J-GLOBAL         Last updated: Oct 10, 2019 at 02:56
Waseda University
Faculty of Science and Engineering School of Advanced Science and Engineering
Job title
MD, PhD(Yamanashi Medical University)
Research funding number

Research Areas


Published Papers

Chiang, Ming Ching; Chiang, Ming Ching; Huang, Arthur J.Y.; Wintzer, Marie E.; Ohshima, Toshio; McHugh, Thomas J.
Behavioural Brain Research      Jan 2018
© 2018 Elsevier B.V. Social recognition memory is crucial for survival across species, underlying the need to correctly identify conspecifics, mates and potential enemies. In humans the hippocampus is engaged in social and episodic memory, however...
Hashimoto, Shoko; Ishii, Ayano; Ishii, Ayano; Kamano, Naoko; Watamura, Naoto; Watamura, Naoto; Saito, Takashi; Saito, Takashi; Ohshima, Toshio; Yokosuka, Makoto; Saido, Takaomi C.
Journal of Biological Chemistry   293(9) 3118-3125   Jan 2018
© 2018 by The American Society for Biochemistry and Molecular Biology, Inc. Endoplasmic reticulum (ER) stress is believed to play an important role in the etiology of Alzheimer's disease (AD). The accumulation of misfolded proteins and perturbatio...
Shitasako, Shiori; Ito, Yoko; Ito, Ryoichi; Ueda, Yuto; Shimizu, Yuki; Ohshima, Toshio
Developmental Neurobiology   77(10) 1206-1220   Oct 2017
© 2017 Wiley Periodicals, Inc. Adult neurogenesis occurs more commonly in teleosts, represented by zebrafish, than in mammals. Zebrafish is therefore considered a suitable model to study adult neurogenesis, for which the regulatory molecular mecha...
Xu, Bozong; Kumazawa, Ayumi; Kumazawa, Ayumi; Kobayashi, Shunsuke; Hisanaga, Shin Ichi; Inoue, Takafumi; Ohshima, Toshio
Developmental Neurobiology   77(10) 1175-1187   Oct 2017
© 2017 Wiley Periodicals, Inc. Cyclin-dependent kinase 5 (Cdk5) is recognized as a unique member among other Cdks due to its versatile roles in many biochemical processes in the nervous system. The proper development of neuronal dendrites is requi...
Nozawa, Keisuke; Lin, Yanbin; Kubodera, Ryota; Shimizu, Yuki; Tanaka, Hideomi; Ohshima, Toshio
Developmental Neurobiology   77(9) 1101-1113   Sep 2017
© 2017 Wiley Periodicals, Inc. Rett syndrome is a severe neurodevelopmental disorder. It is caused by a mutation in methyl-CpG binding protein 2 (MecP2), a transcriptional regulator that recruits protein complexes involved in histone modification ...

Books etc

Cyclin Dependent Kinase5
Ohshima, T.
Spriger   2008   ISBN:978-0-387-78886-9

Conference Activities & Talks

Requirement of Cdk5 for proper cerebellar development and function
2nd international symposium on Cdk5 Tokyo   Jun 2009   

Research Grants & Projects

Elucidation of roles of CRMP in neural circuit formation and regeneration and application for the treatment of spinal cord injury
Project Year: Apr 2014 - Mar 2017
In present study, we analyzed the role of CRMP family proteins in brain development and neural regeneration by using mutant mice of CRMP genes. We reported orientation abnormality of basal dendrites of layer V neurons in cerebral cortex of CRMP4 K...
Functional analysis of Cdk5 by using conditional KO of its activating subunit p35
The purpose of this study is to analyze the function of neuron-specific serine/threonine kinase Cyclin-dependent kinase 5(Cdk5) by using conditional KO mice of its activating subunit p35 trough the behavioral analysis such as spatial learning and ...
Proteomics of phospho-proteins during brain development using mutant mice
Purpose and Method : In this proposal, I attempt to understand the mechanism of brain development by analyzing protein phosphorylations which are important for such processes. Comparison of phospho-proteins between controls and mutant mice which h...
The role of CRMP family proteins in the establishment of neural tissue architectures
In developing brain, axon and dendritic guidance are regulated by repulsive and attractive axon guidance molecules such as semaphorin3A (Sema3A) and netrin. Collpapsin response mediator protein (CRMP) has originally been identified as an intracell...
Identification and functional analysis of Cdk5-mediated phosphorylation of the proteins that are related to brain formation and development
Purpose and Method :Cdk5 is a neuron-specific Ser/Thr protein kinase and Cdk5 KO mice exhibit defective brain development particularly in layer formation of cortical structures. Abnormalities of brain development in Cdk5 KO mice are caused by defe...