MISC

招待有り
1998年5月

Hematopoietic tissues, as a playground of receptor tyrosine kinases of the PDGF-receptor family

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
  • H Yoshida
  • ,
  • N Takakura
  • ,
  • M Hirashima
  • ,
  • H Kataoka
  • ,
  • K Tsuchida
  • ,
  • S Nishikawa
  • ,
  • S Nishikawa

22
3
開始ページ
321
終了ページ
332
記述言語
英語
掲載種別
記事・総説・解説・論説等(学術雑誌)
DOI
10.1016/s0145-305x(98)00008-1
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Three receptor tyrosine kinases of the PDGF receptor family (RTKP) that clustered within 1000 Kb of the mouse chromosome 5 constitute an interesting unit that are expressed in three distinct cell lineages essential for constructing hematopoietic tissues. Namely, the c-kit gene that is expressed in hematopoietic stem cells is flanked by pdgfr alpha and flk genes expressed respectively in stromal cells and vascular endothelial cells. In this article, we review our results on their expression in the embryonic hematopoietic tissues. We found that co-expression of Flk1 and c-Kit was frequently detected either in vascular endothelial cells or hematopoietic cells in the early hematopoietic tissues. On the other hand, the three RTKPs are expressed in different cell lineages in the fetal liver. On the basis of this finding, we propose two modes of embryonic hematopoiesis; hematogenic angiopoiesis and hematopoiesis. (C) 1998 Elsevier Science Ltd. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/s0145-305x(98)00008-1
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9700461
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000075277800007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/s0145-305x(98)00008-1
  • ISSN : 0145-305X
  • PubMed ID : 9700461
  • Web of Science ID : WOS:000075277800007

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