Takafumi SUZUKI

J-GLOBAL         Last updated: Aug 6, 2019 at 20:08
 
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Name
Takafumi SUZUKI
Affiliation
Tohoku University
Section
Graduate School of Medicine
Research funding number
70508308
ORCID ID
0000-0002-3425-8208

Academic & Professional Experience

 
Sep 2010
 - 
Jan 2011
Visiting Researcher, Trinity College Dublin
 

Awards & Honors

 
May 2016
Young Investigator’s Award, The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, and the 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan
 
May 2012
Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo., 日本生化学会東北支部優秀論文賞, 日本生化学会東北支部
 
Oct 2009
日本生化学会大会 優秀プレゼンテーション賞, 第82回日本生化学会大会
 
Nov 2006
Most Impressive Poster Presentation Bronze Award, The 8th AEARU Joint Workshop on Life Sciences
 

Published Papers

 
Suzuki T, Muramatsu A, Saito R, Iso T, Shibata T, Kuwata K, Kawaguchi SI, Iwawaki T, Adachi S, Suda H, Morita M, Uchida K, Baird L, Yamamoto M
Cell reports   28(3) 746-758.e4   Jul 2019   [Refereed]
Kikuchi K, Iida M, Ikeda N, Moriyama S, Hamada M, Takahashi S, Kitamura H, Watanabe T, Hasegawa Y, Hase K, Fukuhara T, Sato H, Kobayashi EH, Suzuki T, Yamamoto M, Tanaka M, Asano K
Journal of immunology (Baltimore, Md. : 1950)   201(2) 635-651   Jul 2018   [Refereed]
Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT
Scientific reports   8(1) 8037   May 2018   [Refereed]
Eiki Yoshida, Takafumi Suzuki, Masanobu Morita, Keiko Taguchi, Kohei Tsuchida, Hozumi Motohashi, Minoru Doita, Masayuki Yamamoto
Genes to Cells   23(5) 386-392   May 2018   [Refereed]
Dayalan Naidu S, Suzuki T, Yamamoto M, Fahey JW, Dinkova-Kostova AT
Molecular nutrition & food research   e1700908   Apr 2018   [Refereed]
Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H
PloS one   13(11) e0203978   2018   [Refereed]
Suzuki T, Yamamoto M
The Journal of biological chemistry   292(41) 16817-16824   Oct 2017   [Refereed]
Sogawa Y, Nagasu H, Iwase S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T, Kashihara N
Scientific reports   7(1) 8801   Aug 2017   [Refereed]
Higashi C, Kawaji A, Tsuda N, Hayashi M, Saito R, Yagishita Y, Suzuki T, Uruno A, Nakamura M, Nakao K, Furusako S, Yamamoto M.
European Journal of Pharmacology   802 76-84   May 2017   [Refereed]
Suzuki T, Seki S, Hiramoto K, Naganuma E, Kobayashi E.H, Yamaoka A, Baird L, Takahashi N, Sato H, Yamamoto M.
Nature Communications   8 14577   Feb 2017   [Refereed]
Hidaka T, Ogawa E, Kobayashi E.H, Suzuki T, Funayama R, Nagashima T, Fujimura T, Aiba S, Nakayama K, Okuyama R, Yamamoto M.
Nature Immunology   18(1) 64-73   2017   [Refereed]
Kobayashi E.H, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M.
Nature Communications   7 11624   May 2016   [Refereed]
