KUSHIBIKI Toshihiro

J-GLOBAL         Last updated: Aug 30, 2019 at 22:45
 
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Name
KUSHIBIKI Toshihiro
Affiliation
National Defense Medical College
Section
Graduate School of EngineeringFrontier Research Base for Global Young Researchers
Research funding number
30403158

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
2008
   
 
- Massachusetts General Hospital visiting researcher
 
2008
   
 
- Harvard Medical School visiting associate professor
 

Awards & Honors

 
2008
Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology in 2008, the Young Scientists' Prize.
 

Published Papers

 
Okawa Shinpei, Hirasawa Takeshi, Sato Ryota, Kushibiki Toshihiro, Ishihara Miya, Teranishi Toshiharu
OPTICAL REVIEW   25(3) 365-374   Jun 2018   [Refereed]
AN EXPERIMENTAL STUDY OF TOPICAL INSULIN-LIKE GROWTH FACTOR-1 DELIVERY TO IMPROVE URETHRAL WOUND HEALING IN A RABBIT MODEL
Shinchi Masayuki, Kushibiki Toshihiro, Mayumi Yoshine, Ito Keiichi, Asano Tomohiko, Ishihara Miya, Horiguchi Akio
JOURNAL OF UROLOGY   199(4) E471-E472   Apr 2018   [Refereed]
Okawa S, Hirasawa T, Kushibiki T, Ishihara M
Quantitative imaging in medicine and surgery   5(1) 78-85   Feb 2015   [Refereed]
Takikawa M, Nakamura S, Ishihara M, Takabayashi Y, Fujita M, Hattori H, Kushibiki T, Ishihara M
The Journal of surgical research   196(2) 247-257   Jun 2015   [Refereed]
Tsujita Y, Horiguchi A, Tasaki S, Isono M, Asano T, Ito K, Asano T, Mayumi Y, Kushibiki T
Oncology reports   38(4) 2197-2204   Oct 2017   [Refereed]
Kushibiki T, Ishihara M
Current gene therapy   18(1) 40-44   2018   [Refereed]
Sei K, Fujita M, Hirasawa T, Okawa S, Kushibiki T, Sasa H, Furuya K, Ishihara M
Journal of clinical monitoring and computing      Jun 2018   [Refereed]
Kushibiki T, Tu Y, Abu-Yousif AO, Hasan T
Scientific reports   5 13114   Aug 2015   [Refereed]
Okawa Shinpei, Hirasawa Takeshi, Kushibiki Toshihiro, Ishihara Miya
OPTICAL REVIEW   24(6) 705-726   Dec 2017   [Refereed]
Okawa Shinpei, Sei Kiguna, Hirasawa Takeshi, Irisawa Kaku, Hirota Kazuhiro, Wada Takatsugu, Kushibiki Toshihiro, Furuya Kenichi, Ishihara Miya
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2017   10064    2017   [Refereed]
Sei K, Fujita M, Okawa S, Hirasawa T, Kushibiki T, Sasa H, Furuya K, Ishihara M
The Journal of surgical research   206(2) 325-336   Dec 2016   [Refereed]
Toshihiro Kushibiki, Shinpei Okawa, Takeshi Hirasawa, Miya Ishihara
International Journal of Photoenergy   2014    Jan 2014   [Refereed]
In optogenetics, targeted illumination is used to control the functions of cells expressing exogenous light-activated proteins. Adoption of the optogenetic methods has expanded rapidly in recent years. In this review, we describe the photosensitiv...
Kushibiki T, Okawa S, Hirasawa T, Ishihara M
Gene therapy   22(7) 553-559   Jul 2015   [Refereed]
Kushibiki T, Hirasawa T, Okawa S, Ishihara M
Stem cells international   2015 974864   2015   [Refereed]
Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
Optical Review   20(5) 442-451   Sep 2013   [Refereed]
An image reconstruction algorithm for biomedical photoacoustic imaging is discussed. The algorithm solves the inverse problem of the photoacoustic phenomenon in biological media and images the distribution of large optical absorption coefficients,...
Kushibiki Toshihiro, Hirasawa Takeshi, Okawa Shinpei, Ishihara Miya
JJSLSM   34(4) 384-393   2014
