NAKAHARA Jin

J-GLOBAL         Last updated: Jun 11, 2019 at 03:05
 
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Name
NAKAHARA Jin
E-mail
nakaharaa6.keio.jp
URL
http://user.keio.ac.jp/~aa603146/index2
Affiliation
Keio University
Section
School of Medicine Department of Internal Medicine (Neurology)
Job title
Professor
Degree
博士(医学)(Keio University)
Other affiliation
Keio University Global Research Institute (KGRI)
Research funding number
60537950

Profile

- Japanese Society of Neurology
District Representative
Delegate
- Japanese Society of Internal Medicine
Councilor
- Japanese Society of Neuroimmunology
Director
- Japanese Society of Neurological Therapeutics
Councilor
- Japanese Society for Neuroinfectious Diseases
Councilor
- Japan Multiple Sclerosis Network
Director
- Pan-Asian Congress for Treatment and Research in Multiple Sclerosis (PACTRIMS)
Central organizing committee member

Research Areas

 
 
  • Clinical internal medicine / Neurology / 

Academic & Professional Experience

 
Apr 2003
 - 
Mar 2004
研究員, COEプログラム(生命科学), 慶應義塾大学
 
Apr 2004
 - 
Mar 2007
特別研究員(DC1), 独立行政法人日本学術振興会
 
Apr 2007
 - 
Nov 2008
特別研究員(PD), 独立行政法人日本学術振興会
 
Dec 2008
 - 
Mar 2013
特任講師, 医学部総合医科学研究センター, 慶應義塾大学
 
Apr 2013
 - 
Mar 2018
助教, 医学部内科学教室(神経), 慶應義塾大学
 

Education

 
Mar 2003
   
 
School of Medicine, Keio University
 
Mar 2007
   
 
生理系専攻, Graduate School, Division of Medicine, Keio University
 

Awards & Honors

 
2017
Best Presentation Award, Sendai Conference
 
2014
MSJ-PACTRIMS investigator award, Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
 
2014
優秀指導教官賞, 日本内科学会
 
2014
MSJ-PACTRIMS Investigator Award, PACTRIMS
 
2014
レジデントクリニカルトーナメント準優勝, 日本神経学会
 
2014
優秀指導教官賞, 内科学サミット2014
 
2011
最優秀口演賞, 日本神経学会
 
2011
最優秀口演賞, 日本神経学会
 
2010
三四会奨励賞, 慶應義塾大学医学部三四会
 
2010
Best poster presentation award, Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
 

Published Papers

 
Kufukihara K., Watanabe Y., Inagaki T., Takamatsu K., Nakane S., Nakahara J., Ando Y., Suzuki S.
Scientific Reports   9(1)    Dec 2019
© 2019, The Author(s). The purposes of the present study were to identify anti-striational antibodies in myasthenia gravis (MG) patients with myositis and/or myocarditis using a combination of cell-based assays and flow cytometry (cytometric cell-...
Seki M., Uruha A., Ohnuki Y., Kamada S., Noda T., Onda A., Ohira M., Isami A., Hiramatsu S., Hibino M., Nakane S., Noda S., Yutani S., Hanazono A., Yaguchi H., Takao M., Shiina T., Katsuno M., Nakahara J., Matsubara S., Nishino I., Suzuki S.
Journal of Autoimmunity   100 105-113   Jun 2019
© 2019 Elsevier Ltd Objective: To characterize the inflammatory myopathy associated with programmed cell death 1 inhibitors (PD-1 myopathy). Methods: We studied 19 Japanese patients with PD-1 myopathy (13 men and 6 women, mean age 70 years), who w...
Nakahara J., Tomaske L., Kume K., Takata T., Kamada M., Deguchi K., Kufukihara K., Schneider R., Gold R., Ayzenberg I.
Neurology: Neuroimmunology and NeuroInflammation   6(3)    May 2019
© 2019 American Academy of Neurology. ObjectiveTo report the course of 3 recent Japanese and European cases of fingolimod-associated progressive multifocal leukoencephalopathy (PML) and to analyze its risk factors and increased incidence in Japan....
Misawa S., Kuwabara S., Sato Y., Yamaguchi N., Nagashima K., Katayama K., Sekiguchi Y., Iwai Y., Amino H., Suichi T., Yokota T., Nishida Y., Kanouchi T., Kohara N., Kawamoto M., Ishii J., Kuwahara M., Suzuki H., Hirata K., Kokubun N., Masuda R., Kaneko J., Yabe I., Sasaki H., Kaida K., Takazaki H., Suzuki N., Suzuki S., Nodera H., Matsui N., Tsuji S., Koike H., Yamasaki R., Kusunoki S., Misawa S., Kuwabara S., Sato Y., Yamaguchi N., Nagashima K., Katayama K., Sekiguchi Y., Iwai Y., Amino H., Suichi T., Yokota T., Nishida Y., Kanouchi T., Kohara N., Kawamoto M., Ishii J., Kuwahara M., Suzuki H., Hirata K., Kokubun N., Masuda R., Kaneko J., Yabe I., Sasaki H., Kaida K., Takazaki H., Suzuki N., Suzuki S., Nodera H., Matsui N., Tsuji S., Koike H., Yamasaki R., Kusunoki S., Nagashima T., Shimizu T., Hirotani M., Kadoya M., Nakahara J., Shimizu J., Tanaka M., Sobue G., Katsuno M., Yamaguchi H., Ogata H.
The Lancet Neurology   17(6) 519-529   Jun 2018
© 2018 Elsevier Ltd Background: Despite the introduction of plasmapheresis and immunoglobulin therapy, many patients with Guillain-Barré syndrome still have an incomplete recovery. Evidence from pathogenesis studies suggests the involvement of com...
