Akifumi Kushiyama

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Name
Akifumi Kushiyama
Nickname
Kushiyama
Affiliation
The Institute for Adult Diseases, Asahi Life Foundation
Job title
Chief Researcher
Research funding number
30435820
ORCID ID
0000-0003-1385-7487

Research Areas

 

Academic & Professional Experience

 
Apr 2019
 - 
Today
Professor, Dept. Pharmacotherapy, Meiji Pharmaceutical University
 
Apr 2010
 - 
Mar 2019
Professor, The Institute for Adult Diseases, Asahi Life Foundation
 
2006
 - 
2019
Assistant Professor, The Institute for Adult Diseases, Asahi Life Foundation
 

Awards & Honors

 
2015
Poster Presentation Award, 6th MCCII
 
2013
Grant-in-Aid for Scientific Research(C)
 
2012
Banyu Foundation Research Grant
 
2011
Grant-in-Aid for Young Scientists(B)
 
May 2010
Physiological role and pathogenesis in insulin resistance of macrophage derived Resistin like molecule beta, President Poster, Japan Diabetes Society
 
2009
Grant-in-Aid for Young Scientists (B)
 
2009
Takeda Science Foundation
 
2008
Japan Heart Foundation Grant For Research on Arteriosclerosis Update
 
2007
Grant-in-Aid for Young Scientists (B)
 

Published Papers

 
Sonoda R, Tanaka K, Kikuchi T, Onishi Y, Takao T, Tahara T, Yoshida Y, Suzawa N, Kawazu S, Iwamoto Y, Kushiyama A, PloS one, vol. 11, no. 2, pp. e0147303
PloS one   11(2) e0147303   2016   [Refereed]
Sonoda R, Tanaka K, Kikuchi T, Onishi Y, Takao T, Tahara T, Yoshida Y, Suzawa N, Kawazu S, Iwamoto Y, Kushiyama A, PloS one, 2016, vol. 11, no. 2, pp. e0147303
Okubo H, Kushiyama A, Nakatsu Y, Yamamotoya T, Matsunaga Y, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Asano T
International journal of molecular sciences   19(10)    Oct 2018   [Refereed]
Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T, Scientific reports, vol. 6, pp. 20157
Scientific reports   6 20157   Jan 2016   [Refereed]
Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T, Scientific reports, 2016, vol. 6, pp. 20157
Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y, Inoue MK, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Ono H, Asano T
Current medicinal chemistry   25(9) 984-1001   2018   [Refereed]
Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T, The Journal of biological chemistry, vol. 290, no. 40, pp. 24255-24266
The Journal of biological chemistry   290(40) 24255-24266   Oct 2015   [Refereed]
Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T, The Journal of biological chemistry, 2015, vol. 290, no. 40, pp. 24255...
Yamazaki H, Kushiyama A, Sakoda H, Fujishiro M, Yamamotoya T, Nakatsu Y, Kikuchi T, Kaneko S, Tanaka H, Asano T
Mediators of inflammation   2018 3062319   2018   [Refereed]
Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T, American journal of physiology. Endocrinology, metabolism, vol. 309, no. 3, pp. E214-23
American journal of physiology. Endocrinology and metabolism   309(3) E214-23   Aug 2015   [Refereed]
Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T, American journal of physiology. Endocrinology and metabolism, 2015, vol. 309, no. 3, pp. E214-23
Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T
Scientific reports   7(1) 13026   Oct 2017   [Refereed]
Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F, Obesity, Silver Spring, Md.), vol. 23, no. 7, pp. 1460-1471
Obesity (Silver Spring, Md.)   23(7) 1460-1471   Jul 2015   [Refereed]
Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F, Obesity (Silver Spring, Md.), 2015, vol. 23, no. 7, pp. 1460-1471
Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology   31(9) 4053-4063   Sep 2017   [Refereed]
