YAMAGUCHI HIDEKI

J-GLOBAL         Last updated: Sep 17, 2019 at 09:31
 
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Name
YAMAGUCHI HIDEKI
Affiliation
Sasaki Institute, Sasaki Foundation
Section
Department of Cancer Cell Research
Job title
Chief
Degree
PhD(Univ. of Tokyo)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2017
 - 
Today
Chief, Department of Cancer Cell Research, Sasaki Institute, Sasaki Foundation
 
Jan 2010
 - 
Mar 2017
Laboratory Head, Division of Refractory and Advanced Cancer, National Cancer Center Research Institute
 
Oct 2007
 - 
Mar 2011
Research Scientist, PRESTO, Japan Science and Technology Agency
 
Oct 2006
 - 
Dec 2009
Lecturer, Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences
 
Apr 2003
 - 
Sep 2006
Research Associate, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine
 
May 2002
 - 
Mar 2006
Research Associate, Department of Cancer Genetics, Institute of Medical Science, University of Tokyo
 
Apr 2002
 - 
Apr 2002
Research Fellowship for Young Scientists, Japan Society for the Promotion of Science
 

Education

 
 
 - 
2002
Ph.D., Department of Pathology, Graduate School of Medicine, University of Tokyo
 
 
 - 
1998
M.S., Department of Chemistry, Graduate School of Science and Technology, Sophia University
 
 
 - 
1996
B.S., Department of Chemistry, Faculty of Science and Technology, Sophia University
 

