Hideki Makishima

Profile Information

Affiliation: Graduate School of Medicine, Kyoto University

Degree: 医学博士

J-GLOBAL ID: 200901077841419309
researchmap Member ID: 6000001035

As a physician-scientist, the focus of my interest is translational research directly targeting hematologic disease. My immediate goals are to systematically clarify the molecular mechanisms of myeloid diseases and ultimately improve management of these conditions. As such, academic research is the best pathway to achieving these goals.

Research Interests

Research Areas

Research History

Apr, 2018 - Present

Graduate School of Medicine, Kyoto University
Mar, 2018 - Present

Associate Professor, Pathology and Tumor Biology, Kyoto University
Mar, 2015

Graduate School of Medicine, Kyoto University
Apr, 2008

ポストドクトラルフェロー, トーシックがんセンター, クリーブランドクリニック
Jun, 2005

Assistant Professor, Shinshu University Shinshu University Hospital, Univeristy Hospital
Apr, 2003

Shinshu University Hospital, Shinshu University
Apr, 1999

博士課程, 信州大学大学院医学研究科
May, 1996

Shinshu University Hospital, Shinshu University
- Mar, 1996

School of Medicine, Nagoya University

Papers

210

前立腺における多段階発癌の遺伝子解析(Genetic analysis of multi-step carcinogenesis in the prostate)

日紫喜公輔, 垣内伸之, 寺本祐記, 北悠希, 木村啓佑, 渡部光一, 山中利之, 家入康輔, 前田紘奈, 西村友美 …

日本癌学会総会記事, 82回 1307-1307, Sep, 2023
Detailed Analysis of the Impact of Clonal Hematopoiesis on the Risk of Severe COVID-19 Infection

Ryunosuke Saiki, Ho Namkoong, Ryuya Edahiro, Kyuto Sonehara, Qingbo S Wang, Takanori Hasegawa, Yukihide Momozawa, Hideki Makishima, Yasuhito Nannya, Nobuyuki Kakiuchi …

Blood, 140(Supplement 1) 5747-5748, Nov 15, 2022
Germline DDX41 mutations define a unique subtype of myeloid neoplasms.

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Claire Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steven Best, Pramila Krishnamurthy, Tetsuichi Yoshizato …

Blood, 141(5) 534-549, Nov 2, 2022
Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms(和訳中)

戚星星, Yoshizatoi Testuichi, 南谷泰仁, Nakagawa Masahiro M., 森拓人, 昆彩奈, 依田成玄, 越智陽太郎, 竹田淳恵, 佐伯龍之介 …

日本癌学会総会記事, 81回 E-1065, Sep, 2022
骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Elucidating the mechanism of clonal evolution of DDX41 mutated cells in myeloid malignancies)

昆彩奈, 中川正宏, 片岡圭亮, 垣内伸之, 牧島秀樹, 越智陽太郎, 中山学, 古関明彦, 南谷泰仁, 小川誠司

日本癌学会総会記事, 81回 E-1066, Sep, 2022
Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms(和訳中)

Qi Xingxing, Yoshizatoi Tetuichi, 南谷泰仁, Nakagawa Masahiro M., 森拓人, 昆彩奈, 依田成玄, 越智陽太郎, 竹田淳恵, 佐伯龍之介 …

日本癌学会総会記事, 81回 P-1255, Sep, 2022
骨髄性腫瘍を標的とした新規スプライシングモジュレーターCTX-712の開発(CTX-712, a novel splicing modulator targeting myeloid neoplasms)

依田成玄, 森下大輔, 越智陽太郎, 水谷明生, 森拓人, 竹田淳恵, 戸崎浩和, 佐藤義彦, 南谷泰仁, 牧島秀樹 …

日本癌学会総会記事, 81回 E-2027, Sep, 2022
がん研究における女性研究者不均衡転座der(1;7)(q10;p10)を有するMDSと関連疾患の特徴(Unbalanced translocation der(1;7)(q10;p10) as a distinct subtype in myelodysplastic syndromes)

奥田瑠璃花, 越智陽太郎, 蝶名林和久, 眞田昌, 半田寛, 白石友一, 千葉滋, 石川隆之, 大屋敷一馬, 熱田由子 …

日本癌学会総会記事, 81回 SS1-4, Sep, 2022
単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)

