SHIRASAKA Yoshiyuki

J-GLOBAL         Last updated: Feb 1, 2019 at 18:46
 
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Name
SHIRASAKA Yoshiyuki
URL
http://www.ps.toyaku.ac.jp/wp/yakubutsudotai/
Affiliation
Tokyo University of Pharmacy and Life Sciences
Section
School of Pharmacy
Job title
Associate Professor
Degree
Ph.D.(Setsunan University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2007
 - 
Mar 2008
Assistant Professor, Faculty of Pharmaceutical Sciences, Tokyo University of Science
 
Apr 2008
 - 
Jan 2012
Assistant Professor, Faculty of Pharmacy, Kanazawa University
 
Jan 2012
 - 
Dec 2014
Visiting Scholar/Scientist, School of Pharmacy, University of Washington
 
Jan 2012
 - 
Jan 2014
Postdoctoral Fellow for Research Abroad, JSPS
 
Jan 2014
 - 
Dec 2014
Research fellow, The Uehara Memorial Foundation
 

Education

 
Apr 1998
 - 
Mar 2002
Faculty of Pharmaceutical Sciences, Setsunan University
 
Apr 2002
 - 
Mar 2004
M.S., Graduate School of Pharmaceutical Sciences, Setsunan University
 
Apr 2004
 - 
Mar 2007
Ph.D., Graduate School of Pharmaceutical Sciences, Setsunan University
 

Committee Memberships

 
2005
 - 
2007
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  SNPEE organizing committee
 
2005
 - 
2006
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  SNPEE Chair
 
2007
 - 
Today
Japan Transporter Research Association (JTRA)  Committee
 
2008
 - 
2010
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  Global Education Seminar (West) Committee
 
2010
 - 
2014
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  Oral Absorption Focus Group Committee
 
2014
 - 
Today
19th North American ISSX Meeting/29th JSSX Meeting  Short Course Co-Chairs
 
2016
 - 
Today
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  English Seminar Committee
 
2016
 - 
Today
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  Drug Interaction Focus Group Committee
 
2016
 - 
Today
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  Journal of Pharmaceutical Science and Technology, Japan (YAKUZAIGAKU) Editorial Board
 
2016
 - 
2018
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  Journal of Pharmaceutical Science and Technology, Japan (YAKUZAIGAKU) Vice Editor-in-chief
 
2016
 - 
Today
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  Councilor
 
2016
 - 
Today
The Japanese Society for the Study of Xenobiotics (JSSX)  Councilor
 
2017
 - 
2018
Workshop for Japan-Korea Young Scientists on Pharmaceutics  Vice-chair
 
2018
 - 
Today
Workshop for Japan-Korea Young Scientists on Pharmaceutics  Chair
 
2018
 - 
Today
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  Global Education Seminar Comittee Vice-chair
 
2018
 - 
Today
The Japanese Society of Digestion and Absorption  49th Annual Meeting Planning Committee
 
2018
 - 
Today
The Academy of Pharmaceutical Science and Technology, Japan (APSTJ)  Journal of Pharmaceutical Science and Technology, Japan (YAKUZAIGAKU) Editor-in-chief
 
2018
 - 
Today
The Pharmaceutical Society of Japan  Division of Clinical Pharmaceutical Scienses, Young Courier
 