Yazawa S., Kato Y., Nakahara J., Miyata T., Oya M.
Japanese Journal of Cancer and Chemotherapy   45(4) 639-642   Apr 2018
© 2018 Japanese Journal of Cancer and Chemotherapy Publishers Inc. All rights reserved. A 56-year-old man with advanced RCC and a past medical history of type 2 diabetes underwent a radical left nephrectomy following a histological diagnosis of pa...
Kappos L., Bar-Or A., Cree B., Fox R., Giovannoni G., Gold R., Vermersch P., Arnold D., Arnould S., Scherz T., Wolf C., Wallström E., Dahlke F., Achiron A., Achtnichts L., Agan K., Akman-Demir G., Allen A., Antel J., Antiguedad A., Apperson M., Applebee A., Ayuso G., Baba M., Bajenaru O., Balasa R., Balci B., Barnett M., Bass A., Becker V., Bejinariu M., Bergh F., Bergmann A., Bernitsas E., Berthele A., Bhan V., Bischof F., Bjork R., Blevins G., Boehringer M., Boerner T., Bonek R., Bowen J., Bowling A., Boyko A., Boz C., Bracknies V., Braune S., Brescia Morra V., Brochet B., Brola W., Brownstone P., Brozman M., Brunet D., Buraga I., Burnett M., Buttmann M., Butzkueven H., Cahill J., Calkwood J., Camu W., Cascione M., Castelnovo G., Centonze D., Cerqueira J., Chan A., Cimprichova A., Cohan S., Comi G., Conway J., Cooper J., Corboy J., Correale J., Costell B., Cottrell D., Coyle P., Craner M., Cui L., Cunha L., Czlonkowska A., da Silva A., de Sa J., de Seze J., Debouverie M., Debruyne J., Decoo D., Defer G., Derfuss T., Deri N., Dihenia B., Dioszeghy P., Donath V., Dubois B., Duddy M., Duquette P., Edan G., Efendi H., Elias S.
The Lancet   391(10127) 1263-1273   Mar 2018
© 2018 Elsevier Ltd Background: No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phospha...
Takahashi S., Akiyama T., Nakahara J., Yoshizaki T., Suzuki N., Yoshida K.
World Neurosurgery   109 409-412   Jan 2018
© 2017 Elsevier Inc. Background Staged angioplasty for carotid artery stenosis has been reported to be effective in preventing postoperative cerebral hyperperfusion syndrome (CHS) in patients with severe carotid stenosis; thus, it is also recommen...
Kitagawa S., Osada T., Kaneko K., Takahashi T., Suzuki N., Nakahara J.
Clinical Neurology   58(12) 737-744   2018
© 2018 Clinical Neurolog. All rights reserved. We report an 18 year-old-male, who had been aware of decreased visual acuity for 6 months, newly presented with paresis and sensory disturbance in his right leg. On admission, his critical flicker fr...
Nakahara J.
Neuro-Ophthalmology Japan   35(1) 17-25   2018
© 2018 Neuro-Ophthalmology Society of Japan. All rights reserved. Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system that affects more than 2.5 million patients worldwide. Dysregulation of the immune sys...
Tanikawa, Mariko, Nakahara, Jin, Hata, Junichi, Suzuki, Shigeaki, Fujiyoshi, Kanehiro, Fujiwara, Hirokazu, Momoshima, Suketaka, Jinzaki, Masahiro, Nakamura, Masaya, Okano, Hideyuki, Takahashi, Shinichi, Suzuki, Norihiro
JOURNAL OF THE NEUROLOGICAL SCIENCES   373 352-357   Feb 2017
Shiihashi, Gen, Suzuki, Shigeaki, Nakahara, Jin, Suzuki, Norihiro, Kaneko, Yuko, Hanaoka, Hironari, Takeuchi, Tsutomu
AUTOIMMUNITY REVIEWS   15(12) 1200-1201   Dec 2016
Ohnuki, Yuko, Suzuki, Shigeaki, Shiina, Takashi, Uruha, Akinori, Watanabe, Yurika, Suzuki, Shingo, Izumi, Shunichiro, Nakahara, Jin, Hamanaka, Kohei, Takayama, Kazuko, Suzuki, Norihiro, Nishino, Ichizo
NEUROLOGY   87(18) 1954-1955   Nov 2016
Yamamoto, Masahiro, Nishiyama, Mitsue, Iizuka, Seiichi, Suzuki, Shigeaki, Suzuki, Norihiro, Aiso, Sadakazu, Nakahara, Jin
WORLD JOURNAL OF GASTROENTEROLOGY   22(44) 9752-9764   Nov 2016
Watanabe, Yurika, Uruha, Akinori, Suzuki, Shigeaki, Nakahara, Jin, Hamanaka, Kohei, Takayama, Kazuko, Suzuki, Norihiro, Nishino, Ichizo
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   87(10) 1038-1044   Oct 2016
Fujiyoshi, Kanehiro, Hikishima, Keigo, Nakahara, Jin, Tsuji, Osahiko, Hata, Junichi, Konomi, Tsunehiko, Nagai, Toshihiro, Shibata, Shinsuke, Kaneko, Shinjiro, Iwanami, Akio, Momoshima, Suketaka, Takahashi, Shinichi, Jinzaki, Masahiro, Suzuki, Norihiro, Toyama, Yoshiaki, Nakamura, Masaya, Okano, Hideyuki
JOURNAL OF NEUROSCIENCE   36(9) 2796-2808   Mar 2016
Katsumata Masahiro, Oki Koichi, Nakahara Jin, Izawa Yoshikane, Abe Takato, Takahashi Shinichi, Suzuki Norihiro
Journal of Stroke and Cerebrovascular Diseases      Jun 2015