中川正宏, 稲垣良作, 南谷泰仁, 佐伯龍之介, 越智陽太郎, 竹田淳恵, 趙蘭英, 威星星, 依田成玄, 昆彩奈 …

日本癌学会総会記事, 81回 IS8-6, Sep, 2022
骨髄異形成症候群におけるSRSF2変異とSTAG2変異と協調的関係(Cooperative effects of SRSF2 and STAG2 mutations on development of myelodysplastic syndrome and its related disorders)

森拓人, 越智陽太郎, 昆彩奈, 吉里哲一, 古関明彦, 依田成玄, 中川正宏, 竹田淳恵, 永田安伸, 吉田健一 …

日本癌学会総会記事, 81回 IS11-6, Sep, 2022
Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia.

June Takeda, Kenichi Yoshida, Masahiro M Nakagawa, Yasuhito Nannya, Akinori Yoda, Ryunosuke Saiki, Yotaro Ochi, Lanying Zhao, Rurika Okuda, Xingxing Qi …

Blood cancer discovery, 3(5) 410-427, Jul 15, 2022
The landscape of genetic aberrations in myxofibrosarcoma.

Yasuhide Takeuchi, Kenichi Yoshida, Adriane Halik, Annegret Kunitz, Hiromichi Suzuki, Nobuyuki Kakiuchi, Yusuke Shiozawa, Akira Yokoyama, Yoshikage Inoue, Tomonori Hirano …

International journal of cancer, 151(4) 565-577, Apr 29, 2022
コルチゾール産生腺腫におけるCTNNB1の新規構造異常と変異に基づく分子分類

藤井陽一, 樋口誠一郎, 佐藤悠佑, 白石友一, 坂本信一, 川合剛人, 牧島秀樹, 宮野悟, 久米春喜, 市川智彦 …

日本泌尿器科学会総会, 109回 AOP14-02, Dec, 2021
Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia

Yotaro Ochi, Kenichi Yoshida, Ying-Jung Huang, Ming-Chung Kuo, Yasuhito Nannya, Ko Sasaki, Kinuko Mitani, Noriko Hosoya, Nobuhiro Hiramoto, Takayuki Ishikawa …

Nature Communications, 12(1), Dec, 2021
コルチゾール産生腺腫におけるCTNNB1の新規構造異常と変異に基づく分子分類

藤井陽一, 樋口誠一郎, 佐藤悠佑, 白石友一, 坂本信一, 川合剛人, 牧島秀樹, 宮野悟, 久米春喜, 市川智彦 …

日本泌尿器科学会総会, 109回 AOP14-02, Dec, 2021
MDS、AMLに対するアザシチジン治療後のクローンサイズは長期予後を予測する(Post-azacitidine clone size predicts long-term clinical outcome of patients with MDS and AML)

南谷泰仁, Magnus Tobiasson, 佐藤信也, Elsa Bernard, 大竹茂樹, 竹田淳恵, 趙蘭英, 日下部学, 柴田悠平, 中村信彦 …

日本血液学会学術集会, 83回 OS1-3, Sep, 2021
一細胞解像度のがん生物学変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用

中川正宏, 稲垣良作, 南谷泰仁, 趙蘭英, 越智陽太郎, 竹田淳恵, 戚星星, 依田成玄, 昆彩奈, 吉里哲一 …

日本癌学会総会記事, 80回 [CS2-6], Sep, 2021
新薬開発に向けた産学連携の問題点と将来展望 SRSF2変異を有する骨髄性腫瘍を標的とした新規CLK阻害剤CTX-712の開発

依田成玄, 森下大輔, 越智陽太郎, 水谷明生, 竹田淳恵, 戸崎浩和, 佐藤義彦, 南谷泰仁, 牧島秀樹, 三宅洋 …

日本癌学会総会記事, 80回 [S15-6], Sep, 2021
クローン性造血と造血器腫瘍、心血管性疾患、固形癌の関係性クローン性造血における遺伝子変異とコピー数異常の統合解析

佐伯龍之介, 桃沢幸秀, 南谷泰仁, 中川正宏, 越智陽太郎, 吉里哲一, 白石友一, 田中洋子, 新井田厚司, 井元清哉 …

日本癌学会総会記事, 80回 [S22-2], Sep, 2021
ETNK1変異の有無を特徴とするder(1;7)(q10;p10)を伴う骨髄異形成症候群

奥田瑠璃花, 南谷泰仁, 越智陽太郎, 蝶名林和久, 牧島秀樹, 永田安伸, 真田昌, 白石友一, 宮野悟, 熱田由子 …

日本癌学会総会記事, 80回 [E7-2], Sep, 2021

Misc.