Low reactive level laser therapy (LLLT) is mainly focused on the activation of intracellular or extracellular chromophore and the initiation of cellular signaling by using low power lasers. Over the past forty decades, it was realized that the las...
Kushibiki T, Hirasawa T, Okawa S, Ishihara M
International journal of molecular sciences   14(7) 13542-13558   Jun 2013   [Refereed]
Hirasawa T, Fujita M, Okawa S, Kushibiki T, Ishihara M
Applied optics   52(35) 8562-8571   Dec 2013   [Refereed]
Kushibiki Toshihiro, Okawa Shinpei, Hirasawa Takeshi, Ishihara Miya
JJSLSM   34(4) 394-401   2014
In this review, we introduce the recent developments of optogenetics, novel methods for controlling gene expression, cell morphology and signaling pathways by using the light technology and genetic engineering. The channelrhodopsins, LOV (light ox...
Kushibiki T, Hirasawa T, Okawa S, Ishihara M
Photomedicine and laser surgery   31(3) 95-104   Mar 2013   [Refereed]
Okawa Shinpei, Hirasawa Takeshi, Kushibiki Toshihiro, Ishihara Miya
JJSLSM   35(2) 140-150   2014
Wideband ultrasonic waves (referred to as photoacoustic waves) are induced as a result of transient thermoelastic expansion of biological tissues irradiated by a laser light. The magnitude of the photoacoustic (PA) waves is proportional to the loc...
KUSHIBIKI Toshihiro, ISHIHARA Miya
レーザー研究   41(8) 606-612   Aug 2013
Kushibiki T, Hirasawa T, Okawa S, Ishihara M
Journal of healthcare engineering   4(1) 87-108   Mar 2013   [Refereed]
Obata Y, Nishino T, Kushibiki T, Tomoshige R, Xia Z, Miyazaki M, Abe K, Koji T, Tabata Y, Kohno S
Acta biomaterialia   8(7) 2688-2696   Jul 2012   [Refereed]
Tsuda T, Nemoto N, Kawakami K, Mochizuki E, Kishida S, Tajiri T, Kushibiki T, Kuwabata S
Chembiochem : a European journal of chemical biology   12(17) 2547-2550   Nov 2011   [Refereed]
KUSHIBIKI Toshihiro, ISHIHARA Miya
JJSLSM   33(4) 392-398   Jan 2013
Photoacoustic microscopy is being established not only for the in vivo imaging but for the in vitro cellular imaging. Especially, to obtain of the internal information of 3D cell culture cluster by using photoacoustic microscopy shou...
Toshihiro Kushibiki, Takako Tajiri, Yutaka Tomioka, Kunio Awazu
International Journal of Clinical and Experimental Medicine   3(2) 110-114   Aug 2010   [Refereed]
Dendritic cells (DC) pulsed with tumor-derived peptides, proteins, genes, or lysates have been studied as therapeutic cancer vaccines. However, the overall therapeutic efficacy of this approach has been limited, indicating a need to either enhance...
Toshihiro Kushibiki, Miya Ishihara
Journal of Analytical Oncology   2 81-97   Jan 2013
Photoacoustic imaging (PAI) is a unique modality that overcomes the resolution and depth limitations of optical imaging of tissues while maintaining relatively high contrast. In this article, we review the biomedical applications of PAI, assisted ...
Tomioka Y, Kushibiki T, Awazu K
Photomedicine and laser surgery   28(3) 385-390   Jun 2010   [Refereed]
Kushibiki T
Journal of biophotonics   3(5-6) 368-372   Jun 2010   [Refereed]
Toshihiro Kushibiki, Toshihiro Kushibiki, Takako Tajiri, Yoshihisa Ninomiya, Kunio Awazu
J Photochem Photobiol   98(3) 211-215   Mar 2010   [Refereed]
Low-level laser therapy (LLLT) has been used as a method for biostimulation. Cartilage develops through the differentiation of mesenchymal cells into chondrocytes, and differentiated chondrocytes in articular cartilage maintain cartilage homeostas...
