MISC

2007年7月

Coregistered ventilation and perfusion SPECT using krypton-81m and Tc-99m - Labeled macroaggregated albumin with multislice CT: Utility for prediction of postoperative lung function in non-small cell lung cancer patients

ACADEMIC RADIOLOGY
  • Yoshiharu Ohno
  • ,
  • Hisanobu Koyama
  • ,
  • Daisuke Takenaka
  • ,
  • Munenobu Nogami
  • ,
  • Yoshikazu Kotani
  • ,
  • Yoshihiro Nishimura
  • ,
  • Masahiro Yoshimura
  • ,
  • Takeshi Yoshikawa
  • ,
  • Kazuro Sugimura

14
7
開始ページ
830
終了ページ
838
記述言語
英語
掲載種別
DOI
10.1016/j.acra.2007.03.013
出版者・発行元
ELSEVIER SCIENCE INC

Rationale and Objective. Coregistered SPECT and CT imaging (SPECT-CT) has potential for more precise evaluation of regional pulmonary function and may be useful for prediction of postoperative lung function in non-small cell lung cancer (NSCLC) patients. The purpose of the present study was to prospectively assess the capability of coregistered SPECT-CT using krypton-81m (Kr-81m) and technetium-99m-labeled macroaggregated albumin (Tc-99m MAA) for prediction of postoperative lung function of NSCLC patients compared with SPECT and planar imaging.
Materials and Methods. Sixty consecutive patients considered candidates for lung resection underwent 16-slice CT, ventilation and perfusion scintigraphy with SPECT examinations, and preoperative and postoperative measurement of FEV1%. In each subject, SPECT and CT data were automatically fused by using commercially available software. Each postoperative FEV1% value was predicted from uptakes of Kr-81m and Tc-99m MAA within total and resected lungs. Then, reproducibility coefficients and the limits of agreement between actual and each predicted postoperative lung function were statistically assessed.
Results. Reproducibility coefficients of SPECT-CT (Kr-81m: 5.1%, Tc-99m MAA: 5.2%) were smaller than those of SPECT and planar image using Kr-81 m (SPECT: 7.4%, planar image: 12.1%) and using Tc-99m MAA (SPECT: 7.2%, planar image: 11.8%). The limits of agreement for SPECT-CT (Kr-81m: 3.3 +/- 10.5%, Tc-99m MAA: 5.4 +/- 11.0%) were also smaller than that of SPECT and planar image and small enough for clinical purposes.
Conclusions. Coregistered SPECT-CT using Kr-81m and Tc-99m MAA was able to more reproducibly and accurately predict postoperative lung function compared with SPECT and planar imaging.

Web of Science ® 被引用回数 : 40

リンク情報
DOI
https://doi.org/10.1016/j.acra.2007.03.013
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000247759600007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.acra.2007.03.013
  • ISSN : 1076-6332
  • Web of Science ID : WOS:000247759600007

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