MISC

2011年4月

XCR1 Expression and Biased V-H Gene Usage Are Distinct Feautres of Diffuse Large B-Cell Lymphoma Initially Manifesting in the Bone Marrow

AMERICAN JOURNAL OF CLINICAL PATHOLOGY
  • Yoriko Yamashita
  • ,
  • Dai Kajiura
  • ,
  • Lee Tang
  • ,
  • Yuichi Hasegawa
  • ,
  • Tomohiro Kinoshita
  • ,
  • Shigeo Nakamura
  • ,
  • Shinya Akatsuka
  • ,
  • Shinya Toyokuni
  • ,
  • Naoyoshi Mori

135
4
開始ページ
556
終了ページ
564
記述言語
英語
掲載種別
DOI
10.1309/AJCPCTDC5PY3LXBP
出版者・発行元
AMER SOC CLINICAL PATHOLOGY

A total of 29 cases of diffuse large B-cell lymphoma initially manifesting in the bone marrow (BM-DLBCL) were analyzed for V-H gene sequence, and expression microarray of chemokines and chemokine receptors and immunohistochemical analysis were done. Seminested polymerase chain reaction (PCR) and sequencing analyses of 18 cases revealed that the V-H gene usage in 6 cases was restricted to V(H)3-7, in 3 cases to V(H)4-34, and in 2 cases to V(H)4-39, which were all previously reported to be autoreactive. In total, 14 of 18 V-H genes were those associated with autoimmune diseases, including V(H)3-21, V(H)3-23, and V(H)3-48. Furthermore, cDNA microarray analysis specific for chemokine and chemokine receptors revealed that chemokine receptor XCR1 expression was significantly elevated in the BM-DLBCL cases (P < .05), which was confirmed by quantitative reverse transcriptase PCR and immunohistochemical analysis. Expression of the chemokine receptor XCR1 and frequent usage of autoreactive V-H genes seem to be distinct characteristics of BM-DLBCL.

Web of Science ® 被引用回数 : 13

リンク情報
DOI
https://doi.org/10.1309/AJCPCTDC5PY3LXBP
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000288685500006&DestApp=WOS_CPL

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