2014年11月
Effects of D-allose in combination with docetaxel in human head and neck cancer cells
INTERNATIONAL JOURNAL OF ONCOLOGY
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- 巻
- 45
- 号
- 5
- 開始ページ
- 2044
- 終了ページ
- 2050
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3892/ijo.2014.2590
- 出版者・発行元
- SPANDIDOS PUBL LTD
In this study we investigated the combined effects of docetaxel and D-allose in HSC3 human oral carcinoma cells. The dose enhancement ratios at the 25% survival level were 1.3 and 1.71 for combined treatment with 10 or 25 mM D-allose, respectively. Apoptosis was significantly increased by addition of D-allose. Additionally, a synchronous increase in the G(2)/M-phase population was observed after docetaxel plus D-allose treatment. In vivo experiments revealed that docetaxel plus D-allose was more effective than either agent alone. Thus, D-allose enhanced the anticancer effects of docetaxel, and combined treatment may be useful to achieve clinical efficacy with reduced toxicity.
- リンク情報
- ID情報
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- DOI : 10.3892/ijo.2014.2590
- ISSN : 1019-6439
- eISSN : 1791-2423
- Web of Science ID : WOS:000342713900029