<p>Background: Various sensory impairments have been reported in patients with lateral medullary syndrome, also known as Wallenberg syndrome. The typical sensory impairments experienced by patients with this condition are ipsilateral facial and co...
Suzuki Shigeaki, Nishikawa Atsuko, Kuwana Masataka, Nishimura Hiroaki, Watanabe Yurika, Nakahara Jin, Hayashi Yukiko K., Suzuki Norihiro, Nishino Ichizo
Orphanet Journal of Rare Diseases   10(1)    May 2015
<p>Background: Anti-signal recognition particle (SRP) antibodies are used as serological markers of necrotizing myopathy, which is characterized by many necrotic and regenerative muscle fibers without or with minimal inflammatory cell infiltration...
[Emerging disease-modifying therapies for multiple sclerosis]
Nakahara Jin
Nihon rinsho. Japanese journal of clinical medicine   72(11) 2031-2037   Nov 2014
<p>Multiple sclerosis(MS) is an inflammatory demyelinating disease of the central nervous system with yet undetermined etiology. The incidence of MS is rapidly rising in Japan, and in addition to four already-approved disease-modifying therapies (...
Natalizumab
Nakahara Jin
Brain and Nerve   66(10) 1149-1158   Oct 2014
<p>Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), in which inflammation develops upon leukocyte invasion into the CNS via the blood-brain barrier. α4-Integrin is an important cell adhesion molecule involved...
Pathogenesis of cognitive impairment in multiple sclerosis
Nakahara Jin
Clinical Neurology   54(12) 1063-1065   2014
<p>Around a half of multiple sclerosis (MS) patients suffer from cognitive impairment such as attention deficit. A similar impairment is already observable in one third of patients with clinical isolated syndrome, suggesting that the symptom canno...
Nakahara Jin
Clinical and Experimental Neuroimmunology   4(2) 155-156   Aug 2013
<p>A recent article published in Nature presents intriguing data suggesting that the activation of neuronal nuclear factor-κB (NF-κB) in the mediobasal hypothalamus (MBH) causes systemic aging through reduced secretion of gonadotropin-releasing ho...
Nakahara Jin, Maeda Michiko, Aiso Sadakazu, Suzuki Norihiro
Clinical Reviews in Allergy and Immunology   42(1) 26-34   Feb 2012
<p>Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system that affects millions of patients worldwide. The current disease-modifying therapies (DMTs) that are widely used to treat MS only show modest effects...
Nakahara Jin
Clinical Neurology   52(11) 1351-1353   2012
<p>Spontaneous remyelination occurs in many early multiple sclerosis (MS) patients, however its capacity decreases as the disease becomes chronic. Even in those chronic MS patients, an enough number of oligodendrocyte precursor cells (OPCs) are pr...
Nakahara Jin, Aiso Sadakazu, Suzuki Norihiro
Archivum Immunologiae et Therapiae Experimentalis   58(5) 325-333   Oct 2010
<p>Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS); it affect millions of patients worldwide and the number of patients is on the rise. Current treatment options are fairly limited ...
Nakahara Jin
Clinical Neurology   50(11) 870   2010
Nakahara Jin, Aiso Sadakazu, Suzuki Norihiro
Expert Opinion on Therapeutic Targets   13(12) 1375-1386   Dec 2009
<p>In the CNS oligodendrocytes produce myelin and ensheath individual axons after birth. Demyelination disables saltatory conduction and leads to loss of neural functions. Oligodendrocyte precursor cells (OPCs) are immature and abundant reservoir ...
Yamamoto Masahiro, Yoshimura Kazunori, Kitada Masaaki, Nakahara Jin, Seiwa Chika, Ueki Toshiyuki, Shimoda Yasushi, Ishige Atsushi, Watanabe Kenji, Asou Hiroaki
Journal of Neuroscience Research   87(2) 503-513   Feb 2009
<p>Recent studies of adult neurogenesis of the mammalian central nervous system have suggested unexpected plasticity and complexity of neural cell ontogenesis. Redefinition and reconstitution of cell classification and lineage relationships, espec...
Nakahara Jin, Kanekura Kohsuke, Nawa Mikiro, Aiso Sadakazu, Suzuki Norihiro
Journal of Clinical Investigation   119(1) 169-181   Jan 2009
<p>Oligodendrocyte precursor cells (OPCs) persist near the demyelinated axons arising in MS but inefficiently differentiate into oligodendrocytes and remyelinate these axons. The pathogenesis of differentiation failure remains elusive. We initiall...
Awaya Norihiro, Adachi Akiko, Mori Taisuke, Kamata Hiroshi, Nakahara Jin, Yokoyama Kenji, Yamada Taketo, Kizaki Masahiro, Sakamoto Michiie, Ikeda Yasuo, Okamoto Shin ichiro
