Koji Nata

J-GLOBAL         Last updated: Oct 3, 2018 at 19:12
 
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Name
Koji Nata
URL
http://gaia-sb.iwate-med.ac.jp/pharm/?page_id=48
Affiliation
Iwate Medical University
Section
School of Pharmacy
Job title
Professor
Degree
M.D. & Ph.D(Tohoku University)
Research funding number
90202233

Research Areas

 
 

Academic & Professional Experience

 
Apr 2007
 - 
Today
Professor, Iwate Medical School School of Pharamacy
 
Apr 1990
 - 
Mar 2007
Research associate, Tohoku University
 
Apr 1988
 - 
Mar 1990
Research fellowship for young scientists, Japan Society for the Promotion of Science
 

Education

 
Apr 1985
 - 
Mar 1988
Graduate School of Medicine, Tohoku University
 
Apr 1978
 - 
Mar 1984
School of Medicine, Toyama Medical and Pharmaceutical University
 

Published Papers

 
Takahashi I, Yamada S, Nata K
Molecular and cellular endocrinology   470 142-150   Jul 2018   [Refereed]
Recombinant Human REG Iα Aggregates Staphylococcus aureus—Exhibits a Lectin-Like Function
Jamal N, Kezuka Y, Nonaka T, Ohashi K, Nata K
Advances in Bioscience and Biotechnology   8 79-90   Mar 2017   [Refereed]
Murakami-Kawaguchi S, Takasawa S, Onogawa T, Nata K, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Yamauchi A, Ota H, Takeda M, Kato M, Okamoto H
Cell and tissue research   355 303-314   Feb 2014   [Refereed]
Nakagawa K, Takasawa S, Nata K, Yamauchi A, Itaya-Hironaka A, Ota H, Yoshimoto K, Sakuramoto-Tsuchida S, Miyaoka T, Takeda M, Unno M, Okamoto H
Biochimica et biophysica acta   1833 2988-2995   Dec 2013   [Refereed]
Takahashi I, Ohashi K, Nata K
Journal of Diabetes Investigation   3(4) 362-370   Aug 2012   [Refereed]
Takahashi I, Ohashi K, Nata K
Journal of Diabetes Investigation   3(4) 362-370   Aug 2012   [Refereed]
Ikeda T, Takasawa S, Noguchi N, Nata K, Yamauchi A, Takahashi I, Yoshikawa T, Sugawara A, Yonekura H, Okamoto H
Molecular and cellular biochemistry   366 69-80   Jul 2012   [Refereed]
Uruno A, Noguchi N, Matsuda K, Nata K, Yoshikawa T, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A
Journal of leukocyte biology   90(2) 235-247   Aug 2011   [Refereed]
Takasawa S, Kuroki M, Nata K, Noguchi N, Ikeda T, Yamauchi A, Ota H, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takahashi I, Yoshikawa T, Shimosegawa T, Okamoto H
Biochemical and biophysical research communications   397(2) 140-145   Jun 2010   [Refereed]
Takahashi I, Noguchi N, Nata K, Yamada S, Kaneiwa T, Mizumoto S, Ikeda T, Sugihara K, Asano M, Yoshikawa T, Yamauchi A, Shervani NJ, Uruno A, Kato I, Unno M, Sugahara K, Takasawa S, Okamoto H, Sugawara A
Biochemical and biophysical research communications   383(1) 113-118   May 2009   [Refereed]
Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda T, Yoshikawa T, Shervani NJ, Suzuki I, Uruno A, Unno M, Okamoto H, Sugawara A
Biochemical and biophysical research communications   379(3) 743-748   Feb 2009   [Refereed]
Noguchi N, Yoshikawa T, Ikeda T, Takahashi I, Shervani NJ, Uruno A, Yamauchi A, Nata K, Takasawa S, Okamoto H, Sugawara A
