OHNO, Kinji

J-GLOBAL         Last updated: Jun 17, 2019 at 11:42
 
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Name
OHNO, Kinji
Affiliation
Nagoya University
Job title
Professor

Academic & Professional Experience

 
Jun 1983
 - 
Mar 1985
Intern, Nagoya National Hospital
 
Apr 1985
 - 
Mar 1988
Neurology Resident and Staff, Nagoya National University
 
Apr 1992
 - 
Mar 1993
JSPS Postdoctoral fellow, Nagoya University Graduate School of Medicine
 
Apr 1993
 - 
Mar 1996
Research Fellow, Dept of Neurology, Mayo Clinic
 
Apr 1996
 - 
Mar 2001
Research Associate, Dept of Neurology, Mayo Clinic
 

Published Papers

 
Li J, Ito M, Ohkawara B, Masuda A, Ohno K
Scientific reports   8(1) 13577--   Sep 2018   [Refereed]
Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Oda E, Ito M, Ohno K, Hattori N
Movement disorders : official journal of the Movement Disorder Society   -(-) ---   Sep 2018   [Refereed]
Ito M, Ohno K
Matrix biology : journal of the International Society for Matrix Biology   68-69(-) 628-636   Aug 2018   [Refereed]
Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, Hagiwara M
Cell reports   23(5) 1326-1341   May 2018   [Refereed]
Nishiwaki H, Ito M, Negishi S, Sobue S, Ichihara M, Ohno K
Free radical research   52(4) 434-445   Apr 2018   [Refereed]
Ito K, Ohkawara B, Yagi H, Nakashima H, Tsushima M, Ota K, Konishi H, Masuda A, Imagama S, Kiyama H, Ishiguro N, Ohno K
Scientific reports   8(1) 434--   Jan 2018   [Refereed]
Yu Y, Lin Y, Takasaki Y, Wang C, Kimura H, Xing J, Ishizuka K, Toyama M, Kushima I, Mori D, Arioka Y, Uno Y, Shiino T, Nakamura Y, Okada T, Morikawa M, Ikeda M, Iwata N, Okahisa Y, Takaki M, Sakamoto S, Someya T, Egawa J, Usami M, Kodaira M, Yoshimi A, Oya-Ito T, Aleksic B, Ohno K, Ozaki N
Translational psychiatry   8(1) 12--   Jan 2018   [Refereed]
Kurahashi H, Azuma Y, Masuda A, Okuno T, Nakahara E, Imamura T, Saitoh M, Mizuguchi M, Shimizu T, Ohno K, Okumura A
Annals of neurology   83(1) 98-106   Jan 2018   [Refereed]
Ohno K, Takeda JI, Masuda A
Wiley interdisciplinary reviews. RNA   9(1) ---   Jan 2018   [Refereed]
Kasai T, Nakatani M, Ishiguro N, Ohno K, Yamamoto N, Morita M, Yamada H, Tsuchida K, Uezumi A
The American journal of pathology   187(12) 2627-2634   Dec 2017   [Refereed]
Gao K, Ren Y, Wang J, Liu Z, Li J, Li L, Wang B, Li H, Wang Y, Cao Y, Ohno K, Zhai R, Liang Z
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme   42(12) 1316-1321   Dec 2017   [Refereed]
Osawa Y, Matsushita M, Hasegawa S, Esaki R, Fujio M, Ohkawara B, Ishiguro N, Ohno K, Kitoh H
Bone   105(-) 42-49   Dec 2017   [Refereed]
Minato T, Maeda T, Fujisawa Y, Tsuji H, Nomoto K, Ohno K, Hirayama M
PloS one   12(11) e0187307--   Nov 2017   [Refereed]
Ohno K, Ohkawara B, Ito M
Expert opinion on therapeutic targets   21(10) 949-958   Oct 2017   [Refereed]
Miyamoto K, Ohkawara B, Ito M, Masuda A, Hirakawa A, Sakai T, Hiraiwa H, Hamada T, Ishiguro N, Ohno K
PloS one   12(9) e0184388--   Sep 2017   [Refereed]
Tabeta K, Du X, Arimatsu K, Yokoji M, Takahashi N, Amizuka N, Hasegawa T, Crozat K, Maekawa T, Miyauchi S, Matsuda Y, Ida T, Kaku M, Hoebe K, Ohno K, Yoshie H, Yamazaki K, Moresco EMY, Beutler B
Scientific reports   7(1) 11717--   Sep 2017   [Refereed]
Ahsan KB, Masuda A, Rahman MA, Takeda JI, Nazim M, Ohkawara B, Ito M, Ohno K
Scientific reports   7(1) 10446--   Sep 2017   [Refereed]
Matsushita M, Esaki R, Mishima K, Ishiguro N, Ohno K, Kitoh H
Scientific reports   7(1) 7371--   Aug 2017   [Refereed]
Ohno Kinji, Nazim Mohammad, Masuda Akio
JOURNAL OF NEUROCHEMISTRY   142(-) 198--   Aug 2017   [Refereed]
Ohno K, Rahman MA, Nazim M, Nasrin F, Lin Y, Takeda JI, Masuda A
Journal of neurochemistry   142 Suppl 2(-) 64-72   Aug 2017   [Refereed]
Kishimoto Y, Ohkawara B, Sakai T, Ito M, Masuda A, Ishiguro N, Shukunami C, Docheva D, Ohno K
PloS one   12(7) e0182051--   Jul 2017   [Refereed]
Takeda JI, Masuda A, Ohno K
Gene   618(-) 57-64   Jun 2017   [Refereed]
Ito M, Ehara Y, Li J, Inada K, Ohno K
Human gene therapy   28(5) 428-436   May 2017   [Refereed]
Nazim M, Masuda A, Rahman MA, Nasrin F, Takeda JI, Ohe K, Ohkawara B, Ito M, Ohno K
Nucleic acids research   45(3) 1455-1468   Feb 2017   [Refereed]
Matsushita M, Mishima K, Esaki R, Ishiguro N, Ohno K, Kitoh H
Journal of neurosurgery. Pediatrics   19(1) 91-95   Jan 2017   [Refereed]
Hasegawa S, Ito M, Fukami M, Hashimoto M, Hirayama M, Ohno K
Redox report : communications in free radical research   22(1) 26-34   Jan 2017   [Refereed]
Ohno K
Clinical calcium   27(3) 421-428   2017   [Refereed]
Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F
Free radical biology & medicine   101(-) 524-533   Dec 2016   [Refereed]
Ohno K, Otsuka K, Ito M
Chemico-biological interactions   259(Pt B) 266-270   Nov 2016   [Refereed]
Shen XM, Okuno T, Milone M, Otsuka K, Takahashi K, Komaki H, Giles E, Ohno K, Engel AG
Human mutation   37(10) 1051-1059   Oct 2016   [Refereed]
Muramatsu Y, Ito M, Oshima T, Kojima S, Ohno K
