Chikara Kokubu

Profile Information

Affiliation: Office for University-Industry Collaboration, Osaka University

Degree: 医学博士(大阪大学)

J-GLOBAL ID: 200901056761491990
researchmap Member ID: 6000003971

External link: http://www.med.osaka-u.ac.jp/pub/mr-envi/www/index.html

Research Interests

Research Areas

Misc.

A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice

Chikara Kokubu, Kyoji Horie, Koichiro Abe, Ryuji Ikeda, Sumi Mizuno, Yoshihiro Uno, Sanae Ogiwara, Masato Ohtsuka, Ayako Isotani, Masaru Okabe …

NATURE GENETICS, 41(8) 946-U121, Aug, 2009
Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd

Takuo Kubota, Toshimi Michigami, Naoko Sakaguchi, Chikara Kokubu, Akira Suzuki, Noriyuki Namba, Norio Sakai, Shigeo Nakajima, Kenji Imai, Keiichi Ozono

JOURNAL OF BONE AND MINERAL RESEARCH, 23(10) 1661-1671, Oct, 2008
Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPAR gamma and C/EBP alpha

Masanobu Kawai, Sotaro Mushiake, Kazuhiko Bessho, Mari Murakami, Norlyuki Namba, Chikara Kokubu, Toshimi Michigami, Keiichi Ozono

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 363(2) 276-282, Nov, 2007
Sleeping Beauty transposase has an affinity for heterochromatin conformation

Ryuji Ikeda, Chikara Kokubu, Kosuke Yusa, Vincent W. Keng, Kyoji Horie, Junji Takeda

MOLECULAR AND CELLULAR BIOLOGY, 27(5) 1665-1676, Mar, 2007
Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system

VW Keng, K Yae, T Hayakawa, S Mizuno, Y Uno, K Yusa, C Kokubu, T Kinoshita, K Akagi, NA Jenkins …

NATURE METHODS, 2(10) 763-769, Oct, 2005
Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

C Kokubu, U Heinzmann, T Kokubu, N Sakai, T Kubota, M Kawai, MB Wahl, J Galceran, R Grosschedl, K Ozono …

DEVELOPMENT, 131(21) 5469-5480, Nov, 2004
Undulated shod-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1

C Kokubu, B Wilm, T Kokubu, M Wahl, Rodrigo, I, N Sakai, F Santagati, Y Hayashizaki, M Suzuki, K Yamamura …

GENETICS, 165(1) 299-307, Sep, 2003
Mutation analysis of the acid ceramidase gene in Japanese patients with Farber disease

T. Muramatsu, N. Sakai, I. Yanagihara, M. Yamada, T. Nishigaki, C. Kokubu, H. Tsukamoto, M. Ito, K. Inui

Journal of Inherited Metabolic Disease, 25(7) 585-592, Nov, 2002
Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse, and pufferfish genomes

Santagati F, Gerber JK, Blusch JH, Kokubu C, Peters H, Adamski J, Werner T, Balling R, Imai K

Mamm Genome, 12 232-7, 2001
Molecular heterogeniety of Krabbe disease

Fu L, Inui K, Nishigaki T, Tatsumi N, Tsukamoto H, Kokubu C, Muramatsu T, Okada S

J Inherit Metab Dis, 22 155-62, 1999
Treatment of fulminant hemophagocytic lymphohistiocytosis with combined administration of OKT-3 and etoposide

Y Osugi, J Hara, C Kokubu, Y Okuda, G Hosoi, T Okamura, H Imanaka, N Taenaka, A Tawa, S Okada

INTERNATIONAL JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY, 4(4) 433-439, 1997
The structure of icosahedral aluminum-magnesium-copper alloy.

Sakurai Y, Kokubu C, Tanaka Y, Watanabe Y, Masuda M, Nanao S

Mater. Sci. Eng., 99 423-26, 1988
Pair distribution function in icosahedral Al-Mn-Si alloy.

Nanao S, Tanaka Y, Sakurai Y, Kokubu C, Watanabe Y, Masuda M, Yasui I

Mater. Sci. Eng., 99 427-430, 1988
The first observation of RHEED intensity oscillation during the growth of Cu/Mo multi-layered films.

Kaneko T, Imafuku M, Kokubu C, Yamamoto R, Doyama M

Journal of the Physical Society of Japan, 55(8) 2903-2904, 1986

Presentations

Mapping by Hopping: A Transposon-Based Chromosomal Engineering to Survey a Large Cis-Regulatory Landscape in the mouse genome.

The 16th CDB Meeting. Cis-sequence Regulation and its Evolution. RIKEN Center for Developmental Biology, Kobe, Japan, 2008
Sleeping Beautyトランスポゾンを用いた挿入変異体作製と染色体エンジニアリング

第54回日本実験動物学会総会, 2007
トランスポゾンを用いたマウス長距離シス調節ゲノム領域の改変/解析法の開発

第40回日本発生生物学会・第59回日本細胞生物学会合同大会., 2007
Mapping by Hopping: Transposon-Based Genome Engineering to Survey a Large Cis-Regulatory Landscape.

Building a Better Mouse II Conference. Vanderbilt University, Nashville, USA., 2007
Region-specific functional genomics in the mouse: Exploitation of Sleeping Beauty transposon’s local hopping trait.

第28回日本分子生物学会年会, 2005
Scanning of genomic regions in mice using Sleeping Beauty’s local hopping trait.

The 3rd Annual International Conference on Transposition and Animal Biotechnology. University of Minnesota, USA., 2005
骨格異常を呈するマウス突然変異ringelschwanz(rs)のポジショナルクローニング

第7回大阪小児骨系統疾患研究会, 2004
Pax1 Un-s mutation leads to ectopic expression of its neighboring gene Nkx2-2 in the somite and the limb buds.

Mouse Molecular Genetics Meeting, Heidelberg, Germany, 2001

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