2003年8月
Vascular development and patterning: making the right choices
CURRENT OPINION IN GENETICS & DEVELOPMENT
- ,
- 巻
- 13
- 号
- 4
- 開始ページ
- 408
- 終了ページ
- 412
- 記述言語
- 英語
- 掲載種別
- 書評論文,書評,文献紹介等
- DOI
- 10.1016/S0959-437X(03)00080-7
- 出版者・発行元
- CURRENT BIOLOGY LTD
The developing vascular system is regulated by a series of intrinsic and extrinsic signaling interactions that result in the formation and specialization of vessels that circulate blood and lymph around the body. Signaling molecules, such as vascular epithelial growth factors (VEGFs) and angiopoietins, that establish the cellular identity of the endothelial cells in the early embryo also play roles in establishing whether developing vessels will be arterial, venous or lymphatic. Genetic studies in zebrafish and mice have suggested a key role for Notch signaling, downstream of VEGF-A, in specifying arterial versus venous fate, and for VEGF-C and -D, along with the transcription factor, Prox1, in specifying lymphatic fate.
- リンク情報
- ID情報
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- DOI : 10.1016/S0959-437X(03)00080-7
- ISSN : 0959-437X
- PubMed ID : 12888015
- Web of Science ID : WOS:000184770100013