HAYASHI Yuichi

J-GLOBAL         Last updated: Jul 2, 2019 at 02:42
 
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Name
HAYASHI Yuichi
Affiliation
Gifu University
Section
University Hospital

Research Interests

 
 

Research Areas

 

Academic & Professional Experience

 
 
   
 
Gifu University University Hospital, Neurology and geriatrics
 

Published Papers

 
Ohno Yuta, Niwa Takashi, Hirai Keita, Suzuki Keiko, Yamada Yuto, Hayashi Yuichi, Hayashi Hideki, Suzuki Akio, Itoh Yoshinori
THERAPEUTIC DRUG MONITORING   40(4) 507-511   Aug 2018   [Refereed]
Nishida Shohei, Hayashi Yuichi, Suzuki Akio, Kobayashi Ryo, Inuzuka Takashi, Itoh Yoshinori
GERIATRICS & GERONTOLOGY INTERNATIONAL   18(7) 1018-1024   Jul 2018   [Refereed]
Yoshikura Nobuaki, Kimura Akio, Fukata Masaki, Fukata Yuko, Yokoi Norihiko, Harada Naoko, Hayashi Yuichi, Inuzuka Takashi, Shimohata Takayoshi
JOURNAL OF NEUROIMMUNOLOGY   319 63-67   Jun 2018   [Refereed]
Hozumi Isao, Kurita Hisaka, Ozawa Kazuhiro, Furuta Nobuyuki, Inden Masatoshi, Sekine Shin-ichiro, Yamada Megumi, Hayashi Yuichi, Kimura Akio, Inuzuka Takashi, Seishima Mitsuru
JOURNAL OF THE NEUROLOGICAL SCIENCES   388 150-154   May 2018   [Refereed]
Kimura Akio, Takemura Masao, Serrero Ginette, Yoshikura Nobuaki, Hayashi Yuichi, Saito Kuniaki, Inuzuka Takashi
JOURNAL OF NEURO-ONCOLOGY   137(3) 455-462   May 2018   [Refereed]
Kimura Akio, Yoshikura Nobuaki, Hayashi Yuichi, Inuzuka Takashi
JOURNAL OF ALZHEIMERS DISEASE   61(2) 581-588   2018   [Refereed]
Nishida Hiroshi, Hayashi Yuichi, Harada Naoko, Sakurai Takeo, Wakida Kenji
INTERNAL MEDICINE   57(4) 605-611   2018   [Refereed]
Hayashi Yuichi, Shibata Hideaki, Kudo Takuya, Nishida Shohei, Ishikawa Rie, Moriya Chie, Suzuki Akio, Kimura Akio, Inuzuka Takashi
INTERNAL MEDICINE   57(10) 1483-1486   2018   [Refereed]
Yoshikura Nobuaki, Kimura Akio, Hayashi Yuichi, Inuzuka Takashi
JOURNAL OF NEUROIMMUNOLOGY   312 66   Nov 2017   [Refereed]
Yoshikura Nobuaki, Kimura Akio, Hayashi Yuichi, Inuzuka Takashi
JOURNAL OF NEUROIMMUNOLOGY   310 150-157   Sep 2017   [Refereed]
日本食品科学工学雑誌      Oct 2017   [Refereed]
Hayashi Yuichi, Yamada Megumi, Kimura Akio, Inuzuka Takashi
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION   4(4)    Jul 2017   [Refereed]
日本食品科学工学雑誌      Oct 2017   [Refereed]
Hayashi Yuichi, Koumura Akihiro, Yamada Megumi, Kimura Akio, Shibata Toshirou, Inuzuka Takashi
HEADACHE   57(7) 1145-1151   Jul 2017   [Refereed]
Yamada Wataru, Takekoshi Akira, Ishida Kyoko, Mochizuki Kiyofumi, Sone Jun, Sobue Gen, Hayashi Yuichi, Inuzuka Takashi, Miyake Yozo
DOCUMENTA OPHTHALMOLOGICA   134(3) 221-226   Jun 2017   [Refereed]
Hayashi Yuichi, Nagasawa Mambru, Asano Takahiko, Yoshida Tomokatsu, Kimura Akio, Inuzuka Takashi
CLINICAL NEUROLOGY AND NEUROSURGERY   157 31-33   Jun 2017   [Refereed]
医学のあゆみ      Aug 2017   [Refereed]
林 祐一、犬塚 貴 2017;262:726-727
Kimura Akio, Takemura Masao, Saito Kuniaki, Serrero Ginette, Yoshikura Nobuaki, Hayashi Yuichi, Inuzuka Takashi
JOURNAL OF NEUROIMMUNOLOGY   305 175-181   Apr 2017   [Refereed]
日本食品科学工学誌      Aug 2017   [Refereed]
林 祐一 2017;64: 446
Neurology Neuroimmunology Neuroinflammation      Jul 2017   [Refereed]
Hayashi Yuichi, Kimura Akio, Nakamura Hiroshi, Mimuro Maya, Iwasaki Yasushi, Hara Akira, Yoshida Mari, Inuzuka Takashi
JOURNAL OF THE NEUROLOGICAL SCIENCES   375 382-387   Apr 2017   [Refereed]
Medicina      Apr 2017   [Refereed]
林 祐一
Hayashi Yuichi, Yasunishi Masahiro, Hayashi Misayo, Asano Takahiko, Kimura Akio, Inuzuka Takashi
JOURNAL OF THE NEUROLOGICAL SCIENCES   373 81-82   Feb 2017   [Refereed]
Hayashi Y, Inuzuka T.
Journal of the Neurological Sciences   375 489   Apr 2017   [Refereed]
Kimura Akio, Takemura Masao, Saito Kuniaki, Yoshikura Nobuaki, Hayashi Yuichi, Inuzuka Takashi
