Masanori Hirashima

Profile Information

Affiliation: Associate Professor, Graduate School of Medical and Dental Sciences Course for Molecular and Cellular Medicine, Niigata University

Degree: 博士（医学）(Mar, 1999, 京都大学)

Researcher number: 40383757
ORCID ID: https://orcid.org/0000-0002-0190-4381
J-GLOBAL ID: 200901023351951689
Researcher ID: ABC-9204-2021
researchmap Member ID: 6000005289

External link: https://www.med.niigata-u.ac.jp/pha/

Research Interests

Research Areas

Research History

Jan, 2019 - Present

Graduate School of Medical and Dental Sciences, Niigata University
Sep, 2007 - Dec, 2018

Graduate School of Medicine, Kobe University
Mar, 2004 - Aug, 2007

School of Medicine, Keio University
Nov, 1999 - Feb, 2004

博士研究員, サミュエル・ルネンフェルド研究所
Apr, 1999 - Oct, 1999

Graduate School of Medicine, Kyoto University

Education

Apr, 1995 - Mar, 1999

京都大学大学院医学研究科博士課程分子医学系専攻
Apr, 1989 - Mar, 1995

Department of Medical Science, Faculty of Medicine, Kyoto University

Awards

Sep, 2009

岡本研究奨励賞（第24回）, 内皮細胞分化と血管・リンパ管形成に関する研究, 成人血管病研究振興財団

Hirashima Masanori
Dec, 2006

Best Young Investigator Award, 第14回日本血管生物医学会学術集会

平島正則

Papers

Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm.

Hiromi Matsuda, Yoshiya Ito, Kanako Hosono, Seri Tsuru, Tomoyoshi Inoue, Shuji Nakamoto, Chie Kurashige, Masanori Hirashima, Shuh Narumiya, Hirotsugu Okamoto …

Arteriosclerosis, thrombosis, and vascular biology, 41(4) 1390-1407, Apr, 2021 Peer-reviewed
MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis.

Kenji Matsuzawa, Hayato Ohga, Kenta Shigetomi, Tomohiro Shiiya, Masanori Hirashima, Junichi Ikenouchi

Communications biology, 4(1) 337-337, Mar 12, 2021 Peer-reviewed
Only plantar lesion of punctate palmoplantar keratoderma with a novel missense mutation in the AAGAB gene: Two Japanese familial case reports and review of reported mutations

Hasegawa, Akito, Hayashi, Ryota, Shimomura, Yutaka, Hirashima, Masanori, Abe, Riichiro

The Journal of Dermatology, 48(12) 1926-1930, 2021
Blood and lymphatic systems are segregated by the FLCN tumor suppressor.

Ikue Tai-Nagara, Yukiko Hasumi, Dai Kusumoto, Hisashi Hasumi, Keisuke Okabe, Tomofumi Ando, Fumio Matsuzaki, Fumiko Itoh, Hideyuki Saya, Chang Liu …

Nature communications, 11(1) 6314-6314, Dec 9, 2020 Peer-reviewed
PROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer.

Ueta K, Otowa Y, Kakeji Y, Hirashima M

Anticancer Res, 38(11) 6139-6145, Nov, 2018 Peer-reviewed
Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction.

Nagaharu Tsukiji, Osamu Inoue, Mitsuru Morimoto, Norifumi Tatsumi, Hiroaki Nagatomo, Koji Ueta, Toshiaki Shirai, Tomoyuki Sasaki, Shimon Otake, Shogo Tamura …

Blood, 132(11) 1167-1179, Sep 13, 2018 Peer-reviewed
VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis

Nicholas Beazley-Long, Catherine Elizabeth Moss, William Robert Ashby, Samuel Marcus Bestall, Fatimah Almahasneh, Alexandra Margaret Durrant, Andrew Vaughan Benest, Zoe Blackley, Kurt Ballmer-Hofer, Masanori Hirashima …

Brain, Behavior, and Immunity, 74 49-67, 2018 Peer-reviewed
Dynamics of angiogenesis in ischemic areas of the infarcted heart

Koichi Kobayashi, Kengo Maeda, Mikito Takefuji, Ryosuke Kikuchi, Yoshihiro Morishita, Masanori Hirashima, Toyoaki Murohara

SCIENTIFIC REPORTS, 7(1) 7156, Aug, 2017 Peer-reviewed
VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis

Jeon Yeob Jang, Sung Yong Choi, Intae Park, Do Young Park, Kibaek Choe, Pilhan Kim, Young Keum Kim, Byung-Joo Lee, Masanori Hirashima, Yoshiaki Kubota …

EMBO MOLECULAR MEDICINE, 9(6) 750-769, Jun, 2017 Peer-reviewed
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.

