論文

査読有り
2020年9月

Literature review of allograft adenovirus nephritis and a case presenting as mass lesions in a transplanted kidney without symptoms of urinary tract infection or acute kidney injury

Transplant infectious disease
  • Watanabe, Megumi
  • ,
  • Kaneko, Shuzo
  • ,
  • Usui, Joichi
  • ,
  • Takahashi, Kazuhiro
  • ,
  • Kawanishi, Kunio
  • ,
  • Takahashi‐Kobayashi, Mayumi
  • ,
  • Shimizu, Tatsuya
  • ,
  • Ishii, Ryota
  • ,
  • Tawara, Takashi
  • ,
  • Tsunoda, Ryoya
  • ,
  • Nagai, Kei
  • ,
  • Kawamura, Tetsuya
  • ,
  • Fujita, Akiko
  • ,
  • Kai, Hirayasu
  • ,
  • Morito, Naoki
  • ,
  • Saito, Chie
  • ,
  • Oda, Tatsuya
  • ,
  • Nagata, Michio
  • ,
  • Yamagata, Kunihiro

Epub
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/tid.13468
出版者・発行元
WILEY

Adenovirus (AdV) infection is a common complication in bone marrow/hematopoietic stem cell transplant and solid organ transplant recipients. AdV infection usually presents as hemorrhagic cystitis, but sometimes it can progress to acute kidney injury showing AdV nephritis (AdVN). We present the case of a 52-year-old Japanese female who had received a living kidney transplantation (KT) from her husband. At 21 months post-KT, the patient presented with a fever, but no renal dysfunction and no abnormal urine findings. A contrast-enhanced computed tomography (CT) scan revealed a few mass lesions with hypoperfusion in the transplanted kidney. An enhanced CT-guided biopsy targeting one of these lesions revealed a necrotizing tubulointerstitial nephritis suggesting AdVN. The polymerase chain reaction tests for ADV were negative in a urine sample but positive in the sera and the frozen kidney biopsy samples. AdVN can manifest as an unusual pattern of acute lobar nephritis/acute focal bacterial nephritis-like localization without symptoms of acute kidney injury or urinary tract infection. Enhanced CT can provide clues for clinical diagnosis.

リンク情報
DOI
https://doi.org/10.1111/tid.13468

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