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   88(2) 126-131   Feb 2017   [Refereed]
Hayashi Yuichi, Godai Ayumi, Yamada Megumi, Yoshikura Nobuaki, Harada Naoko, Koumura Akihiro, Kimura Akio, Okayasu Shinji, Matsuno Yasuko, Kinosada Yasutomi, Itoh Yoshinori, Inuzuka Takashi
GERIATRICS & GERONTOLOGY INTERNATIONAL   17(4) 653-658   Apr 2017   [Refereed]
Kimura Akio, Takemura Masao, Saito Kuniaki, Yoshikura Nobuaki, Hayashi Yuichi, Harada Naoko, Nishida Hiroshi, Nakajima Hideto, Inuzuka Takashi
JOURNAL OF NEUROLOGY   264(2) 373-381   Feb 2017   [Refereed]
日本難病医療ネットワーク学会雑誌      2017   [Refereed]
林 祐一、堀田みゆき、山田 恵、吉倉延亮、村上宗玄、竹腰 顕、木村暁夫、犬塚 貴
日本老年医誌      2017   [Refereed]
安西将大、香村彰宏、林 祐一、西田承平、犬塚 貴
Hayashi Yuichi, Iwasaki Yasushi, Yoshikura Nobuaki, Asano Takahiko, Mimuro Maya, Kimura Akio, Satoh Katsuya, Kitamoto Tetsuyuki, Yoshida Mari, Inuzuka Takashi
PRION   11(4) 284-292   2017   [Refereed]
Hayashi Yuichi, Yoshikura Nobuaki, Takekoshi Akira, Yamada Megumi, Asano Takahiko, Kimura Akio, Satoh Katsuya, Kitamoto Tetsuyuki, Inuzuka Takashi
JOURNAL OF THE NEUROLOGICAL SCIENCES   370 145-151   Nov 2016   [Refereed]
Nakagawa Toshiyuki, Itoh Masanori, Ohta Kazunori, Hayashi Yuichi, Hayakawa Miki, Yamada Yasushi, Akanabe Hiroshi, Chikaishi Tokio, Nakagawa Kiyomi, Itoh Yoshinori, Muro Takato, Yanagida Daisuke, Nakabayashi Ryo, Mori Tetsuya, Saito Kazuki, Ohzawa Kaori, Suzuki Chihiro, Li Shimo, Ueda Masashi, Wang Miao-Xing, Nishida Emika, Islam Saiful, Tana, Kobori Masuko, Inuzuka Takashi
NEUROREPORT   27(9) 671-676   Jun 2016   [Refereed]
Hayashi Yuichi
JOURNAL OF THE NEUROLOGICAL SCIENCES   375 489   Apr 2017   [Refereed]
Hayashi Yuichi, Iwasaki Yasushi, Takekoshi Akira, Yoshikura Nobuaki, Asano Takahiko, Mimuro Maya, Kimura Akio, Satoh Katsuya, Kitamoto Tetsuyuki, Yoshida Mari, Inuzuka Takashi
PRION   10(6) 492-501   Nov 2016   [Refereed]
Geriatrics Gerontology International      2017   [Refereed]
in press
Frailty
Hayashi Yuichi
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI   64(8) 446   2017   [Refereed]
Hayashi Yuichi, Yamada Megumi, Kimura Akio, Asano Takahiko, Satoh Katsuya, Kitamoto Tetsuyuki, Yoneda Makoto, Inuzuka Takashi
PRION   11(6) 454-464   Nov 2017   [Refereed]
Hayashi Y, Nishida S, Takekoshi A, Murakami M, Yamada M, Kimura A, Suzuki A, Inuzuka T.
Japanese Journal of Geriatrics   53(3) 244-249   Jul 2016   [Refereed]
岐阜新聞      Jun 2016   [Refereed]
Differences in 11C-PIB-PET Imaging Patterns Between Alzheimer's Disease Patients with and without Cerebral Cortical/Subcortical Microbleeds
Hayashi Yuichi, Shinoda Jun, Yoshikura Nobuaki, Waza Masahiro, Nishida Hiroshi, Asano Yoshitaka, Kimura Akio, Inuzuka Takashi
NEUROLOGY   86    Apr 2016   [Refereed]
Characterization of Anti-Amyloid beta Autoantibodies and Cerebrospinal Fluid Markers of Cerebral Amyloid Angiopathy-Related Inflammation
Kimura Akio, Yoshikura Nobuaki, Hayashi Yuichi, Inuzuka Takashi
NEUROLOGY   86    Apr 2016   [Refereed]
内科      Apr 2016   [Refereed]
林 祐一、犬塚 貴
神経治療学      Mar 2016   [Refereed]
犬塚 貴、木村暁夫、林 祐一
Inuzuka T, Hayashi Y, Kimura A.
Neuroimmunological Diseases   245-257   2016   [Refereed]
Neuroimmunological Diseases      2016   [Refereed]
An autopsy-verified case of FTLD-TDP with upper motor neuron predominant motor neuron disease mimicking MM2-thalamic-type sporadic Creutzfeldt-Jakob disease
Hayashi Yuichi, Iwasaki Yasushi, Takekoshi Akira, Yoshikura Nobuaki, Kimura Akio, Satoh Katsuya, Kitamoto Tetsuyuki, Yoshida Mari, Inuzuka Takashi
PRION   10 S89   2016   [Refereed]
免疫性神経症候群(I) 第2版. 別冊日本臨牀 新領域別症候群.      Nov 2015   [Refereed]
林 祐一、犬塚 貴
医学のあゆみ      Oct 2015   [Refereed]
木村暁夫、林 祐一、犬塚 貴
Hayashi Y, Inuzuka T.
Nihon rinsho. Japanese journal of clinical medicine   73 735-741   Sep 2015   [Refereed]
