Takashi Matsuo

Last updated: Dec 13, 2019 at 11:29

Name	Takashi Matsuo
Affiliation	Nara Institute of Science and Technology
Job title	Associate Professor

Research Interests

organic synthesis(239) , bioinorganic chemistry(72) , porphyrin(33) , hemoprotein(6) , organometallic(3) , chemical modification(9) , protein(215) , supramolecules(7) , coordination chemistry(194) , metalloprotein(5) , kinetics(21) , catalalysis(1) , heme(15) , organometallics(14) , enzyme(157) , protease(50)

Research Areas

Biological Science / Biophysics /
Biomolecular science / Chemical biology /
Biomolecular science / Biomolecular chemistry /
Chemistry / Organic chemistry /
Chemistry / Inorganic chemistry /
Applied Chemistry / Bio-related chemistry /

Published Papers

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Global Structural Flexibility of Metalloproteins Regulates Reactivity of Transition Metal Ion in the Protein Core: An Experimental Study Using Thiol-subtilisin as a Model Protein

Takashi Matsuo, Takamasa Kono, Isamu Shobu, Masaya Ishida, Katsuya Gonda, Shun Hirota

Chemistry - A European Journal Feb 2018 [Refereed]

Recent developments on creation of artificial metalloenzymes

Takashi Matsuo, Teruyuki Miyake, Shun Hirota

Tetrahedron Letters 60(45) 151226 Nov 2019 [Refereed]

Hydrophobicity of Residue 128 of the Stress-Inducible Sigma Factor RpoS Is Critical for Its Activity

T. Iwase T. Matsuo S. Nishioka A.Tajima Y. Mizunoe

Frontiers in Microbiology 8 656 2017 [Refereed]

Effects of Heme Electronic Structure and Distal Polar Interaction on Functional and Vibrational Properties of Myoglobin

Kanai Yuki, Nishimura Ryu, Nishiyama Kotaro, Shibata Tomokazu, Yanagisawa Sachiko, Ogura Takashi, Matsuo Takashi, Hirota Shun, Neya Saburo, Suzuki Akihiro, others

Inorganic chemistry 55(4) 1613 2016 [Refereed]

Effect of a Procaspase-Activating Compound on the Catalytic Activity of Mature Caspase-3

Matsuo Takashi, Yamada Keita, Ishida Masaya, Miura Yoshiyuki, Yamanaka Masaru, Hirota Shun

Bulletin of the Chemical Society of Japan 88(9) 1221 2015 [Refereed]

Excimer Emission Properties on Pyrene-Labeled Protein Surface: Correlation between Emission Spectra, Ring Stacking Modes, and Flexibilities of Pyrene Probes

Fujii Akira, Sekiguchi Yutaka, Matsumura Hiroyoshi, Inoue Tsuyoshi, Chung Wen-Sheng, Hirota Shun, Matsuo Takashi

Bioconjugate chemistry 26(3) 537 2015 [Refereed]

Artificial enzymes with protein scaffolds: Structural design and modification

Takashi Matsuo, Shun Hirota

Bioorganic & Medicinal Chemistry 22(20) 5638 Oct 2014 [Refereed]

Electronic control of ligand-binding preference of a myoglobin mutant

Nishimura Ryu, Matsumoto Daichi, Shibata Tomokazu, Yanagisawa Sachiko, Ogura Takashi, Tai Hulin, Matsuo Takashi, Hirota Shun, Neya Saburo, Suzuki Akihiro, others

Inorganic chemistry 53(17) 9156 2014 [Refereed]

3P096 一酸化炭素よりも酸素に対して高い親和性を示すミオグロビンの創製 (02. ヘム蛋白質, ポスター, 第 52 回日本生物物理学会年会 (2014 年度))

Nishimura Ryu, Matsumoto Daichi, Shibata Tomokazu, Yanagisawa Sachiko, Ogura Takashi, Tai Hulin, Matsuo Takashi, Hirota Shun, Neya Saburo, Suzuki Akihiro, others

生物物理 54(1) S264 2014 [Refereed]

3P096 Preparation of myoglobin mutants exhibiting preferential binding of oxygen over carbon monoxide (02. Heme proteins, Poster, The 52nd Annual Meeting of the Biophysical Society of Japan (BSJ2014))

