2017年7月
Gonadotropin levels in urine during early postnatal period in small for gestational age preterm male infants with fetal growth restriction
JOURNAL OF PERINATOLOGY
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- 巻
- 37
- 号
- 7
- 開始ページ
- 843
- 終了ページ
- 847
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/jp.2017.55
- 出版者・発行元
- NATURE PUBLISHING GROUP
OBJECTIVE: The objective of this study was to estimate gonadotropin concentrations in small for gestational age (SGA) male infants with the reactivation of the hypothalamic pituitary gonadal axis during'the first few months of life that is important for genital development.
STUDY DESIGN: We prospectively examined 15 SGA and 15 appropriate for gestational age (AGA) preterm male infants between 2013 and 2014 at Kyoto University Hospital. Gonadotropin concentrations (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) were measured in serial urine samples from the postnatal days 7 to 168 and compared between SGA and AGA infants using the Mann Whitney test.
RESULTS: A longitudinal analysis showed that SGA infants had higher LH and lower FSH concentrations (P=0.004 and P=0.006, respectively) than AGA infants.
CONCLUSION: Male infants who are SGA at birth because of fetal growth restriction have gonadotropin secretion abnormalities in the first few months of life. published online 27 April 2017
STUDY DESIGN: We prospectively examined 15 SGA and 15 appropriate for gestational age (AGA) preterm male infants between 2013 and 2014 at Kyoto University Hospital. Gonadotropin concentrations (luteinizing hormone (LH) and follicle-stimulating hormone (FSH)) were measured in serial urine samples from the postnatal days 7 to 168 and compared between SGA and AGA infants using the Mann Whitney test.
RESULTS: A longitudinal analysis showed that SGA infants had higher LH and lower FSH concentrations (P=0.004 and P=0.006, respectively) than AGA infants.
CONCLUSION: Male infants who are SGA at birth because of fetal growth restriction have gonadotropin secretion abnormalities in the first few months of life. published online 27 April 2017
- リンク情報
- ID情報
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- DOI : 10.1038/jp.2017.55
- ISSN : 0743-8346
- eISSN : 1476-5543
- Web of Science ID : WOS:000407873900019