Pediatric pulmonology   51(9) 928-935   Sep 2016   [Refereed]
Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K
Scientific reports   6(-) 31986--   Aug 2016   [Refereed]
Ohno K
Journal of neurology, neurosurgery, and psychiatry   87(8) 801--   Aug 2016   [Refereed]
Bruun GH, Doktor TK, Borch-Jensen J, Masuda A, Krainer AR, Ohno K, Andresen BS
BMC biology   14(-) 54--   Jul 2016   [Refereed]
Shibata A, Okuno T, Rahman MA, Azuma Y, Takeda J, Masuda A, Selcen D, Engel AG, Ohno K
Journal of human genetics   61(7) 633-640   Jul 2016   [Refereed]
Nakashima H, Ohkawara B, Ishigaki S, Fukudome T, Ito K, Tsushima M, Konishi H, Okuno T, Yoshimura T, Ito M, Masuda A, Sobue G, Kiyama H, Ishiguro N, Ohno K
Scientific reports   6(-) 28512--   Jun 2016   [Refereed]
Masuda A, Takeda J, Ohno K
Wiley interdisciplinary reviews. RNA   7(3) 330-340   May 2016   [Refereed]
Chen G, Masuda A, Konishi H, Ohkawara B, Ito M, Kinoshita M, Kiyama H, Matsuura T, Ohno K
Scientific reports   6(-) 25317--   Apr 2016   [Refereed]
Takegami Y, Ohkawara B, Ito M, Masuda A, Nakashima H, Ishiguro N, Ohno K
Biochemical and biophysical research communications   473(1) 255-264   Apr 2016   [Refereed]
Ohno K, Yagi H, Ohkawara B
Neural regeneration research   11(4) 541-542   Apr 2016   [Refereed]
Masuda A, Ohno K
Seikagaku. The Journal of Japanese Biochemical Society   88(2) 244-247   Apr 2016   [Refereed]
Hirayama M, Tsunoda M, Yamamoto M, Tsuda T, Ohno K
Journal of Parkinson's disease   6(2) 423-431   Apr 2016   [Refereed]
Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K
Biochemical and biophysical research communications   470(2) 356-361   Feb 2016   [Refereed]
Gao K, Wang J, Li L, Zhai Y, Ren Y, You H, Wang B, Wu X, Li J, Liu Z, Li X, Huang Y, Luo XP, Hu D, Ohno K, Wang C
International journal of environmental research and public health   13(3) ---   Feb 2016   [Refereed]
Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F
Free radical biology & medicine   91(-) 154-163   Feb 2016   [Refereed]
Yagi H, Ohkawara B, Nakashima H, Ito K, Tsushima M, Ishii H, Noto K, Ohta K, Masuda A, Imagama S, Ishiguro N, Ohno K
PloS one   11(1) e0148470--   Jan 2016   [Refereed]
Mishima K, Kitoh H, Ohkawara B, Okuno T, Ito M, Masuda A, Ishiguro N, Ohno K
EBioMedicine   2(12) 2046-2061   Dec 2015   [Refereed]
Yagi H, Ohkawara B, Nakashima H, Ito K, Tsushima M, Ishii H, Noto K, Ohta K, Masuda A, Imagama S, Ishiguro N, Ohno K
PloS one   10(11) e0142786--   Nov 2015   [Refereed]
Hasegawa S, Goto S, Tsuji H, Okuno T, Asahara T, Nomoto K, Shibata A, Fujisawa Y, Minato T, Okamoto A, Ohno K, Hirayama M
PloS one   10(11) e0142164--   Nov 2015   [Refereed]
Ichihara M, Sobue S, Ito M, Ito M, Hirayama M, Ohno K
Medical gas research   5(-) 12--   Oct 2015   [Refereed]
Otsuka K, Ito M, Ohkawara B, Masuda A, Kawakami Y, Sahashi K, Nishida H, Mabuchi N, Takano A, Engel AG, Ohno K
Scientific reports   5(-) 13928--   Sep 2015   [Refereed]
Kishimoto Y, Kato T, Ito M, Azuma Y, Fukasawa Y, Ohno K, Kojima S
The Journal of thoracic and cardiovascular surgery   150(3) 645-5.40E+04   Sep 2015   [Refereed]
Rahman MA, Azuma Y, Nasrin F, Takeda J, Nazim M, Bin Ahsan K, Masuda A, Engel AG, Ohno K
Scientific reports   5(-) 13208--   Aug 2015   [Refereed]
Selcen D, Ohkawara B, Shen XM, McEvoy K, Ohno K, Engel AG
JAMA neurology   72(8) 889-896   Aug 2015   [Refereed]
Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K
Neuromuscular disorders : NMD   25(8) 667-671   Aug 2015   [Refereed]
Fujii H, Matsubara K, Sakai K, Ito M, Ohno K, Ueda M, Yamamoto A
Brain research   1613(-) 59-72   Jul 2015   [Refereed]
Masuda A, Takeda J, Okuno T, Okamoto T, Ohkawara B, Ito M, Ishigaki S, Sobue G, Ohno K
Genes & development   29(10) 1045-1057   May 2015   [Refereed]
Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G
Nature communications   6(-) 7098--   May 2015   [Refereed]
Sobue S, Yamai K, Ito M, Ohno K, Ito M, Iwamoto T, Qiao S, Ohkuwa T, Ichihara M
Molecular and cellular biochemistry   403(1月2日) 231-241   May 2015   [Refereed]
Tsunoda M, Hirayama M, Tsuda T, Ohno K
Clinica chimica acta; international journal of clinical chemistry   442(-) 52-55   Mar 2015   [Refereed]
Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N
The Lancet. Neurology   14(3) 274-282   Mar 2015   [Refereed]
Matsushita M, Hasegawa S, Kitoh H, Mori K, Ohkawara B, Yasoda A, Masuda A, Ishiguro N, Ohno K
Endocrinology   156(2) 548-554   Feb 2015   [Refereed]
Azuma Y, Nakata T, Tanaka M, Shen XM, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K
Neuromuscular disorders : NMD   25(1) 60-69   Jan 2015   [Refereed]
Nasrin F, Rahman MA, Masuda A, Ohe K, Takeda J, Ohno K
Scientific reports   4(-) 6841--   Oct 2014   [Refereed]
Yamashita Y, Matsuura T, Kurosaki T, Amakusa Y, Kinoshita M, Ibi T, Sahashi K, Ohno K
Neurobiology of disease   69(-) 200-205   Sep 2014   [Refereed]
Asai N, Ohkawara B, Ito M, Masuda A, Ishiguro N, Ohno K