Hayashi Y, Inuzuka T.
Nihon rinsho. Japanese journal of clinical medicine   73 735-741   2015   [Refereed]
成人病と生活習慣病      Apr 2014   [Refereed]
林 祐一、犬塚 貴
新しい診断と治療のABC 神経関連感染症. 最新医学別冊      Apr 2014   [Refereed]
林 祐一、犬塚 貴
神経症候群Ⅱ第2版. 別冊日本臨牀 新領域別症候群      Mar 2014   [Refereed]
林 祐一、犬塚 貴
277-284      Jun 2013   [Refereed]
今日の神経疾患治療指針 第2版      Mar 2013   [Refereed]
林 祐一、犬塚 貴
今日の治療と看護 改訂第3版.      Mar 2013   [Refereed]
林 祐一、犬塚 貴
今日の神経疾患治療指針 第2版.      Mar 2013   [Refereed]
林 祐一、犬塚 貴
104-114      Mar 2013   [Refereed]
森田浩之、林 祐一
Cardiac Sympathetic Function in the Patients with Amyotrophic Lateral Sclerosis: An Analysis Using Cardiac I-123-MIBG Scintigraphy
Tanaka Yuji, Yamada Megumi, Koumura Akihiro, Sakurai Takeo, Hayashi Yuichi, Kimura Akio, Hozumi Isao, Inuzuka Takashi
NEUROLOGY   80    Feb 2013   [Refereed]
Nakamura A, Hayashi Y, Yagasaki H, Takenaka K, Horibe E, Inuzuka T.
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   102(12) 3223-3226   2013   [Refereed]
ジェネラル診療シリーズ  すべての内科医が知っておきたい 神経疾患の診かた、考え方とその対応      Dec 2012   [Refereed]
林 祐一、犬塚 貴
Clinical Neuroscience      Sep 2012   [Refereed]
林 祐一、犬塚 貴
アクチュアル脳・神経疾患の臨床 認知症 神経心理学的アプローチ      Feb 2012   [Refereed]
林 祐一、犬塚 貴
Ann Review 2012 神経      Jan 2012   [Refereed]
林 祐一、木村暁夫、犬塚 貴
神経治療学      2012   [Refereed]
林 祐一、犬塚 貴
Hayashi Yuichi, Choi Pak-Kon
NONLINEAR ACOUSTICS: STATE-OF-THE-ART AND PERSPECTIVES (ISNA 19)   1474 160-163   2012   [Refereed]
Meicina      Aug 2011   [Refereed]
林 祐一、犬塚 貴
Mebio      May 2011   [Refereed]
林 祐一、犬塚 貴
Medical Science Digest      Apr 2011   [Refereed]
林 祐一、犬塚 貴
Is There a Delayed Gastric Emptying of Patients with Multiple System Atrophy? An Analysis Using the C-13-Acetate Breath Test
Tanaka Yuji, Kato Tomohiro, Nishida Hiroshi, Yamada Megumi, Koumura Akihiro, Sakurai Takeo, Hayashi Yuichi, Kimura Akio, Hozumi Isao, Araki Hiroshi, Nagaki Masahito, Moriwaki Hisataka, Inuzuka Takashi
NEUROLOGY   76(9) A215   Mar 2011   [Refereed]
岐阜県内科医会雑誌      2011   [Refereed]
林 祐一、山田 恵、香村彰宏、吉倉延亮、原田斉子、木村暁夫、田中優司、保住 功、犬塚 貴
Uota Masafumi, Hayashi Yuichi, Ohyama Kosei, Takemoto Hirokatsu, Iriki Ryosuke, Kishishita Teppei, Shimoda Makoto, Yoshimura Takumi, Kawasaki Hideya, Sakai Go, Kijima Tsuyoshi
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY   10(9) 5790-5795   Sep 2010   [Refereed]
見分けが肝心、不定愁訴(森田浩之編)      Aug 2010   [Refereed]
林 祐一、保住 功
後期高齢者診療ガイド      2010   [Refereed]
林 祐一、犬塚 貴
機能的脳神経外科      2010   [Refereed]
矢野大仁、梅村 淳、八十川雄図、林 祐一、中山則之、大江直行、野村悠一、保住 功、犬塚 貴、
岩間 亨
Is There Difference in Gastric Emptying of Parkinson's Disease Patients under Long-Term I-Dopa Therapy between with and without Motor Fluctuations? An Analysis Using the C-13-acetate Breath Test
Tanaka Yuji, Nishida Hiroshi, Yamada Megumi, Sakurai Takeo, Hayashi Yuichi, Kimura Akio, Hozumi Isao, Inuzuka Takashi
NEUROLOGY   72(11) A169   Mar 2009   [Refereed]
Identification of Antibodies Against Brain Antigens in Sera of Patients with Neuropsychiatric Systemic Lupus Erythematosus
Kimura Akio, Sakurai Takeo, Yamada Megumi, Hayashi Yuichi, Tanaka Yuji, Hozumi Isao, Inuduka Takashi
NEUROLOGY   72(11) A268   Mar 2009   [Refereed]
機能的脳神経外科      2008   [Refereed]
矢野大仁、梅村 淳、中山則之、大江直行、八十川雄図、林 祐一、保住 功、犬塚 貴、岩間 亨
Takei-Suzuki M, Hayashi Y, Kimura A, Nagasawa M, Koumura A, Sakurai T, Tanaka Y, Hozumi I, Inuzuka T.
Brain and Nerve   60(1) 79-83   2008   [Refereed]
Proliferation of neural stem/progenitor cells in adult rats after facial nerve avulsion
Watabe Kazuhiko, Hayashi Yuichi, Kawazoe Yoko, Ojima Miyoko, Wang Wei, Takazawa Takanori
BRAIN PATHOLOGY   16 S151   Sep 2006   [Refereed]
神経治療学      2005   [Refereed]
林 祐一、松山善次郎、橋爪龍磨、西田 浩、保住 功、犬塚 貴
神経内科      Aug 2004   [Refereed]
林 祐一、松山善次郎、天野雄平、保住 功、犬塚 貴
神経内科.      Dec 2003   [Refereed]
林 祐一、松山善次郎、橋爪龍磨、保住 功、犬塚 貴