Nishimura Ryu, Matsumoto Daichi, Shibata Tomokazu, Yanagisawa Sachiko, Ogura Takashi, Tai Hulin, Matsuo Takashi, Hirota Shun, Neya Saburo, Suzuki Akihiro, others

Seibutsu Butsuri 54(supplement1-2) S264 2014 [Refereed]

Mechanism for ligand discrimination in myoglobin

Yamamoto Y, Nishimura R, Shibata T, Matsumoto D, Tai H, Nagao S, Matsuo T, Hirota S, Ishigami I, Ogura T, others

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19 S245 2014 [Refereed]

NMR spectroscopic study of the complexation behaviors of deuterated cyclodextrins and [60] fullerene

Ikeda Atsushi, Hida Tomohiro, Kikuchi Jun-ichi, Nobusawa Kazuyuki, Matsuo Takashi

Organic letters 15(24) 6194 2013 [Refereed]

Electronic control of discrimination between O2 and CO in myoglobin lacking the distal histidine residue

Nishimura Ryu, Shibata Tomokazu, Ishigami Izumi, Ogura Takashi, Tai Hulin, Nagao Satoshi, Matsuo Takashi, Hirota Shun, Shoji Osami, Watanabe Yoshihito, others

Inorganic chemistry 53(2) 1091 2013 [Refereed]

Reversible Switching of Fluorophore Property Based on Intrinsic Conformational Transition of Adenylate Kinase during Its Catalytic Cycle

Fujii Akira, Hirota Shun, Matsuo Takashi

Bioconjugate chemistry 24(7) 1218 2013 [Refereed]

Effect of Added Salt on Ring-Closing Metathesis Catalyzed by a Water-Soluble Hoveyda--Grubbs Type Complex To Form N-Containing Heterocycles in Aqueous Media

Matsuo Takashi, Yoshida Takefumi, Fujii Akira, Kawahara Keiya, Hirota Shun

Organometallics 32(19) 5313 2013 [Refereed]

Relationship between the Electron Density of the Heme Fe Atom and the Vibrational Frequencies of the Fe-Bound Carbon Monoxide in Myoglobin

Nishimura Ryu, Shibata Tomokazu, Tai Hulin, Ishigami Izumi, Ogura Takashi, Nagao Satoshi, Matsuo Takashi, Hirota Shun, Imai Kiyohiro, Neya Saburo, others

Inorganic chemistry 52(6) 3349 2013 [Refereed]

Reaction Pathway and Free Energy Profile for Conversion of

-Conjugation Modes in Porphyrin Isomer

Matsuo Takashi, Tohi Yuji, Hayashi Takashi

The Journal of organic chemistry 77(20) 8946 2012 [Refereed]

Reaction of cobalt porphycene with hydride reagents: spectroscopic detection of Co--H porphycene species and formation of Co--SnR3 porphycene species

Matsuo Takashi, Komatsuzaki Kunihiko, Tsuji Takanori, Hayashi Takashi

Journal of Porphyrins and Phthalocyanines 16(05n06) 616 2012 [Refereed]

Creation of an artificial metalloprotein with a Hoveyda--Grubbs catalyst moiety through the intrinsic inhibition mechanism of

-chymotrypsin

Matsuo Takashi, Imai Chie, Yoshida Takefumi, Saito Takashi, Hayashi Takashi, Hirota Shun

Chemical Communications 48(11) 1662 2012 [Refereed]

Investigation of Aromaticity and Photophysical Properties in [18]/[20]

Porphycene Derivatives

Kim Kil Suk, Sung Young Mo, Matsuo Takashi, Hayashi Takashi, Kim Dongho

Chemistry-A European Journal 17(28) 7882 2011 [Refereed]

Thermal isomerization of N-bridged cobalt corrole complexes through a transiently formed axial carbenoid

Chattopadhyay Prosenjit, Matsuo Takashi, Tsuji Takanori, Ohbayashi Jun, Hayashi Takashi

Organometallics 30(7) 1869 2011 [Refereed]

Precise Design of Artificial Cofactors for Enhancing Peroxidase Activity of Myoglobin: Myoglobin Mutant H64D Reconstituted with a “Single-Winged Cofactor” Is Equivalent to Native Horseradish Peroxidase in Oxidation Activity

Matsuo Takashi, Fukumoto Kazuki, Watanabe Takuro, Hayashi Takashi

Chemistry--An Asian Journal 6(9) 2491 2011 [Refereed]