Biochemical and biophysical research communications   371(4) 735-740   Jul 2008   [Refereed]
Takasawa S, Ikeda T, Akiyama T, Nata K, Nakagawa K, Shervani NJ, Noguchi N, Murakami-Kawaguchi S, Yamauchi A, Takahashi I, Tomioka-Kumagai T, Okamoto H
FEBS letters   580(2) 585-591   Jan 2006   [Refereed]
Nakazawa T, Takasawa S, Noguchi N, Nata K, Tohgo A, Mori M, Nakagawara K, Akiyama T, Ikeda T, Yamauchi A, Takahashi I, Yoshikawa T, Okamoto H
Gene   360(1) 55-64   Oct 2005   [Refereed]
Shervani NJ, Takasawa S, Uchigata Y, Akiyama T, Nakagawa K, Noguchi N, Takada H, Takahashi I, Yamauchi A, Ikeda T, Iwamoto Y, Nata K, Okamoto H
European journal of clinical investigation   34(11) 752-758   Nov 2004   [Refereed]
Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, Onogawa T, Takasawa S, Okamoto H
Gene   340(1) 161-170   Sep 2004   [Refereed]
Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice.
Unno M, Nata K, Noguchi N, Narushima Y, Akiyama T, Ikeda T, Nakagawa K, Takasawa S, Okamoto H
Diabetes   51 Suppl 3 S478-83   Dec 2002   [Refereed]
Akiyama T, Takasawa S, Nata K, Kobayashi S, Abe M, Shervani NJ, Ikeda T, Nakagawa K, Unno M, Matsuno S, Okamoto H
Proceedings of the National Academy of Sciences of the United States of America   98(1) 48-53   Jan 2001   [Refereed]
Abe M, Nata K, Akiyama T, Shervani NJ, Kobayashi S, Tomioka-Kumagai T, Ito S, Takasawa S, Okamoto H
Gene   246(1-2) 111-122   Apr 2000   [Refereed]
Kobayashi S, Akiyama T, Nata K, Abe M, Tajima M, Shervani NJ, Unno M, Matsuno S, Sasaki H, Takasawa S, Okamoto H
The Journal of biological chemistry   275(15) 10723-10726   Apr 2000   [Refereed]
Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system.
Okamoto H, Takasawa S, Nata K, Kato I, Tohgo A, Noguchi N
Chemical immunology   75 121-145   2000   [Refereed]
Yagui K, Shimada F, Mimura M, Hashimoto N, Suzuki Y, Tokuyama Y, Nata K, Tohgo A, Ikehata F, Takasawa S, Okamoto H, Makino H, Saito Y, Kanatsuka A
Diabetologia   41(9) 1024-1028   Sep 1998   [Refereed]
Ikehata F, Satoh J, Nata K, Tohgo A, Nakazawa T, Kato I, Kobayashi S, Akiyama T, Takasawa S, Toyota T, Okamoto H
The Journal of clinical investigation   102(2) 395-401   Jul 1998   [Refereed]
Takasawa S, Akiyama T, Nata K, Kuroki M, Tohgo A, Noguchi N, Kobayashi S, Kato I, Katada T, Okamoto H
The Journal of biological chemistry   273(5) 2497-2500   Jan 1998   [Refereed]
Okamoto H, Takasawa S, Nata K
Diabetologia   40(12) 1485-1491   Dec 1997   [Refereed]
[Structure and biological function of Reg genes and Reg proteins].
Unno M, Nata K, Narushima Y, Takasawa S, Okamoto H, Matsuno S
Nihon rinsho. Japanese journal of clinical medicine   55 Suppl 817-821   Nov 1997   [Refereed]
Noguchi N, Takasawa S, Nata K, Tohgo A, Kato I, Ikehata F, Yonekura H, Okamoto H
The Journal of biological chemistry   272(6) 3133-3136   Feb 1997   [Refereed]
Tohgo A, Munakata H, Takasawa S, Nata K, Akiyama T, Hayashi N, Okamoto H
The Journal of biological chemistry   272(7) 3879-3882   Feb 1997   [Refereed]
