Papers

International journal
Apr, 2020

Solubilization of poorly water-soluble bioactive molecules in neutral aqueous media by complexation with renatured beta-1,3-1,6-glucan nanoparticles

BIOPOLYMERS
  • Ayumu Kodama
  • ,
  • Akifumi Nakagawa
  • ,
  • Yuki Nonoguchi
  • ,
  • Haruka Sakurai
  • ,
  • Chieko Yano
  • ,
  • Toshio Suzuki
  • ,
  • Kazuya Koumoto

Volume
111
Number
4
First page
e23349
Last page
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/bip.23349
Publisher
WILEY

The design of scaffolds for solubilizing/dispersing poorly water-soluble bioactive molecules in neutral aqueous media is a major challenge of functional food, pharmaceuticals, and cosmetics development, as highlighted by the plethora of corresponding solubilization/dispersion strategies. Herein, renatured beta-1,3-1,6-glucan (r-glucan) nanoparticles prepared by neutralization of alkali-denatured beta-1,3-1,6-glucan and subsequent centrifugation are used as a host to disperse water-insoluble bioactive molecules (curcumin, all-trans-retinoic acid, and rebamipide) by simple mixing of host and guest solutions. Curcumin in the r-glucan cavity is found to be stacked in the form of J-aggregates and twisted along the helix, and is demonstrated to be retained for significantly longer than curcumin in the corresponding gamma-cyclodextrin (gamma-CD) complex. Specifically, curcumin incorporated in gamma-CD is released within 5.5 hours, whereas that in the r-glucan complex is released very slowly, with 12% of curcumin in the latter complex retained after 31-day incubation at 37 degrees C. Thus, inclusion protocol simplicity and slow release ability make r-glucan nanoparticles a potential carrier scaffold for various applications.

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Link information
DOI
https://doi.org/10.1002/bip.23349
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32027026
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000511238000001&DestApp=WOS_CPL
ID information
  • DOI : 10.1002/bip.23349
  • ISSN : 0006-3525
  • eISSN : 1097-0282
  • Pubmed ID : 32027026
  • Web of Science ID : WOS:000511238000001

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