Biochemical and biophysical research communications   451(2) 302-307   Aug 2014   [Refereed]
Ohno K
Journal of neurology, neurosurgery, and psychiatry   85(8) 831--   Aug 2014   [Refereed]
Ohno K, Ito M, Kawakami Y, Ohtsuka K
Journal of molecular neuroscience : MN   53(3) 359-361   Jul 2014   [Refereed]
Kobayashi M, Ohno T, Ihara K, Murai A, Kumazawa M, Hoshino H, Iwanaga K, Iwai H, Hamana Y, Ito M, Ohno K, Horio F
PloS one   9(5) e96271--   May 2014   [Refereed]
Ohkawara B, Cabrera-Serrano M, Nakata T, Milone M, Asai N, Ito K, Ito M, Masuda A, Ito Y, Engel AG, Ohno K
Human molecular genetics   23(7) 1856-1868   Apr 2014   [Refereed]
Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F, Toyokuni S
Free radical biology & medicine   69(-) 324-330   Apr 2014   [Refereed]
Kokunai Y, Nakata T, Furuta M, Sakata S, Kimura H, Aiba T, Yoshinaga M, Osaki Y, Nakamori M, Itoh H, Sato T, Kubota T, Kadota K, Shindo K, Mochizuki H, Shimizu W, Horie M, Okamura Y, Ohno K, Takahashi MP
Neurology   82(12) 1058-1064   Mar 2014   [Refereed]
Takamatsu A, Ohkawara B, Ito M, Masuda A, Sakai T, Ishiguro N, Ohno K
PloS one   9(3) e92699--   Mar 2014   [Refereed]
Inaguma Y, Hamada N, Tabata H, Iwamoto I, Mizuno M, Nishimura YV, Ito H, Morishita R, Suzuki M, Ohno K, Kumagai T, Nagata K
EMBO molecular medicine   6(3) 414-429   Mar 2014   [Refereed]
Nakayama T, Nakamura H, Oya Y, Kimura T, Imahuku I, Ohno K, Nishino I, Abe K, Matsuura T
Journal of human genetics   59(3) 129-133   Mar 2014   [Refereed]
Honda D, Ishigaki S, Iguchi Y, Fujioka Y, Udagawa T, Masuda A, Ohno K, Katsuno M, Sobue G
FEBS open bio   4(-) 1030--   2014   [Refereed]
Nishikawa A, Mori-Yoshimura M, Okamoto T, Oya Y, Nakata T, Ohno K, Murata M
Rinsho shinkeigaku = Clinical neurology   54(7) 561-564   2014   [Refereed]
Matsushita M, Kitoh H, Ohkawara B, Mishima K, Kaneko H, Ito M, Masuda A, Ishiguro N, Ohno K
PloS one   8(12) e81569--   Dec 2013   [Refereed]
Kitoh H, Achiwa M, Kaneko H, Mishima K, Matsushita M, Kadono I, Horowitz JD, Sallustio BC, Ohno K, Ishiguro N
Orphanet journal of rare diseases   8(-) 163--   Oct 2013   [Refereed]
Rahman MA, Masuda A, Ohe K, Ito M, Hutchinson DO, Mayeda A, Engel AG, Ohno K
Scientific reports   3(-) 2931--   Oct 2013   [Refereed]
Ohno K
Journal of neurology, neurosurgery, and psychiatry   84(10) 1064--   Oct 2013   [Refereed]
Fujioka Y, Ishigaki S, Masuda A, Iguchi Y, Udagawa T, Watanabe H, Katsuno M, Ohno K, Sobue G
Scientific reports   3(-) 2388--   Aug 2013   [Refereed]
Selcen D, Shen XM, Milone M, Brengman J, Ohno K, Deymeer F, Finkel R, Rowin J, Engel AG
Neurology   81(4) 370-378   Jul 2013   [Refereed]
Nakata T, Ito M, Azuma Y, Otsuka K, Noguchi Y, Komaki H, Okumura A, Shiraishi K, Masuda A, Natsume J, Kojima S, Ohno K
Human mutation   34(7) 997-1004   Jul 2013   [Refereed]
Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M, Tanaka M
BMC genomics   14(-) 248--   Apr 2013   [Refereed]
Ohno K, Ito M, Kawakami Y, Krejci E, Engel AG
Chemico-biological interactions   203(1) 335-340   Mar 2013   [Refereed]
Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, Ohsawa I, Ohno K, Ito M
Medical gas research   3(1) 6--   Mar 2013   [Refereed]
Sayeed S, Asano E, Ito S, Ohno K, Hamaguchi M, Senga T
Molecular and cellular biochemistry   374(1月2日) 105-111   Feb 2013   [Refereed]
Yamamoto R, Matsushita M, Kitoh H, Masuda A, Ito M, Katagiri T, Kawai T, Ishiguro N, Ohno K
Journal of bone and mineral metabolism   31(1) 26-33   Jan 2013   [Refereed]
Honda D, Ishigaki S, Iguchi Y, Fujioka Y, Udagawa T, Masuda A, Ohno K, Katsuno M, Sobue G
FEBS open bio   4(-) 1-10   2013   [Refereed]
Ishigaki S, Masuda A, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K
Scientific reports   2(-) 529--   Jul 2012   [Refereed]
Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
Molecular therapy : the journal of the American Society of Gene Therapy   20(7) 1384-1392   Jul 2012   [Refereed]
Kurosaki T, Ueda S, Ishida T, Abe K, Ohno K, Matsuura T
PloS one   7(6) e38379--   Jun 2012   [Refereed]
Yamashita Y, Matsuura T, Shinmi J, Amakusa Y, Masuda A, Ito M, Kinoshita M, Furuya H, Abe K, Ibi T, Sahashi K, Ohno K
Journal of human genetics   57(6) 368-374   Jun 2012   [Refereed]
Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, Ohno K
Medical gas research   2(1) 15--   May 2012   [Refereed]
Yoshinaga H, Sakoda S, Good JM, Takahashi MP, Kubota T, Arikawa-Hirasawa E, Nakata T, Ohno K, Kitamura T, Kobayashi K, Ohtsuka Y
Journal of the neurological sciences   315(1月2日) 15-19   Apr 2012   [Refereed]
Matsuura T, Minami N, Arahata H, Ohno K, Abe K, Hayashi YK, Nishino I
Journal of human genetics   57(3) 219-220   Mar 2012   [Refereed]
Masuda A, Andersen HS, Doktor TK, Okamoto T, Ito M, Andresen BS, Ohno K
Scientific reports   2(-) 209--   Jan 2012   [Refereed]
Ohno K, Ito M, Ichihara M, Ito M
Oxidative medicine and cellular longevity   2012(-) 353152--   2012   [Refereed]
Ohno K
Rinsho shinkeigaku = Clinical neurology   52(11) 1306-1308   2012   [Refereed]

