2006年12月
Midkine as a molecular target: Comparison of effects of chondroitin sulfate E and siRNA
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 351
- 号
- 4
- 開始ページ
- 915
- 終了ページ
- 919
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.bbrc.2006.10.123
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Intraperitoneally administered chondroitin sulfate E inhibited the development of antibody-induced arthritis, a model of rheumatoid arthritis, while chondroitin 4-sulfate showed no effects. Chondroitin sulfate E inhibited in vitro differentiation of osteoclasts, which play key roles in the etiology of rheumatoid arthritis. One of the targets of chondroitin sulfate E is midkine, a heparin-binding growth factor or cytokine. Indeed, a chimeric-type siRNA for midkine inhibited the development of antibody-induced arthritis and adhesion of the omentum to the injured abdominal wall. These results indicate the significance of midkine as a molecular target to treat or prevent rheumatoid arthritis and adhesion after surgery, and the utility of chondroitin sulfate E to inhibit midkine in vivo. (c) 2006 Elsevier Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bbrc.2006.10.123
- CiNii Articles
- http://ci.nii.ac.jp/naid/80018760763
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/17094944
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000242425300020&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.bbrc.2006.10.123
- ISSN : 0006-291X
- CiNii Articles ID : 80018760763
- PubMed ID : 17094944
- Web of Science ID : WOS:000242425300020