論文

査読有り 国際誌
2020年4月

A Strategy for Suppressing Macrophage-mediated Rejection in Xenotransplantation.

Transplantation
  • Akira Maeda
  • ,
  • Pei-Chi Lo
  • ,
  • Rieko Sakai
  • ,
  • Yuki Noguchi
  • ,
  • Tasuku Kodama
  • ,
  • Tomohisa Yoneyama
  • ,
  • Chiyoshi Toyama
  • ,
  • Han-Tang Wang
  • ,
  • Emilio Esquivel
  • ,
  • Patmika Jiaravuthisan
  • ,
  • Thuy-Vy Choi
  • ,
  • Chihiro Takakura
  • ,
  • Hiroshi Eguchi
  • ,
  • Yuko Tazuke
  • ,
  • Masahito Watanabe
  • ,
  • Hiroshi Nagashima
  • ,
  • Hiroomi Okuyama
  • ,
  • Shuji Miyagawa

104
4
開始ページ
675
終了ページ
681
記述言語
英語
掲載種別
DOI
10.1097/TP.0000000000003024

Although xenografts are one of the most attractive strategies for overcoming the shortage of organ donors, cellular rejection by macrophages is a substantial impediment to this procedure. It is well known that macrophages mediate robust immune responses in xenografts. Macrophages also express various inhibitory receptors that regulate their immunological function. Recent studies have shown that the overexpression of inhibitory ligands on porcine target cells results in the phosphorylation of tyrosine residues on intracellular immunoreceptor tyrosine-based inhibitory motifs on macrophages, leading to the suppression of xenogenic rejection by macrophages. It has also been reported that myeloid-derived suppressor cells, a heterogeneous population of immature myeloid cells, suppress not only NK and cytotoxic T lymphocyte cytotoxicity but also macrophage-mediated cytotoxicity. This review is focused on the recent findings regarding strategies for inhibiting xenogenic rejection by macrophages.

リンク情報
DOI
https://doi.org/10.1097/TP.0000000000003024
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31634326

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