Photodynamic therapy induces interleukin secretion from dendritic cells.
Kushibiki T, Tajiri T, Tomioka Y, Awazu K
International journal of clinical and experimental medicine   3(2) 110-114   Apr 2010   [Refereed]
SAKAI Makoto, KUSHIBIKI Toshihiro, AWAZU Kunio
JJSLSM   30(4) 405-414   Jan 2010
Photodynamic therapy (PDT) involves the administration of a photosensitizer followed by local illumination of a tumor with light of the appropriate wavelength to activate a specific drug. Efficacy is high for small superficial tumors and, except f...
津田 哲哉, 清野 智史, 櫛引 俊宏
Molten salts   53(1) 27-34   2010
Keiichi Hirose, Akira Marui, Yoshio Arai, Toshihiro Kushibiki, Yu Kimura, Hisashi Sakaguchi, Huang Yuang, B. I R Shyamal Chandra, Tadashi Ikeda, Shigeru Amano, Yasuhiko Tabata, Masashi Komeda
J Thorac Cardiovasc Surg   136(5) 1250-1256   Nov 2008   [Refereed]
Objectives: Pulmonary hypertension is a life-threatening disease, and alternative strategies are essential for patients with critical pulmonary hypertension. We developed a new procedure using microgelatin hydrogel microspheres incorporating basic...
KUSHIBIKI Toshihiro
J Jpn. Soc. Laser Dent.   21(3) 185-191   2010
Mesenchymal stromal cells (MSCs) are multipotent cells present in adult bone marrow that replicate as undifferentiated cells and can differentiate to lineages of mesenchymal tissues. Here, I show that laser irradiation can direct the osteogenesis ...
Kushibiki T, Awazu K
Photomedicine and laser surgery   27(3) 493-498   Jun 2009   [Refereed]
KUSHIBIKI Toshihiro
rle   37(1) 43-47   Jan 2009
Research in laser medicine and photobiology is developed as the new diagnostic and treatment methods. Two specific areas in which I would like to develop applications are photodynamic therapy and regulation of cells function by laser technology. T...
櫛引 俊宏
日本レーザー治療学会誌   8(2) 10-14   2009
Toshihiro Kushibiki, Kunio Awazu
Int J Med Sci   5(6) 319-326   Oct 2008   [Refereed]
Mesenchymal stromal cells (MSCs) are multipotent cells present in adult bone marrow that replicate as undifferentiated cells and can differentiate to lineages of mesenchymal tissues. Homeostatic control of bone remodelling maintains bone mass by i...
Atsushi Tomioka, Motoyoshi Tanaka, Motoyoshi Tanaka, Marco A. De Velasco, Satoshi Anai, Satoshi Takada, Toshihiro Kushibiki, Yasuhiko Tabata, Charles J. Rosser, Hirotsugu Uemura, Yoshihiko Hirao
Mol Cancer Ther   7(7) 1864-1870   Oct 2008   [Refereed]
The tumor suppressor gene MMAC/PTEN located on chromosome10q23.3 has dual phosphatase activity in the phosphoinositide-3-kinase signaling pathway and inhibits Akt activation, a serine-threonine kinase, which is involved in proliferative and antiap...
Toshihiro Kushibiki, Makoto Sakai, Kunio Awazu
Cancer Letters   268(2) 244-251   Sep 2008   [Refereed]
Photodynamic therapy (PDT) involves the administration of a photosensitizer, followed by local illumination of a tumor with a laser (of the appropriate wavelength) to activate a specific drug. However, the cells in a tumor tissue are heterogeneous...
Toshihiro Kushibiki, Atsuhiro Saito, Seiichro Hayashi, Katsunori Ishii, Yoshiki Sawa, Kunio Awazu
Photomedicine and Laser Surgery   26(3) 247-250   Jun 2008   [Refereed]
Objective: Successful tissue regeneration requires cells with high proliferative and differentiation potentials as well as an environment that promotes regeneration. Since cell scaffolds and growth factors provide such an environment and also indu...
