論文

本文へのリンクあり
2021年4月

Salivary CCL20 level as a biomarker for oral squamous cell carcinoma

Cancer Genomics and Proteomics
  • Sei Ueda
  • ,
  • Mitsuo Goto
  • ,
  • Kengo Hashimoto
  • ,
  • Shogo Hasegawa
  • ,
  • Masahiko Imazawa
  • ,
  • Marico Takahashi
  • ,
  • Ichiro Oh-Iwa
  • ,
  • Kazuo Shimozato
  • ,
  • Toru Nagao
  • ,
  • Shuji Nomoto

18
2
開始ページ
103
終了ページ
112
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.21873/CGP.20245

Background/Aim: This study investigated the utility of C-C motif chemokine ligand 20 (CCL20) expression in saliva as a biomarker for oral squamous cell carcinoma (OSCC) and also examined the associated microbiome. Materials and Methods: The study group included patients with OSCC or oral potentially malignant disorder (OPMD), and healthy volunteers (HVs). microarray and qRT-PCR were used to compare salivary CCL20 expression levels among groups. Data on CCL20 levels in oral cancer tissues and normal tissues were retrieved from a public database and examined. Furthermore, next-generation sequencing was used to investigate the salivary microbiome. Results: A significant increase in the expression level of CCL20 was observed in both OSCC tissues and saliva from patients with oral cancer. Fusobacterium was identified as the predominant bacteria in OSCC and correlated with CCL20 expression level. OSCC screening based on salivary CCL20 expression enabled successful differentiation between patients with OSCC and HVs. Conclusion: CCL20 expression may be a useful biomarker for OSCC.

リンク情報
DOI
https://doi.org/10.21873/CGP.20245
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33608307
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85102218861&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85102218861&origin=inward
ID情報
  • DOI : 10.21873/CGP.20245
  • ISSN : 1109-6535
  • eISSN : 1790-6245
  • PubMed ID : 33608307
  • SCOPUS ID : 85102218861

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