論文

2020年11月2日

Anti-PM/Scl Antibody-positive Systemic Sclerosis Complicated by Multiple Organ Involvement

Internal medicine (Tokyo, Japan)
  • Shimizu, Tatsuya
  • ,
  • Saito, Chie
  • ,
  • Watanabe, Megumi
  • ,
  • Ishii, Ryota
  • ,
  • Kawamura, Tetsuya
  • ,
  • Nagai, Kei
  • ,
  • Fujita, Akiko
  • ,
  • Kaneko, Shuzo
  • ,
  • Kai, Hirayasu
  • ,
  • Morito, Naoki
  • ,
  • Usui, Joichi
  • ,
  • Yokosawa, Masahiro
  • ,
  • Kondo, Yuya
  • ,
  • Inoue, Sae
  • ,
  • Okiyama, Naoko
  • ,
  • Yamagata, Kunihiro

advpub
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2169/internalmedicine.5665-20
出版者・発行元
一般社団法人 日本内科学会

A 40-year-old Japanese woman developed malignant-phase hypertension complicated by thrombotic microangiopathy, progressing to end-stage renal disease. Five years later, she was diagnosed with pulmonary arterial hypertension and interstitial pneumonia. Despite a lack of overt skin sclerosis, nucleolar staining in our indirect immunofluorescence analysis and nailfold capillaroscopy facilitated the diagnosis of anti-PM/Scl antibody-positive systemic sclerosis. We observed the persistent presence of anti-PM/Scl antibodies throughout the clinical course, suggesting that her kidney disease was scleroderma renal crisis. Anti-PM/Scl antibodies can be associated with multiple organ diseases. Careful attention to a patient's antinuclear antibody pattern and dermatological findings may help clarify the etiology of undiagnosed diseases.

リンク情報
DOI
https://doi.org/10.2169/internalmedicine.5665-20

エクスポート
BibTeX RIS