KOUMOTO KAZUYA

Profile Information

Affiliation: Faculty of Frontiers of Innovative Research in Science and Technology, Department of Nanobiochemistry, Konan University

Degree: 博士（工学）(九州大学)

J-GLOBAL ID: 200901022400407390
researchmap Member ID: 6000000676

External link: http://www.konan-fiber.jp/

Research Interests

Research Areas

Research History

Apr, 2018 - Present

Professor, Faculty of Frontiers of Innovative Research in Science and Technology Department of Nanobiochemistry, Konan University
2009 - Mar, 2018

甲南大学フロンティアサイエンス学部生命化学科准教授
2004 - 2009

Frontier Institute for Biomolecular Engineering Research, Konan University
2002 - 2004

Faculty of Environmental Engineering, The University of Kitakyushu
2002 - 2002

Faculty of Engineering, Kyushu University
2000 - 2001

科学技術振興事業団日蘭国際共同研究分子転写プロジェクト研究員
Konan University Faculty of Frontiers of Innovative Research in Science and Technology, Department of Nanobiochemistry

Education

- 2000

Kyushu University
- 1997

Kyushu University
- 1995

School of Engineering, Kyushu University

Committee Memberships

2010

幹事, 有機合成化学協会

Papers

Hydrostatic Pressure-Regulated Cellular Calcium Responses.

Minami Fukuchi, Kotaro Oyama, Hiroaki Mizuno, Akihisa Miyagawa, Kazuya Koumoto, Gaku Fukuhara

Langmuir : the ACS journal of surfaces and colloids, 37(2) 820-826, Jan 19, 2021
Modification of the Release Rate of Curcumin from the Cavity of Renatured beta-1,3-1,6-Glucan Nanoparticles by Changing the Molecular Weight of the Constituent Polysaccharide Chains

Yuki Nonoguchi, Ayumu Kodama, Rika Unesaki, Nanako Doi, Toshio Suzuki, Kazuya Koumoto

CHEMISTRY LETTERS, 49(10) 1150-1153, Oct, 2020
Mechanism toward Turn-on of Polysaccharide-Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells

Shodai Hino, Rikushi Funada, Kouta Sugikawa, Riku Kawasaki, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda

CHEMMEDCHEM, 16(5) 793-803, Oct, 2020
Solubilization of poorly water-soluble bioactive molecules in neutral aqueous media by complexation with renatured beta-1,3-1,6-glucan nanoparticles

Ayumu Kodama, Akifumi Nakagawa, Yuki Nonoguchi, Haruka Sakurai, Chieko Yano, Toshio Suzuki, Kazuya Koumoto

BIOPOLYMERS, 111(4) e23349, Apr, 2020
Structural effect of amine N-oxides on the facilitation of alpha-glucosidase-catalyzed hydrolysis reactions

Takuma Aoki, Yuichi Nakagawa, Ryutaro Genjima, Kazuya Koumoto

BIOPROCESS AND BIOSYSTEMS ENGINEERING, 43(3) 541-548, Mar, 2020
Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in beta-(1,3-1,6)-d-Glucan with On-Off Switch

Shodai Hino, Shuhei Satake, Hideyuki Shinmori, Shigeki Kawabata, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Kouta Sugikawa, Riku Kawasaki, Atsushi Ikeda

CHEMISTRY-AN ASIAN JOURNAL, 15(3) 365-370, Feb, 2020
Turn-on fluorescence and photodynamic activity of beta-(1,3-1,6)-d-glucan-complexed porphyrin derivatives inside HeLa cells

Shodai Hino, Rikushi Funada, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Atsushi Ikeda

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 18(12) 2854-2858, Dec, 2019
Cover Picture: Water Solubilization of Fullerene Derivatives by β-(1,3-1,6)-d -Glucan and Their Photodynamic Activities toward Macrophages (Chem. Asian J. 10/2017)

Atsushi Ikeda, Tatsuya Iizuka, Naotake Maekubo, Kazuyuki Nobusawa, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Motofusa Akiyama

Chemistry - An Asian Journal, 12(10) 1025, May, 2017 Peer-reviewed
Water Solubilization of Fullerene Derivatives by beta-(1,3-1,6)-D-Glucan and Their Photodynamic Activities toward Macrophages

Atsushi Ikeda, Tatsuya Iizuka, Naotake Maekubo, Kazuyuki Nobusawa, Kouta Sugikawa, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Motofusa Akiyama

CHEMISTRY-AN ASIAN JOURNAL, 12(10) 1069-1074, May, 2017 Peer-reviewed
Formation of beta-(1,3-1,6)-D-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages

Atsushi Ikeda, Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yuta Kashijima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki

ORGANIC & BIOMOLECULAR CHEMISTRY, 15(9) 1990-1997, Mar, 2017 Peer-reviewed
Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy.

