2006年2月
Midkine, a heparin-binding growth factor, produced by the host enhances metastasis of Lewis lung carcinoma cells
CANCER LETTERS
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- 巻
- 233
- 号
- 1
- 開始ページ
- 16
- 終了ページ
- 20
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.canlet.2005.02.047
- 出版者・発行元
- ELSEVIER IRELAND LTD
Midkine is a heparin-binding growth factor and is expressed by a number of tumor cells, contributing to their growth both in vitro and in vivo. Spontaneous lung metastasis of Lewis lung carcinoma cells, which did not significantly express MK, was significantly less extensive in mice deficient in the midkine gene than in wild-type mice, when the tumor was subcutaneously grown above the thigh. Midkine strongly enhanced migration of Lewis lung carcinoma cells in vitro. Therefore, midkine is also a host factor enhancing tumor metastasis. Anti-midkine therapy for malignancy may act on midkine produced by both the tumor and host. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.canlet.2005.02.047
- ISSN : 0304-3835
- Web of Science ID : WOS:000235851300003