Shuntaro Ogura, Kaori Kurata, Yuki Hattori, Hiroshi Takase, Toshina Ishiguro-Oonuma, Yoonha Hwang, Soyeon Ahn, Inwon Park, Wataru Ikeda, Sentaro Kusuhara …

JCI insight, 2(3) e90905, Feb 9, 2017 Peer-reviewed
PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts

Sally Danno, Koji Kubouchi, Mona Mehruba, Manabu Abe, Rie Natsume, Kenji Sakimura, Satoshi Eguchi, Masahiro Oka, Masanori Hirashima, Hiroki Yasuda …

GENES TO CELLS, 22(2) 220-236, Feb, 2017 Peer-reviewed
Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1

Xinyi Liu, Akiyoshi Uemura, Yoko Fukushima, Yutaka Yoshida, Masanori Hirashima

CELL REPORTS, 17(9) 2299-2311, Nov, 2016 Peer-reviewed
Flt1/VEGFR1 heterozygosity causes transient embryonic edema

Yasunori Otowa, Kazumasa Moriwaki, Keigo Sano, Masanori Shirakabe, Shigenobu Yonemura, Masabumi Shibuya, Janet Rossant, Toshio Suda, Yoshihiro Kakeji, Masanori Hirashima

SCIENTIFIC REPORTS, 6 27186, Jun, 2016 Peer-reviewed
An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo

Takashi Majima, Keisuke Takeuchi, Keigo Sano, Masanori Hirashima, Dimitar P. Zankov, Miki Tanaka-Okamoto, Hiroyoshi Ishizaki, Jun Miyoshi, Hisakazu Ogita

PLoS ONE, 8(6) e68134, Jun 26, 2013 Peer-reviewed
EphrinB2-EphB4 Signals Regulate Formation and Maintenance of Funnel-Shaped Valves in Corneal Lymphatic Capillaries

Hideto Katsuta, Yoko Fukushima, Kazuichi Maruyama, Masanori Hirashima, Kohji Nishida, Shin-Ichi Nishikawa, Akiyoshi Uemura

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(6) 4102-4108, Jun, 2013 Peer-reviewed
Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells

Yoshiko Matsumoto Ikushima, Fumio Arai, Yuka Nakamura, Kentaro Hosokawa, Yoshiaki Kubota, Masanori Hirashima, Hirofumi Toyama, Toshio Suda

Biochemical and Biophysical Research Communications, 430(1) 20-25, Jan 4, 2013 Peer-reviewed
[VEGF receptors].

Sano K, Hirashima M

Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8 31-35, Nov, 2012 Peer-reviewed
Arhgef15 Promotes Retinal Angiogenesis by Mediating VEGF-Induced Cdc42 Activation and Potentiating RhoJ Inactivation in Endothelial Cells

Sentaro Kusuhara, Yoko Fukushima, Shigetomo Fukuhara, Lars Martin Jakt, Mitsuhiro Okada, Yuri Shimizu, Masayuki Hata, Kohji Nishida, Akira Negi, Masanori Hirashima …

PLOS ONE, 7(9) e45858, Sep, 2012 Peer-reviewed
Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells

Makoto Osada, Osamu Inoue, Guo Ding, Toshiaki Shirai, Hirotake Ichise, Kazuyoshi Hirayama, Katsuhiro Takano, Yutaka Yatomi, Masanori Hirashima, Hideki Fujii …

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(26) 22241-22252, Jun, 2012 Peer-reviewed
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice

Shigetomo Fukuhara, Szandor Simmons, Shunsuke Kawamura, Asuka Inoue, Yasuko Orba, Takeshi Tokudome, Yuji Sunden, Yuji Arai, Kazumasa Moriwaki, Junji Ishida …

JOURNAL OF CLINICAL INVESTIGATION, 122(4) 1416-1426, Apr, 2012 Peer-reviewed

Misc.