Misc

 
Clinical Characteristics of Persistent/Intractable Hiccups Caused by VZV Infection
Hayashi Yuichi, Ueda Natsuko, Shibata Hideaki, Yamada Megumi, Yoshikura Nobuaki, Kimura Akio, Ando Kenichi, Shimohata Takayoshi
NEUROLOGY   90    Apr 2018   [Refereed]
岐阜大学医学部記念会館だより      Sep 2017   [Refereed]
日本医事新報      Aug 2017   [Refereed]
2017;4868:47
病院ここがすごい (岐阜大学医学部附属病院編)      Jan 2017   [Refereed]
林 祐一、犬塚 貴
神経疾患 最新の治療2018-2020      2017   [Refereed]
Geriatric Medicine      Mar 2016   [Refereed]
林 祐一、犬塚 貴
Pure Motor Chronic Inflammatory Demyelinating Polyneuropathy
Kimura Akio, Koumura Akihiro, Sakurai Takeo, Hayashi Yuichi, Inuzuka Takashi
NEUROLOGY   80    Feb 2013   [Refereed]
Akihisa Nakamura, Yuichi Hayashi, Hiroto Yagasaki, Katsunobu Takenaka, Eisyun Horibe, Takashi Inuzuka
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   102 3223-3226   Jan 2013
The Clinical Characterstics of Aseptic Meningitis with Selective IgG Subclass 3 Deficiency
Hayashi Yuichi, Yamada Megumi, Yoshikura Nobuaki, Harada Naoko, Koumura Akihiro, Sakurai Takeo, Kimura Akio, Inuzuka Takashi
NEUROLOGY   78    Apr 2012   [Refereed]
Anti-Endothelial Cell Antibodies in Patients with Alzheimer Disease
Kimura Akio, Sakurai Takeo, Yamada Megumi, Koumura Akihiro, Hayashi Yuichi, Tanaka Yuji, Hozumi Isao, Otaki Hirofumi, Chousa Mitsuhiro, Inuzuka Takashi
NEUROLOGY   78    Apr 2012   [Refereed]
Growth Inhibitory Factor Inhibits the Progression of Amyotrophic Lateral Sclerosis Model Mice
Hashimoto Kazunori, Hayashi Yuichi, Inuzuka Takashi, Hozumi Isao
NEUROLOGY   74(9) A436   Mar 2010   [Refereed]
Is There the Delayed Gastric Emptying of Untreated Patients with Early-Stage Parkinson's Disease? An Analysis Using the C-13-Acetate Breath Test
Tanaka Yuji, Nishida Hiroshi, Yamada Megumi, Kohmura Akihiro, Sakurai Takeo, Hayashi Yuichi, Kimura Akio, Hozumi Isao, Nagaki Masahito, Kato Tomohiro, Moriwaki Hisataka, Inuzuka Takashi
NEUROLOGY   74(9) A73   Mar 2010   [Refereed]
Naoko Harada, Minoru Tomita, Akio Kimura, Akihiro Koumura, Yuichi Hayashi, Isao Hozumi, Nobuhiro Kanemura, Hisataka Moriwaki, Gen Sobue, Takashi Inuzuka
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   101 157-160
Yuichi Hayashi, Zenjiro Matsuyama, Michinori Murai, Kuniyasu Shimokawa, Yuhei Amano, Tatsuma Hashizume, Hiroshi Nishida, Isao Hozumi, Takashi Inuzuka
Clinical Neurology   45 422-425
We report here a 65-year-old man with ptosis, diplopia, and progressive lower limb muscle weakness without nasal symptoms. CA19-9 and CEA were elevated in the serum and cerebrospinal fluid (CSF), but Squamous Cell Carcinoma Antigen (SCC) was not. ...
Yuichi Hayashi, Zenjiro Matsuyama, Yukitoshi Takahashi, Kenji Wakida, Tatsuma Hashizume, Akio Kimura, Isao Hozumi, Masahiko Murase, Takashi Inuzuka
Clinical Neurology   45 657-662
We report a 45-year-old woman admitted to our hospital due to fever, consciousness disturbance, and severe seizures. Based on her sings and symptoms and clinical course, a diagnosis of non-herpetic acute encephalitis was made. She received antibio...
Megumi Yamada, Yuji Tanaka, Akio Kimura, Akihiro Koumura, Yuichi Hayashi, Isao Hozumi, Haruki Koike, Gen Sobue, Takashi Inuzuka
Japanese Journal of Geriatrics   50 400-403   Jan 2013
We report an 84-year-old woman with left lower limb muscle weakness and numbness who also had weakness in her right lower limb, which showed spontaneous partial improvement. Neurological examination revealed lower extremity weakness and sensory di...
Y. Hayashi, K. Taku, E. Nitta, T. Nakajima, N. Fukuhara
Clinical Neurology   34 80-82
A patient with subacute sclerosing panencephalitis (SSPE) was treated with an intraventricular alpha interferon (IFN-α) through an Ommaya reservoir. A 17-year-old boy, who had had a history of measles exposure at age 1, showed forgetfulness, diffi...
Mariko Takei-Suzuki, Yuichi Hayashi, Yuichi Hayashi, Akio Kimura, Mamoru Nagasawa, Akihiro Koumura, Takeo Sakurai, Yuji Tanaka, Isao Hozumi, Takashi Inuzuka
Brain and Nerve   60 79-83   Jan 2008
Varicella myelitis is very rarely observed in healthy adult. We report the case of 25-year-old nursing care worker who suffered from chickenpox for the first time. Approximately 2 weeks prior to the development of the symptoms, she cared for an ol...
Yuichi Hayashi, Yuichi Hayashi, Yoko Kawazoe, Tsuyoshi Sakamoto, Miyoko Ojima, Wei Wang, Takanori Takazawa, Daisuke Miyazawa, Wakana Ohya, Hiroshi Funakoshi, Toshikazu Nakamura, Kazuhiko Watabe
Brain Research   1111 187-195
Hepatocyte growth factor (HGF) exhibits strong neurotrophic activities on motoneurons both in vitro and in vivo. We examined survival-promoting effects of an adenoviral vector encoding human HGF (AxCAhHGF) on injured adult rat motoneurons after pe...
Akio Kimura, Takeo Sakurai, Megumi Yamada, Akihiro Koumura, Yuichi Hayashi, Yuji Tanaka, Isao Hozumi, Hirofumi Ohtaki, Mitsuhiro Chousa, Masao Takemura, Mitsuru Seishima, Takashi Inuzuka
Journal of Alzheimer's Disease   29 373-377