Peroxidase activity enhancement of horse cytochrome c by dimerization

Wang Zhonghua, Matsuo Takashi, Nagao Satoshi, Hirota Shun

Organic & biomolecular chemistry 9(13) 4766 2011 [Refereed]

Inside Cover: Precise Design of Artificial Cofactors for Enhancing Peroxidase Activity of Myoglobin: Myoglobin Mutant H64D Reconstituted with a “Single-Winged Cofactor” Is Equivalent to Native Horseradish Peroxidase in Oxidation Activity (Chem. Asian J. 9

Matsuo Takashi, Fukumoto Kazuki, Watanabe Takuro, Hayashi Takashi

Chemistry--An Asian Journal 6(9) 2182 2011 [Refereed]

DNA cleavage by the photocontrolled cooperation of ZnII centers in an azobenzene-linked dizinc complex

Panja Anangamohan, Matsuo Takashi, Nagao Satoshi, Hirota Shun

Inorganic chemistry 50(22) 11437 2011 [Refereed]

Supramolecular protein--protein complexation via specific interaction between glycosylated myoglobin and sugar-binding protein

Nagai Hirokazu, Onoda Akira, Matsuo Takashi, Hayashi Takashi

Supramolecular Chemistry 22(1) 57 2010 [Refereed]

Effect of Heme Modification on Oxygen Affinity of Myoglobin and Equilibrium of the Acid- Alkaline Transition in Metmyoglobin

Shibata Tomokazu, Nagao Satoshi, Fukaya Masashi, Tai Hulin, Nagatomo Shigenori, Morihashi Kenji, Matsuo Takashi, Hirota Shun, Suzuki Akihiro, Imai Kiyohiro, others

Journal of the American Chemical Society 132(17) 6091 2010 [Refereed]

Meso-unsubstituted iron corrole in hemoproteins: remarkable differences in effects on peroxidase activities between myoglobin and horseradish peroxidase

Matsuo Takashi, Hayashi Akihiro, Abe Masato, Matsuda Takaaki, Hisaeda Yoshio, Hayashi Takashi

Journal of the American Chemical Society 131(42) 15124 2009 [Refereed]

Electron transfer and oxidase activities in reconstituted hemoproteins with chemically modified cofactors

Matsuo Takashi, Hayashi Takashi

Journal of Porphyrins and Phthalocyanines 13(10) 1082 2009 [Refereed]

Photocatalytic hydrogen generation using a protein-coated photosensitizer with anionic patches and a monocationic electron mediator

Matsuo Takashi, Asano Atsushi, Ando Tsutomu, Hisaeda Yoshio, Hayashi Takashi

Chemical Communications (31) 3684 2008 [Refereed]

Isolable Iron (II)--Porphycene Derivative Stabilized by Introduction of Trifluoromethyl Groups on the Ligand Framework

Ito Kazuyuki, Matsuo Takashi, Aritome Isao, Hisaeda Yoshio, Hayashi Takashi

Bulletin of the Chemical Society of Japan 81(1) 76 2008 [Refereed]

20# 960 Nonaromatic Porphycene

Matsuo T, Ito K, Kanehisa N, Hayashi T

Synfacts (2) 146 2008 [Refereed]

Effect of peripheral trifluoromethyl groups in artificial iron porphycene cofactor on ligand binding properties of myoglobin

Matsuo Takashi, Ito Kazuyuki, Nakashima Yuji, Hisaeda Yoshio, Hayashi Takashi

Journal of inorganic biochemistry 102(2) 166 2008 [Refereed]

A Structural Isomer of Nonaromatic Porphyrin: Preparation of 20

-Conjugated Porphycene Based on Electronic Perturbation

Matsuo Takashi, Ito Kazuyuki, Kanehisa Nobuko, Hayashi Takashi

Organic letters 9(25) 5303 2007 [Refereed]

Structure and ligand binding properties of myoglobins reconstituted with monodepropionated heme: functional role of each heme propionate side chain

Harada Katsuyoshi, Makino Masatomo, Sugimoto Hiroshi, Hirota Shun, Matsuo Takashi, Shiro Yoshitsugu, Hisaeda Yoshio, Hayashi Takashi

Biochemistry 46(33) 9406 2007 [Refereed]

Porphyrinoid chemistry in hemoprotein matrix: detection and reactivities of iron (IV)-oxo species of porphycene incorporated into horseradish peroxidase

