Kazuma Murakami

J-GLOBAL         Last updated: Jan 8, 2020 at 00:31
 
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Name
Kazuma Murakami
E-mail
alzkazukais.kyoto-u.ac.jp
Affiliation
Kyoto University
Section
Graduate School of Agriculture, Division of Food Science and Biotechnology, Organic Chemistry in Life Science
Job title
Associate Professor
Research funding number
80571281
ORCID ID
0000-0003-3152-1784

Research Areas

 
 

Published Papers

 
Three structural features of functional food components and herbal medicine with amyloid 42 anti-aggregation properties
*Murakami, K, and *Irie, K.
Molecules   24 2125   Jun 2019   [Refereed][Invited]
Role of carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers
Murakami, K., Yoshioka, T., Horii, S., Hanaki, M., Midorikawa, S., Taniwaki, S., Gunji, H., Akagi, K., Kawase, T., Hirose, K., and *Irie, K.
Chem. Commun.   54(49) 6272-6275   Jul 2018   [Refereed]
Hanaki, M., Murakami, K., Katayama, S., Akagi, K., and *Irie, K.
Bioorg. Med. Chem.   26(8) 1538-1546   May 2018   [Refereed]
A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease
Izuo, N., Kasahara, C., Murakami, K., Kume, T., Maeda, M., Irie, K., Yokote, K., and *Shimizu, T.
Sci. Rep.   7(1) 11811   Sep 2017   [Refereed]
Oku Y, Murakami K, Irie K, Hoseki J, *Sakai Y
Cell structure and function   42(1) 71-79   May 2017   [Refereed]
Irie Y, Murakami K, Hanaki M, Hanaki Y, Suzuki T, Monobe Y, Takai T, Akagi KI, Kawase T, Hirose K, *Irie K
ACS Chem. Neurosci.   8(4) 807-816   Apr 2017   [Refereed]
Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie and *H. Shigemori
Heterocycles   94(7) 1280-1287   2017   [Refereed]
Ben Hmidene A, Hanaki M, Murakami K, Irie K, Isoda H, *Shigemori H
Biological & pharmaceutical bulletin   40(2) 238-241   2017   [Refereed]
Yoshioka T, Murakami K, Ido K, Hanaki M, Yamaguchi K, Midorikawa S, Taniwaki S, Gunji H, *Irie K
Journal of natural products   79(10) 2521-2529   Oct 2016   [Refereed]
Murakami K, Tokuda M, Suzuki T, Irie Y, Hanaki M, Izuo N, Monobe Y, Akagi K, Ishii R, Tatebe H, Tokuda T, Maeda M, Kume T, Shimizu T, *Irie K
Scientific Reports   6 29038   Jul 2016   [Refereed]
Hanaki, M., Murakami, K., Akagi, K., and *Irie, K.
Bioorg. Med. Chem.   24(2) 304-313   Jan 2016   [Refereed]
Murakami, K., Suzuki, T., Hanaki, M., Monobe, Y., Akagi, K., and *Irie, K.
Biochem. Biophys. Res. Commun.   466(3) 463-467   Oct 2015   [Refereed]
E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie and H. *Shigemori
Heterocycles   92(11) 1976-1982   2016   [Refereed]
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.
Soejima, N., *Ohyagi, Y., Nakamura, N., Himeno, E., Iimura, K. M., Sakae, N., Yamasaki, R., Tabira, T., Murakami, K., Irie, K., Kinoshita, N., LaFerla, F. M., Kiyohara, Y., Iwaki, T., and Kira, J.
Curr. Alzheimer Res.   10(1) 11-20   Jan 2013   [Refereed]
Kamachi, H., Tanaka, K., Yanagita, R. C., Murakami, A., Murakami, K., Tokuda, H., Suzki, N., Nakagawa, Y., and *Irie, K.
Bioorg. Med. Chem. 21 (10), 2695-2702 (2013).   21(10) 2695-2702   May 2013   [Refereed]
*Kazuma Murakami
Biosci. Biotechnol. Biochem.   78(8) 1293-1305   Aug 2014   [Refereed]
Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H
Cell stem cell   12(4) 487-496   Apr 2013   [Refereed]