Nezu M, Souma T, Yu L, Suzuki T, Saigusa D, Ito S, Suzuki N, Yamamoto M.
Kidney International   91(2) 387-401   2016   [Refereed]
Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee M.-S, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M.
Nature Communications   7 12030   Jun 2016   [Refereed]
Saito R, Suzuki T, Hiramoto K, Asami S, Naganuma E, Suda H, Iso T, Yamamoto H, Morita M, Baird L, Furusawa Y, Negishi T, Ichinose M, Yamamoto M.
Molecular and Cellular Biology   36(2) 271-284   Jan 2016   [Refereed]
Iso T, Suzuki T, Baird L, Yamamoto M.
Molecular and Cellular Biology   36(24) 3100-3112   Dec 2016   [Refereed]
Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M
Science signaling   8(404) ra120   Nov 2015   [Refereed]
Suzuki T, Yamamoto M.
Free Radical Biology and Medicine   88(Part B) 93-100   Nov 2015   [Refereed]
Hiramoto K, Satoh H, Suzuki T, Moriguchi T, Pi J, Shimosegawa T, Yamamoto M
Cancer prevention research (Philadelphia, Pa.)   7(8) 835-844   Aug 2014   [Refereed]
Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   29(4) 783-791   Apr 2014   [Refereed]
Kobayashi E, Suzuki T, Yamamoto M.
Oxidative Medicine and Cellular Longevity   2013 529219   Jun 2013   [Refereed][Invited]
Suzuki T, Motohashi H, Yamamoto M
Trends in pharmacological sciences   34(6) 340-346   Jun 2013   [Refereed]
Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H, Yamamoto M
Molecular and cellular biology   33(12) 2402-2412   Jun 2013   [Refereed]
Ohkoshi A, Suzuki T, Ono M, Kobayashi T, Yamamoto M
Cancer prevention research (Philadelphia, Pa.)   6(2) 149-159   Feb 2013   [Refereed]
Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP
Cell metabolism   16(4) 526-537   Oct 2012   [Refereed]
ユビキチンーピロテアソーム系によるKeap1-Nrf2経路の制御機構 (医学のあゆみ)
鈴木隆史、山本雅之
医学のあゆみ   243 525   Nov 2012
Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW, Yamamoto M
Free radical biology & medicine   53(4) 817-827   Aug 2012   [Refereed]
Suzuki T* Maher JM* and Yamamoto M.
Cancer Research   71(5) 1700-1709   Mar 2011   [Refereed]
Suzuki T* Kawatani Y* Shimizu R Kelly VP and Yamamoto M. (*equal contribution)
Blood   117(3) 986-996   Jan 2011   [Refereed]
Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S
Cancer research   70(22) 9095-9105   Nov 2010   [Refereed]
Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M
Carcinogenesis   31(10) 1833-1843   Oct 2010   [Refereed]
Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M
Molecular and cellular biology   30(12) 3016-3026   Jun 2010   [Refereed]
「環境応答と転写因子」 (転写制御とエピジェネティクスーゲノムでコードに向けてー)
鈴木隆史、山本雅之
転写制御とエピジェネティクスーゲノムでコードに向けてー   143-149   Oct 2008
Keap1-Nrf2システムによるレドックスシグナル応答メカニズム (実験医学)
鈴木隆史、山本雅之
実験医学   24 1737   Oct 2006   [Invited]

