤発性クロイツフェルト・ヤコブ病MV2の新分類
日本神経病理学会総会学術研究会   2014   
Further characterization of PK-resistant PrPsc core fragments in sporadic CJD brains carrying VV or MV at PRNP codon 129
PRION 2014   2014   
Clinical features of Gerstmann-Sträussler-Scheinker syndrome with a P105L mutation and a valine-encoding polymorphic codon 129 in the prion protein gene.
PRION 2014   2014   
Immunohistochemical and neuropathological analyses of the prion protein in genetic Creutzfeldt-Jakob disease with V180I mutation.
PRION 2014   2014   
Revision of Sporadic Creutzfeldt-Jakob Disease with MV2 prions
Asian Pacific Prion Symposium 2013   2013   
脊髄円錐・馬尾に病変を認めた抗アクアポリン4抗体陽性視神経脊髄炎の2症例
高井良樹、三須建郎、中島一郎、高橋利幸、小林篤史、北本哲之、藤原一男、糸山泰人
19 May 2011   
Histidine residues in octapeptide repeats are not essential for the conversion of PrP
Asia-Oceania Symposium on Prion Diseases   2010   
Experimental verification of a traceback phenomenon in prion infection
Asia-Oceania Symposium on Prion Diseases   2010   
ヒト異常型プリオン蛋白特異的抗体の作製
2009年 プリオン研究会   2009   
プリオン蛋白遺伝子のGPIアンカーシグナル配列における1アミノ酸置換と配列の長さがプリオン蛋白の異常化効率に与える影響
2008年プリオン研究会   2008   
プリオン蛋白中のオクタペプチドリピート数が異常化に及ぼす影響
2008年プリオン研究会   2008   
Cross-sequence transmission of sporadic Creutzfeldt-Jakob disease creates a new prion strain
Transmissible Spongiform Encephalopathies The definitive American TSE Meeting   2008   
PrP異常化に対するN-結合型糖鎖結合部位のアミノ酸置換の影響
プリオン研究会   2007   
219Lysプリオン蛋白はvCJD感染において簡単に異常化する
プリオン研究会   2007   
孤発性クロイツフェルト・ヤコブ病プリオンのcross-sequence transmissionは新たなプリオン株を生み出す
プリオン研究会   2007   
Type 1 and type 2 human PrPSc have different aggregation sizes in methionine homozygotes with sporadic, iatrogenic and variant Creutzfeldt-Jakob disease
International symposium PRION DISEASES   2004   

Works

 
難治性疾患等政策研究事業 プリオン病及び遅発性ウイルス感染症に関する調査研究
2014 - 2016
プリオン病自然発病モデル動物を用いたプリオン蛋白異常化メカニズムの研究
2010 - 2012
難治性疾患等克服研究事業 プリオン病及び遅発性ウイルス感染症に関する調査研究班
2008 - 2011
難治性疾患等克服研究事業 プリオン病及び遅発性ウイルス感染症に関する調査研究班
2006 - 2008

Research Grants & Projects

 
鼻疽菌潜伏感染場の摘発に向けた新規血清診断法の開発
日本中央競馬会: 平成31年度日本中央競馬会畜産振興事業
Project Year: Apr 2019 - Mar 2021    Investigator(s): 木村享史
プリオン病におけるプリオンメカニズムの解明
Project Year: Oct 2018 - Sep 2019    Investigator(s): KOBAYASHI Atsushi
Identification of the origin of prion infection
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2008 - 2009    Investigator(s): Atsushi KOBAYASHI

Patents

 
特開2011-46698 : 変異タンパク質の製造方法
北本哲之, 堂浦克美, 小林篤史, 照屋健太, 竹内敦子, 森田将典, 山本幸, 白澤映子
特開WO/2008/099451 : 網羅的アミノ酸置換による高機能蛋白の設計方法