Kenche VB, Hung LW, Perez K, Volitakes I, Ciccotosto G, Kwok J, Critch N, Sherratt N, Cortes M, Lal V, Masters CL, Murakami K, Cappai R, Adlard PA, Barnham KJ
Angewandte Chemie (International ed. in English)   52(12) 3374-3378   Mar 2013   [Refereed]
Sato M, Murakami K, Uno M, Ikubo H, Nakagawa Y, Katayama S, Akagi K, *Irie K
Bioscience, biotechnology, and biochemistry   77(5) 1100-1103   2013   [Refereed]
アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異
Dementia Japan,   26(3) 311-318   2012   [Invited]
Ueno S, Yanagita RC, Murakami K, Murakami A, Tokuda H, Suzuki N, Fujiwara T, *Irie K
Bioscience, biotechnology, and biochemistry   76(5) 1041-1043   2012   [Refereed]
Murakami, K., Murata, N., Noda, Y., Irie, K., Shirasawa, T., and *Shimizu, T.
Biosci. Biotechnol. Biochem. 76 (6), 1098-1103 (2012).   76(6) 1098-1103   2012   [Refereed]
Kurisu M, Miyamae Y, Murakami K, Han J, Isoda H, Irie K, *Shigemori H
Bioscience, biotechnology, and biochemistry   77(6) 1329-1332   2013   [Refereed]
Rosensweig, C. Ono, K., Murakami, K., Lowenstein, D., Bitan, G., and *Teplow, D. B.
Methods. Mol. Biol. 849, 23-31 (2012).   849 23-31   2012   [Refereed]
Tsuji, F., Ishihara, A., Kurata, K., Nakagawa, A., Okada, M., Kitamura, S., Kanamaru, K., Masuda, Y., Murakami, K., Irie, K., and *Sakagami, Y.:
FEBS Lett. 586 (2), 174-179 (2012).   586(2) 174-179   Jan 2012   [Refereed]
Non-toxic conformer of Aβ42 may suppress Aβ42-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy of Alzheimer’s disease.
Izuo, N., Murakami, K., Sato, M., Iwasaki, M., Izumi, Y., Kinoshita, N., Akaike, A., *Irie, K., and *Kume, T.
Biochem. Biophys. Res. Commun.   438(1) 1-5   2013   [Refereed]
Murakami, K., Murata, N., Ozawa, Y., Kinoshita, N., Irie, K., Shirasawa, T., *Shimizu, T.
J. Alzheimers Dis. 26 (1), 7-18 (2011).   26(1) 7-18   2011   [Refereed]
Sato, M., Murakami, K., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K., Masuda, Y., Takegoshi, K., and *Irie, K.
J. Biol. Chem.   288(32) 23212-23224   2013   [Refereed]
Murakami, K., Yokoyama, S., Murata, N., Ozawa, Y., Irie, K., Shirasawa, T., and *Shimizu, T.
Biochem. Biophys. Res. Commun. 409 (1), 34-39 (2011).   409(1) 34-39   May 2011   [Refereed]
Izuo N, Kume T, Sato M, Murakami K, Irie K, Izumi Y, Akaike A
ACS chemical neuroscience   3(9) 674-681   Sep 2012   [Refereed]
Murakami K, *Shimizu T
Communicative & integrative biology   5(3) 255-258   May 2012   [Refereed]
Murakami, K., Horikoshi-Sakuraba, Y., Murata, N., Noda, Y. Masuda, Y., Kinoshita, N., Hatsuta, H., Murayama, S., Shirasawa, T., *Shimizu, T., and *Irie, K.
ACS Chem. Neurosci. 1 (11), 747-756 (2010).   1(11) 747-756   Nov 2010   [Refereed]
*Kulic, L., McAfoose, J., Welt, T., Tackenberg, C., Spani, C., Wirth, F., Finder, V., Konietzko, U., Giese, M., Eckert, A., Kinoshita, N., Shimizu, T., Murakami, K., Irie, K., Rasool, S., Glabe, C., Hock, C., and Nitsch, R.
Transl. Psychiatry 2012, 2, e183 (2012).      2012   [Refereed]
Miyamae, Y., Kurisu, M., Murakami, K., Han, J., Isoda, H., Irie, K., and *Shigemori, H.
Bioorg. Med. Chem. 19 (1), 5844-5849 (2012).   20(19) 5844-5849   Oct 2012   [Refereed]
Murakami, K., Inagaki, J., Saito, M., Ikeda, Y., Tsuda, C., Noda, Y., Kawakami, S., Shirasawa, T., and *T. Shimizu.
Biochem. Biophys. Res. Commun. 382 (2), 457-461 (2009).   382(2) 457-461   May 2009   [Refereed]
