論文

査読有り
2021年9月24日

The Impact of m1A Methylation Modification Patterns on Tumor Immune Microenvironment and Prognosis in Oral Squamous Cell Carcinoma

International Journal of Molecular Sciences
  • Li Gao
  • ,
  • Ru Chen
  • ,
  • Masahiro Sugimoto
  • ,
  • Masanobu Mizuta
  • ,
  • Yo Kishimoto
  • ,
  • Koichi Omori

22
19
開始ページ
10302
終了ページ
10302
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijms221910302
出版者・発行元
MDPI AG

N1-methyladenosine (m1A) modification widely participates in the occurrence and progression of numerous diseases. Nevertheless, the potential roles of m1A in the tumor immune microenvironment (TIME) are still not fully understood. Based on 10 m1A methylation regulators, we comprehensively explored the m1A modification patterns in 502 patients with oral squamous cell carcinoma (OSCC). The m1A modification patterns were correlated with TIME characteristics and the m1A score was established to evaluate the effect of the m1A modification patterns on individual OSCC patients. The TIME characteristics and survival outcomes under the three m1A modification patterns were significantly distinct. OSCC patients in the high m1A score group were characterized by poorer prognosis, lower immune infiltration, lower ssGSEA score, lower expression levels of immune checkpoint molecules, and higher tumor mutation loads. The present study revealed that m1A modification might be associated with the TIME in OSCC, and has potential predictive ability for the prognosis of OSCC.

リンク情報
DOI
https://doi.org/10.3390/ijms221910302
URL
https://www.mdpi.com/1422-0067/22/19/10302/pdf
ID情報
  • DOI : 10.3390/ijms221910302
  • eISSN : 1422-0067

エクスポート
BibTeX RIS