Papers

International journal
Oct, 2020

Mechanism toward Turn-on of Polysaccharide-Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells

CHEMMEDCHEM
  • Shodai Hino
  • ,
  • Rikushi Funada
  • ,
  • Kouta Sugikawa
  • ,
  • Riku Kawasaki
  • ,
  • Kazuya Koumoto
  • ,
  • Toshio Suzuki
  • ,
  • Takeshi Nagasaki
  • ,
  • Atsushi Ikeda

Volume
16
Number
5
First page
793
Last page
803
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/cmdc.202000656
Publisher
WILEY-V C H VERLAG GMBH

beta-(1,3-1,6)-D-Glucan, lambda-carrageenan, tamarind gum, and pullulan can dissolve various porphyrin derivatives via the formation of complexes in water using a high-speed vibration milling method. The aqueous solutions of the resulting complexes exhibit long-term stability. Despite the adverse effects of the self-quenching process, notable fluorescence and improved photodynamic activity of the polysaccharide-complexed porphyrin derivatives were observed in the presence of liposomes, micelles, cyclodextrins, and HeLa cells. It was noted that the type of porphyrins was more important than the type of polysaccharides present in the complex. Porphyrin self-aggregates were monodispersed in the lipid membranes of the liposomes and lysosomes. The polysaccharide-complexed porphyrin derivatives showed increased photodynamic activity toward HeLa cells under photoirradiation between 610 and 740 nm.

Web of Science ® Times Cited Count : 3
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Link information
DOI
https://doi.org/10.1002/cmdc.202000656
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33025719
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000582776800001&DestApp=WOS_CPL
ID information
  • DOI : 10.1002/cmdc.202000656
  • ISSN : 1860-7179
  • eISSN : 1860-7187
  • Pubmed ID : 33025719
  • Web of Science ID : WOS:000582776800001

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