Masafumi Ueda, Kengo Ashizawa, Kouta Sugikawa, Kazuya Koumoto, Takeshi Nagasaki, Atsushi Ikeda

Organic & biomolecular chemistry, 15(7) 1565-1569, Feb 21, 2017 Peer-reviewed
Increased yield of beta-glucosidase-catalyzed hydrolysis reactions in the presence of betaine-type metabolite analog

Shiro Sehata, Ryojun Suzuki, Kazuya Koumoto

BIOPROCESS AND BIOSYSTEMS ENGINEERING, 40(1) 153-159, Jan, 2017
Quick Activation/Stabilization of a alpha-Glucosidase-catalyzed Hydrolysis Reaction by Addition of a Betaine-type Metabolite Analogue

Shiro Sehata, Yuichi Nakagawa, Ryutaro Genjima, Kazuya Koumoto

CHEMISTRY LETTERS, 45(10) 1174-1176, Oct, 2016 Peer-reviewed
Significance of anionic functional group in betaine-type metabolite analogs on the facilitation of enzyme reactions

Yuichi Nakagawa, Kotomi Takagi, Ryutaro Genjima, Kazuya Koumoto

BIOPROCESS AND BIOSYSTEMS ENGINEERING, 38(9) 1811-1817, Sep, 2015
Cryoprotective ability of betaine-type metabolite analogs during freezing denaturation of enzymes

Yuichi Nakagawa, Masahiro Sota, Kazuya Koumoto

BIOTECHNOLOGY LETTERS, 37(8) 1607-1613, Aug, 2015
Enhanced Chromogenic Sensitivity of Horseradish Peroxidase-Catalyzed Oxidative Reactions in the Presence of Betaine-Type Metabolite Analogs

Kotomi Takagi, Yasuhiro Kashima, Satoshi Fujii, Kazuya Koumoto

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 88(8) 1074-1082, Aug, 2015 Peer-reviewed
Enhanced Immunostimulating Activity of Lactobacilli-Mimicking Materials by Controlling Size

Koji Nagahama, Takayuki Kumano, Yuichi Nakagawa, Naho Oyama, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto …

BIOCONJUGATE CHEMISTRY, 26(8) 1775-1781, Aug, 2015 Peer-reviewed
Mechanistic study of unusual enzyme activation caused by addition of inert betaine-type metabolite and the analogs

Yuichi Nakagawa, Kazuya Koumoto

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 249, Mar, 2015
Synthesis and lmmunestimulating Activity of Lactobacilli-Originated Polysaccharide-Polymeric Microparticle Conjugates

Koji Nagahama, Takayuki Kumano, Tsubasa Nakata, Hirokazu Tsuji, Kaoru Moriyama, Kan Shida, Koji Nomoto, Katsuyoshi Chiba, Kazuya Koumoto, Jun Matsui

LANGMUIR, 31(4) 1489-1495, Feb, 2015 Peer-reviewed
Mechanistic study on the facilitation of enzymatic hydrolysis by alpha-glucosidase in the presence of betaine-type metabolite analogs

Yuichi Nakagawa, Shiro Sehata, Satoshi Fujii, Hiroaki Yamamoto, Akihiko Tsuda, Kazuya Koumoto

TETRAHEDRON, 70(35) 5895-5903, Sep, 2014 Peer-reviewed

Misc.

Formation of beta-(1,3-1,6)-D-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages (vol 15, pg 1990, 2017)

Atsushi Ikeda, Motofusa Akiyama, Kouta Sugikawa, Kazuya Koumoto, Yuta Kagoshima, Jiawei Li, Toshio Suzuki, Takeshi Nagasaki

ORGANIC & BIOMOLECULAR CHEMISTRY, 15(45) 9734-9734, Dec, 2017
Cellular zwitterionic metabolite analogs simultaneously enhance reaction rate, thermostability, salt tolerance, and substrate specificity of alpha-glucosidase

Eisuke Deguchi, Kazuya Koumoto

BIOORGANIC & MEDICINAL CHEMISTRY, 19(10) 3128-3134, May, 2011
Molecular receptor for saccharide recognition: boronic acid

Bio industry, 27(2) 18-23, Feb, 2010
糖分子を認識する人工レセプター：ボロン酸

甲元一也, 新海征治

バイオインダストリー, 27(2) 66-72, 2010
Reversible stability switching of a hairpin DNA via a photo-responsive linker unit

Li Wu, Kazuya Koumoto, Naoki Sugimoto

CHEMICAL COMMUNICATIONS, (14) 1915-1917, 2009
Hydration is an important factor to regulate thermodynamic stability of a DNA duplex under molecular crowding conditions

Kazuya Koumoto, Hirofumi Ochiai, Naoki Sugimoto

CHEMISTRY LETTERS, 37(8) 864-865, Aug, 2008
NanoBioNow(10)周辺の分子環境に応答するDNAナノスイッチの構築

狩俣寿枝, 三好大輔, 藤本健史, 甲元一也, WANG Zhong‐Ming, 杉本直己

日本化学会講演予稿集, 88th(2) 823, Mar 12, 2008
Enhanced amplification of polymerase chain reaction by addition of cosolutes derived from a cellular compatible solute.