Recent studies suggest that microvascular abnormalities are involved in pathology and progression of Alzheimer's disease. The purpose of this study was to examine the presence of antibodies against cerebral microvascular endothelial cells specific...
A. Kimura, Y. Kanoh, T. Sakurai, A. Koumura, M. Yamada, Y. Hayashi, Y. Tanaka, I. Hozumi, M. Takemura, M. Seishima, T. Inuzuka
Neurology   74 1372-1379   Apr 2010
Objective: To investigate a target for antibodies in patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Background: Pathogenesis of NPSLE may be related to autoantibody-mediated neural dysfunction, vasculopathy, and coagulopathy....
Akio Kimura, Takeo Sakurai, Megumi Yamada, Akihiro Koumura, Yuichi Hayashi, Yuji Tanaka, Isao Hozumi, Hirofumi Ohtaki, Mitsuhiro Chousa, Masao Takemura, Mitsuru Seishima, Takashi Inuzuka
Current Neurovascular Research   9 296-301
The pathogenesis of cerebral small vessel disease (CSVD) in the elderly is poorly understood. Endothelial cell activation and dysfunction may play a causal role in the pathogenesis of CSVD. It was reported that anti-endothelial cell antibodies (AE...
Yuichi Hayashi, Yuichi Hayashi, Tatsuma Hashizume, Kenji Wakida, Masahiko Satoh, Yoko Uchida, Kazuhiko Watabe, Zenjiro Matsuyama, Akio Kimura, Takashi Inuzuka, Isao Hozumi
Amyotrophic Lateral Sclerosis   7 22-26
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease that selectively affects motor neurons. Reactive oxygen species (ROS) are assumed to be involved in the pathogenesis of ALS. Metallothioneins (MTs) are self-pro...
A. Kimura, A. Kimura, T. Sakurai, Y. Suzuki, Y. Hayashi, I. Hozumi, O. Watanabe, K. Arimura, Y. Takahashi, T. Inuzuka
European Neurology   58 152-158
We investigated the presence of autoantibodies againstglutamate receptor (GluR) ε2 in serum and cerebrospinal fluid (CSF) samples from 12 consecutive patients with acute encephalitis/encephalopathy by immunoblotting using recombinant GluRε2 as ant...
Akio Kimura, Akio Kimura, Nobuaki Yoshikura, Nobuaki Yoshikura, Akihiro Koumura, Akihiro Koumura, Yuichi Hayashi, Yuichi Hayashi, Takashi Inuzuka, Takashi Inuzuka
Journal of the Neurological Sciences   352 79-83
© 2015 Elsevier B.V. All rights reserved. Abstract The B-cell-activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) are important factors for the survival of transitional and mature B ce...
Yuji Tanaka, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Takashi Inuzuka
Journal of Neurology   260 2380-2386
Amyotrophic lateral sclerosis (ALS), which is the most serious form of degenerative motor neuron disease in adults, is characterized by upper and lower motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Some patients with re...
Takeo Sakurai, Yuji Tanaka, Akihiro Koumura, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Makoto Yoneda, Takashi Inuzuka
Brain and Nerve   60 559-565
A 79-year-old female was admitted to our hospital because of unconsciousness and convulsion following mental deterioration. On admission, she exhibited myoclonic movement of the right side of the face and right fingers in addition to rigospasticit...
Akio Kimura, Takeo Sakurai, Nobuaki Yoshikura, Yuichi Hayashi, Masao Takemura, Hitoshi Takahashi, Takashi Inuzuka
Journal of Neuroinflammation   10 
We studied longitudinal changes of the levels of anti-amyloid β (anti-Aβ) antibody, amyloid β (Aβ) protein, and interleukin 8 (IL-8) in cerebrospinal fluid (CSF) of a patient with cerebral amyloid angiopathy-related inflammation (CAA-ri) in whom s...
Mari Takagi, Kazuhiro Ozawa, Hiroshi Yasuda, Mitsuko Douke, Kazunori Hashimoto, Kazunori Hashimoto, Yuichi Hayashi, Yuichi Hayashi, Takashi Inuzuka, Isao Hozumi, Isao Hozumi
Biological Trace Element Research   151 9-13   Jan 2013
The remarkable calcification of the basal ganglia and cerebellum has been traditionally called Fahr's disease, but this nomenclature is criticized for including heterogeneous diseases. To determine the pattern of some biological metals in the hair...
Yuichi Hayashi, Yasushi Iwasaki, Nobuaki Yoshikura, Takahiko Asano, Taku Hatano, Shinsui Tatsumi, Katsuya Satoh, Akio Kimura, Tetsuyuki Kitamoto, Mari Yoshida, Takashi Inuzuka
Journal of the Neurological Sciences   358 447-452
© 2015 Published by Elsevier B.V. We report a case of autopsy-verified MM2-thalamic-type sporadic Creutzfeldt-Jakob disease (sCJD) in a 46-year-old patient with a 16-month history of abnormal behavior, progressive dementia, insomnia, and speech di...
Kenji Wakida, Zenjiro Matsuyama, Yasuyuki Suzuki, Michio Sawada, Hisashi Tsurumi, Akio Kimura, Yuichi Hayashi, Tatsuma Hashizume, Isao Hozumi, Takashi Inuzuka
Brain and Nerve   56 1047-1053
Niemann-Pick disease, type C(NPC) is a neurometabolic genetic disorder that is distinguished from other types of Niemann-Pick disease by its later onset, more insidious progression, variable visceromegaly, and abnormalities of intracellular choles...