Leukemia Research   30(8) 1059-1062   Aug 2006
<p>Post-transplant lymphoproliferative disorder (PTLD) is a complication that can develop after either solid-organ or hematopoietic stem cell transplantation (HSCT). T-cell PTLD is a rare disorder, especially following autologous HSCT. Here we rep...
Nakahara Jin, Aiso Sadakazu
Journal of Neuropathology and Experimental Neurology   65(6) 582-591   Jun 2006
<p>The capacity for spontaneous remyelination in cases of multiple sclerosis (MS) is limited and lesions are not fully repaired. Recent evidence has shown that oligodendrocyte precursor cells and immature oligodendrocytes (OPC/iOligs) are preserve...
Nakahara Jin, Seiwa Chika, Tan-Takeuchi Kyoko, Gotoh Mari, Kishihara Kenji, Ogawa Masaharu, Asou Hiroaki, Aiso Sadakazu
Neuroscience Letters   379(2) 116-121   May 2005
<p>Myelin is a multi-layered membranous lipid insulator surrounding axons that allows the rapid conduction of neuronal impulses. In the central nervous system (CNS), myelin is produced by oligodendrocytes. During development, morphologically immat...
Kawasumi Masaoki, Chiba Tomohiro, Yamada Marina, Miyamae-Kaneko Makiko, Matsuoka Masaaki, Nakahara Jin, Tomita Taisuke, Iwatsubo Takeshi, Kato Shigeaki, Aiso Sadakazu, Nishimoto Ikuo, Kouyama Keisuke
European Journal of Neuroscience   19(10) 2826-2838   May 2004
<p>While the exact aetiology of Alzheimer's disease (AD) is unknown, distinct genetic mutations have been identified for the rare cases of familial AD (FAD). V642I mutation in amyloid precursor protein (APP) co-segregates with FAD with perfect pen...
Seiwa Chika, Nakahara Jin, Komiyama Takatsugu, Katsu Yoshinao, Iguchi Taisen, Asou Hiroaki
Neuroendocrinology   80(1) 21-30   2004
<p>We report studies on the mechanism of action of bisphenol A (BPA) on the differentiation of oligodendrocyte precursor cells (OPCs). Our results show that: (1) BPA inhibits the differentiation of OPCs induced by exposure to thyroid hormone (T<su...
Nakahara Jin, Tan-Takeuchi Kyoko, Seiwa Chika, Gotoh Mari, Kaifu Tomonori, Ujike Azusa, Inui Masanori, Yagi Takeshi, Ogawa Masaharu, Aiso Sadakazu, Takai Toshiyuki, Asou Hiroaki
Developmental Cell   4(6) 841-852   Jun 2003
<p>Dramatic changes in morphology and myelin protein expression take place during the differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes. Fyn tyrosine kinase was reported to play a central role in the diffe...
Nakahara Jin, Takemura Masaaki, Gomi Hiroshi, Tsunematsu Ken ichiro, Itohara Shigeyoshi, Asou Hiroaki, Ogawa Masaharu, Aiso Sadakazu, Tan-Takeuchi Kyoko
Journal of Neuroscience Research   72(3) 279-289   May 2003
<p>Recent in vitro study showed that astrocytes induce oli-godendrocyte processes to adhere to axons. However, the role of astrocytes in myelination in vivo remains unknown. We have, therefore, conducted a study to clarify the possible involvement...
The mechanism of central nervous system myelination
Nakahara Jin, Asou Hiroaki
Seikagaku. The Journal of Japanese Biochemical Society   75(5) 395-399   May 2003
Nakahara Jin, Seiwa Chika, Shibuya Akira, Aiso Sadakazu, Asou Hiroaki
Neuroscience Letters   337(2) 73-76   Feb 2003
<p>Recent advances in neuro-immunology are beginning to elucidate several essential roles of the humoral immunity in both repair and pathogenesis of central nervous system diseases. Immunoglobulin M (IgM) was reported to accelerate the rate of rem...
Kaifu Tomonori, Nakahara Jin, Inui Masanori, Mishima Kenichi, Momiyama Toshihiko, Kaji Mitsuji, Sugahara Akiko, Koito Hisami, Ujike-Asai Azusa, Nakamura Akira, Kanazawa Kiyoshi, Tan-Takeuchi Kyoko, Iwasaki Katsunori, Yokoyama Wayne M., Kudo Akira, Fujiwara Michihiro, Asou Hiroaki, Takai Toshiyuki
Journal of Clinical Investigation   111(3) 323-332   Feb 2003
<p>Deletions in the DAP12 gene in humans result in Nasu-Hakola disease, characterized by a combination of bone fractures and psychotic symptoms similar to schizophrenia, rapidly progressing to presenile dementia. However, it is not known why these...
Nakahara Jin, Tan-Takeuchi Kyoko, Seiwa Chika, Yagi Takeshi, Aiso Sadakazu, Kawamura Koki, Asou Hiroaki
Neuroscience Letters   298(3) 163-166   Feb 2001
<p>Myelin-associated glycoprotein (MAG) has currently been proposed to be a possible igniter of myelination in the central nervous system. We propose here that myelin basic protein (MBP) is prerequisite, which is more diffusely expressed than MAG ...