Awards & Honors

 
2008
APSTJ Focus Group Presentation Award
 
2008
DMPK Award for the Most Frequently Downloaded Article in 2006, 3rd Place
 
2009
APSTJ Global Education Seminar Presentation Award 2009
 
2009
3rd Asia/Pacific ISSX Best Presentation Award, 2nd Place
 
2009
24th APSTJ Best Presentation Award
 
2009
Postdoctoral Presentation Award 2009
 
2009
JSSX Best Presentation Award 2009, 1st Place
 
2010
JSSX Best Presentation Award 2009, Finalist
 
2010
PSJ Hokuriku Best Presentation Award 2010
 
2011
4th Asia/Pacific ISSX Best Presentation Award, 1st Place
 
2013
APSTJ Global Education Seminar Presentation Award 2013
 
2013
10th International ISSX Poster Award, Finalist
 
2015
JSSX Award for Young Scientists 2015
 
2017
APSTJ Award for Young Pharmaceutical Scientist 2017
 
2018
PSJKB Award for Young Pharmaceutical Scientist 2018
 

Published Papers

 
Ichijo K, Oda R, Ishihara M, Okada R, Moteki Y, Funai Y, Horiuchi T, Kishimoto H, Shirasaka Y, Inoue K
Journal of Pharmaceutical Sciences      2017   [Refereed]
Shirasaka Y, Lee N, Daun H, Ho H, Park J, Wang J
Journal of Chemical Neuroanatomy      2017   [Refereed]
Physiologically based pharmacokinetic model of all- trans-retinoic acid with application to cancer populations and drug interactions.
Jing J, Nelson C, Paik J, Shirasaka Y, Amory JK, Isoherranen N
Journal of Pharmacology and Experimental Therapeutics   361(5) 385-388   Feb 2017   [Refereed]
Shirasaka Y, Lee N, Zha W, Wagner D, Wang J
Drug Metabolism and Pharmacokinetics   31(5) 385-388   Oct 2016   [Refereed]
Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia1 JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE
The Pharmacogenomics Journal   16(4) 375-387   Aug 2016   [Refereed]
Kishimoto H, Miyazaki K, Takizawa Y, Shirasaka Y, Inoue K
Journal of pharmaceutical sciences   105(2) 729-733   Feb 2016   [Refereed]
Yin J, Duan H, Shirasaka Y, Prasad B, Wang J
Drug metabolism and disposition: the biological fate of chemicals   43(12) 1872-1881   Dec 2015   [Refereed]
Chaudhry AS, Prasad B, Shirasaka Y, Fohner A, Finkelstein D, Fan Y, Wang S, Wu G, Aklillu E, Sim SC, Thummel KE, Schuetz EG
Drug metabolism and disposition: the biological fate of chemicals   43(8) 1226-1235   Aug 2015   [Refereed]
Shirasaka Y, Mori T, Murata Y, Nakanishi T, Tamai I
Pharmaceutical research   31(8) 2035-2043   Aug 2014   [Refereed]
Shirasaka Y, Shichiri M, Mori T, Nakanishi T, Tamai I
Journal of pharmaceutical sciences   102(9) 3418-3426   Sep 2013   [Refereed]
Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N, Rodrigues AD
Drug metabolism and disposition: the biological fate of chemicals   41(8) 1566-1574   Aug 2013   [Refereed]
Shirasaka Y, Sager JE, Lutz JD, Davis C, Isoherranen N
Drug metabolism and disposition: the biological fate of chemicals   41(7) 1414-1424   Jul 2013   [Refereed]
Shirasaka Y, Shichiri M, Kasai T, Ohno Y, Nakanishi T, Hayashi K, Nishiura A, Tamai I
The Journal of endocrinology   217(3) 265-274   Jun 2013   [Refereed]
Shirasaka Y, Shichiri M, Murata Y, Mori T, Nakanishi T, Tamai I
Drug metabolism and disposition: the biological fate of chemicals   41(3) 615-621   Mar 2013   [Refereed]
Shirasaka Y, Shichiri M, Mori T, Nakanishi T, Tamai I
Journal of pharmaceutical sciences   102(1) 280-288   Jan 2013   [Refereed]
Kugai M, Uchiyama K, Tsuji T, Yoriki H, Fukui A, Qin Y, Higashimura Y, Mizushima K, Yoshida N, Katada K, Kamada K, Handa O, Takagi T, Konishi H, Yagi N, Yoshikawa T, Shirasaka Y, Tamai I, Naito Y, Itoh Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology   32(4) 942-950   2013   [Refereed]
Arakawa H, Shirasaka Y, Haga M, Nakanishi T, Tamai I
Biopharmaceutics & drug disposition   33(6) 332-341   Sep 2012   [Refereed]
Sakuma S, Kanamitsu S, Teraoka Y, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Muraoka M, Nakatsuji Y, Kida T, Akashi M
Molecular pharmaceutics   9(4) 922-929   Apr 2012   [Refereed]
Shirasaka Y, Mori T, Shichiri M, Nakanishi T, Tamai I
Drug metabolism and pharmacokinetics   27(3) 360-364   2012   [Refereed]
Nakanishi T, Fukushi A, Sato M, Yoshifuji M, Gose T, Shirasaka Y, Ohe K, Kobayashi M, Kawai K, Tamai I
Molecular pharmaceutics   8(6) 2142-2150   Dec 2011   [Refereed]
Sugano K, Shirasaka Y, Yamashita S
International journal of pharmaceutics   418(2) 161-167   Oct 2011   [Refereed]
Shirasaka Y, Suzuki K, Nakanishi T, Tamai I
Journal of pharmaceutical sciences   100(9) 3843-3853   Sep 2011   [Refereed]
