J-GLOBAL         Last updated: Sep 14, 2019 at 15:52
International University of Health and Welfare
School of Pharmacy
Job title
Assistant Professor
Research funding number

Research Interests


Research Areas



Biotechnology and Therapeutics, Graduate School, Division of Pharmaceutical Sciences, Osaka University

Awards & Honors

Best Poster Prize in Clinical Toxicology, 11th International Congress of TDM & Clinical Toxicology, Montreal.


Ikeda, K. Myotoku, M. Hirotani, Y.
Pharmazie   63(12) 883-889   Dec 2008
An efflux function induced by multidrug resistance-associated proteins (MRPs) contributes to the mechanisms of resistance to methotrexate (MTX). Since it has been reported that the human Caucasian colon adenocarcinoma cell line (Caco-2) shows high...
Kenji Ikeda, Yuka Kawasaki, Hitomi Matsuda, Saho Kishida, Arina Iwasaki, Sayaka Ohata, Yoko Urashima, Yoshihiko Hirotani
Placenta   71 24-30   Nov 2018
© 2018 Elsevier Ltd Introduction: Placental transport is the first step in chemotherapeutic safety evaluations during pregnancy. However, a well-established in vitro model is not available. We previously reported that a trophoblast layer model usi...
Yoko Urashima, Takeaki Kato, Miho Akai, Mizuki Iwamoto, Yuna Miura, Kenji Ikeda, Yoshihiko Hirotani
Therapeutic Research   39 343-354   Jan 2018
© 2018 Life Science Publishing Co. Ltd. All rights reserved. Some combination of drugs under one-dose packaging has been reported to cause changes in tablet appearance and/or dissolution behavior. In this study, changes in appearance and dissoluti...
Ikeda, Kenji. Yagi, Yuriko. Takegami, Manabu. Lu, Yuquan. Morimoto, Kanehisa. Kurokawa, Nobuo.
Hospital Pharmacy   42(3) 209-218   Jan 2007
Purpose: Antineoplastic drugs are often detected in the plasma and urine of medical staff, despite the adoption of safety measures. This study involves ambulatory chemotherapy, which was prepared on a rotating schedule at the Department of Pharmac...
Mikiko Ueda, Kazuo Harada, Kenji Ikeda, Minako Ohishi, Maria Kitamura, Hiroko Ueda, Katsumi Azenishi, Setsu Inatsuki, Kazunori Niki, Chisato Okajima, Mamoru Tempaku, Yuki Fukuda, Saki Yoshida, Kazumasa Hirata, Shinichiro Suna, Kazusaburo Kataoka, Mikihiko Kogo, Etsuko Uejima
Japanese Journal of Clinical Pharmacology and Therapeutics   48 185-193   Jan 2017
© 2017 the Japanese Society of Clinical Pharmacology and Therapeutics(JSCPT). Enteral feeding is commonly performed in medical and nursing care facilities. Enteral feeding takes a long time; therefore, the dosing of drugs indicated for postprandia...

Conference Activities & Talks

Evaluation of the high-throuput method for the quantification of trophoblast drug transport with differentiating human choriocarcinoma JEG-3 cells.
ISSX 3rd Asian Pacific Regional Meeting, p64 (Abstract No. 104).   2009   
Effect of pH Gradient on Valproic acid Transport across Trophoblasts Using the High-throuput Method with Differentiating Human Choriocarcinoma JEG-3 Cells.
11th International Congress of TDM & Clinical Toxicology, Montreal, Ther Drug Monit 31(5), p637 (Abstract No. 117, #414)   2009   

Research Grants & Projects

Differentiation Patterns in JEG-3 Human Choriocarcinoma Cells Based on Paracellular Permeability
Project Year: 2007 - 2012
Placental drug transport is mainly regulated by the syncytiotrophoblast layers. The human choriocarcinoma cell line JEG-3 has been used as a model for studying placental drug transport. However, a problem associated with this model is that the dru...