笠原敦子 (Atsuko Kasahara) - マイポータル

基本情報

所属: 東北大学生命科学研究科助教

学位: 博士（理学）(筑波大学)

J-GLOBAL ID: 200901036372982384
researchmap会員ID: 6000005507

研究分野

ライフサイエンス / 細胞生物学 /

経歴

学歴

2004年 - 2006年

筑波大学大学院生命環境科学研究科情報生物科学専攻 (博士課程）
2002年 - 2004年

筑波大学大学院バイオシステム研究科バイオシステム専攻 (修士課程）
1998年 - 2002年

筑波大学第二学群生物学類

論文

Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma.

Yongwei Jing, Masahiko Kobayashi, Mahmoud I Shoulkamy, Meiqi Zhou, Ha Thi Vu, Hiroshi Arakawa, Hemragul Sabit, Sadahiro Iwabuchi, Cong Quang Vu, Atsuko Kasahara …

Nature communications 16(1) 2876-2876 2025年4月1日
Mitochondria in Lung Cancer Progression

Masafumi Noguchi, Keiko Iwata, Norihito Shintani, Atsuko Kasahara

Current Pharmacology Reports 2024年8月27日
A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite

Masaya Ueno, Hiroki Sugiyama, Feng Li, Tatsuya Nishimura, Hiroshi Arakawa, Xi Chen, Xiaoxiao Cheng, Shinji Takeuchi, Yumie Takeshita, Toshinari Takamura …

Analytical Chemistry 96(36) 14499-14507 2024年8月26日査読有り
Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation.

Kenta Kurayoshi, Yusuke Takase, Masaya Ueno, Kumiko Ohta, Kyoko Fuse, Shuji Ikeda, Takayoshi Watanabe, Yuki Nishida, Shin-Ichi Horike, Kazuyoshi Hosomichi …

Cell Death & Disease 14(9) 642 2023年9月査読有り
Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line.

Masafumi Noguchi, Susumu Kohno, Anna Pellattiero, Yukino Machida, Keitaro Shibata, Norihito Shintani, Takashi Kohno, Noriko Gotoh, Chiaki Takahashi, Atsushi Hirao …

Cell death & disease 14(4) 241-241 2023年4月5日
RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia

Loc Thi Pham, Hui Peng, Masaya Ueno, Susumu Kohno, Atuso Kasada, Kazuyoshi Hosomichi, Takehiro Sato, Kenta Kurayoshi, Masahiko Kobayashi, Yuko Tadokoro …

Biochemical and Biophysical Research Communications 621 74-79 2022年9月
Therapeutic advantage of targeting lysosomal membrane integrity supported by lysophagy in malignant glioma.

Yongwei Jing, Masahiko Kobayashi, Ha Thi Vu, Atsuko Kasahara, Xi Chen, Loc Thi Pham, Kenta Kurayoshi, Yuko Tadokoro, Masaya Ueno, Tomoki Todo …

Cancer science 113(8) 2716-2726 2022年8月
Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner.

Naho Nomura, Chiaki Ito, Takako Ooshio, Yuko Tadokoro, Susumu Kohno, Masaya Ueno, Masahiko Kobayashi, Atsuko Kasahara, Yusuke Takase, Kenta Kurayoshi …

Scientific reports 11(1) 1666-1666 2021年1月18日
Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples

Masaya Ueno, Takuya Tomita, Hiroshi Arakawa, Takahiro Kakuta, Tada-aki Yamagishi, Jumpei Terakawa, Takiko Daikoku, Shin-ichi Horike, Sha Si, Kenta Kurayoshi …

Communications Chemistry 3(1) 2020年12月
Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.

Ha Thi Vu, Masahiko Kobayashi, Ahmed M Hegazy, Yuko Tadokoro, Masaya Ueno, Atsuko Kasahara, Yusuke Takase, Naho Nomura, Hui Peng, Chiaki Ito …

Cancer science 109(8) 2497-2508 2018年8月査読有り
Mitochondrial dynamics coordinate cell differentiation

Masafumi Noguchi, Atsuko Kasahara

Biochemical and Biophysical Research Communications 500(1) 59-64 2018年5月27日査読有り
ER-mitochondria contacts control surface glycan expression and sensitivity to killer lymphocytes in glioma stem-like cells