Conference Activities & Talks

 
尿細管発生期における転写因子Nrf2の恒常的活性化は腎性尿崩症を引き起こす
鈴木隆史、関詩織、長沼絵理子、高橋信行、佐藤博、山本雅之
ConBio2017   6 Dec 2017   
TBE-31はKeap1Cys151を介してNrf2を活性化し抗炎症に働く
村松亜紀、鈴木隆史、Dinkova-Kostova, 山本雅之
ConBio2017   6 Dec 2017   
酸化ストレス応答におけるKeap1の構造・相互作用解析
井上仁、村松亜紀、鈴木隆史、磯達朗、小柴生造、山本雅之
第56回NMR討論会   14 Nov 2017   
Keap1-Nrf2系による酸化ストレス防御機構
Takafumi SUZUKI
第7回日本分子状水素医学生物学会年会   29 Oct 2017   
Keap1-Nrf2システムによる酸化ストレス応答機構
鈴木隆史、山本雅之
第17回日本蛋白質学会大会   20 Jun 2017   
尿細管発生期における転写因子Nrf2の恒常的活性化は腎性尿崩症を引き起こす
鈴木隆史、関詩織、長沼絵里子、高橋信行、佐藤博、山本雅之.
第60回 日本腎臓学会学術会   26 May 2017   
Air pollution activates Aryl hydrocarbon receptor in murine epidermis, leading to Atopic dermatitis-like pathologies.
Takanori Hidaka, Eri H Kobayashi, Takafumi Suzuki, and Masayuki Yamamoto.
The 41st Annual Meeting of the Japanese Society for Investigative Dermatology   9 Dec 2016   
19F標識技術を利用したKeap1-Nrf2タンパク質の構造機能解析
小柴生造, 渡部暁, 碇正臣, 松田夏子, 磯達郎, 鈴木隆史, 木川隆則, 山本雅之
第39回 日本分子生物学会年会   1 Dec 2016   
オートファジー破綻がもたらす病態のNrf2を標的とした治療戦略
田口恵子, 鈴木隆史, 山本雅之
第10回オートファジー研究会・第4回新学術「オートファジー」班会議   14 Oct 2016   
Keap1センサーシステイン残基による多様なストレス感知機構
鈴木隆史、山本雅之
第89回日本生化学会大会   25 Sep 2016   
A novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice.
Higashi C, Hayashi M, Tsuda N, Kawaji A, Nakao K, Satoh F, Nakamura M, Furusako S, Saito R, Suzuki T, Uruno A, Yamamoto M.
32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis   14 Sep 2016   
Keap1の反応性システイン残基による多様なストレス感知機構
鈴木隆史、山本雅之
第69回日本酸化ストレス学会学術集会   30 Aug 2016   
Protein 19F Labeling Strategy for In-Cell NMR and Functional Analyses.
Seizo Koshiba, Satoru Watanabe, Masaomi Ikari, Natsuko Matsuda, Tatsuo Iso, Tatafumi Suzuki, Masayuki Yamamoto, and Tananori Kigawa.
XXVIIth ICMRBS   21 Aug 2016   
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.
Suzuki T, Saito R, Hiramoto K, Asami S, Naganuma E, Suda H, Iso T, Yamamoto H, Morita M, Baird L, Furusawa Y, Negishi T, Ichinose M, Yamamoto M.
The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, and the 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan   20 May 2016   
AhR activation induces atopic dermatitis.
Takanori Hidaka, Eri Kobayashi, Takafumi Suzuki, Taku Fujimura, Setsuya Aiba, Masayuki Yamamoto.
The 26th Annual Meeting of Korean Society for Investigative Dermatology,   25 Mar 2016   
Air pollution activates Aryl hydrocarbon receptor of un-differentiated keratinocytes, leading to Atopic dermatitis-like pathologiesn.
Takanori Hidaka, Eri H Kobayashi, Takafumi Suzuki, Masayuki Yamamoto.
46th Annual Meeting of the European Society for Dermatological Research.   25 Mar 2016   
Keap1-Nrf2系による生体防御機構
Takafumi SUZUKI
第64回脳研・高度先進合同セミナー   23 Apr 2015   
Myeloid-specific transcriptional regulation by Nrf2.
Eri H. Kobayashi, Takafumi Suzuki, Masayuki Yamamoto.
The Keap1/Nrf2 Pathway in Health and Disease.   6 Jan 2015   
Keap1 Cys273 and Cys288 are functional sensors for 15d-PGJ2 to activate Nrf2 signaling.
Takafumi Suzuki, Ryota Saito, Kei-ichiro Hiramoto, Tatsuro Iso, Masayuki Yamamoto.
The Keap1/Nrf2 Pathway in Health and Disease.   6 Jan 2015   
Multiple Sensor Mechanism of the Keap1-Nrf2 System.