Yuji Tanaka, Yuichi Hayashi, Jun'ichi Kato, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Akio Kimura, Isao Hozumi, Yuichiro Hatano, Yoshinobu Hirose, Tsuyoshi Takami, Hiroshi Nakamura, Senji Kasahara, Hisashi Tsurumi, Hisataka Moriwaki, Takashi Inuzuka
Internal Medicine   50 2021-2024
A 40-year-old man presented with weakness of neck extensor muscles. Cervical magnetic resonance imaging showed high-intensity areas in muscles of the left lateral cervical region on T2-weighted images. Fluorodeoxyglucose-positron emission tomograp...
Kazunori Hashimoto, Akiko Honda, Yuichi Hayashi, Takashi Inuzuka, Masahiko Satoh, Isao Hozumi
Journal of Toxicological Sciences   34 445-448
We present herein transcriptional changes in mouse spinal cords in response to physical exercise on a treadmill using a DNA microarray. By 30-min exercise, the expression of 3 genes was enhanced and expression of 29 genes reduced. By continuous 2-...
Tomokatsu Yoshida, Ikuko Mizuta, Kozo Saito, Ryo Ohara, Hiroshi Kurisaki, Keiko Ohnari, Yuichi Riku, Yuichi Hayashi, Hidekazu Suzuki, Hiroaki Shii, Yasuhiro Fujiwara, Tadahiro Yonezu, Akiko Nagaishi, Masanori Nakagawa
Journal of Human Genetics   58 635-638
Alexander disease (AxD) is a rare neurodegenerative disorder. Most patients with AxD have a de novo dominant missense mutation in the glial fibrillary acidic protein (GFAP) gene. Patients with late-onset AxD exhibit a more variable onset and sever...
Akio Kimura, Takeo Sakurai, Megumi Yamada, Akihiro Koumura, Yuichi Hayashi, Yuji Tanaka, Isao Hozumi, Masao Takemura, Mitsuru Seishima, Takashi Inuzuka
Journal of Stroke and Cerebrovascular Diseases   21 305-309
Background: There are many reports that the antibody against heat shock protein 60 (Hsp60) is present in most patients with coronary artery disease and atherosclerosis, and that its titer correlates with disease severity. However, few reports have...
Megumi Yamada, Megumi Yamada, Masaki Tanaka, Mari Takagi, Seiju Kobayashi, Yoshiharu Taguchi, Shutaro Takashima, Kortaro Tanaka, Tetsuo Touge, Hiroyuki Hatsuta, Shigeo Murayama, Yuichi Hayashi, Yuichi Hayashi, Masayuki Kaneko, Hiroyuki Ishiura, Jun Mitsui, Naoki Atsuta, Gen Sobue, Nobuyuki Shimozawa, Takashi Inuzuka, Shoji Tsuji, Isao Hozumi
Neurology   82 705-712   Apr 2016
Objective: To investigate the clinical, genetic, and neuroradiologic presentations of idiopathic basal ganglia calcification (IBGC) in a nationwide study in Japan. Methods: We documented clinical and neuroimaging data of a total of 69 subjects inc...
K. Hashimoto, Y. Hayashi, T. Inuzuka, I. Hozumi
Neuroscience   163 244-251
Regular exercise has displayed a beneficial effect on the progression of amyotrophic lateral sclerosis (ALS). However, the mechanism is poorly understood. We here present that regular exercise on a treadmill induces metallothioneins (MTs: MT-1, MT...
T. Yoshida, H. Sasayama, I. Mizuta, Y. Okamoto, M. Yoshida, Y. Riku, Y. Hayashi, T. Yonezu, Y. Takata, K. Ohnari, S. Okuda, I. Aiba, M. Nakagawa
Acta Neurologica Scandinavica   124 104-108   Aug 2011
Objective- To clarify the clinical manifestations of adult-onset Alexander disease (AOAD) in Japanese patients with glial fibrillary acidic protein (GFAP) gene mutations. Methods and materials- Twelve patients of AOAD with GFAP mutations detected ...
Megumi Yamada, Takahiko Asano, Kouichirou Okamoto, Yuichi Hayashi, Masayuki Kanematsu, Hiroaki Hoshi, Yasuhisa Akaiwa, Takayoshi Shimohata, Masatoyo Nishizawa, Takashi Inuzuka, Isao Hozumi, Isao Hozumi
Geriatrics and Gerontology International   13 706-710
Aim: To investigate the frequency of calcification in the basal ganglia and the dentate nuclei in the cerebellum, and compare the difference in age and area, we examined the brain computed tomography (CT) images of all patients in two representati...
Isao Hozumi, Akihiro Kohmura, Akio Kimura, Tatsuya Hasegawa, Akiko Honda, Yuichi Hayashi, Kazunori Hashimoto, Megumi Yamada, Takeo Sakurai, Yuji Tanaka, Masahiko Satoh, Takashi Inuzuka
Case Reports in Neurology   2 46-51
Patients with marked calcification of the basal ganglia and cerebellum have traditionally been referred to as having Fahr's disease, but the nomenclature has been criticized for including heterogeneous etiology. We describe 3 patients with idiopat...
A. Kimura, T. Sakurai, A. Koumura, M. Yamada, Y. Hayashi, Y. Tanaka, I. Hozumi, R. Tanaka, M. Takemura, M. Seishima, T. Inuzuka
Journal of Neuroimmunology   219 105-108
We identified the autoantibody against phosphoglycerate mutase 1 (PGAM1), which is a glycolytic enzyme, in sera from multiple sclerosis (MS) patients by proteomics-based analysis. We further searched this autoantibody in sera from patients with ot...
Takeo Sakurai, Akio Kimura, Megumi Yamada, Akihiro Koumura, Yuichi Hayashi, Yuji Tanaka, Isao Hozumi, Takashi Inuzuka
Journal of Neuroimmunology   233 175-180   Apr 2011
We identified the antibody against mitochondrial heat shock protein 70 (mtHSP70) in serum from multiple sclerosis (MS) patients by proteomics-based analysis. The prevalence of the anti-mtHSP70 antibody is significantly higher in serum from MS pati...