Nakatsu Y, Seno Y, Kushiyama A, Sakoda H, Fujishiro M, Katasako A, Mori K, Matsunaga Y, Fukushima T, Kanaoka R, Yamamotoya T, Kamata H, Asano T, American journal of physiology. Gastrointestinal, liver physiology, vol. 309, no. 1, pp. G42-51
American journal of physiology. Gastrointestinal and liver physiology   309(1) G42-51   Jul 2015   [Refereed]
Nakatsu Y, Seno Y, Kushiyama A, Sakoda H, Fujishiro M, Katasako A, Mori K, Matsunaga Y, Fukushima T, Kanaoka R, Yamamotoya T, Kamata H, Asano T, American journal of physiology. Gastrointestinal and liver physiology, 2015, vol. 309, no. 1, pp. G42-51
Fujishiro M, Kushiyama A, Yamazaki H, Kaneko S, Koketsu Y, Yamamotoya T, Kikuchi T, Sakoda H, Suzuki R, Kadowaki T
World journal of gastroenterology   23(36) 6694-6704   Sep 2017   [Refereed]
Nakatsu Y, Kokubo H, Bumdelger B, Yoshizumi M, Yamamotoya T, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Fujishiro M, Kushiyama A, Ono H, Sakoda H, Asano T
International journal of molecular sciences   18(8)    Aug 2017   [Refereed]
Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T
American journal of physiology. Gastrointestinal and liver physiology   308(2) G151-8   Jan 2015   [Refereed]
Tanaka K, Hara S, Hattori M, Sakai K, Onishi Y, Yoshida Y, Kawazu S, Kushiyama A, Journal of diabetes investigation, vol. 6, no. 1, pp. 98-104
Journal of diabetes investigation   6(1) 98-104   Jan 2015   [Refereed]
Tanaka K, Hara S, Hattori M, Sakai K, Onishi Y, Yoshida Y, Kawazu S, Kushiyama A, Journal of diabetes investigation, 2015, vol. 6, no. 1, pp. 98-104
Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T
The Journal of biological chemistry   292(28) 11886-11895   Jul 2017   [Refereed]
Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, Tsuchiya Y, Sakoda H, Fujishiro M, Yamamotoya T, Kamata H, Matsubara A, Asano T, PloS one, vol. 10, no. 6, pp. e0127467
PloS one   10(6) e0127467   2015   [Refereed]
Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, Tsuchiya Y, Sakoda H, Fujishiro M, Yamamotoya T, Kamata H, Matsubara A, Asano T, PloS one, 2015, vol. 10, no. 6, pp. e0127467
Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, Sakoda H
International journal of molecular sciences   18(2)    Feb 2017   [Refereed]
Nakarai H, Yamashita A, Nagayasu S, Iwashita M, Kumamoto S, Ohyama H, Hata M, Soga Y, Kushiyama A, Asano T, Abiko Y, Nishimura F
Innate immunity   18(1) 164-170   Feb 2012   [Refereed]
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T
American journal of physiology. Endocrinology and metabolism   302(3) E286-96   Feb 2012   [Refereed]
Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T
Diabetology & metabolic syndrome   7 50   2015   [Refereed]
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T
Arteriosclerosis, thrombosis, and vascular biology   32(2) 291-298   Feb 2012   [Refereed]
Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T
Mediators of inflammation   2015 125380   2015   [Refereed]
Tanaka K, Hara S, Kushiyama A, Ubara Y, Yoshida Y, Mizuiri S, Aikawa A, Kawatzu S
Clinical and experimental nephrology   15(3) 391-397   Jun 2011   [Refereed]
Qiang S, Nakatsu Y, Seno Y, Fujishiro M, Sakoda H, Kushiyama A, Mori K, Matsunaga Y, Yamamotoya T, Kamata H, Asano T, Diabetology, metabolic syndrome, vol. 7, pp. 104
Diabetology & metabolic syndrome   7 104   2015   [Refereed]
Qiang S, Nakatsu Y, Seno Y, Fujishiro M, Sakoda H, Kushiyama A, Mori K, Matsunaga Y, Yamamotoya T, Kamata H, Asano T, Diabetology & metabolic syndrome, 2015, vol. 7, pp. 104
Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T