Sato M, Wakayama T, Mamada H, Shirasaka Y, Nakanishi T, Tamai I
Biochimica et biophysica acta   1808(6) 1441-1447   Jun 2011   [Refereed]
Nakanishi T, Shibue Y, Fukuyama Y, Yoshida K, Fukuda H, Shirasaka Y, Tamai I
Drug metabolism and disposition: the biological fate of chemicals   39(6) 984-991   Jun 2011   [Refereed]
Imanaga J, Kotegawa T, Imai H, Tsutsumi K, Yoshizato T, Ohyama T, Shirasaka Y, Tamai I, Tateishi T, Ohashi K
Pharmacogenetics and genomics   21(2) 84-93   Feb 2011   [Refereed]
Nakanishi T, Haruta T, Shirasaka Y, Tamai I
Drug metabolism and disposition: the biological fate of chemicals   39(1) 117-122   Jan 2011   [Refereed]
Shirasaka Y, Suzuki K, Shichiri M, Nakanishi T, Tamai I
Drug metabolism and pharmacokinetics   26(2) 171-179   2011   [Refereed]
Carnitine precursor γ-butyrobetaine is a novel substrate of the Na(+)- and Cl(-)-dependent GABA transporter Gat2.
Nakanishi T, Fukuyama Y, Fujita M, Shirasaka Y, Tamai I
Drug metabolism and pharmacokinetics   26(6) 632-636   2011   [Refereed]
Shirasaka Y, Suzuki K, Nakanishi T, Tamai I
Pharmaceutical research   27(10) 2141-2149   Oct 2010   [Refereed]
Kato K, Shirasaka Y, Kuraoka E, Kikuchi A, Iguchi M, Suzuki H, Shibasaki S, Kurosawa T, Tamai I
Molecular pharmaceutics   7(5) 1747-1756   Oct 2010   [Refereed]
Sakuma S, Teraoka Y, Sagawa T, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Ikumi Y, Kida T, Akashi M
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V   75(3) 366-374   Aug 2010   [Refereed]
Quantitation of talinolol in rat plasma by LC-MS-MS.
Li Y, Shirasaka Y, Langguth P, Tamai I
Journal of chromatographic science   48(5) 367-370   May 2010   [Refereed]
Tachibana T, Kitamura S, Kato M, Mitsui T, Shirasaka Y, Yamashita S, Sugiyama Y
Pharmaceutical research   27(3) 442-446   Mar 2010   [Refereed]
Shirasaka Y, Kuraoka E, Spahn-Langguth H, Nakanishi T, Langguth P, Tamai I
The Journal of pharmacology and experimental therapeutics   332(1) 181-189   Jan 2010   [Refereed]
Sato M, Mamada H, Anzai N, Shirasaka Y, Nakanishi T, Tamai I
Biological & pharmaceutical bulletin   33(3) 498-503   2010   [Refereed]
Nakamura T, Fujiwara R, Ishiguro N, Oyabu M, Nakanishi T, Shirasaka Y, Maeda T, Tamai I
Biological & pharmaceutical bulletin   33(4) 691-696   2010   [Refereed]
Fujita M, Nakanishi T, Shibue Y, Kobayashi D, Moseley RH, Shirasaka Y, Tamai I
American journal of physiology. Gastrointestinal and liver physiology   297(4) G681-6   Oct 2009   [Refereed]
Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I
Drug metabolism and disposition: the biological fate of chemicals   37(8) 1676-1681   Aug 2009   [Refereed]
Nakakariya M, Shima Y, Shirasaka Y, Mitsuoka K, Nakanishi T, Tamai I
American journal of physiology. Renal physiology   297(1) F71-9   Jul 2009   [Refereed]
Shirasaka Y, Konishi R, Funami N, Kadowaki Y, Nagai Y, Sakaeda T, Yamashita S
Biopharmaceutics & drug disposition   30(3) 149-152   Apr 2009   [Refereed]
Mitsuoka K, Shirasaka Y, Fukushi A, Sato M, Nakamura T, Nakanishi T, Tamai I
Biopharmaceutics & drug disposition   30(3) 126-137   Apr 2009   [Refereed]
Shirasaka Y, Li Y, Shibue Y, Kuraoka E, Spahn-Langguth H, Kato Y, Langguth P, Tamai I
Pharmaceutical research   26(3) 560-567   Mar 2009   [Refereed]
Sakuma S, Sagawa T, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Ikumi Y, Kida T, Akashi M
Journal of controlled release : official journal of the Controlled Release Society   133(2) 125-131   Jan 2009   [Refereed]
Shirasaka Y, Masaoka Y, Kataoka M, Sakuma S, Yamashita S
Drug metabolism and disposition: the biological fate of chemicals   36(5) 916-922   May 2008   [Refereed]
Takahashi M, Washio T, Suzuki N, Igeta K, Fujii Y, Hayashi M, Shirasaka Y, Yamashita S
Molecular pharmaceutics   5(2) 340-348   Mar 2008   [Refereed]
Shirasaka Y, Sakane T, Yamashita S
Journal of pharmaceutical sciences   97(1) 553-565   Jan 2008   [Refereed]
Morimoto K, Nakakariya M, Shirasaka Y, Kakinuma C, Fujita T, Tamai I, Ogihara T
Drug metabolism and disposition: the biological fate of chemicals   36(1) 6-9   Jan 2008   [Refereed]
Li Y, Sato M, Yanagisawa Y, Mamada H, Fukushi A, Mikami K, Shirasaka Y, Tamai I
Drug metabolism and pharmacokinetics   23(4) 263-270   2008   [Refereed]
Shirasaka Y, Onishi Y, Sakurai A, Nakagawa H, Ishikawa T, Yamashita S
Biological & pharmaceutical bulletin   29(12) 2465-2471   Dec 2006   [Refereed]