36. Takafumi Suzuki, Kai Takaya, Ryota Saito, Keiichiro Hiramoto, Tatsuro Iso and Masayuki Yamamoto.
Symposium for young ubiquitin researchers in Japan “New Era in the Ubiquitin Research”   11 Nov 2014   
Myeloid-specific transcription by Nrf2.
Eri H. Kobayashi, Takafumi Suzuki, and Masayuki Yamamoto.
The Environmental Response IV.   28 Feb 2014   
Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis to the lung.
Keiichiro Hiramoto, Hironori Satoh, Takafumi Suzuki, Takashi Moriguchi, Tooru Shimosegawa and Masayuki Yamamoto.
The Environmental Response IV.   28 Feb 2014   
Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels.
33. Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Hunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H, Yamamoto M.
The Environmental Response IV   28 Feb 2014   
Keap1-Nrf2システムの活性制御機構
新学術領域「ユビキチンネオバイオロジー」平成25年度第2回班会議   11 Dec 2013   
Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels.
鈴木隆史、柴田龍弘、高屋快、本橋ほづみ、山本雅之
第86回日本生化学会大会   11 Sep 2013   
ストレスセンサーKeap1のユビキチンライゲース活性制御機構の解明
新学術領域「ユビキチンネオバイオロジー」平成25年度第1回班会議   26 Jul 2013   
転写因子Nrf2の舌癌予防効果
大越明、鈴木隆史、小林俊光、山本雅之
第61回日本耳鼻咽喉科学会東北地方連合学術講演会   20 Jul 2013   
最優秀演題賞
Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels.
32. Takafumi Suzuki, Tatsuhiro Shibata, Kai Takaya, Hozumi Motohashi, and Masayuki Yamamoto
The 35rd NAITO conference on The Ubiquitin-Proteasome System, From Basic Mechanisms to Pathophysiological Roles,   9 Jul 2013   
Keap1-Nrf2システムによる酸化ストレス防御機構
第31回Kidney, Hypertension & Endocrine Seminar   27 May 2013   
ミエロイド系細胞における酸化ストレス防御機構破綻ががん転移に及ぼす影響
平本圭一郎、佐藤大希、鈴木隆史、山本雅之
平成24年度「個体レベルでのがん研究支援活動」公開シンポジウム   6 Feb 2013   
Aryl Hydroxarbon Receptorを介した大気汚染物質によるアトピー性皮膚炎の発症機序
日高高徳、小林枝里、鈴木隆史、相場節也、山本雅之
第6回リトリート大学院生研究発表会   19 Jan 2013   
ミエロイド系細胞における酸化ストレス防御機構破綻ががん転移に及ぼす影響
平本圭一郎、佐藤大希、鈴木隆史、山本雅之
第6回リトリート大学院生研究発表会   19 Jan 2013   
特定のヘテロ型Keap1変異体は野性型Keap1に対してドミナントネガティブに働く
鈴木隆史、Jonathan Maher, 山本雅之
第71回日本癌学会学術総会   19 Sep 2012   
がん微小環境における酸化ストレス防御機構の意義
鈴木隆史
新学術領域研究「がん微小環境ネットワークの統合的研究」班会議   5 Jul 2012   
In vivo validation of the multiple sensing mechanism of the Keap1-Nrf2 system.
Takafumi Suzuki, Kai Takaya, Hozumi Motohashi, Thomas W Kensler and Masayuki Yamamoto.
The 33rd NAITO conference on Oxygen Biology: Hypoxia, Oxidative stress and Diseases   26 Jun 2012   
Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.
鈴木隆史、Jonathan Maher, 山本雅之
第78回日本生化学会東北支部例会   26 May 2012   
4NQO誘発舌がんにおけるKeap1-Nrf2系の役割
大越明、鈴木隆史、小林俊光、山本雅之
第147回日本耳鼻咽喉科学会宮城県地方部会学術講演会   18 Mar 2012   
トランスジェニックマウスを用いたKeap1-Nrf2システムの機能解析
鈴木隆史、山本雅之
東北大学Network Medicine GCOE冬の合宿2012   4 Feb 2012   
含セレン蛋白質とNrf2による酸化ストレス防御機構の脳発達時期における役割
大越明、鈴木隆史、西島維知子、山本雅之
第34回日本分子生物学会年会   13 Dec 2011   
Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.
Takafumi Suzuki, Jonathan Maher, Masayuki Yamamoto
16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine   6 Oct 2011   
マウス遺伝学解析に基盤とするKeap1-Nrf2システムの解明
山本雅之、鈴木隆史、田口恵子、本橋ほづみ
第70回日本癌学会学術総会   3 Oct 2011   
Keap1による多様なストレス感知機構の実証
高屋快、鈴木隆史、山本雅之
第84回日本生化学会   21 Sep 2011   
Keap1による多様なストレス感知機構
高屋快、鈴木隆史、本橋ほづみ、山本雅之
新学術領域研究「活性酸素シグナル」第6回班会議   14 May 2011   
