論文

査読有り
2014年4月

The exacerbation risk prediction by fractional exhaled nitric oxide in younger and elder children with bronchial asthma

Kawasaki Medical Journal
  • Tokio WAKABAYASHI
  • ,
  • Tetsuya YAMAGUCHI
  • ,
  • Yoko FUKUDA
  • ,
  • Atsushi KATOU
  • ,
  • Hiroki SHIMIZU
  • ,
  • Yasushi OBASE
  • ,
  • Mikio OKA
  • ,
  • Takashi NAKANO
  • ,
  • Kihei TERADA
  • ,
  • Kazunobu OUCHI

40
1
開始ページ
41
終了ページ
46
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.11482/KMJ-E40(1)41
出版者・発行元
川崎医科大学

The usefulness of the Fractional exhaled nitric oxide (FeNO) measurements for asthma exacerbation risk prediction in asthmatic children is controversial. Fifty-seven asthmatic children who were regularly treated and had previously been stable for at least 3 months were enrolled. The asthma excerbations risk prediction by the FeNO levels and age contribution on it were investigated. As analyzed all the patients, FeNO cut off value for the significant risk of asthma exacerbation was 36.9 ppb (risk odds was 5.1 [95% C.I., 1.8 to 15.0], chi square valve = 9.0, p=0.0028). However, sensitivity and specificity were not adequate for predicting asthma exacerbation (Sensitivity, 77.8%; Specificity, 59.9%; Area under the curve [AUC], 0.674). These parameters were improved only when 6-10 year old children were assessed (FeNO threshold=39.9 ppb, risk odds=10.2 [3.1 to 33.1], chi square valve 14.8, p=0.0001); Sensitivity, 80.8%; Specificity, 71.8%; AUC, 0.758). High value of FeNO is a risk factor for the asthma exacerbation, and FeNO measurement may be more useful for asthma control in younger children than elder asthmatic children.

リンク情報
DOI
https://doi.org/10.11482/KMJ-E40(1)41
CiNii Articles
http://ci.nii.ac.jp/naid/110009807872
CiNii Books
http://ci.nii.ac.jp/ncid/AA00710169
URL
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2014en/KMJ-E40(1)41.pdf
URL
http://id.nii.ac.jp/1162/00000560/
URL
http://search.jamas.or.jp/link/ui/2015159748
ID情報
  • DOI : 10.11482/KMJ-E40(1)41
  • ISSN : 0385-0234
  • CiNii Articles ID : 110009807872
  • CiNii Books ID : AA00710169

エクスポート
BibTeX RIS