Conference Activities & Talks

 
Drug X inhibits heterotopic ossification by suppression of Bmp2-smad 1/5/8 signaling
Kusano T, Nakatani M, Uezumi A, Ishiguro N, Ohno K, Yamada H, Tsuchida K
ORS 2019 Annual Meeting   2 Feb 2019   
Zonisamide blocked mild cervicalspondylotic myelopathy progression in chronic compression rat model
Kambara S, Ohkawara B, Koshimizu H, Imagama S, Ishiguro N, Ohno K
ORS 2019 Annual Meeting   2 Feb 2019   
Congenital myasthenic syndromes [Invited]
Ohno K
15th International Congress of Neuromuscular Diseases   6 Jul 2018   
Functional analysis of disease-causing mutations in GFPT1-CMS
Farshadyeganeh P, Ohkawara B, Ohno K
11th Japanese-French Workshop on Muscular Dystrophies   14 Jun 2018   
Splicing regulations in neuromuscular diseases [Invited]
Ohno K, Masuda A
11th Japanese-French Workshop on Muscular Dystrophies   14 Jun 2018   
A global binding map of hnRNP A2/B1
Christensen LL, Doktor TK, Masuda A, Ohno K, Andresen BS
23rd Annual Meeting of the RNA Society   29 May 2018   
Loss of Sfpq causes long-gene transcriptopathy in the brain
Takeuchi A, Iida K, Hosokawa M, Denawa M, Ito M, Ohno K, Hagiwara M
23rd Annual Meeting of the RNA Society   29 May 2018   
Bone formation was promoted in mouse model of distraction osteogenesis with gain-of-function mutation in fgfr3
Osawa Y, Matsushita M, Mishima K, Ishiguro N, Ohno K, Kitoh H
ORS 2018 Annual Meeting   10 Mar 2018   
Decoding aberrant splicing code in human diseases [Invited]
Ohno K
FAN Symposium   6 Oct 2017   
Japanese myotonic dystrophy type 2 patients carry a haplotype different from the European founder haplotype
Matsuura T, Kimura T, Kitao R, Komori T, Toda T, Ohno K
11th International myotonic dystrophy consortium meeting (IDMC-11)   5 Sep 2017   
SRSF1 suppresses selection of intron-distal 5’ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein
Ahsan KB, Masuda A, Rahman MA, Takeda J, Ohkawara B, Ito M, Ohno K
2017 CSHL Meeting: Eukaryotic mRNA Processing   22 Aug 2017   
Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms
Nazim M, Masuda A, Rahman MA, Nasrin F, Takeda J, Ohe K, Ohkawara B, Ito M, Ohno K
2017 CSHL Meeting: Eukaryotic mRNA Processing   22 Aug 2017   
Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling
Miyamoto K, Ohkawara B, Sakai T, Hiraiwa H, Hamada T, Ohno K, Ishiguro N
ORS 2017 Annual Meeting   19 Mar 2017   
Clinically Feasible Dose Of Meclozine Promotes Bone Growth In Mouse Model With Achondroplasia
Matsushita M, Kitoh H, Mishima K, Sugiura H, Kitamura A, Ishiguro N, Ohno K
ORS 2017 Annual Meeting   19 Mar 2017   
Splicing regulation of the human acetylcholinesterase gene [Invited]
Ohno K, Nazim M, Masuda A
XVth International Symposium on Cholinergic Mechanisms   16 Oct 2016   
Molecular hydrogen as an emerging therapeutic agent for neurological and neuromuscular disorders [Invited]
Ohno K
Molecular Hydrogen as Emerging Therapeutic Agent and Its Clinical Application   7 Sep 2016   
Wnt/β-catenin Signaling Contributes To Gene Expressions Related In Tendon Differentiation And Homeostasis
Kishimoto Y, Ohkawara B, Miyamoto K, Ishiguro N, Ohno K, Sakai T
ORS 2016 Annual Meeting   5 Mar 2016   
Radical therapeutic strategy for foramen magnum stenosis and spinal canal stenosis in achondroplasia
Matsushita M, Kitoh H, Mishima K, Sugiura H, Hasegawa S, Ishiguro N, Ohno K
ORS 2016 Annual Meeting   5 Mar 2016   
R-spondin2 is a critical factor for extracellular matrix production and chondrogenesis via Wnt/β-catenin signaling pathway
Takegami Y, Ohkawara B, Seki T, Ohno K, Ishiguro N
ORS 2016 Annual Meeting   5 Mar 2016   
LRP4 Myasthenia. Investigation of second kinship reveals impaired development and maintenance of the neuromuscular junction
Selcen D, Ohkawara B, Shen X-M, McEvoy K, Ohno K, Engel AG
20th International WMS Congress   30 Sep 2015   
Roles of collagen Q in MuSK antibody‐positive myasthenia gravis [Invited]
Ohno K
12th International Meeting of Cholinesterases   27 Sep 2015   
Global binding map of the splicing regulatory factor SRSF5
Bruun GH, Doktor TK, Masuda A, Krainer AR, Ohno K, Andresen BS
65th Annual Meeting of the American Society of Human Genetics   6 Sep 2015   
LGI2 heterozygous variant identified in a Japanese family with autosomal dominant cryptogenic West syndrome
Ishihara N, Azuma Y, Nakata T, Takeuchi T, Okuno T, Ohno K, Natsume J
65th Annual Meeting of the American Society of Human Genetics   6 Sep 2015   
Physiology and hereditary/autoimmune pathology of acetylcholine receptor clustering at the neuromuscular junction [Invited]
Ohno K
10th Japanese-French Workshop“New advances in treatments of neuromuscular diseases: From Basic to Applied Myology”   2 Jul 2015   
Molecular hydrogen is a novel antioxidant to reduce oxidative stress and attenuate disease progression through modification of cell signaling and gene expressions
Sobue S, Inoue C, Hori F, Ito M, Ohno K, Ichihara M
15th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants   22 Jun 2015   
Congenital myasthenic syndrome (CMS) caused by novel mutation in LRP4. Phenotypic heterogeneity and defects in neuromuscular transmission (NMT) identified in a second kinship
Selcen D, Shen X-M, Ohkawara B, McEvoy K, Ohno K, Engel AG
67th Annual Meeting of the American Academy of Neurology   18 Apr 2015   
Alternative splicing of human MUSK exon 10 is physiologically regulated by multiple splicing regulatory cis-elements and cognate trans-factors
Rahman MA, Nasrin F, Masuda A, Ohe K, Takeda J, Ohno K
RNA Biology meeting, Cold Spring Harbor Asia Conference   10 Nov 2014   
Global identification of binding sites for the splicing regulatory factors SRSF5 and hnRNPA1
Bruun GH, Doktor TK, Br?ner S, Masuda A, Palhais B, Krainer AR, Ohno K, Andresen BS
64th Annual Meeting of the American Society of Human Genetics   18 Sep 2014   
IntSplice: A tool to predict aberrant splicing of an SNV at intronic positions -50 to -3
Ohno K, Shibata A, Okuno T, Rahman MA, Azuma Y, Masuda A
64th Annual Meeting of the American Society of Human Genetics   18 Sep 2014   
Maintenance of the neuromuscular junction and its aberrations in hereditary and autoimmune disorders [Invited]
Ohno K
Guarda-Symposium 2014 on the Molecular and Cell Biology of the Neuromuscular System   1 Sep 2014   
IntSplice: A tool to predict the effect on pre-mRNA splicing of intronic nucleotide substitutions
Shibata A, Okuno T, Masuda A, Ohno K
The European Society of Human Genetics 2014   31 May 2014   
Lrp4 is required for extracellular matrix production during chondrogenesis
Asai N, Ohkawara B, Ishiguro N, Ohno K
60th Annual Meeting of the ORS   15 Mar 2014   
Mutations in LRP4 in congenital myasthenia reveal position-specific regulations of agrin and Wnt signaling of LPR4
Ohkawara B, Cabrera M, Nakata T, Shen X, Ito Y, Engel AG, Ohno K
43rd Annual Meeting, Society for Neuroscience   13 Nov 2013   
R-spondin2 is crucial for neuromuscular junction formation
Nakashima H, Ohkawara B, Imagama S, Ito Z, Ishiguro N, Ohno K
43rd Annual Meeting, Society for Neuroscience   13 Nov 2013   
FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD
Fujioka Y, Ishigaki S, Masuda A, Iguchi Y, Udagawa T, Watanabe H, Katsuno M, Ohno K, Sobue G
43rd Annual Meeting, Society for Neuroscience   12 Nov 2013   
RNA Binding Protein Sfpq is required for the expression of neuron-specific long pre-mRNAs essential for brain development
TakeuchiA, Iida K, Ninomiy K, Ito M, Ohno K, Hagiwara M
43rd Annual Meeting, Society for Neuroscience   12 Nov 2013   
FUS regulates transcription termination through binding to nascent RNA
