論文

査読有り
2018年3月1日

MicroRNA-664a-5p promotes neuronal differentiation of SH-SY5Y cells

Genes to Cells
  • Kazunori Watanabe
  • ,
  • Ryuhei Yamaji
  • ,
  • Takashi Ohtsuki

23
3
開始ページ
225
終了ページ
233
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/gtc.12559
出版者・発行元
Blackwell Publishing Ltd

MicroRNAs (miRNAs) belong to a class of small noncoding RNAs that play important roles in the translational regulation of gene expression. A number of miRNAs are known to act as key regulators of diverse processes such as neuronal differentiation. In this study, we have attempted to identify novel miRNAs related to neuronal differentiation via microarray analysis in the human neuronal differentiation model neuroblastoma SH-SY5Y cells. We identified 15 up-regulated and eight down-regulated miRNAs in SH-SY5Y cells treated with all-trans retinoic acid to induce differentiation. We further showed that one of the up-regulated miRNAs, miR-664a-5p, promoted neuronal differentiation of SH-SY5Y cells. These findings enhance our understanding of the miRNAs involved in the process of neurogenesis and, in particular, highlight an important role of miR-664a-5p in SH-SY5Y cell neuronal differentiation. Further studies will be required to confirm the function of miR-664-5p in neuronal development and disease and to identify its relevant target genes.

リンク情報
DOI
https://doi.org/10.1111/gtc.12559

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