Complementary Contribution of Nrf2 Gene Battery and Selenoproteins to Antioxidative Stress Response
Takafumi Suzuki
Seminar of School of Biochemistry and Immunology Trinity College Dublin   27 Jan 2011   
Complementary contribution of Nrf2 gene battery and selenoproteins to antioxidative stress response.
Masayuki Yamamoto, Takafumi Suzuki, Yukie Kawatani, and Vincent Kelly
9th international Symposium on Selenium in Biology and Medicine Selenium 2010.   31 May 2010   
Deletion of selenocysteine tRNA gene results in compensatory gene induction of cytoprotective enzymes by Nrf2.
Takafumi Suzuki, Yukie Kawatani, Akira Okoshi, Vincent Kelly, and Masayuki Yamamoto.
9th international Symposium on elenium in Biology and Medicine Selenium 2010.   31 May 2010   
Hematopoietic deficiency of Nrf2 and selenoproteins leads to severe defects in erythrocytes and lymphocytes.
Yukie Kawatani, Takafumi Suzuki, Vincent Kelly, and Masayuki Yamamoto.
9th international Symposium on elenium in Biology and Medicine Selenium 2010.   31 May 2010   
Cytoprotective systems of skin by selenoproteins and Nrf2.
Mariko Takayama, Takafumi Suzuki, Kai Takaya, Ryuhei Okuyama and Masayuki Yamamoto.
9th international Symposium on elenium in Biology and Medicine Selenium 2010.   31 May 2010   
含セレン蛋白質とNrf2による酸化ストレスに対する2段階防御
山本雅之、鈴木隆史、川谷幸恵、大越明、ケリー・ビンセント
日本生化学会大会   21 Oct 2009   
含セレン蛋白質とNrf2による2段階生体防御機構
鈴木隆史、川谷幸恵、大越明、Vincent Kelly、山本雅之
日本生化学会大会   21 Oct 2009   
Nrf2-Keap1ストレス応答系は両刃の剣:発癌支持作用と化学発癌予防作用
山本雅之、柴田龍弘、太田力、Kit Tong、黒河博文、鈴木隆史、田口恵子、本橋ほづみ
第68回日本癌学会学術総会   1 Oct 2009   
Nrf2は肺における新規転移抑制因子として働く
佐藤大希、田口恵子、森口尚、鈴木隆史、海老名雅仁、貫和敏博、山本雅之
第68回日本癌学会学術総会   1 Oct 2009   
Double-edged Sword of the Nrf2-Keap1 Stress Response System; Carcinogenesis and Cancer Chemoprevention.
Masayuki Yamamoto, Tatsuhiro Shibata, Ohta Tsutomu, Kit Tong, Hirofumi Kurokawa, Takafumi Suzuki, Keiko Taguchi, and Hozumi Motohashi.
第68回 日本癌学会学術総会シンポジウム   1 Oct 2009   
Select heterozygous Keap1 mutations have a dominant-negative effect on wildtype Keap1 in vivo.
Takafumi Suzuki, Jonathan Maher, Yukie Kawatani, Masayuki Yamamoto.
International symposium 2009 on Signaling Functions of Reactive Oxygen Species   18 Jun 2009   
生体におけるKeap1/Nrf2制御系の機能貢献と応答機構
本橋ほづみ、藤田理恵、鈴木隆史、Kit Tong、黒河博文、山本雅之
第62回日本酸化ストレス学会   11 Jun 2009   
含セレン蛋白質とNrf2による2段階生体防御機構
鈴木隆史、川谷幸恵、Vincent Kelly、山本雅之
第62回日本酸化ストレス学会   11 Jun 2009   
Select heterozygous Keap1 mutations have a dominant-negative effect on wild type Keap1 in vivo
Takafumi Suzuki, Jonathan Maher, Yukie Kawatani, Masayuki Yamamoto
JST-international symposium “Molecular Mechanism of Environmental Response to Food and Oxygen III”   9 Feb 2009   
Clara-cell specific Keap1 conditional knockout mice have pulmonary hyperkeratosis and hyperplasia, and are sensitive to bleomycin-induced lung Injury
Jonathan Maher, Takafumi Suzuki, Keiko Taguchi, Yukie Kawatani, Momoko Kimura, Hozumi Motohashi, Jeffrey Whitsett, Masahito Ebina, Yukio Ishii, Masayuki Yamamoto
JST-international symposium “Molecular Mechanism of Environmental Response to Food and Oxygen III”   9 Feb 2009   
Deletion of selenocysteine tRNA gene results in compensatory gene induction of cytoprotective enzymes by Nrf2