Izuo, N., Kume, T., Sato, M., Murakami, K., *Irie, K., Izumi Y., and *Akaike, A.
ACS Chem. Neurosci. 3 (9), 674-681 (2012).      2012   [Refereed]
Tsuji, F., Ishihara, A., Kurata, K., Nakagawa, A., Okada, M., Kitamura, S., Kanamaru, K., Masuda, Y., Murakami, K., Irie, K., and *Sakagami, Y.
Biosci. Biotechnol. Biochem. 76 (8), 1492-1496 (2012).   76(8) 1492-1496   2012   [Refereed]
Murakami K, Murata N, Noda Y, Tahara S, Kaneko T, Kinoshita N, Hatsuta H, Murayama S, Barnham KJ, Irie K, Shirasawa T, *Shimizu T
The Journal of biological chemistry   286(52) 44557-44568   Dec 2011   [Refereed]
*Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T
Rinsho shinkeigaku = Clinical neurology   51(11) 890-891   Nov 2011   [Refereed]
*Murakami K, Shimizu T, Irie K
Journal of amino acids   2011 654207   2011   [Refereed]
Suzuki, T., Murakami, K., Izuo, N., Kume, T., Akaike, A., Nagata, T., Nishizaki, T., Tomiyama, T., Takuma, H., Mori, H., and *Irie, K.
Int. J. Alzheimers Dis. 2011, doi:10.4061/2011/431320 (2011).   2011 431320   2011   [Refereed]
Murakami K, Masuda Y, Shirasawa T, *Shimizu T, *Irie K
Geriatrics & gerontology international   10 Suppl 1 S169-79   Jul 2010   [Refereed]
Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, *Shimizu T
Bioscience, biotechnology, and biochemistry   74(11) 2299-2306   2010   [Refereed]
Rahimi, F., Murakami, K., Summers, J. L., Chen, C. B., and *Bitan, G.
PLoS ONE 4 (11), e7694 (2009).      2009   [Refereed]
Murakami K, Uno M, Masuda Y, Shimizu T, Shirasawa T, Irie K
Biochemical and biophysical research communications   366(3) 745-751   Feb 2008   [Refereed]
Murakami, K., Uno, M., Masuda, Y., Shimizu, T., Shirasawa, T., and *Irie, K.
Biochem. Biophys. Res. Commun. 366 (3), 745-751 (2008).      2008   [Refereed]
Masuda Y, Irie K, Murakami K, Ohigashi H, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T
Bioorganic & medicinal chemistry   13(24) 6803-6809   Dec 2005   [Refereed]
Murakami K, *Irie K, Ohigashi H, Hara H, Nagao M, Shimizu T, Shirasawa T
Journal of the American Chemical Society   127(43) 15168-15174   Nov 2005   [Refereed]
Irie K, Murakami K, Masuda Y, Morimoto A, Ohigashi H, Ohashi R, Takegoshi K, Nagao M, Shimizu T, Shirasawa T
Journal of bioscience and bioengineering   99(5) 437-447   May 2005   [Refereed]
Masuda, Y., *Irie, K., Murakami, K., Ohigashi, H., Ohashi, R., Takegoshi, K., Shimizu, T., and Shirasawa, T.
Bioorg. Med. Chem. 13 (24), 6803-6809 (2005).      2005   [Refereed]
Morimoto A, *Irie K, Murakami K, Masuda Y, Ohigashi H, Nagao M, Fukuda H, Shimizu T, Shirasawa T
The Journal of biological chemistry   279(50) 52781-52788   Dec 2004   [Refereed]
Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T
The Journal of biological chemistry   278(46) 46179-46187   Nov 2003   [Refereed]
Murakami, K., *Irie, K., Morimoto, A., Ohigashi, H., Shindo, M., Nagao, M., Shimizu, T., and Shirasawa, T.
J. Biol. Chem. 278 (46), 46179-46187 (2003).      2003   [Refereed]
Morimoto A, *Irie K, Murakami K, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T
Biochemical and biophysical research communications   295(2) 306-311   Jul 2002   [Refereed]
Murakami, K., *Irie, K., Morimoto, A., Ohigashi, H., Shindo, M., Nagao, M., Shimizu, T., and Shirasawa, T.
Biochem. Biophys. Res. Commun. 294 (1), 5-10 (2002).      2002   [Refereed]