Kushibiki T., Awazu K.
rle   36(0) S2-S5   2008
KUSHIBIKI Toshihiro, AWAZU Kunio
JJSLSM   28(1) 91-96   Apr 2007
Circadian rhythms are oscillations in the behaviour and biochemical reactions of organisms, and occur with a periodicity of approximately twenty-four hours. The mammalian cryptochrome (CRY) have been proposed as circadian photoreceptor pigments. I...
Kazuhiko Doi, Tadashi Ikeda, Akira Marui, Toshihiro Kushibiki, Yoshio Arai, Keiichi Hirose, Yoshiharu Soga, Atsushi Iwakura, Koji Ueyama, Kenichi Yamahara, Hiroshi Itoh, Kazunobu Nishimura, Yasuhiko Tabata, Masashi Komeda
Heart Vessels   22(2) 104-108   Mar 2007   [Refereed]
Recently we have developed new sustained release system of basic fibroblast growth factor (bFGF) using gelatin hydrogel as a carrier. Using this system, we examined the effect of topical sustained release of bFGF on angiogenesis and tissue blood p...
SAKAMOTO Takashi, ISHII Katsunori, KUSHIBIKI Toshihiro, AWAZU Kunio
rle   35(8) 519-522   2007
Photodynamic Diagnoses (PDD) are commonly applied in clinical and basic research areas. A conventional PDD with the maximal absorption wavelength of a photo sensitizer accumulated in the tumor tissue reveals its location. In this study, we evaluat...
Kushibiki Toshihiro, Awazu Kunio
rle   35(0) 249-250   2007
Novel approach to rescue severe pulmonary hypertension (PH) with intratracheal administration of micro gelatin hydrogel microspheres incorporating basic fibroblast growth factor (bFGF)
Hirose Keiichi, Ikeda Tadashi, Marul Akira, Arai Yoshio, Kushibiki Toshihiro, Kimura Yu, Sakaguchi Hisashi, Yuang Huang, Chandra Shyamal B., Tabata Yasuhiko, Komeda Masashi
CIRCULATION   114(18) 392   Oct 2006   [Refereed]
Toshihiro Kushibiki, Ryuji Tomoshige, Ryuji Tomoshige, Kazunori Iwanaga, Masawo Kakemi, Yasuhiko Tabata
J Biomater Sci Polym Ed.   17(6) 645-658   Jun 2006   [Refereed]
The objective of this paper is to compare the in vitro transfection efficiency of a luciferase plasmid DNA using cationized gelatin prepared from different amine compounds. The compounds used here were ethylenediamine, putrescine, spermidine and s...
Kozo Hoshino, Kozo Hoshino, T. Kimura, A. M. De Grand, A. M. De Grand, R. Yoneyama, Y. Kawase, S. Houser, H. Q. Ly, T. Kushibiki, Y. Furukawa, K. Ono, Y. Tabata, J. V. Frangioni, J. V. Frangioni, T. Kita, R. J. Hajjar, R. J. Hajjar, M. Hayase
Gene Ther.   13 1320-1327   Sep 2006
Gelatin hydrogel microspheres (GHMs) have been reported as novel non-viral vectors for gene or protein delivery (GHM therapy). However, the components of an effective catheter-based delivery strategy for GHM therapy are unknown. We evaluated the e...
Hosseinkhani H, Kushibiki T, Matsumoto K, Nakamura T, Tabata Y
Cancer gene therapy   13(5) 479-489   May 2006   [Refereed]
Kushibiki T, Tomoshige R, Iwanaga K, Kakemi M, Tabata Y
Journal of controlled release : official journal of the Controlled Release Society   112(2) 249-256   May 2006   [Refereed]
Goichi Matsumoto, Toshihiro Kushibiki, Yukihiko Kinoshita, Ushaku Lee, Yasushi Omi, Eiro Kubota, Yasuhiko Tabata
Cancer Sci.   97(4) 313-321   Apr 2006   [Refereed]
Double-stranded RNA (dsRNA) plays a major role in RNA interference (RNAi), a process in which segments of dsRNA are initially cleaved by the Dicer into shorter segments (21-23 nt) called small interfering RNA (siRNA). These siRNA then specifically...
Iwanaga K, Kushibiki T, Miyazaki M, Kakemi M