Esen Yonca Bassoy, Atsuko Kasahara, Valentina Chiusolo, Guillaume Jacquemin, Emma Boydell, Sebastian Zamorano, Cristina Riccadonna, Serena Pellegatta, Nicolas Hulo, Valerie Dutoit …

EMBO JOURNAL 36(11) 1493-1512 2017年6月査読有り
Granzyme B-induced mitochondrial ROS are required for apoptosis

G. Jacquemin, D. Margiotta, A. Kasahara, E. Y. Bassoy, M. Walch, J. Thiery, J. Lieberman, D. Martinvalet

CELL DEATH AND DIFFERENTIATION 22(5) 862-874 2015年4月査読有り
Mitochondria: from cell death executioners to regulators of cell differentiation

Atsuko Kasahara, Luca Scorrano

TRENDS IN CELL BIOLOGY 24(12) 761-770 2014年12月査読有り
Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling.

Kasahara A, Cipolat S, Chen Y, Dorn GW, Scorrano L

Science (New York, N.Y.) 342(6159) 734-737 2013年11月査読有り
Normal mitochondrial respiratory function is essential for spatial remote memory in mice

Daisuke Tanaka, Kazuto Nakada, Keizo Takao, Emi Ogasawara, Atsuko Kasahara, Akitsugu Sato, Hiromichi Yonekawa, Tsuyoshi Miyakawa, Jun-Ichi Hayashi

MOLECULAR BRAIN 1 21 2008年査読有り
Deletion-mutant mtDNA increases in somatic tissues but decreases in female germ cells with age

Akitsugu Sato, Kazuto Nakada, Hiroshi Shitara, Atsuko Kasahara, Hiromichi Yonekawa, Jun-Ichi Hayashi

GENETICS 177(4) 2031-2037 2007年12月査読有り
[Mutagens inducing mutations in mammalian mitochondrial DNA].

Watanabe N, Kasahara A, Nakada K, Hayashi J

Nihon rinsho. Japanese journal of clinical medicine 60 Suppl 4 35-38 2002年4月査読有り

MISC

Generation of trans-mitochondrial mice carrying homoplasmic mtDNA with a missense mutation in a structural gene using ES cells

Atsuko Kasahara, Jun-Ichi Hayashi

NEUROMUSCULAR DISORDERS 16 S58-S58 2006年7月
Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells

A Kasahara, K Ishikawa, M Yamaoka, M Ito, N Watanabe, M Akimoto, A Sato, K Nakada, H Endo, Y Suda …

HUMAN MOLECULAR GENETICS 15(6) 871-881 2006年3月
Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells

A Kasahara, K Ishikawa, M Yamaoka, M Ito, N Watanabe, M Akimoto, A Sato, K Nakada, H Endo, Y Suda …

HUMAN MOLECULAR GENETICS 15(6) 871-881 2006年3月
Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion

K Ishikawa, A Kasahara, N Watanabe, K Nakada, A Sato, Y Suda, S Aizawa, JI Hayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 333(2) 590-595 2005年7月
Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion

K Ishikawa, A Kasahara, N Watanabe, K Nakada, A Sato, Y Suda, S Aizawa, JI Hayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 333(2) 590-595 2005年7月
Accumulation of pathogenic ΔmtDNA induced deafness but not diabetic phenotypes in mito-mice.

NAKADA K, SATO A, SONE H, KASAHARA A, IKEDA K, KAGAWA Y, YONEKAWA H, HAYASHI J

Biochem. Biophys. Res. Commun. 323(1) 175-184 2004年10月
Accumulation of pathogenic Delta mtDNA induced deafness but not diabetic phenotypes in mito-mice

K Nakada, A Sato, H Sone, A Kasahara, K Ikeda, Y Kagawa, H Yonekawa, J Hayashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 323(1) 175-184 2004年10月

所属学協会

共同研究・競争的資金等の研究課題

細胞運命決定におけるオルガネラ接触部位制御メカニズムの解明

日本学術振興会科学研究費助成事業基盤研究(C) 2024年4月 - 2027年3月

笠原敦子
がん幹細胞性におけるミトコンドリア動態の果たす役割を明らかにする

日本学術振興会科学研究費助成事業基盤研究(C) 2019年4月 - 2022年3月

笠原敦子
がん悪性化におけるミトコンドリア逆行性制御の解明

日本学術振興会科学研究費助成事業若手研究(B) 2017年4月 - 2019年3月

笠原敦子
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