2011年1月
Islet1 Selectively Promotes Peripheral Axon Outgrowth in Rohon-Beard Primary Sensory Neurons
DEVELOPMENTAL DYNAMICS
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- 巻
- 240
- 号
- 1
- 開始ページ
- 9
- 終了ページ
- 22
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1002/dvdy.22499
- 出版者・発行元
- WILEY-LISS
We isolated a novel zebrafish mutant, lullaby (llb), and showed that the llb locus encodes the zebrafish orthologue of isl1. Rohon-Beard (RB) primary sensory neurons are multipolar neurons that extend their central axons longitudinally within the spinal cord and also extend their peripheral axons under the skin. In llb embryos, the outgrowth of the peripheral axons of RB neurons was selectively impaired, which correlated with down-regulation of the expression of dihydropyrimidinase-like 3 (dpysl3, also known as collapsin response mediator protein 4, crmp4). Antisense morpholino oligonucleotide (AMO)-mediated knockdown of dpysl3 inhibited the outgrowth of the peripheral axons of RB neurons, and semaphorin 3d (sema3d) AMO enhanced this effect. These data indicate that Dpysl3 is cooperating with Sema3d in the peripheral axon outgrowth, and Isl1 is required for the selective outgrowth of the peripheral axons of RB neurons by maintaining the expression of dpysl3. Developmental Dynamics 240: 9-22, 2011. (C) 2010 Wiley-Liss, Inc.
- リンク情報
- ID情報
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- DOI : 10.1002/dvdy.22499
- ISSN : 1058-8388
- Web of Science ID : WOS:000285887900002