Published Papers

 
Identification and characterization of a novel adenomatous polyposis coli mutation in adult pancreatoblastoma
Yamaguchi S, Fujii T, Izumi Y, Fukumura Y, Han M, Yamaguchi H, Akita T, Yamashita C, Kato S, and Sekiya T
Oncotarget   9 10818-10827   2018   [Refereed]
Miyamoto S, Nagamura Y, Nakabo A, Okabe A, Yanagihara K, Fukami K, Sakai R, and Yamaguchi H
Biochem. Biophys. Res. Comm.   495 1942-1947   2018   [Refereed]
Yamamoto Y, Tomiyama A, Sasaki N, Yamaguchi H, Shirakihara T, Nakashima K, Kumagai K, Takeuchi S, Toyooka T, Otani N, Wada K, Narita Y, Ichimura K, Sakai R, Namba H, and Mori K
Biochem. Biophys. Res. Comm.   495 1292-1299   2018   [Refereed]
Nakashima K, Uekita T, Yano S, Kikuchi J, Nakanishi R, Sakamoto N, Fukumoto K, Nomoto A, Kawamoto K, Shibahara T, Yamaguchi H, and Sakai R
Cancer Sci.   108 1049-1057   2017   [Refereed]
Yamaguchi H, Ito Y, Miura N, Nagamura Y, Nakabo A, Fukami K, Honda K, and Sakai R
Eur. J. Cell Biol.   96 685-694   2017   [Refereed]
Ueno H, Tomiyama A, Yamaguchi H, Uekita T, Shirakihara T, Nakashima K, Otani N, Wada K, Sakai R, Arai H, and Mori K
Biochem. Biophys. Res. Comm.   468 240-247   2015   [Refereed]
Yamaguchi H, Yoshida N, Takanashi M, Ito Y, Fukami K, Yanagihara K, Yashiro M, and Sakai R
PLOS ONE   9 e85485   2014   [Refereed]
Yamaguchi H, Takanashi M, Yoshida N, Ito Y, Kamata R, Fukami K, Yanagihara K, and Sakai R
Cancer Sci.   105 528-536   2014   [Refereed]
Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, Nakagawara A, Kitanaka C, Mori K, Yamaguchi H, and Sakai R
Cancer Res.   74 3790-3801   2014   [Refereed]
Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, and Sakai R
Mol. Cancer Res.   11 628-637   2013   [Refereed]
Gligorijevic B*, Wyckoff J*, Yamaguchi H, Wang Y, Roussos E, and Condeelis J
J. Cell Sci.   125 724-734   2012   [Refereed]
Yamaguchi H†
91 902-907   2012   [Refereed]
Kanemaru K*, Nakamura Y*, Sato K, Takahashi S, Yamaguchi M, Ichinohe M, Kiyonari H, Shioi G, Asagiri M, Jamora C, Kouchi Z, Yamaguchi H, and Fukami K
Nature Commun.   3 963   2012   [Refereed]
Sakurai K, Hirata M, Yamaguchi H, Nakamura Y, and Fukami K
Advan. Enzyme Regul.   51 171-181   2011   [Refereed]
Kouchi Z*, Igarashi T*, Shibayama N*, Inanobe S, Sakurai K, Yamaguchi H, Fukuda T, Yanagi S, Nakamura Y, and Fukami K
J. Biol. Chem.   286 8459-8471   2011   [Refereed]
Kouchi Z, Fujiwara Y, Yamaguchi H, Nakamura Y, and Fukami K
Biochem. Biophys. Res. Comm.   408 523-529   2011   [Refereed]
Hirata M*, Suzuki M*, Ishii R*, Kitazumi T, Sasaki T, Kitamura T, Yamaguchi H, Nakamura Y, and Fukami K
Diabetes   60 1926-1937   2011   [Refereed]
Yamaguchi H†, Yoshida S, Muroi E, Yoshida N, Kawamura M, Yoshida N, Kouchi Z, Nakamura Y, Sakai R, and Fukami K
J. Cell. Biol.   193 1275-1288   2011   [Refereed]
Kanemaru K, Nakahara M, Nakamura Y, Hashiguchi Y, Kouchi Z, Yamaguchi H, Oshima N, Kiyonari H, and Fukami K
Gene Expr. Patterns   10 119-126   2010   [Refereed]
Yamaguchi H†, Yoshida S, Muroi E, Kawamura M, Kouchi Z, Nakamura Y, Sakai R, and Fukami K
Cancer Sci.   101 1632-1638   2010   [Refereed]
Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis
Yamaguchi H† and Oikawa T
Oncotarget   1 320-328   2010   [Refereed]
DesMarais V, Yamaguchi H, Oser M, Soon L, Mouneimne G, Sarmiento C, Eddy R, and Condeelis J
Cell Motil. Cytoskeleton   66 303-316   2009   [Refereed]
Oser M, Yamaguchi H, Mader CC, Arias M, DesMarais V, van Rheenen J, Koleske AJ, and Condeelis J
J. Cell Biol.   186 571-587   2009   [Refereed]
Yamaguchi H†, Takeo Y, Yoshida S, Kouchi Z, Nakamura Y, and Fukami K
Cancer Res.   69 8594-8602   2009   [Refereed]
Nakamura Y, Ichinohe M, Hirata M, Matsuura H, Fujiwara T, Igarashi T, Nakahara M, Yamaguchi H, Yasugi S, Takenawa T, and Fukami K
FASEB J.   22 841-849   2008   [Refereed]
Sarmiento C, Wang W, Dovas A, Yamaguchi H, Sidani M, El-Sibai M, DesMarais V, Holman HA, Kitchen S, Backer JM, Alberts A, and Condeelis J
J. Cell Biol.   180 1219-1232   2008   [Refereed]
Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, Sahai E, Condeelis JS, and Gertler FB
Dev. Cell   15 813-828   2008   [Refereed]
Yamaguchi H†, and Condeelis J†
BBA Mol. Cell Res.   1773 642-652   2007   [Refereed]
Ichinohe M, Nakamura Y, Sai K, Nakahara M, Yamaguchi H, and Fukami K
Biochem. Biophys. Res. Comm.   356 912-918   2007   [Refereed]
Terabayashi T, Itoh TJ, Yamaguchi H, Yoshimura Y, Funato Y, Ohno S, and Miki H
J. Neuroscience.   27 13098-13107   2007   [Refereed]
Yamaguchi H†, Pixley F, and Condeelis J
Eur. J. Cell Biol.   85 213-218   2006   [Refereed]
Song X, Chen X, Yamaguchi H, Mouneimne G, Condeelis J and Eddy R
J. Cell Sci.   119 2871-2881   2006   [Refereed]
Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, and Condeelis J
J. Cell Biol.   168 441-452   2005   [Refereed]
Kempiak S, Yamaguchi H, Sarmiento C, Sidani M, Ghosh M, Eddy R, DesMarais V, Way M, Condeelis J, and Segall J
J. Biol. Chem.   280 5836-5842   2005   [Refereed]
Kurisu S, Suetsugu S, Yamazaki D, Yamaguchi H, and Takenawa T
Oncogene   24 1309-1319   2005   [Refereed]
Oda A, Miki H, Wada I, Yamaguchi H, Yamazaki D, Suetsugu S, Nakajima M, Nakayama A, Okawa K, Miyazaki H, Matsuno K, Ochs HD, Machesky LM, Fujita H, and Takenawa T
Blood   105 3141-3148   2005   [Refereed]
Yamaguchi H, Wyckoff J, and Condeelis J
Curr. Opin. Cell Biol.   17 559-564   2005   [Refereed]
Abou Kheir W, Gevrey J, Yamaguchi H, Isaac B, and Cox D
J. Cell Sci.   118 5369-5379   2005   [Refereed]
Lorenz M, Yamaguchi H, Wang Y, Singer RH, and Condeelis JS
Curr. Biol.   14 697-703   2004   [Refereed]
Oikawa T, Yamaguchi H, Itoh T, Kato M, Ijuin T, Yamazaki D, Suetsugu S, and Takenawa T
Nature Cell Biol.   6 420-426   2004   [Refereed]
Neural Wiskott-Aldrich syndrome protein is involved in hepatocyte growth factor-induced migration, invasion, and tubulogenesis of epithelial cells
Yamaguchi H, Miki H, and Takenawa T
Cancer Res.   62 2503-2509   2002   [Refereed]
Yamaguchi H, Miki H, and Takenawa T
Biochem. Biophys. Res. Comm.   297 214-219   2002   [Refereed]
Martinez-Quiles N, Rohatgi R, Anton IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, and Ramesh N
Nature Cell Biol.   3 484-491   2001   [Refereed]
Suetsugu S, Miki H, Yamaguchi H, and Takenawa T
Biochem. Biophys. Res. Comm.   282 739-744   2001   [Refereed]
Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2
Suetsugu S, Miki H, Yamaguchi H, Obinata T, and Takenawa T
J. Cell Sci.   114 4533-4542   2001   [Refereed]
Banzai Y, Miki H, Yamaguchi H, and Takenawa T
J. Biol. Chem.   275 11987-11992   2000   [Refereed]
Yamaguchi H, Miki H, Suetsugu S, Ma L, Kirschner MW, and Takenawa T
Proc. Natl. Acad. Sci. USA   97 12631-12636   2000   [Refereed]
Miki H, Yamaguchi H, Suetsugu S, and Takenawa T
Nature   408 732-735   2000   [Refereed]
Masuda T, Ohmi K, Yamaguchi H, Hasegawa K, Sugiyama T, Matsuda Y, Iino M, and Nonomura Y
Mol. Cell. Biochem.   190 99-104   1999   [Refereed]
Ohmi K, Masuda T, Yamaguchi H, Sakurai T, Kudo Y, Katsuki M, and Nonomura Y
Biochem. Biophys. Res. Comm.   238 154-158   1997   [Refereed]
MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane
Miyagawa T, Hasegawa K, Aoki Y, Watanabe T, Otagiri Y, Arasaki K, Wakana Y, Asano K, Tanaka M, Yamaguchi H, Tagaya M, and Inoue H
J. Cell Biol.   Published online    Sep 2019   [Refereed]