Biological & pharmaceutical bulletin   29(3) 508-512   Mar 2006   [Refereed]
Ohta S, Nitta N, Takahashi M, Sonoda A, Tanaka T, Yamasaki M, Furukawa A, Takazakura R, Murata K, Sakamoto T, Kushibiki T, Tabata Y
Journal of vascular and interventional radiology : JVIR   17(3) 533-539   Mar 2006   [Refereed]
Kushibiki T, Nagata-Nakajima N, Sugai M, Shimizu A, Tabata Y
Journal of controlled release : official journal of the Controlled Release Society   110(3) 610-617   Feb 2006   [Refereed]
T. Kushibiki, K. Matsumoto, T. Nakamura, Y. Tabata
Key Engineering Materials   288-289 121-124   Dec 2005
NK4, composed of the NH2-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts as a potent angiogenesis inhibitor. This study is an investigation to evaluate the feasibility of controlled release of NK4 plasm...
Zhao Y, Shimizu T, Nishihira J, Koyama Y, Kushibiki T, Honda A, Watanabe H, Abe R, Tabata Y, Shimizu H
The American journal of pathology   167(6) 1519-1529   Dec 2005   [Refereed]
Kasper FK, Kushibiki T, Kimura Y, Mikos AG, Tabata Y
Journal of controlled release : official journal of the Controlled Release Society   107(3) 547-561   Oct 2005   [Refereed]
Kushibiki T, Nagata-Nakajima N, Sugai M, Shimizu A, Tabata Y
Biological & pharmaceutical bulletin   28(10) 2007-2010   Oct 2005   [Refereed]
Morino S, Nakamura T, Toba T, Takahashi M, Kushibiki T, Tabata Y, Shimizu Y
Chest   128(2) 920-926   Aug 2005   [Refereed]
Kushibiki T, Nagata-Nakajima N, Sugai M, Shimizu A, Tabata Y
Journal of controlled release : official journal of the Controlled Release Society   105(3) 318-331   Jul 2005   [Refereed]
小畑 陽子, 宮崎 正信, 阿部 克成, 山本 一男, 櫛引 俊宏, 友重 龍治, 夏 志銀, 原田 孝司, 大園 恵幸, 松山 俊文, 小路 武彦, 田畑 泰彦, 河野 茂
腎と透析   58 132-135   Jun 2005
Marui A, Kanematsu A, Yamahara K, Doi K, Kushibiki T, Yamamoto M, Itoh H, Ikeda T, Tabata Y, Komeda M
Journal of vascular surgery   41(1) 82-90   Jan 2005   [Refereed]
Kushibiki T, Tabata Y
Journal of biomaterials science. Polymer edition   16(11) 1447-1461   2005   [Refereed]
KUSHIBIKI Toshihiro, TOMOSHIGE Ryuji, TABATA Yasuhiko
Ensho   24(6) 634-641   Nov 2004
Recent rapid development of molecular biology together with the steady progress of genome projects has been given us some essential and revolutionary informations of gene to elucidate all the biological phenomena at the molecular level. Under thes...
Hosaka A, Koyama H, Kushibiki T, Tabata Y, Nishiyama N, Miyata T, Shigematsu H, Takato T, Nagawa H
Circulation   110(21) 3322-3328   Nov 2004   [Refereed]
Kushibiki T, Matsumoto K, Nakamura T, Tabata Y
Gene therapy   11(15) 1205-1214   Aug 2004   [Refereed]
Nishida T, Kubota S, Kojima S, Kuboki T, Nakao K, Kushibiki T, Tabata Y, Takigawa M
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research   19(8) 1308-1319   Aug 2004   [Refereed]
Kojima K, Ignotz RA, Kushibiki T, Tinsley KW, Tabata Y, Vacanti CA
The Journal of thoracic and cardiovascular surgery   128(1) 147-153   Jul 2004   [Refereed]
Kushibiki T, Matsumoto K, Nakamura T, Tabata Y
Pharmaceutical research   21(7) 1109-1118   Jul 2004   [Refereed]
A new gene delivery system based on controlled release technology.
Kushibiki T, Tabata Y
Current drug delivery   1(2) 153-163   Apr 2004   [Refereed]
Kushibiki T, Matsuoka H, Tabata Y
Biomacromolecules   5(1) 202-208   Jan 2004   [Refereed]
Kushibiki T, Tomoshige R, Fukunaka Y, Kakemi M, Tabata Y
Journal of controlled release : official journal of the Controlled Release Society   90(2) 207-216   Jun 2003   [Refereed]

