笹井研 (Ken Sasai) - マイポータル - researchmap

基本情報

所属: 旧所属北海道大学大学院医学研究科特任助教

学位: 博士（農学）(東京大学)

J-GLOBAL ID: 200901029591073938
researchmap会員ID: 6000001428

研究キーワード

6

研究分野

3

学歴

3

MISC

20

Promoter hypomethylation regulates CD133 expression in human gliomas

Kouichi Tabu, Ken Sasai, Taichi Kimura, Lei Wang, Eiko Aoyanagi, Shinji Kohsaka, Mishie Tanino, Hiroshi Nishihara, Shinya Tanaka

CELL RESEARCH 18(10) 1037-1046 2008年10月
Establishment of a luciferase assay-based screening system: Fumitremorgin C selectively inhibits cellular proliferation of immortalized astrocytes expressing an active form of AKT

Lei Wang, Ken Sasai, Tsuyoshi Akagi, Shinya Tanaka

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 373(3) 392-396 2008年8月
Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O-6-methylguanine-DNA methyltransferase status in glioma - Relationship between immunohistochemistry and methylation analysis

Ken Sasai, Miho Nodagashira, Hiroshi Nishihara, Eiko Aoyanagi, Lei Wang, Masahito Katoh, Junichi Murata, Yoshimaru Ozaki, Tamio Ito, Shin Fujimoto …

AMERICAN JOURNAL OF SURGICAL PATHOLOGY 32(8) 1220-1227 2008年8月
Loss of suppressor-of-fused function promotes tumorigenesis

Y. Lee, R. Kawagoe, K. Sasai, Y. Li, H. R. Russell, T. Curran, P. J. McKinnon

ONCOGENE 26(44) 6442-6447 2007年9月
O-6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies

Ken Sasai, Tsuyoshi Akagi, Eiko Aoyanagi, Kouichi Tabu, Sadao Kaneko, Shinya Tanaka

MOLECULAR CANCER 6(36) 2007年6月
O-6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies

Ken Sasai, Tsuyoshi Akagi, Eiko Aoyanagi, Kouichi Tabu, Sadao Kaneko, Shinya Tanaka

MOLECULAR CANCER 6 36 2007年6月
Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor

Ken Sasai, Justyna T. Romer, Hiromichi Kimura, Derek E. Eberhart, Dennis S. Rice, Tom Curran

CANCER RESEARCH 67(8) 3871-3877 2007年4月
The Ras-MAPK pathway downregulates Caveolin-1 in rodent fibroblast but not in human fibroblasts: implications in the resistance to oncogene-mediated transformation

K. Sasai, K. Kakumoto, H. Hanafusa, T. Akagi

ONCOGENE 26(3) 449-455 2007年1月
FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts

K Kakumoto, K Sasai, T Sukezane, C Oneyama, S Ishimaru, K Shibutani, H Mizushima, E Mekada, H Hanafusa, T Akagi

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103(14) 5490-5495 2006年4月
Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies

K Sasai, JT Romer, Y Lee, D Finkelstein, C Fuller, PJ McKinnon, T Curran

CANCER RESEARCH 66(8) 4215-4222 2006年4月
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-) p53(-/-) mice

JT Romer, H Kimura, S Magdaleno, K Sasai, C Fuller, H Baines, M Connelly, CF Stewart, S Gould, LL Rubin …

CANCER CELL 6(3) 229-240 2004年9月
Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation

T Akagi, K Sasai, H Hanafusa

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100(23) 13567-13572 2003年11月
Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the Golgi apparatus

K Sasai, Y Ikeda, H Ihara, K Honke, N Taniguchi

JOURNAL OF BIOLOGICAL CHEMISTRY 278(28) 25295-25301 2003年7月
Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation.

Akagi T, Sasai K

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13567-72. Epub 2003 Nov 3. 100(23) 13567-13572 2003年
Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus.

Sasai K

J Biol Chem 278(28) 25295-25301 2003年
The action of N-acetylglucosaminyltransferase-V is prevented by the bisecting GlcNAc residue at the catalytic step

K Sasai, Y Ikeda, H Eguchi, T Tsuda, K Honke, N Taniguchi

FEBS LETTERS 522(1-3) 151-155 2002年7月
A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation - A novel function of GnT-V distinct from the original glycosyltransferase activity

T Saito, E Miyoshi, K Sasai, N Nakano, H Eguchi, K Honke, N Taniguchi

JOURNAL OF BIOLOGICAL CHEMISTRY 277(19) 17002-17008 2002年5月
UDP-GlcNAc concentration is an important factor in the biosynthesis of beta 1,6-branched oligosaccharides: regulation based on the kinetic properties of N-acetylglucosaminyltransferase V

K Sasai, Y Ikeda, T Fujii, T Tsuda, N Taniguchi

GLYCOBIOLOGY 12(2) 119-127 2002年2月
The critical role of the stem region as a functional domain responsible for the oligomerization and Golgi localization of N-acetylglucosaminyltransferase V. The involvement of a domain homophilic interaction.

Sasai et a

J Biol Chem 276(1) 759-765 2001年
The critical role of the stem region as a functional domain responsible for the oligomerization and Golgi localization of N-acetylglucosaminyltransferase V. The involvement of a domain homophilic interaction.

Sasai K

J Biol Chem. 276(1) 759-765 2001年

講演・口頭発表等

4

GLI1 but not FOXM1 induces oncogenic transformation of immortalized astrocytes.

第３１回日本分子生物学会年会（神戸） 2008年
Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a Smoothened inhibitor.

Keystone Symoisia: Molecular Targets for Cancer (Whistler, BA, Canada) 2007年
O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies.

Nature-CINO Conference: Oncogenes and Human Cancer-The Next 25 Years (Madrid, Spain) 2007年
Shh pathway activity is maintained in direct allografts of medulloblastoma cells whereas it is irreversibly lost in cell culture: Implications for preclinical studies of Smoothened antagonist.

97th Annual Meeting for American Association for Cancer Research (Washington DC, USA) 2006年

共同研究・競争的資金等の研究課題

3

MGMT 遺伝子の制御機構解明とグリオーマ治療への応用

科学研究費補助金 2008年
Gene Regulation of MGMT in Glioma

Grant-in-Aid for Scientific Research 2008年
ヒト正常細胞を用いた脳腫瘍発症メカニズムの分子生物学的解析

その他の研究制度 2007年