Akio Kimura, Takeo Sakurai, Nobuaki Yoshikura, Akihiro Koumura, Yuichi Hayashi, Hirofumi Ohtaki, Mitsuhiro Chousa, Mitsuru Seishima, Takashi Inuzuka
Current Neurovascular Research   12 25-30
© 2015 Bentham Science Publishers. Antiendothelial cell antibodies (AECAs) have been detected in patients who have autoimmune and inflammatory diseases. Previous studies showed that AECAs against human umbilical vein endothelial cells were detecte...
Akio Kimura, Nobuaki Yoshikura, Akihiro Koumura, Yuichi Hayashi, Yuko Kobayashi, Issei Kobayashi, Takeo Yano, Takashi Inuzuka
Journal of Proteomics   128 450-457
© 2015 Elsevier B.V. Naturally occurring autoantibodies have natural physiologic functions related to normal cell processes. However, the repertoire of naturally occurring autoantibodies against neuronal antigens in CSF is unclear. The purpose of ...
Yuichi Hayashi, Tetsuya Suwa, Takashi Inuzuka
Internal Medicine   52 161-162
Yuji Tanaka, Yuji Tanaka, Tomohiro Kato, Hiroshi Nishida, Hiroshi Nishida, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Hiroshi Araki, Masahiko Murase, Masahito Nagaki, Hisataka Moriwaki, Takashi Inuzuka
Journal of Neurology   258 421-426
During the pre-symptomatic stage of Parkinson's disease (PD), the idiopathic PD related abnormal synuclein immunostaining is confined to the medulla oblongata and olfactory bulb, according to Braak. In the study of the enteric nervous system of PD...
Yuji Tanaka, Yuji Tanaka, Tomohiro Kato, Hiroshi Nishida, Hiroshi Nishida, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Hiroshi Araki, Masahiko Murase, Masahito Nagaki, Hisataka Moriwaki, Takashi Inuzuka
Journal of Neurology   260 1611-1616
Gastrointestinal symptoms are frequent complaints in patients with myotonic dystrophy type 1 (MyD1) and may be associated with reduced gastrointestinal motility caused by smooth muscle dysfunction. Although previous studies have found delayed gast...
Yuji Tanaka, Yuji Tanaka, Tomohiro Kato, Hiroshi Nishida, Hiroshi Nishida, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Hiroshi Araki, Masahiko Murase, Masahito Nagaki, Hisataka Moriwaki, Takashi Inuzuka
Journal of Neurology   259 1448-1452
Autonomic failure is one of the criteria according to the second consensus statement for the diagnosis of multiple system atrophy (MSA). Gastrointestinal symptoms are frequent complaints in patients with MSA and may be associated with reduced gast...
Yuji Tanaka, Nobuaki Yoshikura, Naoko Harada, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Takashi Inuzuka
Internal Medicine   51 579-584
Objective The population in Japan is aging at a faster rate than in other countries in the world. It is speculated that the number of patients with late-onset amyotrophic lateral sclerosis (ALS) will increase even more in the future. However, few ...
Yuichi Hayashi, Takehiro Kato, Yuji Tanaka, Megumi Yamada, Akihiro Koumura, Akio Kimura, Isao Hozumi, Takashi Inuzuka
Internal Medicine   49 517
K. Hashimoto, K. Hashimoto, Y. Hayashi, K. Watabe, T. Inuzuka, I. Hozumi
Neuroscience   189 293-298
Defect of metallothionein-III (MT-III) has been reported to be a contributor to the progression of amyotrophic lateral sclerosis (ALS). We explored the expression and effects of MT-III on the motor neurons of spinal cords of ALS model mice (G93A C...
Ken Ikeda, Ken Ikeda, Masashi Aoki, Yoko Kawazoe, Tsuyoshi Sakamoto, Yuichi Hayashi, Aya Ishigaki, Makiko Nagai, Rieko Kamii, Shinsuke Kato, Yasuto Itoyama, Kazuhiko Watabe, Kazuhiko Watabe
Journal of Neuroscience Research   82 63-70
We investigated motoneuron degeneration after proximal nerve injury in presymptomatic transgenic (tg) rats expressing human mutant Cu/Zn superoxide dismutase (SOD1). The right facial nerves of presymptomatic tg rats expressing human H46R or G93A S...
Akio Kimura, Takeo Sakurai, Akihiro Koumura, Megumi Yamada, Yuichi Hayashi, Yuji Tanaka, Isao Hozumi, Hiide Yoshino, Tatsuhiko Yuasa, Takashi Inuzuka
Journal of Neurology   257 621-629   Apr 2010
We reviewed the clinical, electrophysiological an laboratory findings, plus the therapeutics and evolution of patients with motor-dominant Chronic inflammatory demyelinating polyneuropathy (CIDP) and compared them with those of other CIDP patients...
T. Hashizume, Y. Sakai, Y. Hayashi
Kakuigaku   37 319-325
An evaluation of myocardial fatty acid metabolism in hypertensive patients with major complication has not been previously established. To assess the myocardial fatty acid metabolism in hypertensive patients with intracranial hemorrhage (IH), we p...
Yuji Tanaka, Yuji Tanaka, Nobuaki Yoshikura, Naoko Harada, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Yuichi Hayashi, Akio Kimura, Isao Hozumi, Hisataka Moriwaki, Takashi Inuzuka
Internal Medicine   50 2829-2832
We report cases of Japanese sisters with neuromyelitis optica (NMO). The elder sister was 25, when she was diagnosed with right optic neuritis. After 3 months, she developed left optic neuritis and myelitis. At age 27, she had the second relapse, ...