Misc

 
Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   9323    Jan 2015
© 2015 SPIE. Quantification of the optical properties of the tissues and blood by noninvasive photoacoustic (PA) imaging may provide useful information for screening and early diagnosis of diseases. Linearized 2D image reconstruction algorithm bas...
T. Hirasawa, S. Okawa, M. Fujita, T. Kushibiki, M. Ishihara
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   8943    Jan 2014
We proposed a method of quantifying the effective attenuation coefficients of optical absorbers which uses the continuous wavelet transform to calculate the time-resolved frequency spectra of photoacoustic (PA) signals. In order to apply the metho...
Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   8943    Jan 2014
Reconstruction of the absorption coefficient from photoacoustic signals is discussed. The photoacoustic (PA) signals were acquired by using a ring-shaped P(VDF-TrFE) acoustic sensor coaxially arranged with an optical fiber. The acoustic sensor sca...
KUSHIBIKI T, HIRASAWA T, OKAWA S, ISHIHARA M
レーザー学会研究会報告 = Reports on the Topical meeting of the Laser Society of Japan   446 7-13   Jul 2013
KUSHIBIKI Toshihiro, OKAWA Shinpei, ISHIHARA Miya
レーザー研究   41(7) 537-539   Jul 2013
Takeshi Hirasawa, Masanori Fujita, Shinpei Okawa, Toshihiro Kushibiki, Miya Ishihara
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   8581    May 2013
Quantification of the optical absorption coefficients of optical absorbers using photoacoustic (PA) pressure waves with broadband frequency was reported. We proposed to use continuous wavelet-transform (CWT) to obtain time-resolved frequency spect...
Shinpei Okawa, Takeshi Hirasawa, Toshihiro Kushibiki, Miya Ishihara
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   8581    May 2013
A method to reconstruct the optical properties in the inhomogeneous medium from the photoacoustic (PA) signal is discussed. The forward modeling of the propagations of the excitation light and of the photoacoustic pressure is carried out with the ...
OKAWA Shinpei, HIRASAWA Takeshi, KUSHIBIKI Toshihiro, ISHIHARA Miya
電気学会研究会資料. OQD, 光・量子デバイス研究会   2012(25) 27-31   Sep 2012
Toshihiro Kushibiki, Kunio Awazu
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   6435    Apr 2007
Mesenchymal stromal cells (MSCs) are multipotent cells, which are present in adult bone marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage...
AWAZU Kunio, KUSHIBIKI Toshihiro
電気学会研究会資料. OQD, 光・量子デバイス研究会   2008(1) 39-43   Feb 2008
Toshihiro Kushibiki, Hideo Eda, Tomoko Sano, Kunio Awazu
2006 World Automation Congress, WAC'06      Dec 2007
In this study, a new type of cell-cultivation system based on laser processing has been developed for the on-chip cultivation of living cells. We introduce a "laser cell-chip". A sheet prepared from epoxy resin was processed by KrF excimer laser (...
櫛引 俊宏
生産と技術   60(4) 35-37   2008
KUSHIBIKI T., AWAZU K.
レーザー学会研究会報告 = Reports on the Topical meeting of the Laser Society of Japan   370 15-18   Jan 2008
Toshihiro Kushibiki, Kunio Awazu
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   6632    Nov 2007
Mesenchymal stromal cells (MSCs) are multipotent cells, which are present in adult bone marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage...
Katsunori Ishii, Akinori Kimura, Toshihiro Kushibiki, Toshihiro Kushibiki, Kunio Awazu
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   6628    Nov 2007
Tissue specific progenitor cells and its differentiations have got a lot of attentions in regenerative medicine. The process of differentiations, the formation of tissues, has become better understood by the study using a lot of cell types progres...
ISHII Katsunori, YAMAOKA Yoshihisa, KUSHIBIKI Toshihiro, AWAZU Kunio
The Review of laser engineering   35(9) 602-605   Sep 2007
Katsunori Ishii, Zhenhe Ma, Yoshihisa Ninomiya, Minori Takegoshi, Toshihiro Kushibiki, Toshihiro Kushibiki, Masaya Yamamoto, Monica Hinds, Yasuhiko Tabata, Ruikang K. Wang, Kunio Awazu
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   6439    Aug 2007
Tendon and ligament are the transition tissues from a hard tissue to a soft tissue. The regenerative medicine of tendons needs reasonable biomaterials to regenerate precisely from the view point of composition and adhesion properties. In regenerat...