203

Amplified EPOR/JAK2 genes definea unique subtype of acute erythroid leukemia.

June Takeda, Kenichi Yoshida, Masahiro M. Nakagawa, Yasuhito Nannya, Akinori Yoda, Ryunosuke Saiki, Yotaro Ochi, Lanying Zhao, Rurika Okuda, Xingxing Qi …

CANCER RESEARCH, 82(12), Jun, 2022
EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia

June Takeda, Kenichi Yoshida, Masahiro Marshall Nakagawa, Yasuhito Nannya, Akinori Yoda, Daisuke Morishita, Ryunosuke Saiki, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi …

BLOOD, 138, Nov, 2021
The functional role of compound DDX41 germline and somatic R525H mutations in the development of myeloid neoplasms

Ayana Kon, Masahiro Nakagawa, Ryosaku Inagaki, Keisuke Kataoka, Yotaro Ochi, Hideki Makishima, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa

CANCER SCIENCE, 112 454-454, Feb, 2021
Early Clonal evolution of myeloid malignancies

Masahiro Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi …

CANCER SCIENCE, 112 969-969, Feb, 2021
Genetic profiling and prognosis of blast crisis in chronic myeloid leukemia

Yotaro Ochi, Kenichi Yoshida, Ko Sasaki, Noriko Hosoya, Yusuke Shiozawa, Yasuhito Nannya, Takayuki Ishikawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka …

CANCER SCIENCE, 112 454-454, Feb, 2021
Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.

Rurika Okuda, Yasuhito Nannya, Yotaro Ochi, Kazuhisa Chonabayashi, Maria Creignou, Hideki Makishima, June Takeda, Ayana Kon, Satoru Miyano, Hiroshi Handa …

CANCER SCIENCE, 112 310-310, Feb, 2021
JAK STAT Pathway is a Promising Therapeutic target in Acute Erythroid Leukemia

June Takeda, Kenichi Yoshida, Akinori Yoda, Yasuhito Nannya, Masahiro Nakagawa, Yotaro Ochi, Ayana Kon, Tetsuichi Yoshizato, Yusuke Shiozawa, Yuichi Shiraishi …

CANCER SCIENCE, 112 453-453, Feb, 2021
CTX-712, a novel CLK inhibitor targeting myeloid neoplasms with SRSF2 mutation

Akinori Yoda, Daisuke Morishita, Akio Mizutani, Yotaro Ochi, Hirokazu Tozaki, Yoshihiko Satoh, June Takeda, Yasuhito Nannya, Hideki Makishima, Hiroshi Miyake …

CANCER SCIENCE, 112 250-250, Feb, 2021
Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma

Yasuhide Takeuchi, Hiromichi Suzuki, Kenichi Yoshida, Yuichi Shiraishi, Nobuyuki Kakiuchi, Yusuke Shiozawa, Yoshikage Inoue, Kenichi Chiba, Hideki Makishima, Satoru Miyano …

CANCER SCIENCE, 112 850-850, Feb, 2021
The molecular pathogenesis of DDX41-mutated myeloid neoplasms

昆彩奈, 中川正宏, 片岡圭亮, 片岡圭亮, 稲垣良作, 牧島秀樹, 越智陽太郎, 中山学, 古関明彦, 南谷泰仁 …

日本血液学会学術集会抄録(Web), 83rd, 2021
骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明

昆彩奈, 中川正宏, 片岡圭亮, 片岡圭亮, 稲垣良作, 牧島秀樹, 越智陽太郎, 中山学, 古関明彦, 南谷泰仁 …

日本癌学会学術総会抄録集(Web), 80th, 2021
変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用