Conference Activities & Talks

 
New challenges of pharmaceutical-pharmacokinetic collaboration in innovative drug development
Yoshiyuki Shirasaka
32nd APSTJ Annual Meeting   13 May 2017   
Utilization of Transporter-Mediated Cellular Uptake of D-Luciferin for in vivo Bioluminescence Imaging
Takahito Furuya, Kazunari Takehara, Asuka Shimura, Hisanao Kishimoto, Hiroaki Yuasa, Yoshiyuki Shirasaka, Katsuhisa Inoue
32nd APSTJ Annual Meeting   13 May 2017   
Development of a Simple Method to Evaluate the Membrane Permeation of Micellized Drug
Hiroshi Fujisawa, Hisanao Kishimoto, Kanako Kimata, Yoshiyuki Shirasaka, Katsuhisa Inoue
32nd APSTJ Annual Meeting   13 May 2017   
Effect of Mucus Layer on the Intestinal Membrane Permeability of Lipophilic Drugs
Kaori Miyazaki, Hisanao Kishimoto, Miho Muratani, Ayane Tano, Yoshiyuki Shirasaka, Katsuhisa Inoue
32nd APSTJ Annual Meeting   13 May 2017   
Kinetic Analysis of Physiological Functions of Gastrointestinal Tract to Predict Oral Drug Absorption
Yoshiyuki Shirasaka
32nd APSTJ Annual Meeting   13 May 2017   
Gastrointestinal Water Absorption (3): Simulation Analysis of Nonlinear Drug Absorption in Controlled-Release Formulation
Ren Okada, Yoshiyuki Shirasaka, Satoru Suzuki, Akari Eguchi, Hisanao Kishimoto, Peter Langguth, Katsuhisa Inoue
32nd APSTJ Annual Meeting   12 May 2017   
Gastrointestinal Water Absorption (2): Kinetic Analysis of Intestinal Water Absorption and Secretion
Kazuki Ichijo, Yoshiyuki Shirasaka, Marika Ishihara, Yuta Funai, Rika Oda, Hisanao Kishimoto, Katsuhisa Inoue
32nd APSTJ Annual Meeting   12 May 2017   
Enhancement of Xenobiotic Excretion by a Serotonin Metabolite
Ko Kobayashi, Syogo Ishida, Hisanao Kishimoto, Yoshiyuki Shirasaka, Yu Toyoda, Tappei Takada, Hiroshi Suzuki, Katsuhisa Inoue
32nd APSTJ Annual Meeting   11 May 2017   
Multiple transport systems involved in the intestinal absorption of antidiabetic metformin
Marie Hatakeyama, Yoshiyuki Shirasaka, Yuko Kurokawa, Maria Seki, Hisanao Kishimoto, Joanne Wang, Katsuhisa Inoue
32nd APSTJ Annual Meeting   11 May 2017   
Gastrointestinal Water Absorption (1): Osmolality-Dependent Drug Interactions with Beverages
Marika Ishihara, Yoshiyuki Shirasaka, Yuta Funai, Kazuki Ichijo, Rika Oda, Hisanao Kishimoto, Katsuhisa Inoue
32nd APSTJ Annual Meeting   11 May 2017   
Transporter-Mediated Cellular Uptake of D-Luciferin and Its Application for Bioluminescence Imaging
Takahito Furuya, Kazunari Takehara, Asuka Shimura, Hisanao Kishimoto, Hiroaki Yuasa, Yoshiyuki Shirasaka, Katsuhisa Inoue
137th PSJ Annual Meeting   23 Mar 2017   
Effect of Water Absorption on the Intestinal Drug Absorption and Interactions
Yoshiyuki Shirasaka, Marika Ishihara, Rika Oda, Kazuki Ichijo, Yuta Funai, Hisanao Kishimoto, Katsuhisa Inoue
22nd Forum for Young Pharmaceutical Scientists   26 Nov 2016   
Characteristic and Kinetic Analysis of Gastrointestinal Drug Concentration: Impact on Drug Absorption, Transport and Delivery
