2016年7月1日
Photoinduced apoptosis using a peptide carrying a photosensitizer.
Bioorganic & medicinal chemistry letters
- ,
- ,
- ,
- 巻
- 26
- 号
- 13
- 開始ページ
- 3115
- 終了ページ
- 3118
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.bmcl.2016.04.091
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
A novel molecule, TatBim-Alexa, consisting of the HIV1 Tat cell-penetrating peptide, the Bim apoptosis-inducing peptide, and Alexa Fluor 546 was synthesized for photoinducion of apoptosis. The Alexa Fluor 546 was used as a photosensitizer and covalently attached at the C-terminus of TatBim peptide by the thiol-maleimide reaction. Photo-dependent cytosolic internalization of TatBim-Alexa and photo-dependent apoptosis using TatBim-Alexa were demonstrated in several kinds of mammalian cells including human cancer cell lines.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bmcl.2016.04.091
- ISSN : 0960-894X
- eISSN : 1464-3405
- PubMed ID : 27165853
- Web of Science ID : WOS:000377470600030