論文

2020年7月

Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • Yokoe, Yuki
  • ,
  • Tsuboi, Naotake
  • ,
  • Imaizumi, Takahiro
  • ,
  • Kitagawa, Akimitsu
  • ,
  • Karasawa, Munetoshi
  • ,
  • Ozeki, Takaya
  • ,
  • Endo, Nobuhide
  • ,
  • Sawa, Yuriko
  • ,
  • Kato, Sawako
  • ,
  • Katsuno, Takayuki
  • ,
  • Maruyama, Shoichi
  • ,
  • Yamagata, Kunihiro
  • ,
  • Usui, Joichi
  • ,
  • Nagata, Michio
  • ,
  • Sada, Ken-Ei
  • ,
  • Sugiyama, Hitoshi
  • ,
  • Amano, Koichi
  • ,
  • Arimura, Yoshihiro
  • ,
  • Atsumi, Tatsuya
  • ,
  • Yuzawa, Yukio
  • ,
  • Dobashi, Hiroaki
  • ,
  • Takasaki, Yoshinari
  • ,
  • Harigai, Masayoshi
  • ,
  • Hasegawa, Hitoshi
  • ,
  • Makino, Hirofumi
  • ,
  • Matsuo, Seiichi

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/ndt/gfaa097

[BACKGROUND] The detection of leukocyte-derived CD11b (α subunit of integrin Mac-1) and CD163 (scavenger receptor) in urine may reflect renal inflammation in antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN). The objective of this study was to evaluate the clinical significance of urinary CD11b (U-CD11b) and CD163 (U-CD163) in ANCA-GN.
[METHODS] U-CD11b and U-CD163 were examined using enzyme-linked immunosorbent assay in ANCA-GN urine samples from our institutional cohort (n = 88) and a nationwide cohort (n = 138), and their association with renal histology was subsequently analyzed. Logistic regression analyses were performed on a nationwide ANCA cohort to determine the associations of the two urinary molecules with renal remission failure at 6 months or with yearly estimated glomerular filtration rate (eGFR) slope over a 24-month observation period.
[RESULTS] U-CD11b and U-CD163 were significantly associated with cellular crescent formation and leukocyte accumulation in glomerular crescents. With regard to interstitial inflammation, both levels of U-CD11b and U-CD163 at diagnosis remarkably increased in ANCA-GN compared with the levels observe

リンク情報
DOI
https://doi.org/10.1093/ndt/gfaa097

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