Masuda A, Okuno T, Okamoto T, Ohno K
43rd Annual Meeting, Society for Neuroscience   11 Nov 2013   
Global analysis reveals relationship between RNA-binding sites of FUS and transcriptional regulation
Masuda A, Okuno T, Okamoto T, Ohno K
8th Brain Research Conference   7 Nov 2013   
Exome sequencing analysis reveals a mutation of Kir3.4 in a patient with Andersen-Tawil syndrome
Kokunai Y, Nakamori M, Kubota T, Mochizuki H, Takahashi MP, Nakata T, Ohno K, Sakata S, Okamura Y, Kimura H, Itoh H, Horie M, Osaki Y, Shindo K
18th International Congress of the World-Muscle-Society (WMS)   1 Oct 2013   
Meclozine facilitates chondrocyte proliferation and differentiation by attenuating abnormally activated fibroblast growth factor receptor 3 (FGFR3) signaling in achondroplasia
Matsushita M, Kitoh H, Kaneko H, Mishima K, Ishiguro N, Ohno K
11th International Skeletal Dysplasia Society (ISDS) Meeting Bologna 2013   28 Aug 2013   
Mutations in the third ?-propeller domain of LRP4 in congenital myasthenia compromise agrin-mediated MuSK signaling in a position-specific manner
Ohkawara B, Cabrera M, Nakata T, Milone M, Ito Y, Engel AG, Ohno K
36th Annual Meeting of the Japan Neuroscience Society   22 Jun 2013   
A comparative analysis of the transcriptome profiles of TDP-43 and FUS in the primary cortical neurons
Honda D, Iguchi Y, Fujioka Y, Masuda A, Watanabe H, Katsuno M, Ohno K, Ishigaki S, Sobue G
36th Annual Meeting of the Japan Neuroscience Society   22 Jun 2013   
Comparison of FUS-regulated transcriptome in four primary cell lineages in the central nervous system reveals cell-specific regulations in association with ALS/FTLD
Fujioka Y, Ishigaki S, Masuda A, Iguchi Y, Katsuno M, Ohno K, Sobue G
36th Annual Meeting of the Japan Neuroscience Society   21 Jun 2013   
What is the role of RNA-binding proteins in the process of brain formation through regulating mRNA processing ?
Takeuchi A, Iida K, Ninomiya K, Ito M, Wanezaki K, Nakagawa M, Ohno K, Hagiwara M
36th Annual Meeting of the Japan Neuroscience Society   21 Jun 2013   
Molecular hydrogen on oxidative stress diseases in nervous system [Invited]
Ohno K
36th Annual Meeting of the Japan Neuroscience Society   20 Jun 2013   
Collagen Q is a key player for developing rational therapy for congenital myasthenia and for causing anti-MuSK myasthenia gravis [Invited]
Ohno K, Ito M, Kawakami Y, Ohtsuka K, Krejci E
XIV International Symposium on Cholinergic Mechanisms   5 May 2013   
Drug Screening for Treating Osteoarthritis through Regulation of Wnt Signaling
Takamatsu A, Ohkawara B, Sakai T, Ohno K, Ishiguro N.
World Congress of the Osteoarthritis-Research-Society-International (OARSI)   18 Apr 2013   
Molecular mechanism of the inhibitory effect of hydrogen on inflammation
Ito M, Itoh T, Ohno K, Nozawa Y
90th Annual Meeting of the Physiological Society of Japan   28 Mar 2013   
Investigation of 11 patients with GFPT1-myasthenia reveals clinical, structural, and electrophysiologic heterogeneity
Selcen D, Shen X-M, Milone M, Brengman J, Ohno K, McQuillen M, Deymeer F, Finkel R, Rowin J, Engel AG
65th American Academy of Neurology   16 Mar 2013   
RNA diseases caused by defects in cis-acting elements and trans-acting factors [Invited]
Ohno K
"Danish-Japanese joint seminar on aberrant RNA splicing in neuromuscular disease", Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU)   7 Mar 2013   
Alternative RNA splicing regulating the molecular architecture of NMJ
Nasrin F, Rahman MA, Ohe K, Masuda A, Ohno K
5th NAGOYA Global Retreat   2 Feb 2013   
Drug repositioning for inhibiting the FGFR3 signaling in the treatment of short stature in achondroplasia
Matsushita M, Kitoh H, Ishiguro N, Ohno K
Orthopaedic Research Society 2013 Annual Meeting   26 Jan 2013   
Molecular hydrogen alters signaling pathways and gene expression profiles in multiple mouse organs
Sobue S, Yamai K, Ito M, Ohno K, Ito M, Ohkuwa T, Ichihara M
52nd Annual Meeting of the American Society for Cell Biology   15 Dec 2012   
HMGA1a is responsible for inducing an isoform of Estrogen receptor-alpha and modulates growth in MCF-7 mammary carcinoma cells
Ohe K, Miyajima S, Kuwasako K, Yoshimura N, Ohno K, Harada N, Muto Y, Utsumi T, Mayeda A
4th GCOE International Symposium   15 Nov 2012   
A comprehensive and efficient algorithm to predict splicing consequences of intronic nucleotide substitutions in the human genome
Shibata A, Masuda A, Ohno K
62nd Annual Meeting of the American Society of Human Genetics   6 Nov 2012   
Global mapping of FUS-binding sites and global profiling of FUS-mediated RNA metabolisms in the mouse brain
Masuda A, Ishigaki S, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K
62nd Annual Meeting of the American Society of Human Genetics   6 Nov 2012   
Mutation in congenital myasthenic syndrome reveals opposite splicing regulatory effects of hnRNPs L and LL
Rahman MA, Ohe K, Masuda A, Ito M, Hutchinson DO, Engel AG, Ohno K
35th Annual Meeting of the Japan Neuroscience Society   18 Sep 2012   
Global mapping and global expression profiling of RNA-binding proteins that are associated with neurological and neuromuscular diseases [Invited]
Ohno K
35th Annual Meeting of the Japan Neuroscience Society   18 Sep 2012   
Molecular bases and therapeutic intervention of neuromuscular transmission defects [Invited]
Ohno K
Ninth French-Japanese Workshop on Muscular Dystrophies   7 Sep 2012   
Congenital defects of neuromuscular signal transduction [Invited]
Ohno K
3rd Berlin Summer School for Myology   18 Jun 2012   
Functional characterization of GFPT1 during myogenesis and NMJ formation
Ohkawara B, Fuse Y, Nakashima H, Ohno K
The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center   7 Jun 2012   
Global analysis of RNA-binding sites of CUGBP1 and MBNL1 reveal their preferential binding to 3’ UTRs to regulate mRNA stability
Masuda A, Andersen HS, Doktor TK, Okamoto T, Ito I, Andresen BS, Ohno K
The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center   7 Jun 2012   
In myotonic dystrophy type 1 Peroxiredoxin-2 of RBC membrane protein was reduced, compared with a normal subject
Kinoshita M, Morita S, Ohno K, Hirose K
The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center   7 Jun 2012   
EMG findings at non-myotonia and myotonia states in patients with Na channelopathies
Kinoshita M, Kokunai Y, Kubota T, Takahashi M, Sasaki R, Ohno K, Hirose K
The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center   7 Jun 2012   
Protein-anchoring therapy for delivering acetylcholinesterase to the neuromuscular junction
Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
The 11th International Meeting on Cholinesterases   4 Jun 2012   
Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis [Invited]
Ohno K
The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center   4 Jun 2012   
Anti-MuSK antibodies in myasthenia gravis block binding of collagen Q to MuSK expressed at the neuromuscular junction
Kawakami Y, Ito M, Hirayama M, Sahashi K, Ohkawara B, Masuda A, Hishida H, Mabuchi N, Engel AG, Ohno K
41st Annual Meeting, Society for Neuroscience   15 Nov 2011   
Glut1 deficiency syndrome with a SLC2A1 splice site mutation and normal erythrocyte glucose uptake
Ishihara N, Azuma Y, Yanagihara K, Yokoi S, Nakata T, Aso K, Ohno K, Natsume J
12th International congress of human genetics   11 Oct 2011   
Genome-wide analysis of RNA-binding sites of HuR
Masuda A, Ito M, Fujita Y, Ohno K
16th Annual Meeting of the RNA Society   14 Jun 2011   
