論文

査読有り
2014年7月

Preparation of an autologous heart valve with a stent (stent-biovalve) using the stent eversion method

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
  • Takeshi Mizuno
  • ,
  • Yoshiaki Takewa
  • ,
  • Hirohito Sumikura
  • ,
  • Kentaro Ohnuma
  • ,
  • Takeshi Moriwaki
  • ,
  • Masashi Yamanami
  • ,
  • Tomonori Oie
  • ,
  • Eisuke Tatsumi
  • ,
  • Masami Uechi
  • ,
  • Yasuhide Nakayama

102
5
開始ページ
1038
終了ページ
1045
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/jbm.b.33086
出版者・発行元
WILEY-BLACKWELL

We designed a novel method for constructing an autologous heart valve with a stent, called a stent-biovalve. In constructing completely autologous heart valves, named biovalves, which used in-body tissue architecture technology, tissues for leaflets were formed via ingrowths into narrow apertures in the preparation molds, frequently leading to delayed or incomplete biovalve preparation. In this technique, self-expandable nitinol stents after everting were mounted on an acrylic column-shaped part and partially covered with an acrylic cylinder-shaped part with three slits. This assembled mold was placed into subcutaneous abdominal pouches in beagles or goats for 4 weeks. Upon removing the acrylic parts after harvesting and trimming of capsulated tissues, a tubular hollow structure with three pocket-flaps of membranous tissue rigidly fixed to the stent's outer surface was obtained. Then, the stent was turned inside out to the original form, thus moving the pocket-flaps from outside to the inside. Stent-biovalves with a sufficient coaptation area were thus obtained with little tissue damage in all cases. The valve opened smoothly, and high aperture ratio was noted. This novel technique was thus highly effective in constructing a robust, completely autologous stent-biovalve with adequate valve function. (C) 2013 Wiley Periodicals, Inc.

リンク情報
DOI
https://doi.org/10.1002/jbm.b.33086
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000337667900015&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/jbm.b.33086
  • ISSN : 1552-4973
  • eISSN : 1552-4981
  • Web of Science ID : WOS:000337667900015

エクスポート
BibTeX RIS