Yoshiyuki Shirasaka
University of Washington, School of Pharmacy, Special Seminar   18 Nov 2016   
Impact of Water Absorption/Secretion on the Intestinal Drug Absorption and Drug-Beverage Interactions
Yoshiyuki Shirasaka, Rika Oda, Kazuki Ichijo, Ren Okada, Yuta Funai, Satoru Suzuki, Takuya Horiuchi, Yuko Kurokawa, Hisanao Kishimoto, Katsuhisa Inoue
2016 AAPS Annual Meeting and Exposition   13 Nov 2016   
Optimization of Bioluminescence Imaging by Utilization of Transporter
Takahito Furuya, Kazunari Takehara, Asuka Shimura, Hisanao Kishimoto, Hiroaki Yuasa, Yoshiyuki Shirasaka, Katsuhisa Inoue
1st Kuroshio Conference   23 Oct 2016   
Quantitative Prediction of the Effect of Controlled-Release Formulation on the Intestinal Absorption of P-Glycoprotein Substrates
Yoshiyuki Shirasaka, Akari Eguchi, Ren Okada, Satoru Suzuki, Hisanao Kishimoto, Marija Tubic、Peter Langguth, Katsuhisa Inoue
31st JSSX Annual Meeting   14 Oct 2016   
Impact of Water Absorption on the Intestinal Drug Absorption and Interactions
Rika Oda, Yoshiyuki Shirasaka, Marika Ishihara, Kazuki Ichijo, Ren Okada, Yuri Moteki, Yuta Funai, Takuya Horiuchi, Hisanao Kishimoto, Katsuhisa Inoue
31st JSSX Annual Meeting   13 Oct 2016   
Contribution of Multiple Transport Mechanisms to the Intestinal Absorption of Antidiabetic Metformin
Maria Seki, Yoshiyuki Shirasaka, Marie Hatakeyama, Yuko Kurokawa, Hisanao Kishimoto, Nora Lee, Joanne Wang, Katsuhisa Inoue
31st JSSX Annual Meeting   13 Oct 2016   
Effects of Mucosal Protective Agents on the Expression Levels of Mucus Layer Components in Human Intestinal Cell Lines
Hisanao Kishimoto, Nanami Murata, Miho Muratani, Kaori Miyazaki, Yoshiyuki Shirasaka, Katsuhisa Inoue
31st JSSX Annual Meeting   12 Oct 2016   
Influence of Water Absorption on the Intestinal Drug Absorption
Kazuki Ichijo, Yoshiyuki Shirasaka, Marika Ishihara, Rika Oda, Ren Okada, Yuta Funai, Takuya Horiuchi, Yuko Kurokawa, Hisanao Kishimoto, Katsuhisa Inoue
60th PSJ Kanto Branch Annual Meeting   17 Sep 2016   
Effect of Controlled-Release Formulation on the Intestinal Absorption of P-Glycoprotein Substrates
SHIRASAKA Yoshiyuki
60th PSJ Kanto Branch Annual Meeting   17 Sep 2016   
Quantitative Analysis of the Effect of Controlled-release on Intestinal Drug Absorption
Akari Eguchi, Yoshiyuki Shirasaka, Ren Okada, Hisanao Kishimoto, Marija Tubic, Peter Langguth, Katsuhisa Inoue
31st APSTJ Annual Meeting   19 May 2016   
Impact of Water Absorption on the Intestinal Drug Absorption
Rika Oda, Yoshiyuki Shirasaka, Marika Ishihara, Ren Okada, Kazuki Ichijo, Yuri Moteki, Hisanao Kishimoto, Katsuhisa Inoue
31st APSTJ Annual Meeting   19 May 2016   
Multiple Transport Mechanisms Involved in the Intestinal Absorption of Antidiabetic Metformin
Maria Seki, Yoshiyuki Shirasaka, Marie Hatakeyama, Hisanao Kishimoto, Nora Lee, Joanne Wang, Katsuhisa Inoue
31st APSTJ Annual Meeting   19 May 2016   
Effect of Mucus Layer on the Intestinal Absorption of Drugs