Protein-anchoring therapy for delivering acetylcholinesterase to the neuromuscular junction [Invited]
Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
4th International Congress of Myology   9 May 2011   
The role of Rspo3 in head cartilage morphogenesis
Ohkawara B, Ohno K, Niehrs C
16th International Conference of the International Society of Differentiation   15 Nov 2010   
Mutations at the C-terminal domain (CTD)of collagen Q (ColQ) causing acetylcholinesterase (AChE) deficiency prevent anchoring of ColQ to the neuromuscular junction (NMJ)
Sugiyama A, Ito M, Nakata T, Azuma Y, Masuda A, Okumura A, Komaki H, Ohno K
40th Annual Meeting, Society for Neuroscience   13 Nov 2010   
AG-independence of the 3' splice site determines tolerance to aberrant splicing due to a mutation at the first nucleotide of an exon
Fu Y, Masuda A, Ito M, Ohno K
Computational Biology, Cold Spring Harbor Asia Conferences (Platform), Shanghai, China   2 Nov 2010   
rAAV8-Mediated Protein-Anchoring Therapy for Targeting Collagen Q-Tailed Acetylcholinesterase to the Neuromuscular Junction
Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
American Society of Gene & Cell Therapy 13th Annual Meeting   17 May 2010   
A mutation on a nonfunctional exon P3A in CHRNA1 identified in a patient with congenital myasthenic syndrome loses binding affinity for a splicing-suppressing hnRNP L and gains binding affinity for a splicing-enhancing hnRNP LL
Rahman MA, Masuda A, Ito M, Ohno K
2nd Nagoya Global Retreart Symposium   26 Feb 2010   
Degeneracy of splicing cis-elements and tolerance to disease-causing mutations [Invited]
Ohno K
2nd GCOE International Symposium   26 Nov 2009   
Aberrantly spliced genes in human diseases - a deep sequencing approach
Andersen HS, Docter TK, Serup J, Sundahl L, Masuda A, Ohno K,resen BS
2nd GCOE International Symposium   26 Nov 2009   
AG-independence of the 3' splice site determines tolerance to aberrant splicing due to a mutation at the first nucleotide of an exon
Fu Y, Masuda A, Ito M, Ohno K
2nd GCOE International Symposium   26 Nov 2009   
A mutation on a nonfunctional exon P3A in CHRNA1 identified in a patient with congenital myasthenic syndrome loses binding affinity for a splicing-suppressing hnRNP L and gains binding affinity for a splicing-enhancing hnRNP LL
Rahman MA, Masuda A, Ito M, Ohno K
2nd GCOE International Symposium   26 Nov 2009   
Exploratory analyses of gene expression profile and aberrant splicing in schizophrenia using exon array [Invited]
Ito Y, Yamada S, Aleksic B, Kushima I, Nakamura Y, Yoshimi A, Nagai T, Noda Y, Ohno K, Ozaki N
XVII World Congress of Psychiatric Genetics   4 Nov 2009   
Misregulation of diacylglycerol kinase eta (DGKη) splicing as a potential cause of neuropsychiatric symptoms in myotonic dystrophy type 1
Matsuura T, Amakusa Y, Yamashita Y, Shinmi J, Kurosaki T, Kinoshita M, Aizawa H, Kimura T, Yahara O, Abe K, Ohno K
7th International Myotonic Dystrophy Consortium Meeting   9 Sep 2009   
Molecular mechanisms and regulations of congenital neuromuscular transmission defects [Invited]
Ohno K
Paris Descartes University Seminar   6 Jul 2009   
Protein anchoring therapy for endplate acetylcholinesterase deficiency [Invited]
Ohno K, Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Takeda S, Krejci E.
Eighth French-Japanese Workshop on Muscular Dystrophies   3 Jul 2009   
Molecular Hydrogen as an Antioxidant - Review and our experience - [Invited]
Ohno K
University of Fukui Biomedical Imaging Research Center Research seminar   2 Feb 2009   
Degeneracy of Splicing Cis-Elements and Tolerance to Disease-Causing Mutations in Human [Invited]
Ohno K
"The expanding world of post-transcriptional regulation of gene expression"   13 Dec 2008   
Pathomechanisms of congenital defects of neuromuscular signal transduction -Progress of therapies against intractable muscular diseases- [Invited]
Ohno K
Fujita Health University COE International Workshop   4 Dec 2006   
Underestimated aberrant splicings in neuromuscular disorders [Invited]
Ohno K
MEXT Grant-in-Aid for Scientific Research on Priority Areas "Spaciotemporal Network of RNA Information Flow" International Symposium 2005   8 Aug 2005   
Splicing abnormalities in congenital myasthenic syndromes [Invited]
Ohno K, Engel AG
Sixth French-Japanese Workshop on Muscular Dystrophies "Further progress toward therapy for muscular dystrophies"   1 Jul 2005   
Congenital myasthenic syndromes: Multiple molecular targets at the neuromuscular junction [Invited]
Engel AG, Ohno K, Sine SM
XIth International Symposium on Cholinergic Mechanisms   5 May 2002   
How does an A-to-G splice donor site mutation at position +3 result in aberrant splicing? A lesson learned from a mutation in the COLQ gene
Ohno K, Brengman JM, Engel AG
49th Annual Meeting of the American Society of Human Genetics   19 Oct 1999   
Acetylcholine receptor β-subunit mutations causing endplate AChR deficiency and reduced assembly with the δ subunit
Quiram PA, Ohno K, Milone M, Patterson MC, Pruitt NJ, Brengman JM, Sine SM, Engel AG
51st Annual Meeting of the American Academy of Neurology   18 Apr 1999   
Unusual congenital myasthenic syndrome with endplate AChR deficiency caused by α subunit mutations and a remitting-relapsing clinical course
Milone M, Shen X-M, Ohno K, Harper CM, Fukudome T, Stilling G, Brengman JM, Engel AG
51st Annual Meeting of the American Academy of Neurology   18 Apr 1999   
Congenital endplate acetylcholinesterase deficiency caused by nonsense, splice-site, missense mutations in the collagenic tail subunit of asymmetric AChE
Ohno K, Brengman, JM, Nakano S, Walsh P, Heidenrich F, Vincent A, Nagwany S, Engel AG
51st Annual Meeting of the American Academy of Neurology   18 Apr 1999   
A mutation in the promoter region of acetylcholine receptor ε subunit gene causes congenital myasthenic syndrome
Brengman JM, Ohno K, Anlar B, Engel AG
48th Annual Meeting of the American Society of Human Genetics   27 Oct 1998   
Congenital endplate acetylcholinesterase deficiency: Novel missense and null mutations in the collagen-like tail subunit of the asymmetric enzyme
Ohno K, Brengman JM, Milone M, Shen X-M, Tsujino A, Anlar B, Engel AG
48th Annual Meeting of the American Society of Human Genetics   27 Oct 1998   
Congenital endplate acetylcholinesterase deficiency: Novel missense, null, splice-site mutations in the collagen-like tail subunit of the asymmetric enzyme
Ohno K, Brengman JM, Milone M, Anlar B, Felice KJ, Engel AG
123rd Annual Meeting of the American Neurological Association (Works in Progress)   18 Oct 1998   
Congenital myasthenic syndrome due to a splice site and a novel one codon deletion mutation in the acetylcholine receptor ε subunit gene
Shen X-M, Ohno K, Fukudome T, Brengman JM, Engel AG
IXth International Congress on Neuromuscular Diseases   30 Aug 1998   
Acetylcholine receptor channel blockade for treatment of the slow-channel congenital myasthenic syndrome
Fukudome T, Ohno K, Brengman JM, Engel AG
IXth International Congress on Neuromuscular Diseases   30 Aug 1998   
Low-affinity fast channel congenital myasthenic syndrome caused by new missense mutations in the acetylcholine receptor α subunit
Milone M, Ohno K, Brengman JM, Batocchi AP, Tonali PA, Engel AG
IXth International Congress on Neuromuscular Diseases   30 Aug 1998   
Congenital myasthenic syndrome due to two novel mutations in the acetylcholine receptor ε subunit gene
Brengman JM, Ohno K, Shen X-M, Engel AG
IXth International Congress on Neuromuscular Diseases   30 Aug 1998   