中川正宏, 稲垣良作, 南谷泰仁, 趙蘭英, 趙蘭英, 越智陽太郎, 竹田淳恵, 戚星星, 依田成玄, 昆彩奈 …

日本癌学会学術総会抄録集(Web), 80th, 2021
クローン性造血における遺伝子変異とコピー数異常の統合解析

佐伯龍之介, 桃沢幸秀, 南谷泰仁, 中川正宏, 中川正宏, 越智陽太郎, 吉里哲一, 白石友一, 田中洋子, 新井田厚司 …

日本癌学会学術総会抄録集(Web), 80th, 2021
赤白血病におけるゲノム解析と治療標的の検討

竹田淳恵, 吉田健一, 依田成玄, 南谷泰仁, 越智陽太郎, 中川正宏, 佐伯龍之介, 白石友一, 永田安伸, 高折晃史 …

日本癌学会学術総会抄録集(Web), 80th, 2021
Post-Treatment Clone Size Predicts Survival Independently of IPSS-R and Response after Azacitidine Therapy for MDS

Yasuhito Nannya, Magnus Tobiasson, Shinya Sato, Elsa Bernard, Maria Creignou, Lanying Zhao, June Takeda, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka …

BLOOD, 136, Nov, 2020
Functional Characterization of Compound DDX41 Germline and Somatic R525H Mutations in the Development of Myeloid Malignancies

Ayana Kon, Masahiro Marshall Nakagawa, Ryosaku Inagaki, Keisuke Kataoka, Hideki Makishima, Yotaro Ochi, Manabu Nakayama, Haruhiko Koseki, Yasuhito Nannya, Seishi Ogawa

BLOOD, 136, Nov, 2020
Clinical Impacts of Germline DDX41 Mutations on Myeloid Neoplasms

Hideki Makishima, Yasuhito Nannya, June Takeda, Yukihide Momozawa, Ryunosuke Saiki, Tetsuichi Yoshizato, Yoshiko Atsuta, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi …

BLOOD, 136, Nov, 2020
Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Masahiro Marshall Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Qi Xingxing, Akinori Yoda, Ayana Kon …

BLOOD, 136, Nov, 2020
Genotype-Phenotype Relationships and Therapeutic Targets in Acute Erythroid Leukemia

June Takeda, Kenichi Yoshida, Akinori Yoda, Lee-Yung Shih, Yasuhito Nannya, Yotaro Ochi, Ayana Kon, Kenichi Chiba, Yuichi Shiraishi, Yusuke Shiozawa …

BLOOD, 136, Nov, 2020
Genetic analysis of metachronous pancreatic cancers

Hirano Tomonori, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Yoshikage Inoue, Tomomi Nishimura, Yoichi Fujii, Akira Yokoyama, Hideki Makishima, Toshihiko Masui, Shinji Uemoto …

CANCER RESEARCH, 80(16), Aug, 2020

Teaching Experience

Professional Memberships

Research Projects

comprehensive studies on the molecular basis of early development and clonal evolution in cancer using advanced genomics.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2024
Clinical application of germline and somatic mutations in bone marrow failure syndromes.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2024
Research on cancer evolution and heterogeneity using large-scale sequencing

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2015 - Mar, 2020

OGAWA SEISHI
Molecular pathogenesis of bone marrow failure elucidated by comprehensive sequencing.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

MAKISHIMA HIDEKI, YOSHIDA Kenichi, KON Ayana, KATAOKA Keisuke, ONO Kinji, KOSEKI Haruhiko, Miyazaki Yasushi, Chiba Shigeru, Nakao Shinji
骨髄系腫瘍における網羅的エクソーム・ゲノム解析

科学研究費助成事業, 研究活動スタート支援, 日本学術振興会, Aug, 2015 - Mar, 2016

牧島秀樹
わが国におけるセリアック病の頻度と合併症に関する検索

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2006 - 2008

牧島秀樹

Industrial Property Rights

特開2017-104035 ヒトにおける骨髄腫瘍の発症又は発症リスクを検査する指標の取得方法、ヒトにおけるDDX41遺伝子の体細胞変異の存在又は将来的な発生を予測する指標の取得方法、並びに、これらの検査又は予測のためのキット

小川誠司, 牧島秀樹, 吉田健一