International journal of molecular sciences   17(9)    Sep 2016   [Refereed]
Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T
American journal of physiology. Cell physiology   293(5) C1576-85   Nov 2007   [Refereed]
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi S, Kurihara H, Uchida T, Asano T
The Journal of biological chemistry   286(23) 20812-20822   Jun 2011   [Refereed]
Kushiyama A, Kikuchi T, Tanaka K, Tahara T, Takao T, Onishi Y, Yoshida Y, Kawazu S, Iwamoto Y
World journal of diabetes   7(11) 230-238   Jun 2016   [Refereed]
Asano T, Fujishiro M, Kushiyama A, Nakatsu Y, Yoneda M, Kamata H, Sakoda H
Biological & pharmaceutical bulletin   30(9) 1610-1616   Sep 2007   [Refereed]
Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K, Inoue Y, Sakoda H, Fujishiro M, Ono H, Asano T
Mediators of inflammation   2016 8603164   2016   [Refereed]
Physiological significance of resistin and resistin-like molecules in the inflammatory process and insulin resistance.
Asano T, Sakosda H, Fujishiro M, Anai M, Kushiyama A, Horike N, Kamata H, Ogihara T, Kurihara H, Uchijima Y
Current diabetes reviews   2(4) 449-454   Nov 2006   [Refereed]
Viana AY, Sakoda H, Anai M, Fujishiro M, Ono H, Kushiyama A, Fukushima Y, Sato Y, Oshida Y, Uchijima Y, Kurihara H, Asano T
Diabetes research and clinical practice   73(2) 135-142   Aug 2006   [Refereed]
Sakoda H, Fujishiro M, Fujio J, Shojima N, Ogihara T, Kushiyama A, Fukushima Y, Anai M, Ono H, Kikuchi M, Horike N, Viana AY, Uchijima Y, Kurihara H, Asano T
American journal of physiology. Endocrinology and metabolism   289(3) E474-81   Sep 2005   [Refereed]
Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, Fujishiro M, Sakoda H, Shojima N, Kushiyama A, Fukuda S, Anai M, Ono H, Oka M, Shimizu Y, Kurihara H, Nagai R, Ishikawa T, Asano T, Omata M
European journal of pharmacology   502(3) 243-252   Oct 2004   [Refereed]
Fukushima Y, Ishikawa T, Saitoh T, Tateishi K, Ogihara T, Fujishiro M, Shojima N, Honda M, Kushiyama A, Anai M, Sakoda H, Ono H, Onishi Y, Otsuka H, Katagiri H, Nagai R, Omata M, Asano T
Digestion   68(2-3) 145-152   2003   [Refereed]
Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T, American journal of physiology. Gastrointestinal, liver physiology, vol. 308, no. 2, pp. G151-8
308(2) G151-8   Jan 2015   [Refereed]
Okubo H, Nakatsu Y, Sakoda H, Kushiyama A, Fujishiro M, Fukushima T, Matsunaga Y, Ohno H, Yoneda M, Kamata H, Shinjo T, Iwashita M, Nishimura F, Asano T, American journal of physiology. Gastrointestinal and liver physiology, 2015, vol. 308, no. 2,...
Kushiyama A, Tanaka K, Hara S, Kawazu S
World journal of diabetes   5(6) 787-795   Dec 2014   [Refereed]
Hashikata A, Yamashita A, Suzuki S, Nagayasu S, Shinjo T, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Asano T, Abiko Y, Kushiyama A, Nagasaka S, Nishimura F
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   29(3) 611-618   Mar 2014   [Refereed]
Okubo H, Sakoda H, Kushiyama A, Fujishiro M, Nakatsu Y, Fukushima T, Matsunaga Y, Kamata H, Asahara T, Yoshida Y, Chonan O, Iwashita M, Nishimura F, Asano T
American journal of physiology. Gastrointestinal and liver physiology   305(12) G911-8   Dec 2013   [Refereed]
Kushiyama A, Yoshida Y, Kikuchi T, Suzawa N, Yamamoto M, Tanaka K, Okayasu M, Tahara T, Takao T, Onishi Y, Kawazu S
Journal of diabetes investigation   4(6) 540-545   Nov 2013   [Refereed]
Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T
Arteriosclerosis, thrombosis, and vascular biology   33(8) 1986-1993   Aug 2013   [Refereed]
Zhang J, Nakatsu Y, Shinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T