Kazuya Koumoto, Hirofumi Ochiai, Naoki Sugimoto

Nucleic acids symposium series (2004), 52(52) 257-8, 2008
Structural effect of synthetic zwitterionic cosolutes on the stability of DNA duplexes

Kazuya KouMoto, Hirofumi Ochiai, Naoki Sugimoto

TETRAHEDRON, 64(1) 168-174, Jan, 2008
分子クラウディング環境下においてDNA二重鎖の安定性に及ぼす水和の影響

甲元一也, 落合洋文, 狩俣寿枝, 中野修一, 杉本直己

高分子学会予稿集(CD-ROM), 56(2 Disk1) 2X15, Sep 4, 2007
Delivery of antisense oligonucleotides to nuclear telomere RNA by use of a complex between polysaccharide and polynucleotide

Jusaku Minari, Takanori Kubo, Hideki Ohba, Naohiko Shimada, Yoich Takeda, Ryouji Karinaga, Takahisa Anada, Kazuya Koumoto, Takeshi Kawazu, Takeshi Nagasaki …

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 80(6) 1091-1098, Jun, 2007
Artificial G-wire switch with 2,2 '-bipyridine units responsive to divalent metal ions

Daisuke Miyoshi, Hisae Karimata, Zhong-Ming Wang, Kazuya Koumoto, Naoki Sugimoto

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129(18) 5919-5925, May, 2007
Conformational switch of a functional nanowire based on the DNA G-quadruplex.

Hisae Karimata, Daisuke Miyoshi, Takeshi Fujimoto, Kazuya Koumoto, Zhong-Ming Wang, Naoki Sugimoto

Nucleic acids symposium series (2004), 51(51) 251-2, 2007
CpG DNA/zymosan complex to enhance cytokine secretion owing to the cocktail effect

T Anada, N Okada, J Minari, R Karinaga, M Mizu, K Koumoto, S Shinkai, K Sakurai

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(5) 1301-1304, Mar, 2006
Galactose-PEG dual conjugation of beta-(1 -> 3)-D-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake

R Karinaga, T Anada, J Minari, M Mizu, K Koumoto, J Fukuda, K Nakazawa, T Hasegawa, M Numata, S Shinkai …

BIOMATERIALS, 27(8) 1626-1635, Mar, 2006
Linear double-stranded DNA that mimics an infective tail of virus genome to enhance transfection

T Anada, R Karinaga, K Koumoto, M Mizu, T Nagasaki, Y Kato, K Taira, S Shinkai, K Sakurai

JOURNAL OF CONTROLLED RELEASE, 108(2-3) 529-539, Nov, 2005
Cholesterol-appended beta-(1 -> 3)-D-glucan schizophylllan for antisense oligonucleotides delivery to enhance the cellular uptake

K Koumoto, M Mizu, T Anada, T Nagasaki, S Shinkai, K Sakurai

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 78(10) 1821-1830, Oct, 2005
PEG-appended beta-(1 -> 3)-D-glucan schizophyllan to deliver antisense-oligonucleotides with avoiding lysosomal degradation

R Karinaga, K Koumoto, M Mizu, T Anada, S Shinkai, K Sakurai

BIOMATERIALS, 26(23) 4866-4873, Aug, 2005
Parallel vs. anti-parallel orientation in a curdlan/oligo(dA) complex as estimated by a FRET technique

M Numata, K Koumoto, M Mizu, K Sakurai, S Shinkai

ORGANIC & BIOMOLECULAR CHEMISTRY, 3(12) 2255-2261, Jun, 2005
In situ monitoring of polysaccharide-polynucleotide interaction using a schizophyllan-immobilized QCM device

DH Yang, AH Bae, K Koumoto, SW Lee, K Sakurai, S Shinkai

SENSORS AND ACTUATORS B-CHEMICAL, 105(2) 490-494, Mar, 2005

Books and Other Publications

絵で見てわかるナノDDS 遺伝子医学MOOK別冊

メディカルドゥ, 2007
Macromolecular Nanostructured Material

Springer, 2004

Professional Memberships

Research Projects

Understanding of stabilization and activation mechanism for biomolecules induced by the addition of cellular metabolite analogs

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

KOUMOTO Kazuya
細胞内代謝産物群を利用した酵素活性化

科学研究費補助金, 2008 - 2011
Understanding of cellular function of compatible solutes utilizing a synthetic approach

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2008 - 2009

KOUMOTO Kazuya
Investigations of the molecular crowding effect on nucleic acid structures and development of nucleotide switches

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2005 - 2007

SUGIMOTO Naoki, NAKANO Shu-ichi, MIYOSHI Daisuke, KOMOTO Kazuya
機能性核酸コンジュゲートの合成

学術研究支援事業, 2004

Profile Information

Research Interests

Research Areas

Research History

Education

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Papers

Misc.

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