Regulation of endothelial cell differentiation and arterial specification by VEGF and Notch signaling

Masanori Hirashima

ANATOMICAL SCIENCE INTERNATIONAL, 84(3) 95-101, Sep, 2009 Invited
Differentiation of arterial and venous endothelial cells and vascular morphogenesis

M Hirashima, T Suda

ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH, 13(2) 137-145, Mar, 2006 Invited
Vascular development and patterning: making the right choices

J Rossant, M Hirashima

CURRENT OPINION IN GENETICS & DEVELOPMENT, 13(4) 408-412, Aug, 2003 Invited
Cell biology of vascular endothelial cells.

Nishikawa SI, Hirashima M, Nishikawa S, Ogawa M

Ann N Y Acad Sci, 947 35-40, Dec, 2001 Invited
Hematopoietic tissues, as a playground of receptor tyrosine kinases of the PDGF-receptor family

H Yoshida, N Takakura, M Hirashima, H Kataoka, K Tsuchida, S Nishikawa, S Nishikawa

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 22(3) 321-332, May, 1998 Invited

Teaching Experience

Apr, 2019 - Present

基礎薬理 (新潟大学)
組織学 (京都大学, 神戸大学)
先端医科学研究概説 (新潟大学)
発生学 (神戸大学, 新潟大学)
細胞分子医学特論 (神戸大学)
解剖学 (神戸大学)
Research in Biomedical Science (Kobe University)
Literature Analysis and Presentation (Kobe University)
Embryology (Kobe University)
Cellular and Molecular Medicine (Kobe University)
Basic Course of Bioscience (Kobe University)

Professional Memberships

Research Projects

血小板とリンパ管内皮細胞の相互作用を標的にした新たなリンパ浮腫治療の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

植木春香, 田中宏明, 平島正則, 松田健, 椎谷友博
リンパ管・血管分離を維持する血小板放出因子の作用機序

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

椎谷友博, 平島正則
リンパ節におけるリンパ洞フィルターの分子・細胞基盤と免疫応答制御

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

片貝智哉, 奥田修二郎, 平島正則
血小板のリンパ組織発生における役割：生理活性物質の運び手としての血小板

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

井上克枝, 築地長治, 平島正則, 佐々木知幸, 白井俊光
ヒト胎児疾患モデルマウスの新規スクリーニング法の確立

学術研究助成基金助成金／挑戦的研究（萌芽）, Apr, 2017 - Mar, 2019

平島正則
生理的リンパ管・静脈吻合の形成機構と機能的意義

学術研究助成基金助成金／基盤研究(C), Apr, 2014 - Mar, 2017

平島正則
リンパ管腔形成と維持におけるＡｓｐｐ１の役割と分子機構

科学研究費補助金／新学術領域研究, Apr, 2012 - Mar, 2014

平島正則
A-STEP「高眼圧の早期診断と創薬に向けたスクリーニング系の開発」

研究成果最適展開支援プログラムフィージビリティスタディステージ探索タイプ, 2013

平島正則
Analysis of the function of Rap1-activating factors which mediate the cross-talks between different species of small G proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

KATAOKA Tohru, SATOH Takaya, SHIMA FUMI, EDAMATSU Hironori, HIRASHIMA Masanori
胎生期浮腫を示す内皮細胞遺伝子変異マウスの病態と分子機構

科学研究費補助金／基盤研究(C), 2010

平島正則
リンパ管内皮細胞の分子生物学的解析～プロスタノイドレセプターを巡って～

科学研究費補助金／基盤研究(C), 2010

野村正
血管内皮細胞の動・静脈アイデンティティーを決定する細胞外環境

科学研究費補助金／特定領域研究, 2007

平島正則
マウス胚における動・静脈形成

科学研究費補助金／若手研究(B), 2007

平島正則

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Teaching Experience

Professional Memberships

Research Projects

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