Conference Activities & Talks

 
Regulation of tumorigenesis and cancer progression by membrane trafficking [Invited]
Yamaguchi H, Tomiyama A, and Sakai R
89th Annual Meeting of Japanese Biochemical Society   2016   
Molecular mechanisms of invadopodium formation by cancer cells and its role in tumor metastasis [Invited]
Yamaguchi H
73rd Annual Meeting of The Japanese Cancer Association   2014   
Molecular mechanisms of invadopodium formation and its role in cancer invasion and metastasis [Invited]
Yamaguchi H
22nd Annual Meeting of The Japanese Association for Metastasis Research   2013   
Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells [Invited]
Yamaguchi H and Sakai R
Cell Migration and Invasion in Physiology and Pathology   2013   
The role of PI3-kinase signaling pathway in invadopodia formation [Invited]
Yamaguchi H
Podosomes, Invadopodia, and Focal Adhesions in Physiology and Pathology   2011   
Phosphoinositide 3-kinase signaling pathway mediated by p110alpha regulates invadopodia formation
Yamaguchi H, Fukami K, and Sakai R
102nd Annual meeting of the American Association for Cancer Research   2011   
Molecular mechanisms of invadopodium formation: the roles of phosphoinositides and lipid microdomains
Yamaguchi H, and Fukami K
5th Korea-Japan Conference on Cellular Signaling for Young Scientists   2007   
Invadopodia: Key structures for cancer cell invasion. [Invited]
Yamaguchi H
EMBO Conference: Common molecular mechanisms of mammary grand development and breast cancer progression   2006   
Molecular mechanisms of invadopodium formation: The role of the N-WASP-Arp2/3 complex pathway and cofilin [Invited]
Yamaguchi H, Lorenz M, Kempiak S, Sarmiento C, Coniglio S, Symons M, Segall J, Eddy R, Miki H, Takenawa T, and Condeelis J
1st Adhesion meeting   2005   The New York Blood Center
Molecular mechanisms of invadopodium formation and its role in cancer invasion and metastasis
Yamaguchi H
45th The American Society for Cell Biology Annual Meeting   2005   
Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP
Yamaguchi H, Miki H, Suetsugu S, and Takenawa T
7th Korea-Japan joint symposium on cellular and molecular biology   2000