Teaching Experience

 

Research Grants & Projects

 
ミエリンマップ法を用いた多発性硬化症における髄鞘病理の画像解析
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2018 - Mar 2023    Investigator(s): 中原 仁
髄鞘の可視化技術による多発性硬化症の病型分類に関する研究
文部科学省: Grant-in-Aid for Scientific Research
Project Year: Apr 2013 - Mar 2016    Investigator(s): 中原仁
髄鞘を標的とした神経変性疾患・脊髄損傷に対する新規治療戦略に関する研究
文部科学省: Grant-in-Aid for Scientific Research
Project Year: Apr 2013 - Mar 2016    Investigator(s): 中原仁
アストロサイトによるin vivoケトン体生合成機構の解明
文部科学省: Grant-in-Aid for Scientific Research
Project Year: Apr 2010 - Mar 2013    Investigator(s): 中原仁
内在性オリゴデンドロサイト前駆細胞の分化誘導を基盤とする中枢神経系髄鞘再生医薬の開発
独立行政法人医薬基盤研究所: -
Project Year: Apr 2009 - Mar 2012    Investigator(s): 中原仁

Patents

 
8252540 : Drug delivery system toward demyelinating lesion and biochemical marker of demyelinating lesions
7901678 : Medicinal compositions containing Fc receptor γ chain activator
4214249 : Fc受容体γ鎖活性化物質を含有する医薬組成物