The Journal of biological chemistry   288(28) 20692-20701   Jul 2013   [Refereed]
Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T
Biochemical and biophysical research communications   434(2) 197-202   May 2013   [Refereed]
Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T
Adipocyte   2(1) 28-32   Jan 2013   [Refereed]
Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuch T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T
The Journal of biological chemistry   287(53) 44526-44535   Dec 2012   [Refereed]
Kumamoto S, Kushiyama A, Nakatsu Y, Sakoda H, Fujishiro M, Iwashita M, Ohno H, Zhang J, Guo Y, Aburatani H, Kamata H, Nishimura F, Asano T
Obesity research & clinical practice   6(4) e263-346   Oct 2012   [Refereed]
Kikuchi T, Zhang J, Sakoda H, Koketsu Y, Fujishiro M, Kushiyama A, Nakatsu Y, Kamata H, Inoki K, Takahashi S, Kurihara H, Hideki K, Oka Y, Asano T
Obesity research & clinical practice   6(3) e175-262   Jul 2012   [Refereed]
Kikuchi T, Zhang J, Sakoda H, Koketsu Y, Fujishiro M, Kushiyama A, Nakatsu Y, Kamata H, Inoki K, Takahashi S, Kurihara H, Hideki K, Oka Y, Asano T, Obesity research & clinical practice, 2012, vol. 6, no. 3, pp. e175-262
Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
American journal of physiology. Cell physiology   300(5) C1047-54   May 2011   [Refereed]
Matsuzaki G, Kushiyama A, Uto K, Shoda M, Seko Y
BMJ case reports   2011    Feb 2011   [Refereed]
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi S, Kurihara H, Uchida T, Asano T
The Journal of biological chemistry   285(43) 33018-33027   Oct 2010   [Refereed]
Yoneda M, Guo Y, Ono H, Nakatsu Y, Zhang J, Cui X, Iwashita M, Kumamoto S, Tsuchiya Y, Sakoda H, Fujishiro M, Kushiyama A, Koketsu Y, Kikuchi T, Kamata H, Nishimura F, Asano T
Obesity research & clinical practice   4(3) e163-246   Jul 2010   [Refereed]
Horike N, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Kamata H, Nishiyama K, Uchijima Y, Kurihara Y, Kurihara H, Asano T
The Journal of biological chemistry   283(49) 33902-33910   Dec 2008   [Refereed]
Koketsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima Y, Ono H, Anai M, Kikuchi T, Fukuda T, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T
American journal of physiology. Endocrinology and metabolism   294(4) E719-25   Apr 2008   [Refereed]
Fujio J, Kushiyama A, Sakoda H, Fujishiro M, Ogihara T, Fukushima Y, Anai M, Horike N, Kamata H, Uchijima Y, Kurihara H, Asano T.
Diabetes Res Clin Pract. 2008 Jan;79(1):2-10.   
Kushiyama A, Shojima N, Ogihara T, Inukai K, Sakoda H, Fujishiro M, Fukushima Y, Anai M, Ono H, Horike N, Viana AY, Uchijima Y, Nishiyama K, Shimosawa T, Fujita T, Katagiri H, Oka Y, Kurihara H, Asano T.
J Biol Chem. 2005 Dec 23;280(51):42016-25.   
Shojima N, Ogihara T, Inukai K, Fujishiro M, Sakoda H, Kushiyama A, Katagiri H, Anai M, Ono H, Fukushima Y, Horike N, Viana AY, Uchijima Y, Kurihara H, Asano T.
Diabetologia. 2005 May;48(5):984-92.   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2009 - 2010    Investigator(s): Akifumi KUSHIYAMA
We revealed the innate immune reaction induced by macrophage-derived RELMβ played important roles in atherogenesis.
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2007 - 2008    Investigator(s): Akifumi KUSHIYAMA
Resistin like molecule beta (RELMβ) exhibited endothelial growth activity, migration activity, and angiogenesis progression, whereas endothelial dysfunction. Elevated serum RELMβ resulted atherosclerosis progression in vivo. It was suggested that ...
The linkage of diabetes and atherosclerosis