Kaori Miyazaki, Hisanao Kishimoto, Miho Muratani, Yoshiyuki Shirasaka, Katsuhisa Inoue
31st APSTJ Annual Meeting   19 May 2016   
Effect of Serotonin on Glycoside Hydrolytic Enzyme
Sawako Kon, Kazumi Yamada, Hisanao Kishimoto, Yoshiyuki Shirasaka, Kinya Ota, Hiroaki Yuasa, Katsuhisa Inoue
31st APSTJ Annual Meeting   19 May 2016   
Effect of Mucus Layer on the Intestinal Absorption of Lipophilic Drugs
Hisanao Kishimoto, Kaori Miyazaki, Miho Muratani, Yusuke Takizawa, Yoshiyuki Shirasaka, Katsuhisa Inoue
136th PSJ Annual Meeting   27 Mar 2016   
Impact of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Considerations for Modeling CYP3A-Mediated Drug-Drug Interactions [Invited]
Yoshiyuki Shirasaka
The 7th SUGIYAMA Laboratory (RIKEN) Open Symposium   16 Feb 2016   
Contribution of Metabolites to Drug-Drug Interactions [Invited]
Yoshiyuki Shirasaka
36th JSCPT Annual Meeting   10 Dec 2015   
Enhancing Nitric Oxide Effect on the Intestinal Absorption of Hydrophobic Drugs
Hisanao Kishimoto, Kaori Miyazaki, Yusuke Takizawa, Yoshiyuki Shirasaka, Katsuhisa Inoue
21st Forum for Young Pharmaceutical Scientists   28 Nov 2015   
Mechanistic and Kinetic Analysis of Intestinal Drug Absorption Mediated by Transporters and Metabolic Enzymes
Yoshiyuki Shirasaka
30th JSSX Annual Meeting   13 Nov 2015   
Effect of nitric oxide on the Intestinal Absorption of Hydrophobic Drugs
Kaori Miyazaki, Hisanao Kishimoto, Yusuke Takizawa, Yoshiyuki Shirasaka, Katsuhisa Inoue
20 Jun 2015   
Effect of Nitric Oxide on the Intestinal Drug Absorption
Kaori Miyazaki, Hisanao Kishimoto, Yusuke Takizawa, Yoshiyuki Shirasaka, Katsuhisa Inoue
30th APSTJ Annual Meeting   23 May 2015   
The Movement of History -Ten Years since the Beginning of SNPEE- [Invited]
Yoshiyuki Shirasaka
30th APSTJ Annual Meeting SNPEE2015   22 May 2015   
Multiple Binding Sites (MBS) Hypothesis: Substrate- and Dose-Dependent Drug Interactions Caused by Multiple Binding Sites on OATP2B1 [Invited]
Yoshiyuki Shirasaka
1st APSTJ Drug Interaction Focus Group Symposium   17 Feb 2015   
Interindividual Variability of CYP2C19-Catalyzed Drug Metabolism Due to Differences in Gene Diplotypes and Cytochrome P450 Oxidoreductase Content
Yoshiyuki Shirasaka, Amarjit S. Chaudhry, Matthew McDonald, Bhagwat Prasad, Timothy Wong, Justina C. Calamia, Alie Fohner, Timothy A. Thornton, Nina Isoherranen, Jashvant D. Unadkat, Allan E. Rettie, Erin G. Schuetz, Kenneth E. Thummel
2014 AAPS Annual Meeting and Exposition   2 Nov 2014   
Multiple Transport Mechanisms Involved in the Intestinal Absorption and Disposition of Antidiabetic Metformin
Yoshiyuki Shirasaka, Nora Lee, Haichuan Duan, Weibin Zha, Joanne Wang
19th North American ISSX Meeting/29th JSSX Meeting   19 Oct 2014   
Interindividual Variability of CYP2C19-Catalyzed Drug Metabolism Due to Differences in the Diplotypes
Yoshiyuki Shirasaka, Amarjit S. Chaudhry, Timothy Wong, Justina C. Calamia, Nina Isoherranen, Allan E. Rettie, Erin G. Schuetz, Kenneth E. Thummel