Research Grants & Projects

 
先天性無力症候群治療薬開発のためのiPS由来神経筋接合部誘導研究(筋疾患に対する治療薬の創出を目指した研究(課題番号:H29:JP17bm0804005/ H30:JP18bm0804005/H31:JP19bm0804005)
Japan Agency for Medical Research and Development (AMED): (Research Center Network for Realization of Regenerative Medicine)
Project Year: Apr 2017 - Mar 2023    Investigator(s): 櫻井 英俊(分担:大野 欽司)
Wnt/βカテニン・ADAM10阻害による新規作用機序の変性関節症治療薬の開発(石黒 直樹)
Japan Society for the Promotion of Science (JSPS): 科研費 基盤研究(B)(一般)
Project Year: Apr 2019 - Mar 2022    Investigator(s): 石黒 直樹(分担:大野 欽司)
多系統萎縮症の脳内αシヌクレイン異常凝集に対する腸内細菌叢の関与の解明(前田 哲也)
Japan Society for the Promotion of Science (JSPS): 科研費 基盤研究(C)(一般)
Project Year: Apr 2019 - Mar 2022    Investigator(s): 前田 哲也(分担:大野 欽司)
パーキンソン病の起因となる腸管α-synuclein異常蓄積に対する腸内細菌叢の関与の解明(課題番号:H29:JP17gm1010002、H30:JP18gm1010002)
Japan Agency for Medical Research and Development (AMED): (Advanced Research and Development Programs for Medical Innovation)
Project Year: Apr 2016 - Mar 2022    Investigator(s): 大野 欽司
パーキンソン病の起因となる腸管α-synuclein異常蓄積に対する腸内細菌叢の関与の解明(課題番号:H28:16gm1010002h0001、H29:JP17gm1010002、H30:JP18gm1010002)
Japan Agency for Medical Research and Development (AMED): (Advanced Research and Development Programs for Medical Innovation)
Project Year: Apr 2016 - Mar 2022    Investigator(s): 大野 欽司
Dkk1分子発現亢進による新規変形性関節症治療薬の開発(石黒 直樹)
Japan Society for the Promotion of Science (JSPS): 科研費 挑戦的萌芽
Project Year: Apr 2019 - Mar 2020    Investigator(s): 石黒 直樹(分担:大野 欽司)
Drug repositioning 戦略による整形外科領域の新規医療開発(石黒 直樹)
Japan Society for the Promotion of Science (JSPS): 科研費 基盤B
Project Year: Apr 2019 - Mar 2020    Investigator(s): 石黒 直樹(分担:大野 欽司)
抗てんかん薬ゾニサミドの神経根症に対する治療効果の研究(19188087)(今釜 史郎)
Japan Agency for Medical Research and Development (AMED): 臨床研究・治験推進研究事業
Project Year: Apr 2019 - Mar 2020    Investigator(s): 今釜 史郎(分担:大野 欽司)
中部東海圏IRUDゲノム解析拠点?先端情報技術の融合による包括的遺伝子診断の提供(荻 朋男)
Japan Agency for Medical Research and Development (AMED): 難治性疾患等実用化研究事業 難治性疾患実用化研究事業
Project Year: Apr 2018 - Mar 2020    Investigator(s): 荻 朋男(分担:大野 欽司)
ゲノム不安定性疾患群を中心とした希少難治性疾患の次世代マルチオミクス診断拠点構築(荻 朋男)
Japan Agency for Medical Research and Development (AMED): 難治性疾患等実用化研究事業 難治性疾患実用化研究事業
Project Year: Apr 2017 - Mar 2020    Investigator(s): 荻 朋男(分担:大野 欽司)
神経筋接合部・筋の信号伝達障害の病態機構解明と治療研究(筋ジストロフィー関連疾患の分子病態解明とそれに基づく診断法・治療法開発(課題番号:29-4)
National Center of Neurology and Psychiatry(NCNP): Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP
Project Year: Apr 2017 - Mar 2020    Investigator(s): 西野 一三(分担:大野 欽司)
希少難治性筋疾患に関する調査研究(課題番号:H29-Nanchi-Ippan-030 )
Ministry of Health, Labour and Welfare (MHLW): Health and Labor Science Research Grants, Research on intractable diseases)
Project Year: Apr 2017 - Mar 2020    Investigator(s): 青木 正志(分担:大野 欽司)
神経筋接合部・骨格筋の興奮伝達障害に対する新規治療法開発(研究課題番号:H29:JP17ek0109230、H30:JP18ek0109230)
Japan Agency for Medical Research and Development (AMED): (Practical Research Project for Rare / Intractable Diseases)
Project Year: Apr 2017 - Mar 2020    Investigator(s): 大野 欽司
神経筋接合部の正常分子構築解明と先天性筋無力症候群の分子病態研究(課題番号:15H04840)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2015 - Mar 2018    Investigator(s): 大野 欽司
複合性局所疼痛症候群の汎用的で客観的な重症度評価技術の開発(JP17ek0610009)
Japan Agency for Medical Research and Development (AMED): Research Project on Elucidation of Chronic Pain
Project Year: Apr 2015 - Mar 2018    Investigator(s): 平田 仁(分担:大野 欽司)
ドラッグ・リポジショニングによる軟骨無形成症治療薬の開発研究(16lk0103017h0003)
Ministry of Health, Labour and Welfare (MHLW): Health and Labor Science Research Grants, Research on intractable diseases
Project Year: Apr 2014 - Mar 2017    Investigator(s): 鬼頭 浩史(分担:大野 欽司)
神経筋接合部・骨格筋の興奮伝達障害の病態解明と治療法開発研究(16ek0109017h0003)
Japan Agency for Medical Research and Development (AMED): Practical Research Project for Rare / Intractable Diseases
Project Year: Apr 2014 - Mar 2017    Investigator(s): 大野 欽司
希少難治性筋疾患に関する調査研究(H26-Nanchi-Ippan-079)
Ministry of Health, Labour and Welfare (MHLW): Health and Labor Science Research Grants, Research on intractable diseases
Project Year: Apr 2014 - Mar 2017    Investigator(s): 青木 正志(分担:大野 欽司)
難治性筋疾患の疫学・自然歴の収集および治療開発促進を目的とした疾患レジストリー研究(H26-Nanchi-Ippan-086)
Ministry of Health, Labour and Welfare (MHLW): Health and Labor Science Research Grants, Research on intractable diseases
Project Year: Apr 2014 - Mar 2017    Investigator(s): 木村 円(分担:大野 欽司)
神経筋接合部・筋の信号伝達障害の病態機構解明と治療研究(筋ジストロフィー関連疾患の基盤的診断・治療開発研究 (26-8)
National Center of Neurology and Psychiatry(NCNP): Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP
Project Year: Apr 2014 - Mar 2017    Investigator(s): 西野 一三(分担:大野 欽司)
下部神経管閉鎖障害の病態・制御研究(H24−神経・筋−一般−005)
Ministry of Health, Labour and Welfare (MHLW): Division of Neurological, Psychiatric and Brain Research
Project Year: Apr 2014 - Mar 2017    Investigator(s): 大野 欽司
超早期診断技術開発プロジェクト
Aichi Science and Technology Foundation: 「知の拠点」重点研究プロジェクト プロジェクト3
Project Year: Apr 2010 - Mar 2016    Investigator(s): プロジェクトリーダー:太田美智男(分担:大野 欽司)
神経筋疾患におけるスプライシング異常(Aberrant splicing in neuromuscular diseases)
Japan Science and Technology Agency(JST): 戦略的国際科学技術協力推進事業 日本(JST)−デンマーク(DASTI)研究交流
Project Year: Apr 2009 - Mar 2016    Investigator(s): 大野 欽司
神経変性疾患関連RNA結合タンパクFUSによる転写抑制機構解明(課題番号:25118508)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2013 - Mar 2015    Investigator(s): 大野 欽司