Matsuo Takashi, Murata Dai, Hisaeda Yoshio, Hori Hiroshi, Hayashi Takashi

Journal of the American Chemical Society 129(43) 12906 2007 [Refereed]

Supramolecular Hemoprotein Linear Assembly by Successive Interprotein Heme- Heme Pocket Interactions

Kitagishi Hiroaki, Oohora Koji, Yamaguchi Hiroyasu, Sato Hideaki, Matsuo Takashi, Harada Akira, Hayashi Takashi

Journal of the American Chemical Society 129(34) 10326 2007 [Refereed]

Stoichiometric oxidations of

-bonds: Radical and possible non-radical pathways

Mayer James M, Mader Elizabeth A, Roth Justine P, Bryant Jasmine R, Matsuo Takashi, Dehestani Ahmad, Bales Brian C, Watson Eric J, Osako Takao, Valliant-Saunders Karine, others

Journal of Molecular Catalysis A: Chemical 251(1) 24 2006 [Refereed]

Ligand binding properties of two kinds of reconstituted myoglobins with iron porphycene having propionates: Effect of

-pyrrolic position of two propionate side chains in porphycene framework

Matsuo Takashi, Ikegami Takahiro, Sato Hideaki, Hisaeda Yoshio, Hayashi Takashi

Journal of inorganic biochemistry 100(7) 1265 2006 [Refereed]

Construction of glycosylated myoglobin by reconstitutional method

Matsuo Takashi, Nagai Hirokazu, Hisaeda Yoshio, Hayashi Takashi

Chemical Communications (29) 3131 2006 [Refereed]

Iron Porphyrin- Cyclodextrin Supramolecular Complex as a Functional Model of Myoglobin in Aqueous Solution

Kano Koji, Kitagishi Hiroaki, Dagallier Camille, Kodera Masahito, Matsuo Takashi, Hayashi Takashi, Hisaeda Yoshio, Hirota Shun

Inorganic chemistry 45(11) 4448 2006 [Refereed]

An Extremely Long-Lived Singlet 4, 4-Dimethoxy-3, 5-diphenylpyrazolidine-3, 5-diyl Derivative: A Notable Nitrogen-Atom Effect on Intra-and Intermolecular Reactivity

Abe Manabu, Kubo Emi, Nozaki Koichi, Matsuo Takashi, Hayashi Takashi

Angewandte Chemie International Edition 45(46) 7828 2006 [Refereed]

Crystal structure and peroxidase activity of myoglobin reconstituted with iron porphycene

Hayashi Takashi, Murata Dai, Makino Masatomo, Sugimoto Hiroshi, Matsuo Takashi, Sato Hideaki, Shiro Yoshitsugu, Hisaeda Yoshio

Inorganic chemistry 45(26) 10530 2006 [Refereed]

Preparation and O2 binding study of myoglobin having a cobalt porphycene

Matsuo Takashi, Tsuruta Takashi, Maehara Keiko, Sato Hideaki, Hisaeda Yoshio, Hayashi Takashi

Inorganic chemistry 44(25) 9391 2005 [Refereed]

Hydrophobic vitamin B12. Part 20: Supernucleophilicity of Co (I) heptamethyl cobyrinate toward various organic halides

Shimakoshi Hisashi, Maeyama Yasunori, Kaieda Takeshi, Matsuo Takashi, Matsui Eiki, Naruta Yoshinori, Hisaeda Yoshio

Bulletin of the Chemical Society of Japan 78(5) 859 2005 [Refereed]

Oxidations of NADH analogues by cis-[RuIV (bpy) 2 (py)(O)] 2+ occur by hydrogen-atom transfer rather than by hydride transfer

Matsuo Takashi, Mayer James M

Inorganic chemistry 44(7) 2150 2005 [Refereed]

Ligand Binding Properties of Myogiobin Reconstituted with iron Porphycene: Unusual O 2 Binding Selectivity against CO Binding 1

Sato Hideaki, Hisaeda Yoshio, Hori Hiroshi, Ikegami Takahiro, Murata Dai, Hirota Shun, Matsuo Takashi, Hayashi Takashi, Dejima Hirohisa

Journal of the American Chemical Society: JACS 126(49) 16007 2004 [Refereed]

Enhancement of enzymatic activity for myoglobins by modification of heme-propionate side chains

