論文

国際誌
2020年10月

Mechanism toward Turn-on of Polysaccharide-Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells

CHEMMEDCHEM
  • Shodai Hino
  • ,
  • Rikushi Funada
  • ,
  • Kouta Sugikawa
  • ,
  • Riku Kawasaki
  • ,
  • Kazuya Koumoto
  • ,
  • Toshio Suzuki
  • ,
  • Takeshi Nagasaki
  • ,
  • Atsushi Ikeda

16
5
開始ページ
793
終了ページ
803
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/cmdc.202000656
出版者・発行元
WILEY-V C H VERLAG GMBH

beta-(1,3-1,6)-D-Glucan, lambda-carrageenan, tamarind gum, and pullulan can dissolve various porphyrin derivatives via the formation of complexes in water using a high-speed vibration milling method. The aqueous solutions of the resulting complexes exhibit long-term stability. Despite the adverse effects of the self-quenching process, notable fluorescence and improved photodynamic activity of the polysaccharide-complexed porphyrin derivatives were observed in the presence of liposomes, micelles, cyclodextrins, and HeLa cells. It was noted that the type of porphyrins was more important than the type of polysaccharides present in the complex. Porphyrin self-aggregates were monodispersed in the lipid membranes of the liposomes and lysosomes. The polysaccharide-complexed porphyrin derivatives showed increased photodynamic activity toward HeLa cells under photoirradiation between 610 and 740 nm.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1002/cmdc.202000656
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33025719
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000582776800001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/cmdc.202000656
  • ISSN : 1860-7179
  • eISSN : 1860-7187
  • PubMed ID : 33025719
  • Web of Science ID : WOS:000582776800001

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