ES細胞由来運動神経細胞に対する神経筋接合部形成促進薬の網羅的探索法に関する研究(平田仁)(課題番号:24659673)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2012 - Mar 2015    Investigator(s): 平田 仁(分担:大野 欽司)
神経筋接合部の正常構築と分子病態研究(課題番号:24390221)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2012 - Mar 2015    Investigator(s): 大野 欽司
神経筋接合部分子LRP4の分子構築解明(課題番号:25670164)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2013 - Mar 2014    Investigator(s): 大野 欽司
希少難治性筋疾患に関する調査研究(H24−難治等(難)−一般−028)
Ministry of Health, Labour and Welfare (MHLW): Health and Labor Science Research Grants, Research on intractable diseases
Project Year: Apr 2012 - Mar 2014    Investigator(s): 青木 正志(分担:大野 欽司)
神経筋接合部疾患・筋強直性ジストロフィーの病態解明・制御研究(筋ジストロフィーおよび関連疾患の診断・治療開発を目指した基盤研究)(23-5)
National Center of Neurology and Psychiatry(NCNP): Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP
Project Year: Apr 2011 - Mar 2014    Investigator(s): 西野 一三(分担:大野 欽司)
網羅的スプライシング暗号解析に基づくRNA病の解明と治療技術の探索(エクソン特異的アレイ・CLIPによるスプライシング制御配列の網羅的解析)
Ministry of Education, Culture, Sports, Science and Technology-Japan: Innovative Cell Biology by Innovative Technology
Project Year: Apr 2010 - Mar 2014    Investigator(s): 萩原 正敏(分担:大野 欽司)
先天性筋無力症候群の診断・病態・治療法開発研究(H22:H22-難治-一般-028、H23-H24:H23-難治-一般-073 )
Ministry of Health, Labour and Welfare (MHLW): Research on Measures for Intractable Diseases
Project Year: Apr 2010 - Mar 2013    Investigator(s): 大野 欽司
Schwartz-Jampel症候群のわが国における診断システム確立とモデルマウ スによる病態解明と治療研究(H23-難治-一般-055)
Ministry of Health, Labour and Welfare (MHLW): Research on Measures for Intractable Diseases
Project Year: Apr 2011 - Mar 2012    Investigator(s): 平澤 恵理(分担:大野 欽司)
筋強直性ジストロフィー治療薬の開発
Japan Science and Technology Agency (JST): Intellectual Property Utilization Support Program, Science and Technology Commons
Project Year: Apr 2010 - Mar 2012    Investigator(s): 大野 欽司
筋チャネル病および関連疾患の診断・治療指針作成および新規治療法開発に向けた基盤整備のための研究(筋強直性ジストロフィーのスプライシング異常の網羅的な解析とその制御研究)(H22-難治-一般-118)
Ministry of Health, Labour and Welfare (MHLW): Research on Measures for Intractable Diseases
Project Year: Apr 2010 - Mar 2012    Investigator(s): 高橋 正紀(分担:大野 欽司)
神経筋接合分子欠損症におけるmRNA病態研究と治療法開発研究(課題番号:21390266)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2009 - Mar 2012    Investigator(s): 大野 欽司
スプライシング暗号の解読による神経発生過程の解明(萩原正敏)(課題番号:21249013 )
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2009 - Mar 2012    Investigator(s): 萩原 正敏(分担:大野 欽司)
分子状水素による健康増進・疾患抑制の新規分子機構の解明(伊藤雅史)(課題番号:22300244)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2010 - Mar 2011    Investigator(s): 伊藤 雅史(分担:大野 欽司)
筋強直性ジストロフィーのスプライシング異常を補正する既認可薬オフラベル薬効の患者培養細胞・動物実験における検証
Japan Science and Technology Agency(JST): 研究成果最適展開支援事業A-STEPフィージビリティスタディ(シーズ顕在化)
Project Year: Apr 2009 - Mar 2011    Investigator(s): 大野 欽司
先天性筋無力症候群の分子病態解明と治療法開発研究(筋ジストロフィーおよびその関連疾患の分子病態解明、診断法確立と薬物治療の開発に関する研究)(20委-13)
Ministry of Health , Labour and Welfare   (National Center of Neurology and Psychiatry, Japan) *H22〜National Center of Neurology and Psychiatry(NCNP): 精神・神経疾患研究委託費
Project Year: Apr 2008 - Mar 2011    Investigator(s): 砂田 芳秀(分担:大野 欽司)
分子状水素の抗酸化作用分子機構の解明と新規生理活性分子の同定による神経変性疾患発症予防法の開発
Japan Science and Technology Agency(JST): 地域イノベーション創出総合支援事業 重点地域研究開発推進プログラム 平成21年度「シーズ発掘試験」 A(発掘型)
Project Year: Apr 2009 - Mar 2010    Investigator(s): 大野 欽司
In silico解析とin vitro解析によるRNAスプライシング機構の研究(課題番号:20016011)
Ministry of Education, Culture, Sports, Science and Technology-Japan: 科学研究費助成事業
Project Year: Apr 2008 - Mar 2009    Investigator(s): 大野 欽司
神経筋接合分子欠損症および他の筋疾患におけるmRNA病態研究と治療法開発研究(課題番号:19390237)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2007 - Mar 2009    Investigator(s): 大野 欽司
優性遺伝性非翻訳リピート病の異常スプライシング病態研究(松浦徹)(課題番号:19590988)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2007 - Mar 2009    Investigator(s): 松浦 徹
ヒトゲノム配列解析によるRNAスプライシングとRNA代謝機構の研究(課題番号:18016011)
Ministry of Education, Culture, Sports, Science and Technology-Japan: 科学研究費助成事業
Project Year: Apr 2006 - Mar 2008    Investigator(s): 大野 欽司
神経筋接合部分子欠損症のRNA分子病態と治療法開発研究(筋ジストロフィーおよびその関連する疾患の病態生理の解明と治療薬物の開発に関する研究)(17指-10)
Ministry of Health, Labour and Welfare (MHLW) (National Center of Neurology and Psychiatry, Japan): 精神・神経疾患研究委託費
Project Year: Apr 2005 - Mar 2008    Investigator(s): 清水 輝夫(分担:大野 欽司)
終板アセチルコリンエステラーゼ欠損症、及び、他の細胞外マトリックス分子欠損症におけるタンパク標的療法の開発研究(H17:H17-こころ-023/H18〜19:H17-こころ-一般-023)
H17:Ministry of Health, Labour and Welfare (MHLW)/H18〜19:National Center of Neurology and Psychiatry, Japan: 厚生労働科学研究費補助金「こころの健康科学研究事業」
Project Year: Apr 2005 - Mar 2008    Investigator(s): 大野 欽司
mRNAの1次塩基配列と2次構造予測に基づくsiRNA設計アルゴリズムの開発研究(課題番号:18651098)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2006 - Mar 2007    Investigator(s): 大野 欽司
先天性筋無力症候群に関与する神経筋接合部分子の分子病態研究(課題番号:17390252)
Japan Society for the Promotion of Science (JSPS): 科学研究費助成事業
Project Year: Apr 2005 - Mar 2007    Investigator(s): 大野 欽司
神経筋疾患の原因となるpre-mRNAスプライシング異常症の分子病態研究(課題番号:17026016)
Ministry of Education, Culture, Sports, Science and Technology-Japan: 科学研究費助成事業
Project Year: Apr 2005 - Mar 2007    Investigator(s): 大野 欽司

Patents

 
平田 仁, 大河原 美静, 大野 欽司, 赤根 真央
大野 欽司, 石黒 直樹, 大河原 美静, 八木 秀樹, 大田 恭太郎
大野 欽司, 平田 仁, 大河原 美静, 石井 久雄