Young Eun Park, Yukiko K. Hayashi, Kanako Goto, Hirofumi Komaki, Yuichi Hayashi, Takashi Inuzuka, Satoru Noguchi, Ikuya Nonaka, Ichizo Nishino
Neuromuscular Disorders   19 29-36   Jan 2009
Autosomal forms of Emery-Dreifuss muscular dystrophy (AD-/AR-EDMD) and limb-girdle muscular dystrophy type 1B (LGMD1B) are caused by mutations in the gene encoding A-type lamins (LMNA). A-type lamins are major components of nuclear lamina and know...
Yuichi Hayashi, Takashi Inuzuka
Brain and Nerve   65 385-393
Paraneoplastic neurological syndrome (PNS) is a rare disorder caused by the remote effects of cancer is considered as caused by humoral or cell-mediated immunity. Several autoantibodies related to PNS have been discovered since the 1980s. These an...
Takashi Inuzuka, Yuichi Hayashi, Akio Kimura
Clinical Neurology   51 834-837   Dec 2011
Paraneoplastic neurological syndrome (PNS) is a rare disorder caused by the remote effects of cancer and is considered as immune-responses to the molecules on cancer which cross-react with self-antigens in the nervous system. Since the 1980s, seve...
Isao Hozumi, Tatsuya Hasegawa, Akiko Honda, Kazuhiro Ozawa, Yuichi Hayashi, Kazunori Hashimoto, Kazunori Hashimoto, Megumi Yamada, Akihiro Koumura, Takeo Sakurai, Akio Kimura, Yuji Tanaka, Masahiko Satoh, Takashi Inuzuka
Journal of the Neurological Sciences   303 95-99
We measured the levels of some biological metals: copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), and zinc (Zn) in the cerebrospinal fluid (CSF) in patients with neurodegenerative diseases (52 patients with amyotrophic lateral sclerosis (A...
Yuichi Hayashi, Nobuaki Yoshikura, Akio Kimura, Takashi Inuzuka
Neurology   79 1625
Kazuhiko Watabe, Kazuhiko Watabe, Yuichi Hayashi, Yoko Kawazoe
Neuropathology   25 371-380   Dec 2005
We have used adult rat peripheral nerve avulsion models to evaluate the effects of neuroprotective molecules on motoneuron degeneration. The right facial nerves of adult Fischer 344 male rats were avulsed and adenoviral vectors encoding glial cell...
Yuichi Hayashi, Akio Kimura, Shimon Kato, Akihiro Koumura, Takeo Sakurai, Yuji Tanaka, Isao Hozumi, Yuji Sunden, Yuji Sunden, Yasuko Orba, Hirofumi Sawa, Hirofumi Sawa, Hitoshi Takahashi, Takashi Inuzuka
Journal of the Neurological Sciences   268 195-198
We report progressive multifocal leukoencephalopathy (PML) and CD4+ T-lymphocytopenia in a 71-year-old man with Sjögren syndrome (SjS). The patient was admitted to our hospital because of progressive dementia and gait disturbance. T2-weighted MR i...
Takeo Sakurai, Akio Kimura, Megumi Yamada, Yuichi Hayashi, Yuji Tanaka, Isao Hozumi, Takashi Inuzuka
Brain and Nerve   62 527-531
A 46-year-old woman was diagnosed with having idiopathic aqueductal stenosis for which she underwent ventriculoperitoneal (V-P) shunting. One year after the surgery, she developed acute parkinsonism and sylvian aqueduct syndrome. Brain magnetic re...
Jun Nagasao, Jun Nagasao, Jun Nagasao, Yuichi Hayashi, Yuichi Hayashi, Yoko Kawazoe, Emiko Kawakami, Kazuhiko Watabe, Kiyomitsu Oyanagi, Kiyomitsu Oyanagi
Journal of Neuroscience Research   86 435-442
Motoneuron number and expression of cytoplasmic RNA and ribosomal RNA (rRNA) gene transcription activity in the facial nucleus were examined quantitatively and chronologically for up to 4 weeks in rats after facial nerve axotomy and avulsion in or...
Yuichi Hayashi, Takeo Sakurai, Akio Kimura, Takahide Ikeda, Zenjiro Matsuyama, Yoshihiro Suzuki, Yuji Tanaka, Isao Hozumi, Hideo Hosoe, Hitoshi Takahashi, Takashi Inuzuka
Muscle and Nerve   38 1065-1069
A 20-year-old woman with selective cauda equina hypertrophy presented with muscle weakness and severe pain in the lower extremities. Serial immunotherapy was not effective. We performed biopsy of the cauda equina, and laminectomy and duraplasty of...
Yuichi Hayashi, Akio Kimura, Norihito Watanabe, Megumi Yamada, Takeo Sakurai, Yuji Tanaka, Isao Hozumi, Takashi Inuzuka
Internal Medicine   49 475-477
A 52-year-old man presented with hyperhydrosis, painful pseudomyotonia and gait disturbance. The condition was diagnosed as Isaacs' syndrome on the basis of characteristic findings noted on an electromyogram. Carbamazepine treatment was only parti...

Books etc

 
Actual Approach to Neurological practive. Dementia Neurophysiological approach, X-ray CT and MRI
Yuichi Hayashi, Takashi Inuzuka (Part:Joint Work, 83-93)
Nakayama Shoten Co. Ltd.   Mar 2012   ISBN:978-4-52-73439-2

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: Apr 2011 - Mar 2014    Investigator(s): Yuichi HAYASHI
St8Sia1 is one of the important protein concerning about progression of Alzheimer's disease experimental mouse model. The mRNA St8sia1 is down regulated by daily exercise in adult mice. The St8sia1 protein is slightly down regulated by daily exerc...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2007 - 2009    Investigator(s): Yuichi HAYASHI
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: 2014 - 2016