Nata K, Takamura T, Karasawa T, Kumagai T, Hashioka W, Tohgo A, Yonekura H, Takasawa S, Nakamura S, Okamoto H
Gene   186(2) 285-292   Feb 1997   [Refereed]
Okamoto H, Takasawa S, Tohgo A, Nata K, Kato I, Noguchi N
Methods in enzymology   280 306-318   1997   [Refereed]
Deficiency of Phenylethanolamine N-Methyltransferase in Norepinephrine-Producing Pheochromocytoma.
Kimura N, Togo A, Sugimoto T, Nata K, Okamoto H, Nagatsu I, Nagura H
Endocrine pathology   7 131-136   1996   [Refereed]
Kato I, Takasawa S, Akabane A, Tanaka O, Abe H, Takamura T, Suzuki Y, Nata K, Yonekura H, Yoshimoto T
The Journal of biological chemistry   270(50) 30045-30050   Dec 1995   [Refereed]
Takasawa S, Ishida A, Nata K, Nakagawa K, Noguchi N, Tohgo A, Kato I, Yonekura H, Fujisawa H, Okamoto H
The Journal of biological chemistry   270(51) 30257-30259   Dec 1995   [Refereed]
Nata K, Sugimoto T, Tohgo A, Takamura T, Noguchi N, Matsuoka A, Numakunai T, Shikama K, Yonekura H, Takasawa S
Gene   158(2) 213-218   Jun 1995   [Refereed]
Nakagawara K, Mori M, Takasawa S, Nata K, Takamura T, Berlova A, Tohgo A, Karasawa T, Yonekura H, Takeuchi T
Cytogenetics and cell genetics   69(1-2) 38-39   1995   [Refereed]
Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.
Tohgo A, Takasawa S, Noguchi N, Koguma T, Nata K, Sugimoto T, Furuya Y, Yonekura H, Okamoto H
The Journal of biological chemistry   269(46) 28555-28557   Nov 1994   [Refereed]
Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.
Takasawa S, Tohgo A, Noguchi N, Koguma T, Nata K, Sugimoto T, Yonekura H, Okamoto H
The Journal of biological chemistry   268(35) 26052-26054   Dec 1993   [Refereed]
Takasawa S, Nata K, Yonekura H, Okamoto H
Science (New York, N.Y.)   262(5133) 585   Oct 1993   [Refereed]
Nata K, Sugimoto T, Kohri K, Hidaka H, Hattori E, Yamamoto H, Yonekura H, Okamoto H
Gene   130(2) 183-189   Aug 1993   [Refereed]
Cloning and structural determination of human peptide YY cDNA and gene.
Kohri K, Nata K, Yonekura H, Nagai A, Konno K, Okamoto H
Biochimica et biophysica acta   1173(3) 345-349   Jun 1993   [Refereed]
Takasawa S, Nata K, Yonekura H, Okamoto H
Science (New York, N.Y.)   259(5093) 370-373   Jan 1993   [Refereed]
Nata K, Yonekura H, Yamamoto H, Okamoto H
Biochemical and biophysical research communications   171(1) 330-335   Aug 1990   [Refereed]
Hasegawa S, Terazono K, Nata K, Takada T, Yamamoto H, Okamoto H
FEBS letters   264(1) 117-120   May 1990   [Refereed]
Sugawara A, Nata K, Inoue C, Takasawa S, Yamamoto H, Okamoto H
Biochemical and biophysical research communications   166(3) 1501-1507   Feb 1990   [Refereed]
Mosaic evolution of prepropancreatic polypeptide. II. Structural conservation and divergence in pancreatic polypeptide gene.
Yonekura H, Nata K, Watanabe T, Kurashina Y, Yamamoto H, Okamoto H
The Journal of biological chemistry   263(6) 2990-2997   Feb 1988   [Refereed]
Mosaic evolution of prepropancreatic polypeptide.
Yamamoto H, Nata K, Okamoto H
The Journal of biological chemistry   261(14) 6156-6159   May 1986   [Refereed]

