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International journal
Feb, 2020

Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in beta-(1,3-1,6)-d-Glucan with On-Off Switch

CHEMISTRY-AN ASIAN JOURNAL
  • Shodai Hino
  • ,
  • Shuhei Satake
  • ,
  • Hideyuki Shinmori
  • ,
  • Shigeki Kawabata
  • ,
  • Kazuya Koumoto
  • ,
  • Toshio Suzuki
  • ,
  • Takeshi Nagasaki
  • ,
  • Kouta Sugikawa
  • ,
  • Riku Kawasaki
  • ,
  • Atsushi Ikeda

Volume
15
Number
3
First page
365
Last page
370
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1002/asia.201901582
Publisher
WILEY-V C H VERLAG GMBH

5,15-Diazaporphyrins, which have a large absorption at wavelengths over 600 nm, were dissolved in water by complex formation with beta-(1,3-1,6)-d-glucans. Aqueous solutions of these complexes were relatively stable compared with their trimethyl-beta-cyclodextrin-complexed analogues. beta-Glucan-complexed diazaporphyrins showed quenched fluorescence and had low singlet-oxygen-generation abilities owing to random self-aggregation. However, external stimuli, such as the presence of liposomes or intracellular uptake, restored the fluorescence and singlet-oxygen-generation abilities of beta-glucan-complexed diazaporphyrins. Consequently, beta-glucan-complexed diazaporphyrins showed very high photodynamic activities toward HeLa cells.

Web of Science ® Times Cited Count : 10
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Link information
DOI
https://doi.org/10.1002/asia.201901582
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31828944
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000504793000001&DestApp=WOS_CPL
ID information
  • DOI : 10.1002/asia.201901582
  • ISSN : 1861-4728
  • eISSN : 1861-471X
  • Pubmed ID : 31828944
  • Web of Science ID : WOS:000504793000001

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