10th International ISSX Meeting   30 Sep 2013   
Inhibition of CYP2C19 and CYP3A4 by Omeprazole and its Metabolites
Jennifer E. Sager, Yoshiyuki Shirasaka, Justin D. Lutz, Connie Davis, Nina Isoherranen
18th International Conference on Cytochrome P450   19 Jun 2013   
Research Activities at University of Washington –Based on Research Abroad for Improving English, Experiencing Other Cultures, Meeting New People, Challenging Myself, and Becoming Global Expert in Pharmaceutics- [Invited]
Yoshiyuki Shirasaka
Setsunan University, Special Lecture   29 May 2013   
Research Activities at University of Washington -Predictions of Transporter- and Metabolic Enzymes (P450)-Mediated Drug-Drug Interactions- [Invited]
Yoshiyuki Shirasaka
Ritsumeikan University, Special Seminar   28 May 2013   
Research Activities at University of Washington -Risk Assessment of Cytochrome P450-Mediated Drug-Drug Interactions-
Yoshiyuki Shirasaka
Kanazawa University, Special Seminar   27 May 2013   
Impact of CYP3A5 Expression on CYP3A-Mediated Drug-Drug Interactions –Based on Research Abroad for Improving English, Experiencing Other Cultures, Meeting New People, Challenging Myself, and Becoming Global Expert in Pharmaceutics- [Invited]
Yoshiyuki Shirasaka
28th APSTJ Global Education Seminar Workshop   25 May 2013   
Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions
Yoshiyuki Shirasaka, Jennifer Sager, Justin Lutz, Connie Davis, Nina Isoherranen
28th APSTJ Annual Meeting   25 May 2013   
A Role of Prostaglandin Transporter in Regulating PGE2 Release from Human Bronchial BEAS-2B Cells under Inflammatory Conditions
Yoshiyuki Shirasaka, Takeo Nakanishi, Taku Kasai, Megumi Scichiri, Kazuyuki Hayashi, Akio Nishiura, Ikumi Tamai
27th JSSX Annual Meeting   21 Nov 2012   
Substrate-Dependent Drug-Grapefruit Juice Interactions Caused by Multiple Binding Sites on OATP2B1
Takanori Mori, Yoshiyuki Shirasaka, Yukiko Murata, Takeo Nakanishi, Ikumi Tamai
27th JSSX Annual Meeting   21 Nov 2012   
Long-Lasting Effect of Fruit Juice on Intestinal Absorptive Transporter OATP2B1
Yukiko Murata, Megumi Shichiri, Takanori Mori, Yoshiyuki Shirasaka, Takeo Nakanishi, Ikumi Tamai
27th JSSX Annual Meeting   21 Nov 2012   
Impact of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Considerations for Modeling CYP3A-Mediated Drug-Drug Interactions
Yoshiyuki Shirasaka, Chi-Chi Peng, Shu-Ying Chang, Mary F. Grubb, Stephen R. Johnson, A. David Rodrigues, Kenneth E. Thummel, Nina Isoherranen
18th North American Regional ISSX Meeting   15 Oct 2012   
Species Difference in the Transporter-Mediated Drug Absorption between Human and Rat -Impact of OATP and P-gp on Grapefruit Juice-Drug Interaction-
Yoshiyuki Shirasaka
University of Washington, Special Seminar   27 Sep 2012   
Functional Pleiotropy of OATP2B1 Due to Multiple Binding Sites
Yoshiyuki Shirasaka, Takanori Mori, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi, Ikumi Tamai
26th JSSX Annual Meeting   16 Nov 2011   

