2007年5月
Diffuse large B-cell lymphoma initially manifesting in the bone marrow
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- ,
- ,
- 巻
- 127
- 号
- 5
- 開始ページ
- 762
- 終了ページ
- 769
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1309/2GW5W7KQBXF6LFAW
- 出版者・発行元
- AMER SOC CLINICAL PATHOLOGY
We histologically and immunohistochemically studied 37 cases of diffuse large B-cell lymphoma (DLBCL) initially manifesting in the. bone marrow (BM). We also compared these cases with the Asian variant of intravascular large B-cell lymphoma (AIVL). Histologically, the neoplastic cells of the BM mostly had large and round nuclei and formed clusters. Immunohistochemically, all cases were positive for B-cell markers. Factor VIII staining revealed neoplastic cells within the sinusoids of BM in 8 cases; however, these cells accounted for fewer than 20% of the overall neoplastic cells. In several cases, the neoplastic cells infiltrated liver, spleen, kidneys, lungs, stomach, and adrenal glands with a mainly leukemic and infrequently intravascular pattern. Although our cases share some clinical features with AIVL, we consider DLBCL initially manifesting in the BM to be a unique entity because the neoplastic cells proliferate mainly in BM, with infrequent involvement of the sinusoids and occasional leukemic infiltration in various organs.
- リンク情報
- ID情報
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- DOI : 10.1309/2GW5W7KQBXF6LFAW
- ISSN : 0002-9173
- Web of Science ID : WOS:000245875100010