Yukie Kawatani, Takafumi Suzuki, Vincent Kelly, and Masayuki Yamamoto
JST-international symposium “Molecular Mechanism of Environmental Response to Food and Oxygen III”   9 Feb 2009   
Keap1変異体によるドミナントネガティブ効果のトランスジェニックレスキュー法を用いた検証
鈴木隆史、Jonathan Maher、川谷幸恵、山本雅之
日本分子生物学会   9 Dec 2008   
転写因子Nrf2の恒常的活性化による組織学的変化
田口恵子、Jonathan M. Maher、川谷幸恵、鈴木隆史、山本雅之
2008年度がん若手ワークショップ   3 Sep 2008   
Deletion of Selenocysteine tRNA Gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2
鈴木隆史
第二回セレン研究会   4 Aug 2008   
SeCys-tRNA遺伝子条件付き遺伝子破壊マウスを用いた造血幹細胞におけるNrf2の生理的意義
川谷幸恵、鈴木隆史、Vincent Kelly、山本雅之
第二回セレン研究会   4 Aug 2008   
トランスジェニックレスキュー法を用いたKeap1変異体によるドミナントネガティブ効果の検証
鈴木隆史、Jonathan Maher、山本雅之
遺伝情報DECODE平成20年度合同班会議   30 Jun 2008   
SeCys-tRNA遺伝子条件付き破壊マウスを用いた造血組織におけるNrf2の生理的意義
川谷幸恵、鈴木隆史、Vincent Kelly、山本雅之
遺伝情報DECODE平成20年度合同班会議   30 Jun 2008   
Clara-cell specific Keap1 conditinal knockout mice have strong Nrf2 activation but are sensitive to bleomycin-induced lung injury.
Jonathan Maher, Takafumi Suzuki, Keiko Taguchi, Yukie Kawatani, Hozumi Motohashi, Yukio Ishii, Masayuki Yamamoto.
The 21st NAITO conference on Nuclear Dynamics and RNA [I]   24 Jun 2008   
Phenotypic analyses of constitutive Nrf2 activation by partially disruption of Keap1
Keiko Taguchi, Martin Y. Pfeiffer, Jonathan M. Maher, Yukie Kawatani, Takafumi Suzuki and Masayuki Yamamoto.
Environmental Response Project International Symposium “The Enviromental Response” in Tsukuba   21 Dec 2007   
Deciphering Key Reactive Cysteines that Determine Nrf2 Activation In Vivo.
Takafumi Suzuki, Tae Yamamoto, Akira Kobayashi, Junko Wakabayashi, Jonathan Maher, Hozumi Motohashi, and Masayuki Yamamoto.
The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium “The Enviromental Response” in Tsukuba   21 Dec 2007   
Hematopoietic Cell Differentiation in SeCys tRNA Gene Conditional Knockout Mice.
Yukie Kawatani, Takafumi Suzuki, Vincent Kelly, Susumu Nishimura, and Masayuki Yamamoto.
The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium “The Enviromental Response” in Tsukuba   21 Dec 2007   
Clara-Cell Specific Keap1 Conditional Knockout Mice have strong Nrf2 Activation but are Sensitive to Bleomycin-induced lung Injury.
Jonathan Maher, Takafumi Suzuki, Keiko Taguchi, Yukie Kawatani, Hozumi Motohashi, Yukio Ishii, Masayuki Yamamoto.
The 2nd JST-ERATO Yamamoto Environmental Response Project International Symposium “The Enviromental Response” in Tsukuba   21 Dec 2007   
Clara-Cell Specific Keap1 Conditional Knockout Mice have strong Nrf2 Activation but are Sensitive to Bleomycin-induced lung Injury.
Jonathan Maher, Takafumi Suzuki, Keiko Taguchi, Yukie Kawatani, Hozumi Motohashi, Yukio Ishii, Masayuki Yamamoto.
The 8 th International ISSX Meeting in Sendai   9 Oct 2007   
Deletion of the Selenocysteine tRNA Gene (Trsp) in Macrophage and Liver Results in Compensatory Gene Induction of Cytoprotective Enzymes by the Nrf2 Transcription Factor
Takafumi Suzuki1, Vincent P. Kelly1,4, Osamu Nakajima2,3, Satoru Takahashi2, Hozumi Motohashi2, Susumu Nishimura4 and Masayuki Yamamoto1,2