Misc

 
Murakami, K., Irie, K., Morimoto, A., Ohigashi, H., Shindo, M., Nagao, M., Shimizu, T., and Shirasawa, T.
Japan-Korea Young Scientists Meeting on Bioorganic and Natural Products Chemistry, Hiroshima, Japan      Sep 2002   [Refereed]
New aggregation model of amyloid β by the systematic proline replacement.
Murakami, K., Irie, K., Morimoto, A., Masuda, Y., Ohigashi, H., Nagao, M., Fukuda, H., Shimizu, T., and Shirasawa, T.
1st Asia-Pacific International Peptide Symposium, 41st Japanese Peptide Symposium, Fukuoka, Japan      Nov 2004   [Refereed]
Structural analysis of amyloid β.
Ohashi, R., Takegoshi, K., Terao, T., Masuda, Y., Murakami, K., Irie, K.
XXI International Conference on Magnetic Resonance in Biological Systems, (Hyderabad, Andhra Pradesh, India),      Jan 2005
Alzheimer’s 42-mer β peptide-specific mechanism of neurotoxicity through radical formation.
Murakami, K., Irie, K., Ohigashi, H., Hara, H., Nagao, M., Shimizu, T., and Shirasawa, T.
35th Annual Meeting of Society for Neuroscience, Washington DC, USA      Nov 2005   [Refereed]
New aggregation model of 42-mer amyloid β by the systematic proline replacement.
Irie, K., Murakami, K., Masuda, Y., Morimoto, A., Ohigashi, H., Hara, H., Nagao, M., Shimizu, T., and Shirasawa, T.
35th Annual Meeting of Society for Neuroscience, Washington DC, USA      Nov 2005   [Refereed]

Books etc

 
New aggregation model of amyloid β by the systematic proline replacement.
Murakami, K., *Irie, K., Morimoto, A., Masuda, Y., Ohigashi, H., Nagao, M., Fukuda, H., Shimizu, T., and Shirasawa, T.
In Peptide Science 2004, ed. Shimohigashi, Y., The Japanese Peptide Society, 179-182 (2005).   2005   
Structure of β-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer’s disease.
*Irie, K., Murakami, K., Masuda, Y., Morimoto, A., Ohigashi, H., Ohashi, R., Takegoshi, K., Nagao, M., Shimizu, T., and Shirasawa, T.
J. Biosci. Bioeng. 99 (5), 437-447 (2005).   2005   
‘Malignant’ conformation of Alzheimer’s β peptides (Aβ42) through radical formation.
Murakami, K., *Irie, K., Ohigashi, H., Hara, H., Nagao, M., Shimizu, T., and Shirasawa, T.
In Peptide Science 2006, eds. Ishida, H. & Mihara, H., The Japanese Peptide Society, 19-20 (2006).   2006   
The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer’s disease.
*Irie, K, Murakami, K., Masuda, Y., Morimoto, A., Ohigashi, H., Hara, H., Ohashi, R., Takegoshi K., Fukuda, H., Nagao, M., Shimizu, T., and Shirasawa, T.
Mini-Rev. Med. Chem. 7 (10), 1001-1008 (2007).   2007   
Amyloids and protein aggregation – analytical methods.
Li, H., Rahimi, F., Sinha, S., Maiti, P., *Bitan, G., Murakami, K.
Encyclopedia Anal. Chem. doi: 10.1002/9780470027318.a9038 (2009).   2009   

Conference Activities & Talks

 
Session Chairs of Molecular and Cell Biology: Aβ/amyloid (O3-01-01~06)
Kazuma Murakami and Lucía Chávez-Gutiérrez
Alzheimer's Association International Conference 2019   16 Jul 2019   
Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry
7th Asia-Pacific EPR/ESR Symposium   12 Oct 2010   Convention Center (Jeju, 韓国)
‘Toxic’ turn formation at positions 22 and 23 in Aβ42 and its relevance to oxidative stress in AD
Neurodegeneration Research Meeting   14 Aug 2009   Melbourne大学 (Melbourne, Australia)

Research Grants & Projects

 
Chemistry of amyloid beta peptide in Alzheimer's disease
Project Year: 2007 - 2009

Patents

 
特許US 8,710,193; CN ZL201080046483.9 : Antibody recognizing turn structure in amyloid β
Irie, K., Murakami, K., Masuda, Y., Shimizu, T., Shirasawa, T., Seito, T.