2019年9月5日
Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.
Nature communications
- 巻
- 10
- 号
- 1
- 開始ページ
- 4007
- 終了ページ
- 4007
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41467-019-11978-0
Gut microbiota mediates the effects of diet, thereby modifying host metabolism and the incidence of metabolic disorders. Increased consumption of omega-6 polyunsaturated fatty acid (PUFA) that is abundant in Western diet contributes to obesity and related diseases. Although gut-microbiota-related metabolic pathways of dietary PUFAs were recently elucidated, the effects on host physiological function remain unclear. Here, we demonstrate that gut microbiota confers host resistance to high-fat diet (HFD)-induced obesity by modulating dietary PUFAs metabolism. Supplementation of 10-hydroxy-cis-12-octadecenoic acid (HYA), an initial linoleic acid-related gut-microbial metabolite, attenuates HFD-induced obesity in mice without eliciting arachidonic acid-mediated adipose inflammation and by improving metabolic condition via free fatty acid receptors. Moreover, Lactobacillus-colonized mice show similar effects with elevated HYA levels. Our findings illustrate the interplay between gut microbiota and host energy metabolism via the metabolites of dietary omega-6-FAs thereby shedding light on the prevention and treatment of metabolic disorders by targeting gut microbial metabolites.
- リンク情報
-
- DOI
- https://doi.org/10.1038/s41467-019-11978-0
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/31488836
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728375
- 共同研究・競争的資金等の研究課題
- 「リポクオリティ」領域研究の推進
- 共同研究・競争的資金等の研究課題
- 脂肪酸クオリティの最先端リピドミクスと生理的意義の解明
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85071762031&origin=inward
- ID情報
-
- DOI : 10.1038/s41467-019-11978-0
- PubMed ID : 31488836
- PubMed Central 記事ID : PMC6728375