論文

査読有り
2017年6月

The NADPH Oxidase Inhibitor Apocynin Suppresses Preneoplastic Liver Foci of Rats

TOXICOLOGIC PATHOLOGY
  • Fuji, Satoshi
  • ,
  • Suzuki, Shugo
  • ,
  • Naiki-Ito, Aya
  • ,
  • Kato, Hiroyuki
  • ,
  • Hayakawa, Masashi
  • ,
  • Yamashita, Yoriko
  • ,
  • Kuno, Toshiya
  • ,
  • Takahashi, Satoru

45
4
開始ページ
544
終了ページ
550
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1177/0192623317710013
出版者・発行元
SAGE PUBLICATIONS INC

Reactive oxygen species (ROS) have been revealed to be important factors for carcinogenesis and tumor progression. Therefore, we focused on an ROS-generating protein, nicotinamide adenine dinucleotide phosphate oxidase, and evaluated whether its inhibitor, apocynin, could suppress hepatocarcinogenesis in a medium-term rat liver bioassay. The number and size of glutathione S-transferase placental form (GST-P)-positive foci were significantly reduced by apocynin in a dose-dependent manner. The reduction of ROS generation by apocynin was confirmed by dihydroethidium staining. Apocynin treatment also significantly reduced Ki-67 positivity, downregulated cyclooxygenase 2, and suppressed the activation of the c-Myc pathway. Meanwhile, ROS generation was not different between GST-P-positive foci and surrounding GST-P-negative areas of the liver. In conclusion, the present data suggest that apocynin possesses a potential antihepatocarcinogenic property.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1177/0192623317710013
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28573935
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000404172000008&DestApp=WOS_CPL

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