The 8th AEARU Joint Workshop on Life Sciences   4 Nov 2006   
Molecular Mechanisms of Nrf2-Keap1 Response against Oxidative and Electrophilic Stresses. [Invited]
Masayuki Yamamoto, Kit I. Tong, Akira Kobayashi, Takafumi Suzuki, Tae Yamamoto, Hozumi Motohashi, Ken Itoh.
The 20th IUBMB Congress and 11th FAOBMB Congress   18 Jun 2006   
Molecular Mechanisms of Nrf2-Keap1 Response against Oxidative and Electrophilic Stress. [Invited]
Masayuki Yamamoto, Kit Y. Tong, Akira Kobayashi, Takafumi Suzuki, Tae Yamamoto, Hozumi Motohashi, Ken Itoh.
20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress   18 Jun 2006   
Functional Analysis of Keap1 in vivo as a Electrophile-Responsive Regulator of Nrf2.
Takafumi Suzuki, Tae Yamamoto, Akira Kobayashi, Hozumi Motohashi, and Masayuki Yamamoto.
The 1st Asia Pacific ISSX Meeting   18 Jun 2006   
Players Regulating and Supporting Cytoprotective Function of Nrf2. [Invited]
Hozumi Motohashi, Takafumi Suzuki, Hiromi Okawa, Kit tong, Fumiki Katsuoka, Akira Kobayashi, and Masayuki Yamamoto.
The 1st Asia Pacific ISSX Meeting   24 May 2006   
Regulation by Nrf2-Keap1 System of Cellular Defense Mechanisms against Electrophiles and Carcinogenesis. [Invited]
Masayuki Yamamoto, Takafumi Suzuki, Kit Y. Tong and Akira Kobayashi.
CNIO Cancer Conference on "Inflammation and Cancer"   22 May 2006   
Transgenic complementation analysis of Nrf2-Keap1 system regulating cellular defense mechanisms against electrophiles and reactive oxygen species. [Invited]
Masayuki Yamamoto, Takafumi Suzuki, Tae Yamamoto, Hiromi Okawa and Hozumi Motohashi.
HUGO Asia-Pacific 06; Animal Models of Human Diseases   6 Mar 2006   
Macrophage-specific disruption of selenocysteine tRNA gene revealed Nrf2-mediated compensatory mechanisms.
Takafumi Suzuki, Vincent Kelly, Osamu Nakajima, Hozumi Motohashi, Susumu Nishimura, and Masayuki Yamamoto.
JST-ERATO Yamamoto Environmental Response Project International Symposium   10 Mar 2005   
Transcriptional regulation of zebrafish GSTP gene.
Takafumi Suzuki, Yaeko Takagi, Hitoshi Osanai, Makoto Kobayashi, Masayuki Yamamoto.
JBS Bio-Frontier Symposium 2003   5 Jun 2003   
Identification of the phylogenic conservation of the Nrf2-Keap1 system regulating detoxification and antioxidant enzymes.
Makoto Kobayashi Ken Itoh, Takafumi Suzuki, Hitoshi Osanai, Keizo Nishikawa, Yasutake Katoh, Yaeko Takagi, Masayuki Yamamoto.
5th International Conference on Zebrafish Development & Genetics   12 Jun 2002   
Gene regulation of the zebrafish Six4 in the cranial sensory placodes
Makoto Kobayashi, Takafumi Suzuki, Masayuki Yamamoto.
14th International Congress of Development Biology   8 Jul 2001   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(スタートアップ))
Project Year: 2008 - 2009    Investigator(s): Takafumi SUZUKI
In this study, we investigated the physiological function of stress sensor Keap1 by mouse genetics. We have found that partial repression of Keap1 leads to activation of transcriptional factor Nrf2, resulting in up-regulation of detoxifying enzyme...

Others

 
Sep 2010
Institutional Program for Young Researcher Overseas Visits