論文

2016年7月

Photoinduced apoptosis using a peptide carrying a photosensitizer

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Kazunori Watanabe
  • ,
  • Hayato Fujiwara
  • ,
  • Mizuki Kitamatsu
  • ,
  • Takashi Ohtsuki

26
13
開始ページ
3115
終了ページ
3118
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bmcl.2016.04.091
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

A novel molecule, TatBim-Alexa, consisting of the HIV1 Tat cell-penetrating peptide, the Bim apoptosis-inducing peptide, and Alexa Fluor 546 was synthesized for photoinducion of apoptosis. The Alexa Fluor 546 was used as a photosensitizer and covalently attached at the C-terminus of TatBim peptide by the thiol-maleimide reaction. Photo-dependent cytosolic internalization of TatBim-Alexa and photo-dependent apoptosis using TatBim-Alexa were demonstrated in several kinds of mammalian cells including human cancer cell lines. (C) 2016 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1016/j.bmcl.2016.04.091
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000377470600030&DestApp=WOS_CPL

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