論文

査読有り 責任著者 国際誌
2019年10月1日

Data for positive selection test and co-evolutionary analysis on mammalian cereblon

Data in Brief
  • Wataru Onodera
  • ,
  • Toru Asahi
  • ,
  • Naoya Sawamura

26
開始ページ
104499
終了ページ
104499
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.dib.2019.104499

© 2019 The Author(s) Cereblon (CRBN) is a substrate recognition subunit of the CRL4 E3 ubiquitin ligase complex, directly binding to specific substrates for poly-ubiquitination followed by proteasome-dependent degradation of proteins. Cellular CRBN is responsible for energy metabolism, ion-channel activation, and cellular stress response through binding to proteins related to the respective pathways. As CRBN binds to various proteins, the selective pressure at the interacting surface is expected to result in functional divergence. Here, we present two mammalian CRBN datasets of molecular evolutionary analyses. (1) The multiple sequence alignment data shows that positive selection occurred, determined with a dN/dS calculation. (2) Data on co-evolutionary analysis between vertebrate CRBN and related proteins are represented by calculating the correlation coefficient based on the comparison of phylogenetic trees. Co-evolutionary analysis shows the similarity of evolutionary traits of two proteins. Further molecular, functional interpretation of these analyses is explained in ‘Positive selection of Cereblon modified function including its E3 Ubiquitin Ligase activity and binding efficiency with AMPK’ (W. Onodera, T. Asahi, N. Sawamura, Positive selection of cereblon modified function including its E3 ubiquitin ligase activity and binding efficiency with AMPK. Mol Phylogenet Evol. (2019) 135:78-85. [1]).

リンク情報
DOI
https://doi.org/10.1016/j.dib.2019.104499
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31667262
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811870
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072335809&origin=inward
ID情報
  • DOI : 10.1016/j.dib.2019.104499
  • PubMed ID : 31667262
  • PubMed Central 記事ID : PMC6811870
  • SCOPUS ID : 85072335809

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