MISC

国際誌
2020年6月

The pretreatment neutrophil-to-lymphocyte ratio is a novel biomarker for predicting clinical responses to pembrolizumab in platinum-resistant metastatic urothelial carcinoma patients.

Urologic oncology
  • Koichiro Ogihara
  • Eiji Kikuchi
  • Keisuke Shigeta
  • Takashi Okabe
  • Seiya Hattori
  • Ryo Yamashita
  • Shunsuke Yoshimine
  • Suguru Shirotake
  • Ryuto Nakazawa
  • Kazuhiro Matsumoto
  • Ryuichi Mizuno
  • Satoshi Hara
  • Masafumi Oyama
  • Takeshi Masuda
  • Masashi Niwakawa
  • Mototsugu Oya
  • 全て表示

38
6
開始ページ
602.e1-602.e10
終了ページ
記述言語
英語
掲載種別
DOI
10.1016/j.urolonc.2020.02.005

PURPOSE: We investigated the relationship between pretreatment neutrophil-to-lymphocyte ratio (pre-NLR) levels just before the initiation of treatment with pembrolizumab and clinical outcomes in platinum-resistant metastatic urothelial carcinoma (UC) patients treated with pembrolizumab. METHODS: Our study population comprised 78 patients diagnosed with metastatic UC and treated with pembrolizumab after platinum-based chemotherapy at our institutions between December 2017 and April 2019. We examined the relationships between pre-NLR levels just before pembrolizumab treatment and clinical outcomes. A pre-NLR level of ≥3.35 was defined as elevated according to a calculation by a receiver-operating curve analysis. RESULTS: The high pre-NLR group consisted of 33 patients (42.3%). Overall, 29.5% of patients had a clinical response and the sum of the target lesion longest diameter was decreased in 18.8% of the high pre-NLR group, which was significantly lower than that in the low pre-NLR group (58.1%, P = 0.005). Six-month progression-free survival and cancer-specific survival rates for the high pre-NLR group were 9.1 and 58.0%, which were significantly lower than those for their counterpart (45.9 and 89.1%, P < 0.001 and P = 0.002, respectively). The pre-NLR level was an independent indicator of disease progression and cancer-specific death (P < 0.001 and P = 0.003). Furthermore, patients with a postpembrolizumab NLR level that had decreased ≥25% from the pre-NLR level had significantly lower disease progression and cancer-specific death rates than their counterparts (P = 0.01 and P = 0.022, respectively). CONCLUSIONS: Elevated pre-NLR may be a novel biomarker for identifying poor responders to pembrolizumab among platinum-resistant metastatic UC patients.

リンク情報
DOI
https://doi.org/10.1016/j.urolonc.2020.02.005
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32139290
ID情報
  • DOI : 10.1016/j.urolonc.2020.02.005
  • PubMed ID : 32139290

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