Toshihiro Kushibiki, Kunio Awazu
Optics InfoBase Conference Papers      Jan 2007
Mesenchymal stromal cells (MSCs) are multipotent cells, which are present in adult bone marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage...
Katsunori Ishii, Akinori Kimura, Toshihiro Kushibiki, Toshihiro Kushibiki, Kunio Awazu
Optics InfoBase Conference Papers      Jan 2007
Tissue specific progenitor cells and its differentiations have got a lot of attentions in regenerative medicine. The process of differentiations, the formation of tissues, has become better understood by the study using a lot of cell types progres...
Katsunori Ishii, Toshihiro Kushibiki, Kunio Awazu
IFMBE Proceedings   14 3345-3347   Jan 2007
© International Federation for Medical and Biological Engineering 2007. Stem cells and its differentiation get a lot of attentions in the area of regenerative medicine recently. The differentiation of stem cells is mainly evaluated by the morpholo...
Katsunori Ishii, Akinori Kimura, Toshihiro Kushibiki, Toshihiro Kushibiki, Kunio Awazu
Progress in Biomedical Optics and Imaging - Proceedings of SPIE   6439    Aug 2007
Stem cells and its differentiations have got a lot of attentions in regenerative medicine. The process of differentiations, the formation of tissues, has become better understood by the study using a lot of cell types progressively. These studies ...
ISHII Katsunori, UCHIZONO Takeyuki, KUSHIBIKI Toshihiro, YOSHIHASHI SUZUKI Sachiko, ISHIHARA Miya, OHMI Masato
日本レーザー医学会誌 = The Journal of Japan Society for Laser Medicine   27(2) 120-123   Jul 2006
Toshihiro Kushibiki, Tomoko Sano, Katsunori Ishii, Sachiko Yoshihashi-Suzuki, Kunio Awazu
Proceedings of SPIE - The International Society for Optical Engineering   6080    May 2006
A new type of cell-cultivation system based on laser processing has been developed for the on-chip cultivation of living cells. We introduce a "laser cell-chip", on which migration of cells, such as stem cells, tumor cells or immunocompetent cells...
Cell migration imaging and its functional analysis
   2006
Katsunoti Ishii, Yoshihisa Ninomiya, Minori Takegoshi, Toshihiro Kushibiki, Sachiko Yoshihashi-Suzuki, Masaya Yamamoto, Yasuhiko Tabata, Kunio Awazu
Proceedings of SPIE - The International Society for Optical Engineering   6084    May 2006
Phosphorylation and dephosphorylation are considered to be important reactions that control the active and inactive factors of proteins. In regenerative medicine of the osteoconnective tissue (a tendon, a ligament), it has been reported that the b...
Development of laser cell-chip system for cell functional analysis
International Journal of Intelligent Computing in Medical Sciences and Image Processing   1    2008
Controlling mesenchymal stromal cell differentiation by regulating a circadian clock protein with laser irradiation
   2007
Gelatin-based nanomicells.
Nanoparticles for Pharmaceutical Applications   Chapter 22 377-384    2007
Toshihiro Kushibiki, Kunio Awazu
Photomedicine and Laser Surgery   6991    Jun 2008
Successful tissue regeneration required both cells with high proliferative and differentiation potential and an environment permissive for regeneration. These conditions can be achieved by providing cell scaffolds and growth factors that induce an...
Marquis Who's Who in the World
26th Edition   26th Edition    2008
Marquis Who's Who in the World
   2009
Marquis Who's Who in Medicine and Healthcare
   2009
Toshihiro Kushibiki, Natsuki Nakajima-Nagata, Manabu Sugai, Akira Shimizu, Yasuhiko Tabata
Polymer Preprints, Japan   54 2143   Dec 2005
Renal interstitial fibrosis is the common pathway of chronic renal disease, while it causes an end-stage renal failure. Transforming growth factor-β (TGF-β) is well recognized to be one of the primary mediators to induce accumulation of extracellu...
A. Marui, K. Doi, T. Kushibiki, Y. Tabata, M. Komeda
Transactions - 7th World Biomaterials Congress   1181   Dec 2004
The advantages of therapeutic angiogenesis by controlled release system of basic fibroblast growth factor (bFGF) from biodegradable gelatin hydrogels (GH) were discussed. The advantages of therapeutic angiogenesis is that it is safe and less invas...

Research Grants & Projects

 
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Controlling cells function with light technology
Project Year: 2005