Books etc

 
NANZANDO'S MEDICAL DICTIONARY
Koji Nata (Part:Joint Work)
Apr 2015   
Human CD38 and Related Molecules
Koji Nata (Part:Joint Work)
Karger   2000   
Molecular biology of the islets of Langerhans
Koji Nata (Part:Joint Work)
Cambridge   1990   

Conference Activities & Talks

 
Molecular cloning, expression and chromosomal localization of novel human REG family gene, REG III.
Koji Nata
American Diabetes Association 65th Scientific Sessions   Jun 2005   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Koji NATA
EXTL3 functions as a glycosyltransferase involved in heparan sulfate proteoglycans biosynthesis. We generated pancreatic β-cell specific Extl3 knockout (βExtl3KO) mice. In βExtl3KO mice at 2-8 weeks old, the β-cell proliferation activity was decre...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2006 - 2007    Investigator(s): Koji NATA
Reg (Regenerating gene) gene encodes a secretory protein that induces pancreatic 13-cell proliferation as an autocrine/paracrine growth factor via Reg receptor (RegR). Accumulating in vitro and in vivo evidence- including that using Reg transgenic...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2006    Investigator(s): Shin TAKASAWA
Intracellular Ca^<2+> mobilization in a variety of cells is known to be mediated by two major systems, the inositol 1,4,5-trisphosphate and cyclic ADP-ribose (cADPR) systems, and in normal islets, it has been proposed to be mediated by the cADPR-d...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2002    Investigator(s): 加藤一郎, Shin TAKASAWA
CD38 catalyzes both the formation and hydrolysis of cyclic ADP-ribose (cADPR). To elucidate whether the CD38/cADPR signaling system plays a significant role in Ca^<2+> cycling in vivo, we analyzed the myocardium of CD38 knockout mice (CD38KO).In C...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2000 - 2001    Investigator(s): 東郷暁, Koji NATA
Cyclic ADP-ribose (cADPR) induces the release of Ca^<2+> from microsomes of pancreatic islets for insulin secretion. It has been demonstrated that cADPR binds to FK506-binding protein (FKBP) on rat islet ryanodine receptor and that the binding of ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1999 - 2001    Investigator(s): Koji NATA
Regenerating gene (Reg) encodes a secretory protein with a growth stimulating effect on pancreatic β cells. Reg and Reg-related genes have been revealed to constitute a multigene family which consists of three subtypes. We have isolated three type...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Koji NATA
In 1984, we found that the administration of poly(ADP-ribose) synthetase inhibitors such as nicotinamide (NA) to 90% depancreatized rats induced islet regeneration, thereby ameliorating the surgical diabetes (Diabetes 33, 401). We isolated a gene,...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 1996 - 1998    Investigator(s): Ichiro KATO
1. We produced CD38 (+/-) mice by homologous recombination in ES cells and subsequent Cre-lox P recombination. By crosses between heterozygous mutants (+/-), homozygotes (-/-) were yielded in the F2 generation in a distribution following Mendelian...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1996 - 1997    Investigator(s): Masaru KOIZUMI
We studied genetic abnormalities affecting familial chronic pancreatitis (CP) in order to understandg its pathogenesis. We reviewed the reports of familial pancreatitis in Japan and the world. Hereditary pancreatitis was diagnosed according to Gro...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 1996 - 1997    Investigator(s): Koji NATA
1.To generate mutant mice lacking Reg I gene, the mutated Reg I gene, in which exon 2-3 was replaced by neomycin resistant gene, was electroporated in ES cells, and an ES cell clone mutated the Reg I allele was obtained. A male chimera transmitted...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1994 - 1995    Investigator(s): Masaru KOIZUMI
We studied the genetic abnormality affected the familial chronic pancreatitis (CP) for understanding the pathogenesis of chronic pancreatitis. Wereviewed the reports of familial pancreatitis. Seventy-four hereditary chronic pancreatitis patients f...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B))
Project Year: 1994 - 1995    Investigator(s): 高澤伸, 高沢伸, 高澤伸, Shin TAKASAWA
1.We isolated a cDNA for CD38, which has been reported to be a human leukocyte atigen, from a human insulinoma and expressed the cDNA in COS-7 cells. When we incubated the plasma membrane with fraction NAD^+ or cyclic ADP-ribose (cADPR) and analyz...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(試験研究(B))
Project Year: 1993 - 1995    Investigator(s): Hideto YONEKURA
Recently, cyclic ADP-ribose, a metabolite from NAD^+, has been shown to be a second messenger for intracellular Ca^<2+> mobilization and to play an essential role in insulin secretion from pancreatic beta-cells. Thus, a quantitative method for det...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1993 - 1994    Investigator(s): Tsukasa SASAKI
We investigated the basic electrophysiological characteristics of airway cells including tracheal submucosal gland acinar cells and tracheal smooth muscle. In addition, some roles of newly identified calcium mobilizing second messenger cyclic ADP-...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(試験研究(B))
Project Year: 1991 - 1993    Investigator(s): Hiroshi OKAMOTO
Many peptide hormones and neurotransmitters have the C-terminal alpha-amide structure and these alpha-amidated peptides are enzymatically synthesized from their glycine-extended precursors. The C-terminal alpha-amidation reaction proceeds via a tw...
Function and proliferation of insulin-producing pancreatic beta cell