論文

2014年9月

mTOR regulates the nucleoplasmic diffusion of Xrn2 under conditions of heat stress

FEBS LETTERS
  • Kazunori Watanabe
  • ,
  • Kenichi Ijiri
  • ,
  • Takashi Ohtsuki

588
18
開始ページ
3454
終了ページ
3460
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.febslet.2014.08.003
出版者・発行元
ELSEVIER SCIENCE BV

Stress induces various responses, including translational suppression and tRNA degradation in mammals. Previously, we showed that heat stress induces degradation of initiator tRNA(Met) (iMet) through 5'-3' exoribonuclease Xrn1 and Xrn2, respectively. In addition, we found that rapamycin inhibits the degradation of iMet under heat stress conditions. Here, we report that the mammalian target of rapamycin (mTOR) regulates the diffusion of Xrn2 from the nucleolus to the nucleoplasm, facilitating the degradation of iMet under conditions of heat stress. Our results suggest a mechanism of translational suppression through mTOR-regulated iMet degradation in mammalian cells. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1016/j.febslet.2014.08.003
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000341450600021&DestApp=WOS_CPL

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