Research Grants & Projects

 
Kinetic Analysis of Gastrointestinal Water Absorption to Quantitatively Predict Drug-Beverage and -Food Interactions
Japan Research Foundation for Clinical Pharmacology: 2017 (42nd) Research Grant
Project Year: 2017 - 2019    Investigator(s): SHIRASAKA Yoshiyuki
Development of in vitro System to Evaluate Oral Drug Absorption Using Intestinal Villus Epithelial Model
Ministry of Education, Culture, Sports, Science and Technology: Grant-in-Aid for Challenging Exploratory Research
Project Year: 2016 - 2018    Investigator(s): SHIRASAKA Yoshiyuki
Quantitative Analysis of Site-Dependent Intestinal Absorption of Drugs
The Sumitomo Foundation: Grant for Basic Science Research Projects
Project Year: 2015 - 2016    Investigator(s): Yoshiyuki SHIRASAKA
Quantitative Analysis of the Effect of Controlled-release on Intestinal Absorption of P-gp and CYP3A Substrate Drugs
Nakatomi Foundation: Research Grant
Project Year: 2015 - 2016    Investigator(s): SHIRASAKA Yoshiyuki
Kinetic Analysis of Transporters- and Metabolic Enzymes-Mediated Drug Absorption
The Uehara Memorial Foundation: Uehara Research Fellowship for Research Abroad
Project Year: 2014 - 2014    Investigator(s): Yoshiyuki SHIRASAKA
Quantitative Evaluation of the Effect of Transporters and Metabolic Enzymes on Oral Drug Absorption
Ministry of Education, Culture, Sports, Science and Technology: JSPS Postdoctoral Fellowship for Research Abroad
Project Year: 2012 - 2014    Investigator(s): Yoshiyuki SHIRASAKA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research (C)
Project Year: 2011 - 2013    Investigator(s): Yoshiyuki SHIRASAKA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research (B)
Project Year: 2009 - 2011    Investigator(s): Ikumi TAMAI
Ministry of Education, Culture, Sports, Science and Technology: Grant-in-Aid for Young Scientists (Start-up)
Project Year: 2009 - 2010    Investigator(s): Takeo NAKANISHI
Ministry of Education, Culture, Sports, Science and Technology: Grant-in-Aid for Young Scientists (B)
Project Year: 2009 - 2010    Investigator(s): Yoshiyuki SHIRASAKA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research (B)
Project Year: 2007 - 2008    Investigator(s): Ikumi TAMAI