Hayashi Takashi, Sato Hideaki, Matsuo Takashi, Matsuda Takaaki, Hitomi Yutaka, Hisaeda Yoshio

Journal of Porphyrins and Phthalocyanines 8(03) 255 2004 [Refereed]

Chemical properties of sperm whale myoglobins reconstituted with monopropionate hemins

Hayashi Takashi, Nakagawa Tomoyuki, Harada Katsuyoshi, Matsuo Takashi, Hitomi Yutaka, Hisaeda Yoshio

Chemistry letters 33(11) 1512 2004 [Refereed]

Cumene Oxidation by cis-[RuIV (bpy) 2 (py)(O)] 2+, Revisited

Bryant Jasmine R, Matsuo Takashi, Mayer James M

Inorganic chemistry 43(4) 1587 2004 [Refereed]

Ligand Binding Properties of Myoglobin Reconstituted with Iron Porphycene: Unusual O2 Binding Selectivity against CO Binding1

Matsuo Takashi, Dejima Hirohisa, Hirota Shun, Murata Dai, Sato Hideaki, Ikegami Takahiro, Hori Hiroshi, Hisaeda Yoshio, Hayashi Takashi

Journal of the American Chemical Society 126(49) 16007 2004 [Refereed]

Role of heme-propionate side chains in myoglobin function

Hayashi Takashi, Matsuo Takashi, Harada Katsuyoshi, Hisaeda Yoshio, Hirota Shun, Funasaki Noriaki

Journal of Inorganic Biochemistry 96(1) 50 2003 [Refereed]

Syntheses of new water-soluble dicobalt complexes having two cobalt carbon bonds and their ability for DNA cleavage

Shimakoshi Hisashi, Kaieda Takeshi, Matsuo Takashi, Sato Hideaki, Hisaeda Yoshio

Tetrahedron letters 44(28) 5197 2003 [Refereed]

Iron Twin-Coronet Porphyrins as Models of Myoglobin and Hemoglobin: Amphibious Electrostatic Effects of Overhanging Hydroxyl Groups for Successful CO/O2 Discrimination

Tani Fumito, Matsu-ura Mikiya, Ariyama Kiyoko, Setoyama Toshikazu, Shimada Takayuki, Kobayashi Shinjiro, Hayashi Takashi, Matsuo Takashi, Hisaeda Yoshio, Naruta Yoshinori

Chemistry-A European Journal 9(4) 862 2003 [Refereed]

Reductive activation of dioxygen by a myoglobin reconstituted with a flavohemin

Matsuo Takashi, Hayashi Takashi, Hisaeda Yoshio

Journal of the American Chemical Society 124(38) 11234 2002 [Refereed]

Contribution of heme-propionate side chains to structure and function of myoglobin: chemical approach by artificially created prosthetic groups

Hayashi Takashi, Matsuo Takashi, Hitomi Yutaka, Okawa Kazufumi, Suzuki Akihiro, Shiro Yoshitsugu, Iizuka Tetsutaro, Hisaeda Yoshio, Ogoshi Hisanobu

Journal of inorganic biochemistry 91(1) 94 2002 [Refereed]

Blue myoglobin reconstituted with an iron porphycene shows extremely high oxygen affinity

Hayashi Takashi, Dejima Hirohisa, Matsuo Takashi, Sato Hideaki, Murata Dai, Hisaeda Yoshio

Journal of the American Chemical Society 124(38) 11226 2002 [Refereed]

Kinetic study on conformational effect in hydrolysis of p-nitroanilides catalyzed by

-chymotrypsin

Kawai Yasushi, Matsuo Takashi, Ohno Atsuyoshi

Journal of the Chemical Society, Perkin Transactions 2 (4) 887 2000 [Refereed]

Conformational Effect (Induced-Fit) on Catalytic Activity of

-Chymotrypsin

Kawai Yasushi, Matsuo Takashi, Ohno Atsuyoshi

Bulletin of the Chemical Society of Japan 71(9) 2187 1998 [Refereed]

Research Grants & Projects

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Investigation on the reaction mechanism of heme oexygenase having non-natural tetrapyrrolic cofactors

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))

Project Year: 2007 - 2008 Investigator(s): Takashi MATSUO

Reactivities of Porphyrinoids in Protein Matrices

Construction of artificial biomolecules organometallic complexes with unique fuinctions

Clarification of pro-enzymes activation